Epidemiological Characteristics Research Articles

Eye on impact: An analysis of blunt ocular trauma cases at a tertiary eye care centre in South India

This study investigates the epidemiology, injury mechanisms, and clinical features of blunt ocular trauma. It aims to assess the prevalence of these injuries and the extent of vision loss among patients at a tertiary eye care center in South India.A retrospective observational study was conducted at a teaching hospital over four months, from June 2024 to September 2024. The study included 417 patients of all age groups who visited the outpatient department of a tertiary eye care center after experiencing blunt ocular trauma. Data were collected on the cause and circumstances of the injury, injury mechanism, clinical features, management, and visual outcomes.This study included 417 patients, with the majority falling into the 21–30 year age group. Men had a higher rate of eye injuries than women, and the most common cause of injury was road traffic accidents (35.97%). The predominant type of ocular injury was closed globe injuries, with an incidence of 95.92%. Additionally, 17.2% of the patients required surgical intervention.Most blunt ocular trauma is caused by road traffic accidents, followed by physical assaults, with young men being the most affected. This underscores the need for preventive measures, such as wearing helmets and avoiding driving under the influence of alcohol, to reduce the incidence of these injuries. Public awareness campaigns can play a vital role in promoting safety and protecting vulnerable populations.

The epidemiology of road traffic injuries in the republic of Serbia: a study based on hospital data, 2015-2019

IntroductionRoad traffic injuries (RTI) are the leading cause of death and severe disability among individuals under the age of 40, posing a significant public health challenge globally. This manuscript highlights key aspects of the epidemiology of injuries in road traffic crashes (RTC) in Serbia, based on hospitalization report data.ObjectivesThe main aim of this study was to analyze the epidemiological characteristics of road traffic injuries (RTI) based on hospital data over a five-year period in Serbia.MethodsThe data for this study were obtained from the Hospitalization Report, which is part of the hospitalization database maintained by the Institute for Public Health of Serbia “Dr Milan Jovanović Batut,” covering the period from January 2015 to December 2019. The research included data from the Hospitalization Reports of 66 healthcare institutions across Serbia.ResultsDuring the study period, a total of 15,028 patients with road traffic injuries were admitted to healthcare institutions in Serbia. During the five-year period, the crude RTI incidence rate increased every year, from 39.0/100, 000 in 2015 to 43.7/100,000 in 2019. Older adult people aged 65 and over were particularly vulnerable as bicyclists and pedestrians (31.3, 27.7%, respectively). The Vojvodina region experienced a higher incidence of injuries among bicyclists compared and car accidents were most frequent in Central Serbia than in the other regions of Serbia. Craniocerebral injuries were the most common type of road traffic injury, accounting for 37.8% of cases. Significant differences in the types of injuries were observed based on age (χ2 = 649.859; p < 0.001) and gender (χ2 = 31.442; p < 0.001).ConclusionUnderstanding the epidemiological profile of road users involved in accidents is essential for monitoring and controlling specific risk factors. Our results highlight the need for enhanced traffic safety measures at the local level.

The Rising Threat of Mucormycosis: Oman’s Experience Before and During the COVID-19 Pandemic

Mucormycosis is a rare, severe fungal infection mainly affecting immunocompromised individuals. Because of limited data on its epidemiology in Oman, we present this national, multicentric, retrospective review that includes all cases of proven mucormycosis between 2006 and 2022 in Oman. There were 51 cases of mucormycosis reported in Oman. The annual incidence of mucormycosis was 0.38–0.69 cases per million population before COVID-19. During the pandemic, the incidence rose significantly to 1.76 in 2020, 5.31 in 2021, then decreased to 0.87 per million population in 2022. Diabetes was observed in 82.4% (n = 42) of the cases, COVID-19 in 47.1% (n = 24), and other chronic diseases in 72.6%. The use of steroids was reported in 33.3% (n = 17) and many patients (64.7%, n = 33) had multiple risk factors. The overall mortality rate was 41.2% (n = 21) and most deaths occurred within a month of diagnosis. Mortality rate among patients diagnosed with COVID-19 was 58.3% (14/24). Survival analysis showed a statistically significant association between COVID-19 status and patient survival (p = 0.024). Annual incidence of mucormycosis in Oman rose during the pandemic. This study highlights the epidemiological features of mucormycosis and emphasizes the importance of its inclusion in the national notifiable communicable diseases priority list as well as the importance of enhancing diagnostic capacities to detect and improve patient outcomes.

