Ethylenediaminediacetic Acid Research Articles

Metal-ligand complexes involved in rheumatoid arthritis—VII Formation of binary and ternary complexes between 2,3-diaminopropionic acid, histidine and Cu(II), Ni(II) and Zn(II)

Formation constants for the systems listed in the title and for ethylenediaminediacetic acid (EDDA)—Cu(II), Ni(II) and Zn(II) systems are reported and used in computer simulation studies to assess the possibilities of such complexes (a) being formed in vivo, (b) being able to be absorbed into plasma following subcutaneous or oral administration, and (c) being able to mobilize copper from plasma into tissues to treat arthritis. It is concluded that further synthetic, simulation and animal screening studies based upon EDDA are desirable.

The Conformations of Copper(II) Complexes with edda-Type Optically Active Polyamino Carboxylic Acids in Aqueous Solutions

Abstract A copper(II) complex with (S,S)-1,1′-ethylenedipyrrolidine-2,2′-dicarboxylic acid (H2epro) was prepared, and its absorption and CD spectra were measured in an aqueous solution. A weak absorption band at 9500 cm−1 was indicative of the apical coordination of the carboxylate group. Furthermore, from the fact that the effect of unidentate bases, such as pyridine and ammonia, on the absorption and CD spectra of the epro complex was quite different from that of bidentate bases, the epro complex was expected to take a Λ-uns-cis conformation. In addition, the base-addition effect was measured for the complexes of (S,S)-α,α′-dimethyl-N,N′-ethylenediaminediacetic acid(H2eddp), (S,S)-α,α′-diisopropyl-N,N′-ethylenediaininediacetic acid(H2eddv), and (S,S)-α,α′-dibenzy-N,N′-ethylenediaminediacetic acid(H2eddc). The conformations of these complexes are also discussed on the basis of the information obtained for the epro complex.

IR spectroscopic study of ethylenediaminediacetic acid and its salts

1. Ethylenediaminediacetic acid and its salts were investigated by the method of IR spectroscopy. The highly characteristic nature of the absorption bands of the CN and NH bonds in the spectra of the compounds studied was demonstrated. 2. The presence of the absorption bands of the CH bond, belonging to two different types of methylene groups — from ethylenediamine and from the aceto groups — was established in the spectra of the acid and its derivatives. Of the absorption bands of the CH bond, the low-frequency bands belonging to the methylene groups of ethylenediamine are characteristic.

Importance of asymmetric nitrogens to the circular dichroism of alkyl-substituted ethylenediaminediacetic acid complexes of cobalt(III)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTImportance of asymmetric nitrogens to the circular dichroism of alkyl-substituted ethylenediaminediacetic acid complexes of cobalt(III)Carolyn W. Maricondi and Bodie E. DouglasCite this: Inorg. Chem. 1972, 11, 4, 688–691Publication Date (Print):April 1, 1972Publication History Published online1 May 2002Published inissue 1 April 1972https://doi.org/10.1021/ic50110a005RIGHTS & PERMISSIONSArticle Views71Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (512 KB) Get e-Alerts Get e-Alerts

Chromium(III) Complexes with N,N′-Ethylenediaminediacetic Acid

Abstract The following chromium(III) complexes containing N,N′-ethylenediaminediacetic acid (EDDA) were newly prepared: [Cr(Hedda)2]Cl·3H2O (red) (I), [Cr2(OH)2(edda)2]·6H2O (purple) (II), H[Cr(edda)(ox)]·2H2O (purple) (III), [Cr(edda)(dip)]I·5H2O (orange) (IV), K[Cr(NCS)2(edda)]·H2O (reddish purple) (V) and [Cr(Cl)(edda)(H2O)]·3H2O (bluish purple) (VI), where edda, ox and dip are the abbreviations of the N,N′-ethylenediaminediacetate and oxalate anions, and α,α′-dipyridyl respectively. On the basis of the experimental results, it was concluded that EDDA is coordinated as a terdentate ligand in complex I and as a quadridentate in the other complexes prepared in the present work. Furthermore, it was also suggested that complex II has a dimer structure and complex V has trans configuration (with respect to the coordinated carboxylate oxygen).

Circular dichroism of trans-N,N'-ethylenediaminediacetic acid cobalt(III) complexes

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCircular dichroism of trans-N,N'-ethylenediaminediacetic acid cobalt(III) complexesJ. Ivan Legg, Dean W. Cooke, and Bodie E. DouglasCite this: Inorg. Chem. 1967, 6, 4, 700–706Publication Date (Print):April 1, 1967Publication History Published online1 May 2002Published inissue 1 April 1967https://doi.org/10.1021/ic50050a014RIGHTS & PERMISSIONSArticle Views114Altmetric-Citations59LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (765 KB) Get e-Alerts Get e-Alerts

Complexes of the Rare Earths. III. Mixed Complexes with N-Hydroxyethylethylenediaminetriacetic Acid

The tendency of the 1: 1 rare earth-N- hydroxyethylethylenediaminetriacetic acid (Ln(HEDTA)) chelates to form mixed 1: 1: 1 chelates with glycine, ethylenediaminediacetic acid (EDDA), iminodiacetic acid (IMDA), and N-hydroxyethyliminodiacetic acid (HIMDA) was investigated. Mixed complex formation was found in all cases but formation constants could only be obtained for the IMDA, HIMDA, and some of the EDDA complexes. The mixed complexes were quite stable and the formation constants exhibited trends, which can reasonably be explained by the properties of the ligands and steric factors. Evidence for a coordination number larger than six in the rare earths is summarized and additional evidence is presented, which indicates that in the mixed chelates the rare earths have an expanded coordination number.

Complexes of the rare earths—II: N,N′-ethylenediamine-diacetic acid

Step-wise stoicheiometric formation constants have been determined for the rare earths (including yttrium) with N,N′-ethylenediaminediacetic acid. The measurements have been made in aqueous solutions of ionic strength μ = 0·1 (KNO 3) and a temperature of 25°C. The data have been interpreted in terms of 1:1 and 2:1 chelates. Trends in the values of log K 1 and log K 2 are discussed and compared with similar values for other aminopolycarboxylate complexes. It is further shown that the values of log K 2 are of such a magnitude as to suggest that the rare-earth ions exhibit a co-ordination number larger than six.

Dekorporation von radionukliden durch veresterte Polyaminopolycarbonsäuren

Based on certain assumptions concerning the mode of action of chelating agents, the effect of the ester resp. lactone of the hydroxyethylethylenediaminetriacetic acid and bis(2-hydroxycyclohexyl)ethylenediaminediacetic acid on the behaviour of radio-cerium and radio-yttrium in the organism of the rat was studied. Whereas the calcium chelates of the polyamino acids are ineffective, the esters, even given orally, induce a pronounced reduction of the radionuclide content of the liver. The radionuclides in this case are preferentially excreted with the faeces. The effectiveness of the esters depend largely on the time of the administration. The implications of the experimental findings are discussed.

Stability of Metal Chelates. IV. N,N'-Ethylenediaminediacetic Acid and N,N'-Ethylenediaminediacetic-N,N'-dipropionic Acid

Stability of Metal Chelates. IV. N,N'-Ethylenediaminediacetic Acid and N,N'-Ethylenediaminediacetic-N,N'-dipropionic Acid