Erythematous Edematous Plaques Research Articles

32372 Eosinophilic cellulitis secondary to trimethoprim-sulfamethoxazole

A 51-year-old female presented with 3 weeks of multiple itchy plaques on her left leg and right forearm. Her medical history was significant for recent bilateral mastectomy with lymphatic drain placement for treatment of invasive ductal carcinoma. Several days after drain placement, she was started on trimethoprim-sulfamethoxazole for concern of cellulitis at the drain site. Nine days later, she developed this eruption without systemic symptoms. Physical examination revealed multiple erythematous edematous plaques located on the left buttock, left thigh, and right forearm.

34468 Autoimmune progesterone dermatitis following infertility treatment

A 50-year-old woman with a medical history of polycystic ovarian syndrome presented for acute onset of a pruritic rash on bilateral upper and lower extremities. On examination, erythematous edematous plaques consistent with urticaria were present on the bilateral upper and lower extremities. A punch biopsy of a thigh lesion showed urticaria with no evidence of vasculitis. She was prescribed cetirizine for acute urticaria. At her 1-month follow-up visit, she reported continued urticaria nightly along with erythema and swelling of the hands and fingers, dizziness, and nausea.

Burning urticarial plaques in a middle-aged woman

Burning urticarial plaques in a middle-aged woman

Contact Dermatitis With the Homoeopathic Medicine Calendula officinalis: A Rare Case Report

Introduction: Herbal medicines and other traditional medicines are well accepted in India and are readily available as over-the-counter preparations. With their increased use, the safety and quality of homoeopathic medicines have become a major concern for health authorities, pharmaceutical industries, and consumers. It is difficult to assess the adverse effects of homoeopathic medicines due to a lack of scientific evidence regarding their safety and efficacy in clinical trials or post-marketing surveillance. Here, we reported a patient with contact dermatitis due to the homoeopathic medicine Calendula officinalis. Case presentation: A 33-year-old previously healthy woman presented with pruritus, redness, and swelling over the entire face and upper neck. The symptoms developed within about 1 hour after the use of a homoeopathic skin ointment containing 2% Calendula officinalis as the major ingredient in an aqueous base. Cutaneous examination revealed periorbital edema and facial swelling with multiple vesicular eruptions over erythematous edematous plaques on the face. A clinical diagnosis of contact dermatitis was considered. Discussion: Many herbal preparations in India are available without safety data. Calendula officinalis extract (oil expressed from seeds) is used in various skin products. The exact allergens present in Calendula officinalis are unknown, but the flowers reportedly contain a variety of phenolic acids and phenylpropanoids that have elicited contact dermatitis. Conclusion: Anecdotal case reports of accidental exposure/sensitization and experimental studies provide sufficient evidence to confirm the causal relationship between contact dermatitis with Calendula Officinalis. Post-marketing surveillance of all homoeopathic medicines should be mandatory, and the availability of such preparations as over-the-counter drugs must be restricted.

A rare case of Acute Febrile Neutrophilc Dermatosis – Sweet’s syndrome

Sweet syndrome is an inflammatory dermatosis characterized by non-itchy, sometimes tender, erythematous plaques and papules most commonly distributed on the arms, upper body, head and neck. Histological findings include a dense dermal neutrophilic infiltrate with oedema. We report a case of 32year old female patient with solitary well defined erythematous edematous plaques with whitish scales at the centre of the lesion present over the extensor aspect of left forearm since 5days with sparing of palms , soles and mucosae. Laboratory investigations and histopathology were suggestive of Neutrophilic dermatoses (Sweet’s syndrome). This case was presented to highlight Atypical presentationof sweet syndrome – annular morphology and localization of lesions only over left forearm Therefore high index of suspicion is needed for its diagnosis in cases of solitary and isolated presentation along with necessary histopathological and laboratory investigations.

A rheumatoid arthritis patient with chronic recurrent annular neutrophilic dermatosis: Are we dealing with a new type of rheumatoid arthritis-associated dermatosis?

Abstract Neutrophilic dermatoses comprise a heterogeneous group of disorders, which are characterized by inflammatory skin lesions that share a common histopathological feature, intense inflammatory infiltration consisting primarily of neutrophils, with no evidence of vasculitis. We describe a 75-year-old man with rheumatoid arthritis, who presented with erythematous edematous plaques. The histopathological findings indicated neutrophilic dermatosis; however, the patient was afebrile and without an elevated white blood cell count or systemic involvement. We think that the most suitable expression for this variant with clinical manifestations different from those of classical Sweet syndrome is chronic recurrent annular neutrophilic dermatosis, as introduced by Christensen et al. 1

Treatment of Bullous Systemic Lupus Erythematosus.

