554 Background: In this study we present the updated 10-year results of our randomized trial, assessing the efficacy of 2 cycles of adjuvant etoposide + cisplatin (EP) combination following 4 cycles of standard doxorubicin (Adriamycin) + cyclophosphamide (AC) in premenapausal patients with operable breast cancer and axillary lymph node metastasis. Methods: Premenopausal patients with positive axillary lymph nodes following curative modified radical mastectomy were randomized to either 4 cycles of AC (Adriamycin + Cyclophosphamide) or 4 cycles of AC + 2 cycles of EP (Etoposide + Cisplatin) from May 1992 to May 1996. The doses were as follows: Cyclophosphamide 600 mg/m2 iv, adriamycin 60 mg/m2 iv, Etoposid 100 mg/d x 5 days iv, and cisplatinum 20 mg/m2/d x 5 days iv.Chemotherapy was repeated every 3 weeks. Results: One hundred and sixty five patients were enrolled (82 randomized to AC, 83 to AC + EP). Four patients from AC+EP group and 1 from AC group were excluded because of stage IIIb or IV disease. One h...