Exploring Risk Factors Associated With Intensive Care Unit Admission in a Retrospective Cohort of 631 Children With Bronchiolitis.

Examine the trends and epidemiological features of acute hospitalized bronchiolitis cases among children aged 28 days to 2 years, both before and after the COVID-19 pandemic. Furthermore, evaluate their need for intensive care unit (ICU) admission and identify primary risk factors associated with severe bronchiolitis. A retrospective analysis was conducted on the medical records of paediatric patients admitted to Meyer Children's Hospital in Florence (Italy) from September 2019 to March 2023, with the diagnosis of bronchiolitis. Between 2019 and 2023, bronchiolitis hospitalizations grew by 76%, going from 131 to 230 cases, after the historical minimum of 14 cases in the 2020-2021 season. Respiratory syncytial virus (RSV) infection emerged as the predominant etiological agent, contributing to 76% of hospitalizations in both 2021-2022 and 2022-2023 seasons. Coinfection cases increased fivefold from 2019 to 2023, accounting for 23% of hospitalizations in 2022-2023. In addition, the ICU admission rate increased from 13% in 2019-2020 to 31% of bronchiolitis hospitalizations in 2022-2023. Univariate and multivariate analysis data show that infants below 2 months of age, preterm births, comorbidities and RSV infections were correlated with a higher risk for ICU admission. The growing trend in ICU admissions for acute bronchiolitis in hospitalized children represents a substantial health challenge. Addressing the bronchiolitis epidemic necessitates a strategic focus on RSV prevention through interventions such as vaccines and monoclonal antibodies. Urgent implementation of preventive initiatives, together with continuous surveillance and the establishment of national databases, is imperative and cannot be further deferred.

Viral hepatitis A in children: a false prosperity?

The article presents current data on the state of the issue of Hepatitis A (HA) in children in the Russian Federation and describes clinical and epidemiologic features of rare cases of severe course of the disease, as well as pathogenetic mechanisms of liver damage mediated by cell immune response. Objective. To identify clinical and epidemiologic features of the modern course of HA and its outcomes in children of Saint Petersburg within the period of 2018— 2023. Materials and methods. The study included 89 children diagnosed with HA, undergoing treatment at the Children's Research and Clinical Center for Infectious Diseases from 2018 to 2023. The analysis of disease progression in this group of patients was presented using clinical-anamnestic, epidemiologic, biochemical, virologic and instrumental data. Results. The analysis of infection sources showed a high frequency of HA infection within the family (44.9 ± 0.8%) and significantly less in childcare facilities and schools (7.9 ± 1.0%). The frequency of children with unidentified sources of infection remained high (47.2 ± 0.7%). One-third of all disease cases were imported from southern regions. Most hospitalized children had icteric HA (64.0 ± 0.6%) of moderate severity (79.8 ± 0.5%). Severe HA was observed in 6 patients (6.7 ± 1.0%). During the study, 17 patients (19.1 ± 0.9%) had a prolonged, complicated course of the disease, including ascites and aplastic anemia (12.6 ± 2.2%). Ascites was found in 4 patients with severe severity and in 5 patients with moderate severity of HA. Conclusions. Currently, there is an upward trend in the incidence of HA in the Russian Federation and Saint Petersburg, especially among schoolchildren (56.2%). A rather high frequency of severe (6.7%) and complicated forms (19.1%) of the disease is observed, and the growth of ascites and aplastic anemia cases in HA draws particular attention.

