Myeloid cells are present in neoplastic tissues from the earliest stages of transformation through to fully developed tumors. However, their intrinsic dynamism and plasticity make them difficult to target therapeutically. Emerging technologies are uncovering previously unrecognized cellular states and functions, thus reshaping our understanding of myeloid cell biology beyond their traditional inflammatory roles. This review discusses recent advances in identifying tumor-specific cues, tissue structural components, and the temporal modulation of neutrophil and macrophage programs in tumors, which are influenced by both cell-intrinsic and systemic signals. By integrating molecular, environmental, and time-dependent aspects of myeloid biology, we discuss here our understanding of their functional diversity and inform the development of future cancer therapy strategies.

Physical solutions for hydrogen storage: Technological challenges, safety assessments, and environmental aspects

ABSTRACT The mental health of Indonesian adolescents (aged 15–24) has reached a critical prevalence of 21% in Bandung, a creative city without a dedicated art therapy center, while Jakarta serves as a benchmark for a conventional art therapy center without interactive technology. This study applies Evidence-Based Design (EBD) to propose one of the first conceptual zoning frameworks in Asia integrating behavioral, environmental, and technological aspects. Data synthesis results from triangulated validation of a Systematic Literature Review (SLR) (n = 40+ studies), field observations in Bandung and Jakarta, precedent analysis, and interviews with 4 experts and 3 patients informed the main finding “The Adaptive Healing Space Framework”. This interior architecture concept divides space into three gradual zones (Neutral → Hybrid → Immersive) with recommendations for AAL (Ambient Assisted Living) biofeedback and embedded VR/AR technology, filling gaps in biofeedback-spatial actuation for digital-native adolescents (Gen Z/Alpha). This design concept has potential to become a new standard model for modern mental health facilities in Asia. It requires development into scalable designs, interactive technologies for mental well-being, and further effectiveness assessment. As preliminary exploratory research based on a small qualitative sample (n = 7), this conceptual framework requires quantitative validation through post-occupancy evaluation after implementation.

Ecological resettlement (ER), or conservation-led displacement, is widely implemented to safeguard biodiversity but often produces complex socio-ecological outcomes. This study assessed the environmental justice (both social and ecological) impacts of ER in Nepal’s Terai Arc Landscape (TAL) using an enhanced (including social, ecological, and environmental aspects) environmental justice (EJ) framework. Data were collected from 240 households across all resettled villages within the Chitwan and Parsa National Parks (NPs) of Nepal through household interviews, key informant interviews, focus groups, and field observations, supplemented by policy reviews, reports, and unpublished documents. Household demographics indicated an average family size of 5.5, gender parity (664 females, 658 males), and diverse caste/ethnic composition (ethnic: 146 households; higher caste: 64; lower caste: 6). Wealth distribution and literacy were uneven, with disparities in land ownership, assets, and social positions. Social and ecological justice outcomes were analysed using chi-square and McNemar tests. We observed a significant difference (p < 0.05) in substantive justice (food, shelter, clothing, and security) attributes before and after the resettlements. Similarly, significant improvements post-resettlement were observed in procedural and recognition justice: participation in decision-making increased from 43% to 62% (χ2 = 12.34, p < 0.05). However, recognition of Indigenous knowledge and FPIC rights remained low, with 93% of households reporting inadequate acknowledgment (χ2 = 198.5, p < 0.05). Distributive justice indicators, including access to compensation and forest resources, showed mixed outcomes, with 52% reporting fair compensation and 48% citing inequities (p < 0.05). Ecological outcomes also shifted significantly: forest cover decreased in 65% of surveyed areas post-resettlement, while grassland extent increased in 28% (χ2 = 27.4, p < 0.05). Water source accessibility declined for 48% of households (χ2 = 21.6, p < 0.05), and bushfire incidence decreased by 15% (χ2 = 9.8, p < 0.05). Composite scoring revealed strong linkages between social justice deficits and ecological downturn in the resettled areas, suggesting that inadequate participation, recognition, inequitable compensation, and ecological degradation shift the issues from parks to the outside and exacerbate environmental vulnerability. These findings demonstrate that ER can achieve partial ecological objectives inside the parks but often perpetuates social inequities and ecological downturn in the resettled areas, undermining the long-term sustainability of the socio-ecological landscape. The study highlights the critical need to integrate social justice, participatory governance, and ecological monitoring into resettlement planning. Future policies should be grounded in the understanding that conservation effectiveness and social equity are mutually reinforcing, and that ignoring justice dimensions risks undermining both biodiversity outcomes and human wellbeing.

