Background: Modern livestock health care is still at its lowest stage in Ethiopia and most modern veterinary services like drugs and veterinary professionals are not accessible and affordable to the majority of pastoral farmers. As a result, they are heavily relying on their traditional knowledge and practices on locally available materials mainly plants in the management of animal diseases. However, this traditional knowledge has not yet been well documented and analyzed. Therefore, this study was conducted to identify medicinal plants and examine factors that threaten ethno-veterinary. Methods: This study was conducted in Ethiopian Somaliland regional state, Shinle zone. Survey was conducted to gather information from 180 households on indigenous knowledge using a semi-structured questionnaire and filed guided observations. The data was collected and analyzed using SPSS. The variability of documented knowledge and the homogeneity of the information given by the respondents were estimated by informant consensus factor. Results: Thirty-one plant species belonging to eighteen families used against fourteen types of livestock health problems. Majority of plant identified fall under Fabaceae (22.5%) and Euphorbiaceae (16.1%) family that are largely shrubs. The most commonly used plant parts were roots (35.5%) followed by leaves (25.8%). Remedy preparation was mainly through chop and soak in concoction of water and salt. Oral, topical and nasal route were the common mode of administration with no standardized dosing and treatment duration. The principal threats of medicinal plants were invasive plants, drought, over grazing, agricultural activity and firewood collection. Indigenous knowledge on ethno-veterinary medicinal plants was accepted orally from healer’s forefathers and transmitted similarly. Conclusion: Awareness should be raised and ethno-veterinary medicine should be integrated in to livestock extension delivery systems for the need to exploit the possibility of discovering more medicinally viable plants. Further studies needed under controlled conditions on the efficacy of such plants.