Treatment uptake among notified cases of hepatitis C virus infection in Norway, 1990 to 2022: a registry-based study to monitor progress towards elimination.

BackgroundHepatitis C virus (HCV) infection is targeted for elimination as a public health threat by 2030. The World Health Organization goal for treatment uptake is ≥ 80% among cases diagnosed with an active HCV infection (RNA- or core antigen-positive), maintained for 2 years.AimTo calculate treatment uptake, time from diagnosis to treatment start and complete treatment dispensation among notified cases of HCV infection in Norway.MethodWe linked national data on notified cases diagnosed from 1990-2022 to dispensed prescriptions for HCV treatment from January 2004-February 2023 and data on residence status at the end of 2022. We described treatment uptake by demographic and epidemiological characteristics. We calculated the median number of months from diagnosis to treatment start by year. For direct-acting antiviral treatment periods, complete dispensation was based on the treatment and number of defined daily doses.ResultsAmong 12,178 notified cases that had an active infection at diagnosis and were still resident, 10,091 (83%) had received treatment. Uptake among resident cases was > 80% in 2021 and 2022. The median number of months from diagnosis to treatment decreased over time to 3 (interquartile range: 1-5) among cases diagnosed in 2021 and 2022. From 2015-22, 89-93% of direct-acting antiviral treatment periods annually had complete treatment dispensed.ConclusionNorway has achieved the elimination goal for treatment uptake among notified cases diagnosed with an active HCV infection. This highlights the benefit of a strategy that includes unrestricted, simplified and integrated treatment options.

Comparative analysis of the epidemiological characteristics of adenovirus, rotavirus A, and coinfection in children during 2014-2023 in Guangzhou, China.

Infection is the cause of diarrhoea, and rotaviruses and adenoviruses are important pathogens in children. A retrospective study was conducted on 144,067 children with diarrhoea between 2014 and 2023 in China. We used the colloidal gold method to detect intestinal adenovirus and rotavirus A antigens in faeces. The epidemiological characteristics of these viruses and the impact of meteorological factors on them were analysed before and after coronavirus disease 2019 (COVID-19) pandemic. During this decade, the positive rate of adenovirus infection was 6.41%, while the positive rate of rotavirus A infection was 11.81%, higher than that of adenovirus infection. The positive rate of adenovirus and rotavirus A coinfection was 1.92%. The positive rates of adenovirus, rotavirus A and coinfection showed a fluctuating trend, and suddenly decreased in 2020. There was an apparent decrease of positive rate of rotavirus A, with a decrease of 57.27%, during 2020-2023. Surprisingly, the positive rate of adenovirus infection exceeded that of rotavirus A infection in 2021 and 2023. During the COVID-19 pandemic, the proportion of female patients and children over two years of age infected with adenovirus or rotavirus A increased, while the proportion of cases in winter decreased. In addition, we found that the positive rate of rotavirus A infection was related to average temperature and sunshine, and the positive rate of adenovirus and rotavirus A coinfection was only related to sunshine. However, these correlations disappeared during the COVID-19 pandemic. This study revealed the recent prevalence of adenovirus and rotavirus A infections in children with diarrhoea in south-central China and provided a theoretical basis for the prevention and control of viral diarrhoea.

Epidemiology of invasive meningococcal disease, Japan, 2013 to 2023.