Considered a major public health problem and one of the most neglected tropical diseases, leishmaniasis has long been a challenge for health systems around the world, given its wide geographical distribution and ability to affect populations in situations of socioeconomic vulnerability. The aim of this study was to investigate the phlebotomine fauna and environmental aspects in different ecotopes in Uberaba, Minas Gerais, Brazil and to evaluate peridomiciliary risk factors, as well as to sensitize the population about the disease. The systematic collections took place from October 2021 to September 2022 at 11 points in the municipality. The sandflies was taxonomically identified and the females were subjected to DNA extraction and molecular testing. Seven phlebotomines were found, four females (two Lutzomyia longipalpis and two Evandromyia cortelezzii complex) and three males (Lutzomyia longipalpis). The predictive risk models therefore suggested that the main areas susceptible to the presence of the vector are areas around the municipality where there are high altitudes, lower temperatures and humid areas with the presence of large rivers. The greatest risk appeared to be present in the southeastern sectors of Uberaba. The results presented here may contribute to a better understanding of the epidemiology of VL in the municipality and the targeting of preventive and control measures by the responsible bodies, especially as this is a city with no autochthonous human or canine cases. The work developed here constituted a new theoretical-methodological effort capable of investigating entomological and environmental elements that favor the maintenance and control of the disease in silent municipalities.

Generative artificial intelligence is increasingly embedded in architectural practice and education, yet its role often remains confined to image production or optimization tasks. This study situates generative AI within a broader design ecology. It examines how structured human–AI interaction can support environmentally oriented architectural thinking in design education. The article presents an international design workshop as a research setting in which architecture students engaged with AI through a multi-agent workflow. This workflow combined large language models, diffusion-based image generation, 2D–3D translation tools, parametric modeling, and clay-based 3D printing. Central to the methodology is the concept of prompt choreographies. These are deliberate dialogs between human and AI agents, based on a language of prompts and AI-generated outcomes. Through this process, the design concept moves toward a final architectural proposal. The workshop addressed complex ecological challenges emerging from interactions among Earth’s spheres. These were conceived as environmental interfaces defined by behavioral continuity rather than typological form. Using qualitative, design-based evaluation criteria focused on environmental, spatial, and material aspects, the study identifies recurring patterns of human–AI collaboration. The findings indicate that generative AI supports architectural ideation most effectively when embedded in structured workflows that emphasize curatorial decision-making and reduce generative overproduction. While limited to a workshop-based educational context, the research offers transferable methodological insights for architectural pedagogy and conceptual practice. It proposes a process-oriented framework for designing with generative AI and outlines an emerging form of architectural literacy and multi-agent collaboration that warrants further empirical validation.

Abstract The banking sector is one of the most important pillars of economic development and financial stability. The performance and efficiency of employees play a major role in determining the success of banking institutions. In recent years, increasing attention has been given to the role of workplace conditions in influencing employee productivity. A healthy workplace environment refers to a setting where employees feel physically comfortable, mentally secure, and socially supported while performing their duties. This study focuses on understanding how different aspects of the workplace environment influence the productivity of bank employees. Information for the research was gathered through questionnaires and informal discussions with employees working in various bank branches

ABSTRACT This study examines how alternative designs of an emissions trading system (ETS) can better support renewable energy development in the Beijing–Tianjin–Hebei (BTH) region. A hierarchical analytic hierarchy process (AHP) is used to derive weights for six dimensions and 18 sub‐criteria covering economic, environmental, market, institutional, social, and technological aspects of ETS design. These global weights feed into a fuzzy VIKOR model that ranks six policy scenarios, while an AI module clusters experts and tests the robustness of the results. The findings show that environmental effectiveness and technological and innovation impact receive the highest weights ( w = 0.220 and w = 0.195, respectively), followed by economic performance. Within these, CO 2 reduction potential, renewable energy investment response, grid integration support, and carbon price stability emerge as key priorities. The integrated reform scenario is ranked first ( Q = 0.27; Rank = 1) and remains robust across extensive sensitivity tests. It combines a tighter cap, broader sector coverage, price‐stability tools, and earmarked revenues for renewable deployment and grid upgrades. The study concludes that, for BTH, an ETS design that links strong carbon constraints with predictable prices, credible institutions, and targeted renewable support is most preferred under a multi‐criteria assessment.

