Carbendazim disrupts cellular lipid homeostasis and induces fat accumulation by upregulation of Δ9-desaturases in Caenorhabditis elegans.

Dual-transformed CuO nanoparticles modulate plant nutrition and stress physiology in copper-starved plants.

Environmental risk assessment following Brazilian mining dam collapse: A diffusion approach.

Effects of a formulation of the veterinary drug moxidectin on the performance of a plant-insect food chain.

PFNA dominates the association between PFAS mixture exposure and hypertension risk: The mediating role of estradiol in the U.S. adults.

A novel framework integrating a coupled mixing rule with deep learning for toxicity prediction and environmental risk assessment of antibiotic mixtures.

Release mechanisms of plasticizers from emerging biodegradable plastics and their aging behavior.

"Bentogypsum", a phosphoric acid purification residue: Characterization and implications for environmental and human health risk in Gabes (SE Tunisia).

Source identification and coastal export of sulfate in a megacity river: Insights from sulfur isotopes and inverse model.

PFOS exposure at environmentally relevant concentrations promote papillary thyroid carcinoma progression through PI3K/AKT/mTOR-mediated epithelial-mesenchymal transition.

UV-328 disrupts mineral nutrient homeostasis and secondary metabolism in Arabidopsis thaliana: Linking physiological responses to molecular mechanisms.

Organophosphorus flame retardants (OPFRs) in lithium-ion batteries: Classification, physicochemical properties, environmental behavior, human exposure and toxicity.

Transcriptomic and metabolic reprogramming of durum wheat under nanoplastic exposure

Subacute dimethylated monothioarsenate (DMMTA) exposure induces hepatotoxicity and disrupts the gut microbiota-bile acid-liver axis: A multi-omics study in mice.

The toxicity differences of lithium-ion battery cathode materials, lithium iron phosphate (LFP) and lithium cobalt oxide (LCO) to zebrafish(Danio rerio): Mechanisms and environmental impacts.

Hospital wastewater as a hotspot for environmental dissemination of a carbapenem representative and enzyme inhibitors: insights from a multi-hospital study.

Nanoparticle-plant interactions: Uptake, transport, physiological effects, and environmental implications

Organophosphorus herbicides play an important role in agricultural development and are widely used worldwide. Glyphosate, glufosinate, DMPA, amiprophos-methyl, butamifos, piperophos, and other organophosphorus herbicides are overused worldwide. Organophosphorus herbicides are detected in different environmental media and play a toxic role in causing ecological health risks, causing serious concern among people. This review discusses the concentration levels of organophosphorus herbicides in water, soil, plants, and other environmental media and finds that the content of organophosphorus herbicides in soil is high, the concentration range is 12-129 μg/g, and finally summarizes the concentration levels of organophosphorus herbicides in organisms and human beings and finds that the concentration of organophosphorus herbicides in pesticide industry workers is relatively high. From the point of view of detection methods, the traditional methods and advanced technologies of herbicide detection are discussed in detail, and the advantages and disadvantages of these methods are pointed out. Finally, the ecological health risks, toxic effects, and molecular mechanisms of organophosphorus herbicides are discussed. Epidemiological investigations in China, Africa, and America showed that organophosphorus herbicides were prone to induce neurotoxicity, genotoxicity, and metabolic toxicity. These findings provide a theoretical basis for environmental management and ecological health risk assessment of organophosphorus herbicides.

In our study, the sequential extractions and environmental risk assessment of Cu, Zn, Pb, Ni, Cr, Ba, Mn were performed in soil depth profiles and in sediments transported by surface runoff in two vineyards with contrasted soil pH in NE Hungary. Our data indicate that while both sites showed Cu contamination from fungicide applications, the slightly acidic soil in Tállya had considerably higher Cu levels (131 ± 38mg/kg) than the alkaline soil in Tokaj (51 ± 15mg/kg) due to longer-term pesticide use history in the former. Potentially toxic elements (PTEs) exhibited overall low mobility in both vineyard soils, with Cr and Ni being strongly retained in the residual fractions (≥ 64-95%). However, Cu revealed high extractability in Tállya (> 57%) down to a depth of 40cm, further corroborating its predominantly anthropogenic origin and more labile character within the slightly acidic conditions. Contamination and risk assessments using the geoaccumulation index (Igeo) and the Risk Assessment Code (RAC) showed similar patterns between the two vineyards: while Ni, Cr, Mn, Ba, and Pb were of geogenic origin, Cu and Zn exhibited moderate to heavy contamination status (Igeo up to 3.17 (sediment)-3.34 (topsoil) for Cu in Tállya), with sediments showing Cu enrichment compared to topsoil in Tokaj. Copper emerged as the dominant concern, reaching medium risk levels (RAC ≥ 10%) at both sites due to substantial proportions detected in the acid-soluble fraction. This study highlights two critical management priorities for winegrowers: monitoring mobile PTE fractions and preventing contaminated sediment transport to adjacent surface waters.

The Fish Plasma Model (FPM) predicts steady-state concentrations of active pharmaceutical ingredients (APIs) in fish blood plasma based on partitioning from the surrounding (water) environment. Total plasma concentration is then compared to the human therapeutic concentration to indicate environmental risk, assuming that human pharmaceutical targets are conserved in fish. However, only the unbound fraction (fu) of API is available for pharmacological action and plasma protein binding, and the binding of APIs may differ between species. We quantify fu for 44 APIs with wide ranging physicochemical properties in three fish species: a salmonid, rainbow trout (Oncorhynchus mykiss) and two cyprinids, fathead minnow (Pimephales promelas), and koi carp (Cyprinus rubrofuscus), and draw comparisons with fu in humans. We examine interspecies differences in fu in relation to blood physicochemistry and protein and lipid composition. We show that anionic APIs often exhibit substantially (×10) higher fu in fish compared with humans, and this was most apparent in rainbow trout, despite this species possessing protein(s) orthologous to human serum albumin, a major binding protein for anionic APIs in humans. We recommend accounting for fu in fish versus humans and using rainbow trout as a conservative species in the FPM for modeling API availability and effects in fish.