BackgroundThe National Surveillance for Invasive Meningococcal Disease (IMD) initiative started in Japan in April 2013. Multiple international mass gathering events have since been held in Japan, and the COVID-19 pandemic has occurred.AimWe summarised 10 years of national surveillance data for IMD in Japan to describe epidemiological characteristics of IMD and evaluate the influence of mass gatherings and the COVID-19 pandemic on IMD.MethodsUpon diagnosis of IMD, patient information and specimens were collected and reported to local health centres. We analysed the epidemiology of IMD cases reported between 1 April 2013 and 31 March 2023.ResultsAmong 274 cases reported (median age: 55 years; 55% male), no outbreaks related to mass gathering events were identified. The annual reported incidence of IMD was 0.001-0.039 cases per 100,000 individuals between 2014 and 2022, with a notable decrease after 2020. The overall case fatality rate was 12% (33/274). The most frequent serogroups were Y and B (46 and 17%). Multilocus sequence typing revealed a predominance of clonal complex (cc) 23, followed by cc2057, while cc11 was detected in eight cases.ConclusionThe reported incidence of IMD in Japan is low compared with high-endemic countries and decreased further during the COVID-19 pandemic. This unique epidemiology of IMD in Japan lacks a clear explanation. However, distribution of meningococcal strains, such as predominance of serogroup Y, could be a contributing factor. Maintaining high-quality surveillance, including of serogroups and sequence types, is crucial to manage and prevent future IMD cases in Japan effectively.

Epidemiologic and genomic characterization of an outbreak of Rift Valley fever among humans and dairy cattle in northern Tanzania.

A peri-urban outbreak of Rift Valley fever virus (RVFV) among dairy cattle from May through August 2018 in northern Tanzania was detected through testing samples from prospective livestock abortion surveillance. We sought to identify concurrent human infections, their phylogeny, and epidemiologic characteristics in a cohort of febrile patients enrolled from 2016-2019 at hospitals serving the epizootic area. From September 2016 through May 2019, we conducted a prospective cohort study that enrolled febrile patients hospitalized at two hospitals in Moshi, Tanzania. Archived serum, plasma, or whole blood samples were retrospectively tested for RVFV by PCR. Human samples positive for RVFV were sequenced and compared to RVFV sequences obtained from cattle through a prospective livestock abortion study. Phylogenetic analysis was performed on complete RVFV genomes. Among 656 human participants, we detected RVFV RNA in four (0.6%), including one death with hepatic necrosis and other end-organ damage at autopsy. Humans infected with RVFV were enrolled from June through August 2018, and all resided in or near urban areas. Phylogenetic analysis of human and cattle RVFV sequences demonstrated that most clustered to lineage B, a lineage previously described in East Africa. A lineage E strain clustering with lineages in Angola was also identified in cattle. We provide evidence that an apparently small RVFV outbreak among dairy cattle in northern Tanzania was associated with concurrent severe and fatal infections among humans. Our findings highlight the unidentified scale and diversity of inter-epizootic RVFV transmission, including near and within an urban area.

INCIDÊNCIA E CARACTERÍSTICAS CLÍNICO-EPIDEMIOLÓGICAS DA TUBERCULOSE EM IMPERATRIZ – MA

INTRODUCTION: Tuberculosis (TB) is an infectious disease transmitted by Mycobacterium tuberculosis, which spreads through the airways when infected individuals cough, sneeze or speak, releasing aerosols containing active bacilli. OBJECTIVE: To analyze the incidence and clinical-epidemiological characteristics of tuberculosis in Imperatriz - Ma, between 2019 and 2023. MATERIALS AND METHODS: Descriptive epidemiological study, with a quantitative approach, carried out from compulsory notifications of new cases of the disease available via DATASUS. The incidence coefficients were calculated for each year of the disease. The epidemiological variables were treated using descriptive statistics. RESULTS: During the period under investigation, 447 new cases of tuberculosis were reported in the city of Imperatriz. The detection rate of new cases was higher in 2022 and lower in 2021. Regarding the epidemiological characteristics, most cases were male, brown race/color, pulmonary clinical form, first positive sputum culture, negative TB/HIV coinfection, DOT not performed, non-smoker, non-alcoholic and with evolution to cure. In addition, the age group of 20 to 29 years, incomplete 5th to 8th grade of PE and 6th month bacilloscopy not performed stood out. FINAL CONSIDERATIONS: It is essential to invest in strategies that expand access and adherence to treatment, promote a more humanized approach in patient monitoring, and develop intersectoral actions to address socioeconomic and educational barriers.

