Catechins for use in cardiovascular disease: Molecular mechanisms and contemporary bioassays.

EGCG inhibits hepatic stellate cell activity and liver fibrosis by targeting the MDM2/MUC5AC-mediated TGF-β1/Smad signaling pathway.

Formation and characterization of soy protein isolate-chitosan-epigallocatechin gallate ternary complexes: Molecular interactions and functional properties.

Thermal processing modulates the interaction between whey proteins with variable hydrolysis and polyphenols: Implications for structural and functional properties.

EGCG alleviates colitis in inflammatory bowel disease via gut microbiota-derived LCA and inhibition of NLRP3 inflammasome.

Dual targeting of human and bacterial hyaluronidases by skincare bioactives: Mechanistic basis and functional evidence.

Ultrastructural investigation of pellicle modification by statherin-derived peptide associated with epigallocatechin-3-gallate to prevent dental erosion: In situ proof-of-concept.

EGCG attenuates Cd reproductive toxicity in Caenorhabditis elegans by modulating ER-mitochondrial interactions.

The combination of epigallocatechin gallate with exopolysaccharides from Bacillus subtilis STB22 enhances α-amylase inhibitory activity.

Multi-scale quality evaluation and geographical origins discrimination of Ankang green tea by intelligent sensory analysis, selenium elemental analysis and quantitative non-volatile sensometabolomics.

Insights into the soybean protein isolate hydrolysates-EGCG complex: Performance characterization, emulsion construction and digestive behavior.

Engineering microalgae-based oxygenators for hypoxia relief and enhanced photodynamic therapy against biofilms in diabetic wounds healing.

Ferroptosis, an instance of iron-dependent programmable cell death that results from oxidative stress & lipid peroxidation, has garnered interest due to its associations with cardiovascular diseases, such as atherosclerosis, myocardial infarction, as well as heart failure. Unlike necrosis or apoptosis, ferroptosis involves unique metabolic pathways that disrupt cellular redox balance and lipid homeostasis, leading to substantial cell damage in cardiovascular tissues. It is becoming recognized that phytoconstituents-bioactive compounds derived from plants-can modify ferroptosis pathways and provide cardioprotective advantages. Compounds including curcumin, resveratrol, quercetin, tanshinone IIA, and epigallocatechin gallate (EGCG) have shown potential in preclinical studies by concentrating on significant ferroptotic processes. Finally, by controlling iron homeostasis, boosting antioxidant responses (such as Nrf2 pathway activation), and reducing lipid peroxidation, these phytochemicals may mitigate ferroptosisinduced cardiac cell death. In animal studies, these natural compounds have shown promise in reducing oxidative damage and improving heart function after injury. This article summarises the mechanisms via which a variety of phytoconstituents influence ferroptosis and discusses their potential as an adjuvant treatment for CVD. While these findings are encouraging, further research is needed to use them in clinical settings, with a focus on long-term safety in human populations, optimal dose, and absorption. The cardioprotective properties of phytoconstituents, which focus on ferroptosis, may provide a unique, plant-based therapeutic strategy for the treatment of CVDs.

Formation mechanism analysis of bitterness and astringency during Enshi Yulu green tea processing by metabolomics and sensomics.

Developing artificial reactors for the synthesis of peroxy (O-O) bonds offers a new route to the creation of flexible intermediate platforms. Herein, we report a selective spontaneous reaction of flavonoid with γ-cyclodextrin (γ-CD) in cyclodextrin metal-organic framework (CD-MOF-1). Remarkably, simple incubation of flavonoids within CD-MOF-1 at ambient conditions in the dark leads to the spontaneous formation of an O-O bond between flavonoid and γ-CD. Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) and nuclear magnetic resonance (NMR) results confirm that the isolated flavonoid-γ-CD compounds involve O-O bonds and preferentially form at the hydroxyl in the flavonol C ring (e.g., quercetin) or at the meta-phenol hydroxyl on the flavone B ring (e.g., epigallocatechin gallate, EGCG). Intriguingly, flavonoids bearing both meta- and para-hydroxyl groups in the B ring (e.g., EGCG) or those with an adjacent carbonyl on the C ring (e.g., quercetin) underwent this reaction, whereas flavonoids lacking these features (e.g., taxifolin, luteoline, apigenin, naringenin, hesperetin and daidzein) cannot trigger this reaction. Density functional theory (DFT) calculations indicate that potassium (K+) cations in the CD-MOF-1 reduce the bond dissociation energies (BDEs) of the relevant hydroxyl groups, catalyzing O-O bond formation. This work reveals that CD-MOF-1 can orchestrate the precise arrangement of reactants and activate their specific sites, enabling selective O-O bond formation under mild and dark conditions. We expect this discovery to encourage further development of CD-MOF-1-based platforms for mild, selective oxidative transformations and the generation of novel intermediates.

A hierarchically EGCG-coated black phosphorus/PI scaffold for vascularized bone regeneration in large infectious area.

Metal-phenolic networks assisted construction of multi-layered endothelium-mimetic polyelectrolyte coating with nitric oxide generation and glycocalyx functionalization.

Epigallocatechin gallate modified nanoliposome for co-delivery of quercetin and 5-aminolevulinic acid enhances the inhibitory efficiency of growth and metastasis in breast cancer cells

The combination of epigallocatechin gallate with exopolysaccharides from Bacillus subtilis STB22 alleviates hyperglycemia by regulating gut microbiota and metabolites in type 2 diabetic mice

Synergistic antioxidant action and enhanced digestive utilization of Corbicula fluminea protein enabled by binding to epigallocatechin gallate