PurposeThe purpose of this study was to evaluate the effect of surface treatments on zirconia-resin bonding and the effect of aging on bond durability for one year.MethodThree hundred and twenty zirconia blocks were divided into 4 equal study groups. Group 1 (control): as-sintered, group 2: (GB): grit-blasted, group 3: (LAS): laser-etched, group 4: (SIE): selective infiltration etching. Composite cylinders were bonded to the zirconia with resin cement and ceramic primer. Aging was performed following 3 different aging protocols: thermocycling, storage in distilled water, or storage in an enzymatic esterase solution. Micro-shear bond strength test (μSBS) was recorded using a universal testing machine. μSBS values were analyzed using two-way Analysis of Variance followed by Tukey post-hoc tests. Level of significance was set at 0.05.ResultsGB, LAS and SIE groups showed significantly higher values when compared to control. Groups GB, LAS and SIE reported a significant decrease up to 50% in μSBS after water storage and enzymatic degradation, while control group reported a 90% decrease. Failure analysis showed mainly adhesive failure for control group, while the percentage of cohesive failure in resin cement was higher in SIE group compared to GB and LAS groups.ConclusionWater aging and esterase solutions played a significant role by increasing bond degradation. A minimum of one-year water and esterase storage medium should be used to evaluate the durability of the bond between resin cement and zirconia.