Epidemiological survey of 32,786 culture-positive dermatophytosis cases in Hangzhou from 2018 to 2023.

With the rapid development of the economy and changes in lifestyle in recent years, the epidemiological pattern of dermatophytosis has changed. We analyzed the epidemiological features of dermatophytosis in a hospital in Hangzhou from 2018 to 2023. Data from patients with culture-positive dermatophytosis were obtained from the Laboratory Information System of the Mycology Laboratory of our hospital. Dermatophyte isolates were mainly identified by macroscopic and microscopic features of the colonies. There were 32,786 patients with culture-positive dermatophytosis during the 6-year period, including 16,789 male patients and 15,990 female patients. Patients' ages ranged from 1month to 97years. Tinea unguium accounted for the largest proportion (14,879, 45.38%), which was mainly prevalent among females (8946, 60.13%). Significant gender differences were observed in all clinical types of dermatophytosis, except for tinea pedis. In total, 15,486 (47.73%) patients aged 21-40years. The median age of patients with tinea manum and tinea capitis was the highest (49years) and the lowest (5years), respectively. Nine species of isolated dermatophytes were identified, of which Trichophyton rubrum accounted for 90.20% (29,573 cases). M. canis accounted for 66.80% of isolated dermatophytes from tinea capitis. The isolation rates of zoophilic species were 43.41% in tinea faciei and 18.90% in tinea corporis. T. rubrum was absolutely predominant agent of dermatophytosis except tinea capitis in which M. canis was the most common organism. The prevalence of zoophilic dermatophytes has increased in tinea faciei and tinea corporis. Tinea unguium was the major clinical form of dermatophytosis, and it was more prevalent among females. The onset peak of dermatophytosis was in the age group of 21-40years, except for tinea capitis.

The epidemiological and histopathological factors for delayed local recurrence in oral squamous cell carcinoma.

Oral squamous cell carcinoma (OSCC) is a prevalent malignancy in oral cancer. Approximately 26% of OSCC cases recur after initial curative treatment, with over 80% of these recurrences occurring within the first 2years. Delayed local recurrence (DLR) occurring beyond the 2-year period in cases of OSCC is infrequent. The aim of this study is to investigate the histopathological characteristics associated with DLR. This study included 197 patients diagnosed with OSCC who underwent primary surgery from 2006 to 2022. Epidemiological features, such as age and gender, and histopathological features, including primary tumor sites, TNM staging, histopathological grading, depth of invasion, the presence of lymphovascular or perineural invasion, and the utilization of radiation therapy (RT) and neck dissection (ND) were analyzed. The mean interval until local recurrence was 22 ± 27months. There were 10 cases of DLR (20.83%) among 51 patients with local recurrence. The epidemiological and histopathological analysis of these cases is as follows: 10 patients (3 males and 7 females) aged 51-80years (median, 56.5years). Primary tumor sites were tongue (n = 3), maxillary gingiva (n = 1), mandibular gingiva (n = 3), retromolar trigone (n = 1), and buccal mucosa (n = 2). Tumor size was advanced (T3/T4) in 5 cases, while a smaller size (T1/T2) was observed in 5 cases. No lymph node metastasis was 80.0%. Histopathological grading was well differentiated in 9 cases and moderately differentiated in 1 case, with no cases of poorly differentiated tumors. Depth of invasion > 5mm was 70.0% of the cases (n = 7). Lymphovascular invasion and perineural invasion were not present. Three patients received RT, and 8 patients underwent ND. There were 2 patients who consumed alcohol, and 2 patients who smoked tobacco. The results showed that histological differentiation had a significant relationship with the interval (p = 0.031). DLR, occurring more than 2years after the initial tumor resection surgery, is infrequent. Histological differentiation is associated with tumor recurrence intervals. Patients with a higher histological grading require more precise follow-up observation during the initial 2years after surgery.

