Natural ventilation significantly enhances building energy efficiency and indoor air quality, thereby reducing virus transmission risks, especially crucial in teaching buildings on university campuses frequently occupied by large numbers of students. This study investigates the design impacts of teaching building complexes on indoor and outdoor wind environments, aiming to propose practical design recommendations. Firstly, a typological analysis of teaching building complexes from ten universities in Guangzhou University Town (GUT) was conducted, screening out several archetypes representing diverse design features. Computational fluid dynamics (CFD) simulations were then performed on 16 hypothetical teaching building complexes derived from these archetypes. The wind velocity distributions and area-weighted wind velocities across various hypothetical scenarios were compared and analyzed, allowing for a thorough assessment of the natural ventilation performance associated with different block shapes and layout patterns. The findings reveal that canyons between buildings have a marginal impact on natural ventilation within scenarios characterized by aligned layouts. In contrast, staggered layouts notably enhance natural ventilation, particularly with orthogonal prevailing winds. Furthermore, semi-enclosed courtyard blocks outperform fully enclosed courtyard blocks in natural ventilation, especially when their openings align with prevailing wind directions. Finally, several practical recommendations were summarized for achieving sustainable teaching building design in similar climate regions. Key contributions include demonstrating the significant influence of block shape and layout on ventilation performance and offering novel insights into optimizing building designs for improved natural ventilation.