Erythroplasia Research Articles

Oral Squamous Cell Carcinoma: A Case Report and Review of Literature

Oral squamous cell carcinoma (OSCC) is the most common malignancy in the oral cavity. Its etiology is multifactorial, being the most important risk factors tobacco smoking and alcohol consumption. Predominantly affects older people, mostly male, from 40 years with a peak at the age of 60 years. The most common locations are the tongue and floor of the mouth. The clinical presentation is variable, highlights ulcerating type, such as leukoplakia, erythroplasia or a combination of both. Often their behavior is aggressive and the diagnosis is often made at a late stage, with lesions of considerable size and invasive in depth. The aim of this paper is to present a case of OSCC in advanced stage, located in the left buccal mucosa and demonstrate the importance of early diagnosis.

Treatment of erythroplasia of Queyrat: current status and advances

Erythroplasia of Queyrat (EQ) , an in situ intraepidermal squamous cell carcinoma, is considered as Bowen′s disease of the glans and prepuce. EQ is seen almost exclusively in uncircumcised middle-aged or older men, and may progress into invasive squamous cell carcinoma in about 33% of patients. Effective treatments include local excision, Mohs surgery, partial or total penectomy, topical 5-fluorouracil 5% ointment or imiquimod 5% cream, cryotherapy, radiotherapy, laser therapy, photodynamic therapy, and so on. Traditional topical treatment is simple to operate and easily accepted by patients, but recurrence is frequent. Recently, photodynamic therapy and laser therapy have developed rapidly and become the first-line therapy of EQ. However, surgical treatment is still considered the golden standard therapy for EQ with reduced recurrence. The recurrence rate is lower than 2% in patients with EQ of the glans and prepuce after removal of lesions, but the appearance and function of the penis are usually affected by surgical operation. The selection of treatment approaches depends on the immune status of, lesional sites in and will of patients. Key words: Erythroplasia; Neoplasms, squamous cell; Surgical procedures, operative; External application drugs; Clinical protocols

Papulose bowenóide: um aspecto clínico da infecção pelo HPV

Papulose bowenóide é uma doença que acomete a pele da região anogenital e que se caracteriza pelas múltiplas pequenas pápulas planas ou aveludadas e de coloração que varia do róseo ao castanho-escuro. É provocada pelo HPV e a transmissão sexual é a forma mais freqüente de contaminação. As queixas mais comuns são prurido e dor. O aspecto é característico e o exame histopatológico confirma o diagnóstico. Junto com a doença de Bowen e a eritroplasia de Queyrat, é considerada como carcinoma in situ, ou neoplasia intra-epitelial de alto grau (NIAA), a lesão precursora do carcinoma espinocelular (CEC) anal. Sem tratamento, a maioria das lesões permanece benigna e estável. Várias modalidades terapêuticas estão disponíveis, incluindo as medicações tópicas para citodestruição e as técnicas ablativas. Os esquemas tópicos são efetivos. Cabe ao profissional médico escolher a terapia adequada, tendo em mente que a doença é benigna e raramente evolui para carcinoma. Como as recidivas são freqüentes e ainda persistem dúvidas quanto ao potencial de malignização, os doentes devem ser examinados periodicamente para diagnosticar as lesões iniciais.

Circumcision and Genital Rashes

The presence of a foreskin is a well-known risk factor for penile squamous cell carcinoma, erythroplasia of Queyrat, and sexually transmitted diseases.