Differential diagnosis of visceral leishmaniasis in children: a five-year retrospective study at a pediatric referral hospital.

Visceral leishmaniasis (VL) is a zoonotic disease caused by protozoa of the genus Leishmania and is transmitted by sandflies of the genus Lutzomyia. Children under 15 years are disproportionately affected. In pediatric patients, the clinical and laboratory features of VL often overlap with those of other infectious and hematology-oncology diseases, making differential diagnosis challenging. Rapid and accurate identification of VL is critical for effective treatment. This study aimed to evaluate the epidemiological, clinical, and laboratory characteristics of pediatric patients initially suspected of having VL and to compare their final diagnoses upon discharge from a referral hospital. We retrospectively analyzed medical records of children with suspected VL, admitted between July 2014 and June 2019. Infectious diseases were confirmed in 61% of cases (86 patients), with VL confirmed in 55 cases. Hematology-oncology diseases were the second most common diagnosis, affecting 22.7% of patients (32 cases). Comparisons between the VL-confirmed group and those with other diagnoses revealed no significant age difference (p = 0.690). However, female sex, spleen size, and leukopenia were identified as significant predictors of VL. Female sex, spleen size, and leukopenia were key predictors for differentiating VL from other pediatric diseases in a referral center in the Northeast Region of Brazil.

Pathogenesis of comorbidity between pulmonary tuberculosis and lung cancer

Pulmonary tuberculosis and lung cancer are both common clinical diseases and serious public health problems. These two diseases can form a comorbidity by promoting each other under the influence of multiple factors during their occurrence and development. In recent years, some progress has been made in understanding the mechanism and exploring the diagnosis and treatment of comorbidity. However, there are still some unclear mechanisms that require further investigation. This paper briefly introduces the epidemiological characteristics of the comorbidity between pulmonary tuberculosis and lung cancer, and focuses on the potential pathogenesis of the comorbidity. It highlights the current challenges and looks ahead to potential future research directions, including suggestions for the development of new diagnostic and therapeutic strategies for the comorbidity.

Epidemiological investigation of traumatic spinal cord injury caused by object strike in China: strategies for workplace safety improvement.

Being struck by an object is a major cause of traumatic spinal cord injury in China. This study aims to investigate epidemiological characteristics of spinal cord injury caused by object strike. This research analysed data from 435 cases of strike-induced spinal cord injury from 2013 to 2022. The collected information encompassed gender, age, level of neurological injury, surgical interventions, expense, occupation, and other relevant factors. χ2tests and Mann-Whitney U test were used with a statistical significance level of 0.05. The male-to-female ratio was 11.8:1. The 30-44 age group was more likely to suffer from complete spinal cord injuries (70.5%). The predominant occupations were workers (58.9%) and farmers (15.2%). Manual labourers are usually injured in the workplace (89.4%) with a high surgical rate (95.3%). Young and middle-aged males engaged in manual work constitute the primary demographic for strike-induced spinal cord injury. Safety education in workplaces such as construction sites and mines should be emphasized to reduce the occurrence of spinal cord injuries caused by object strikes.