Bullous systemic lupus erythematosus (BSLE) is an autoantibody-mediated vesiculobullous disease in patients with SLE. Autoimmunity in BSLE is characterized by the presence of circulating anti-type VII collagen antibodies. BSLE patients often present with multiple, tense, clear fluid-filled vesicles and bullae overlying erythematous edematous plaques. Skin biopsy from BSLE patients shows subepidermal bullae with numerous neutrophils and only occasional eosinophils. Furthermore, immunofluorescence examination showed linear deposition of lgG, lgA, C3, and C1q along the basement membrane zone. BSLE patients with corticosteroids treatment constantly do not receive a marked improvement, while dapsone generally dramatically improved the skin condition. Recently, it has been reported that quite a few cases of BSLE were successfully treated with other immune suppressive drugs. Therefore, a comprehensive review of the treatment of BSLE would be beneficial to cure the disease.

Allergic contact dermatitis due to ginkgo tree fruit and leaf

The patient was a 66-year-old woman who had picked ginkgo tree fruit from among ginkgo leaves with a glove in a field and collected ginkgo nuts within the fruit. Five days later, she developed erythematous edematous plaques and papulovesicles accompanied by pruritus on her forearms (figure 1A), face and neck (figure 1B). Her medical history included allergic contact dermatitis with lacquer trees and mangos. A biopsy specimen from erythematous edematous plaques on her forearm showed spongiosis, exocytosis, [...]

SÍNDROME DE SWEET - RELATO DE CASO E REVISÃO DE COMO INVESTIGAR E TRATAR

Introdução: A sindrome de Sweet é uma dermatose neutrofílica que apresenta lesões cutâneas agudas na forma de placas e nódulos eritemato edematosos. Outras alterações como febre, leucocitose periférica, artralgia, mialgia, cefaléia, acometimento ocular, oral e de órgãos internos podem ocorrer. O objetivo deste trabalho é discu- tir o quadro clínico, critérios diagnósticos, abordagem investigativa e possíveis tratamentos para esta enfermidade. Caso Clínico: Paciente, sexo feminino, 45 anos, branca, com sindrome de Sweet idiopática tratada com glicocorti- cóides. Ao exame, apresentava placas eritematosas, edematosas com pseudovesiculação na face, tronco, membros superiores e inferiores. O exame histopatológico mostrou intenso edema, infiltrado de neutrófilos, leucocitoclasia e extravasamento de hemácias na derme superior. Discussão: A sindrome de Sweet pode estar relacionada ao uso de medicamentos, gestação, inflamações, infecções e malignidades. As neoplasias mais frequentemente associadas são as hematológicas, em especial a leucemia mielóide aguda. Apesar de os glicocorticóides serem tratamentos de elei- ção na sindrome de Sweet, existem outras alternativas terapêuticas. PALAVRAS-CHAVE – Síndrome de Sweet; Síndrome paraneoplásica; Dermatose neutrofílica.

Dermatosis neutrofílica crónica recurrente: una posible variante en el espectro de las dermatosis neutrofílicas

Neutrophilic dermatoses constitute a clinically heterogeneous group of diseases that share a common histological substrate, consisting of a dense dermal inflammatory infiltrate of mature polymorphonuclear neutrophils and no evidence of vasculitis. We describe the case of a 56-year-old man with a 6-month history of painful generalized erythematous edematous plaques. Histopathology indicated neutrophilic dermatosis but the patient did not have fever, elevated white blood cell count, or systemic involvement. Tests to rule out possible inflammatory, neoplastic, or infectious processes were negative. We consider the term chronic recurrent annular neutrophilic dermatosis, first used by Christensen et al, to be the most appropriate to define this variant with clinical findings that differ from classic Sweet syndrome.

Chronic Recurrent Neutrophilic Dermatosis: A Possible Variant in the Spectrum of Neutrophilic Dermatoses

Neutrophilic dermatoses constitute a clinically heterogeneous group of diseases that share a common histological substrate, consisting of a dense dermal inflammatory infiltrate of mature polymorphonuclear neutrophils and no evidence of vasculitis. We describe the case of a 56-year-old man with a 6-month history of painful generalized erythematous edematous plaques. Histopathology indicated neutrophilic dermatosis but the patient did not have fever, elevated white blood cell count, or systemic involvement. Tests to rule out possible inflammatory, neoplastic, or infectious processes were negative. We consider the term chronic recurrent annular neutrophilic dermatosis, first used by Christensen et al, to be the most appropriate to define this variant with clinical findings that differ from classic Sweet syndrome.