Prevalence of diseases of digestive organs in children in the Udmurt Republic

Introduction. Conducting targeted epidemiological studies allows objectively characterizing the health status of the population. Purpose of the work is to characterize current trends in the epidemiology of digestive diseases in children in the Udmurt Republic based on a special study. Materials and methods. Survey of 2516 children of age 6–17 years: 6–14 years — 1,482, 15–17 years adolescents — 1,034. The study was continuous, all students of two secondary schools in Izhevsk. Stages: survey of schoolchildren (n = 2,516) and parents; clinical examination (n = 2,516); laboratory and instrumental examination in children suspected of having pathology of the digestive organs based on the results of stages I and II; IV — summing up and forming a group of children with proven pathology of the digestive organs (n = 1,141). Assessment of the reliability of differences in indicators based on Student’s t-test. Results. The prevalence of gastroenterological diseases among all children does not have a gender component (p = 0.1). In the younger age group, girls and boys get sick with the same incidence. In adolescents, the prevalence of gastroenterological pathology in girls is higher than in boys (p < 0.001). The prevalence among boys of different ages does not have a statistical difference, and among girls of different ages, older schoolgirls are more often affected (p < 0.001). In the structure of pathology of the digestive organs in 6-17 years children dominated due to diseases of the stomach and duodenum. The prevalence of diseases of the hepato-pancreatic-biliary system and intestines was the same. The prevalence of digestive diseases is 453.5 ± 9.9 per 1000 subjects. The proportion of functional diseases is 9.9–96.7%, depending on age and the affected area of ​​the gastrointestinal tract. Conclusion. The true prevalence of digestive diseases exceeds official statistics. The structure is dominated by diseases of the gastroduodenal zone. Epidemiological features include an increase in the prevalence of pathology in girls of puberty. In children aged 6–14 years, functional diseases predominate; in children aged 15–17 years, the proportion of organic diseases increases.

Epidemiological and clinical characteristics of dengue fever in Fuzhou, China, in 2023.

This study aimed to analyze the epidemiological and clinical characteristics of dengue fever (DF) in Fuzhou, the capital city of Fujian Province, southeast China. A retrospective analysis was performed on 251 cases of DF diagnosed at the fever clinic of the Second Affiliated Hospital of Fujian University of Chinese Medicine in Fuzhou City, Fujian Province. Epidemic characteristics, such as the number of cases, age distribution, sex distribution, seasonal distribution, and spatial distribution in each region, were analyzed. The patients' clinical manifestations, signs, auxiliary examinations, and prognoses were analyzed. The age distribution of DF cases was mainly concentrated in 30-39 years (20.72%) and 50-59 years (21.12%). There were no sex differences among the patients. Of these cases, 60.16% were concentrated on the lower floors, with retirees having the highest proportion. The seasonal peak of DF in Fuzhou area was from September to November. The SDE plot showed that the cases were mainly concentrated in Jin'an and Gulou districts. Etiological tests revealed serum NS1 antigen (97.61%), serum IgM antibody (15.14%), and serum IgG antibody (0.40%). There were no significant differences in clinical manifestations between the children's and non-children's groups. Laboratory tests have shown that the disease is prone to multi-system dysfunction, including the blood system, digestive system, urinary system and internal environment. ROC curve analysis showed that WBC, N, LY, PLT, and CRP levels had specific diagnostic values for DF. The epidemiological situation and clinical characteristics of DF in Fuzhou City were analyzed to guide the formulation of reasonable prevention and treatment measures.

NCOG-14. THE ROLE OF POSTOPERATIVE BLOOD PRESSURE MANAGEMENT IN EARLY POSTOPERATIVE HEMORRHAGE IN AWAKE CRANIOTOMY GLIOMA PATIENTS

Abstract INTRODUCTION Awake surgery is widely used to maximize the extent of resection and enhance neuro-oncological outcome in gliomas. Postoperative hemorrhage can severely deteriorate the patients’ neurological outcome. Higher postoperative blood pressure can increase the risk of postoperative hemorrhage, but optimal perioperative patient and blood pressure management is unclear. The aim of this study was to investigate the role of postoperative blood pressure and other common radiological and epidemiological features with the incidence of postoperative hemorrhage. MATERIAL & METHODS In this retrospective analysis, we included all patients who underwent awake surgery between 2010 and 2023 at our institution. We assessed the blood pressure both intra- and postoperatively as well as the heart rate for the first 12 hours. We compared a cohort with postoperative hemorrhage, who required further treatment (surgical revision or intravenous antihypertensive therapy), with a cohort with no postoperative hemorrhage. RESULTS We included 48 patients with a median age of 39 years. 9 patients (19%) showed a preoperative history of arterial hypertension, 8 of them were on antihypertensive treatment. 23 patients (48%) showed signs of a hemorrhage on early postoperative MRI, of whom 9 (19%) required further treatment, which was surgery in 2 cases and conservative therapy in 7 cases. Patients with postoperative hemorrhage showed significantly higher postoperative systolic blood pressure during the hours 3-12 (p<0.05) as well as intraoperatively during the hours 1-5 (p<0.05). In ROC and Youden Test, a strong impact of systolic blood pressure over 140 mmHg during the early postoperative course could be shown. DISCUSSION Postoperative hemorrhage is a serious complication in awake surgery glioma patients. However, with early treatment, no significant difference in Performance scores at follow-up could be found. To avoid postoperative hemorrhage, treating physicians should aim strictly on systolic blood pressure of under 140 mmHg for the postoperative course.

CLINICAL, EPIDEMIOLOGICAL, AND NOSOLOGICAL CHARACTERISTICS OF INJURED INDIVIDUALS WITH MASSIVE BLOOD LOSS

Severe mechanical trauma is one of the major medical and social issues in modern society, resulting in more than 5.8 million deaths worldwide each year. The leading potentially preventable cause of death in such cases is massive, uncontrolled blood loss. Objective: to study and analyze the clinical, epidemiological, and nosological characteristics of injuries, as well as age, sex, and peculiarities of traumagenesis, in order to enhance the effectiveness of emergency medical care for victims with traumatic blood loss, in accordance with the standards of evidence-based medicine. Results. The study found that trauma cases leading to massive blood loss occur more frequently in males (78.4% men vs. 21.6% women). The largest proportion of male victims are aged 21 to 30 years (21.8%). Most injuries resulted from domestic incidents (29.3%), road traffic accidents (21.2%), and criminal acts (19.2%). The most common injury types were stab wounds (40.1%) and direct blows (23.3%). In terms of injury localization, the upper limb was most commonly affected (21.9%), followed closely by the lower limb (21.6%). Individuals injured in hostilities predominantly sustained mine-blast injuries, often associated with multifactorial combined injuries. Conclusions: The clinical-epidemiological and nosological characteristics of victims with massive traumatic blood loss indicate distinct risk groups based on age, sex, type, and mechanism of injury. It has established that these clinical and epidemiological features significantly influence both the outcome of the traumatic process and the effectiveness of emergency medical care.

Pediatric Dermatological Emergencies: A Systematic Review

Pediatric dermatological emergencies encompass a wide array of conditions that demand immediate medical attention and can have significant implications for a child's health and wellbeing. Despite the critical nature of these conditions, a comprehensive overview of the current state of knowledge is essential to improve recognition and management. This systematic review aims to address this gap by synthesizing the latest evidence related to pediatric dermatological emergencies, with a specific focus on studies published between 2020 and 2022. The primary objective of this systematic review is to provide an in-depth analysis of the epidemiology, clinical presentation, diagnostic approaches, management strategies, and outcomes of pediatric dermatological emergencies. A systematic search was conducted across prominent databases, including PubMED, Embase, and Web of Science. The review includes 21 studies that met stringent inclusion criteria, which were subsequently analyzed for patient demographics, clinical characteristics, diagnostic methodologies, therapeutic interventions, and patient outcomes. The findings from the 21 selected studies consistently highlight the critical importance of early recognition and timely intervention in the management of pediatric dermatological emergencies. On average, approximately 85% of cases demonstrated improved outcomes when appropriate care was initiated promptly. The review discusses various common conditions, including severe drug reactions, cutaneous infections, inflammatory skin disorders, and traumatic dermatological emergencies, shedding light on their epidemiology and clinical features. This systematic review underscores the significance of a multidisciplinary approach, involving dermatologists, pediatricians, and critical care specialists, in addressing pediatric dermatological emergencies. It also emphasizes the evolving insights into the pathophysiology and management of these conditions and highlights the unique ...