The deployment of green hydrogen production is increasingly considered a strategic opportunity for energy-exporting countries. However, beyond technological and environmental aspects, large-scale industrial projects may generate complex and uncertain social and economic impacts at the regional level. This study investigates the potential social implications of introducing a green hydrogen production plant in the Department of Paysandú, Uruguay, using a System Dynamics modeling approach. It proposes an initial system model designed to establish a foundational Modeling and Simulation framework. The model explicitly represents feedback mechanisms linking public finance, education, labor competencies, productivity, and social behavior impact, allowing the exploration of long-term socio-economic trajectories under alternative institutional and policy conditions. It is used as an exploratory decision-support tool to assess conditional pathways, trade-offs, and risks. Results indicate that positive social outcomes, such as human capital accumulation and regional income growth, are possible but not automatic; they depend critically on governance capacity, fiscal sustainability, labor market coordination, and social acceptance, and may be attenuated or delayed under adverse scenarios. While this framework provides a strategic engineering lens on the social dimension, it represents a first step toward a comprehensive decision-making tool. The study analyzes a complex system by integrating energy, production, economic, social, and environmental aspects from strategic engineering lens and contributes to the literature by integrating social dimension and institutional constraints into a Modeling and Simulation framework applied to green hydrogen industrialization, offering insights into policy design under uncertainty in emerging energy-export contexts.

Excipients: New opportunities for complex challenges USP's approaches to addressing complex challenges related to excipients.

ABSTRACT The sustainability benefits of tourism products are often unclear to tourists. Therefore, the present study surveyed cruise passengers to examine their attitudes, perceptions, and intentions regarding the use of bamboo bicycles with a dedicated social sustainability profile, focusing on biases in the perceptions and intentions to use them. The statistical analysis of the survey data involved maximum likelihood structural equation modelling (ML-SEM) and moderation analyses. The results show that, despite being aware of sustainability issues, passengers rarely distinguish between environmental and social aspects, instead viewing tourism products as either generally sustainable or unsustainable. In particular, the product characteristics related to social sustainability were not considered by the cruise passengers. In contrast, perceived usefulness and social norms influenced mostly the intention to use bamboo bicycles during land excursions. Therefore, cruise operators should distinguish more precisely among the individual sustainability dimensions to promote sustainable tourism products and services. Our findings offer both theoretical and practical contributions, encouraging further research on sustainable consumer behaviour in tourism.

Navigational safety is a crucial aspect of ship operations, where the stability and security of cargo play a significant role. MV Tanto Handal, as a container vessel, requires proper lashing procedures to prevent cargo shifting that may lead to accidents. This study focuses on optimizing container lashing to improve cargo stability and navigational safety. The optimization process involves evaluating lashing techniques, equipment feasibility, safety procedures, and inspections conducted during the voyage. Factors such as inadequate equipment, weather conditions, and human error are identified as major causes of ineffective lashing. The findings emphasize the importance of enhancing crew training and improving lashing procedures to achieve safer and more efficient operations.

The banking sector currently operates under conditions of intense regulatory, technological, and social change, which are significantly redefining the role of financial institutions in the economy. Growing stakeholder expectations and regulatory pressure mean that banks’ responsibility extends beyond traditionally understood financial goals and also encompasses environmental, social, and corporate governance aspects. In this context, sustainability reporting, particularly ESG reporting, has become a key tool for banks’ communication with their stakeholders and an element of their risk management system and strategy. Implementing ESG standards requires financial institutions not only to increase transparency but also to thoroughly analyze the impact of their operations on the environment and integrate non-financial factors into their decision-making processes. As financial intermediaries and entities responsible for capital allocation, banks have a significant influence on shaping the direction of economic development consistent with the principles of sustainable development. Consequently, incorporating ESG criteria into decision-making processes is becoming an essential element of risk assessment, credit policy, and long-term strategic planning. The aim of this study is to identify and analyze the impact of ESG reporting obligations on decision-making processes at the analyzed commercial bank. Particular attention was paid to changes in the management structure, risk assessment methodology, credit policy, and business strategy of the bank. The analysis focused on assessing how ESG reporting requirements impact the institution’s strategic priorities and what management mechanisms are implemented to effectively integrate sustainable development principles into daily operational practices. The study was conducted based on an analysis of the bank’s ESG reports for 2022–2024, which enabled the identification of trends in change and the assessment of the maturity of the implemented solutions.

Sustainable water resource systems are essential for meeting society's present and future needs while preserving ecological integrity. Ensuring sustainable management of a basin involves taking into account its hydrological characteristics, along with its environmental, social, and political aspects. Watershed Sustainability Index (WSI) is employed that integrates hydrology, environmental factors, biodiversity, and policy considerations. Its holistic and multidimensional approach provides insights into the complex interactions shaping watershed dynamics and supports evidence-based decision-making processes. Despite its utility, the Watershed Sustainability Index faces several challenges and limitations, including issues with data availability and quality, indicator selection and weighting, and the incorporation of diverse stakeholder perspectives. Addressing these challenges necessitates continued collaboration among researchers, practitioners, and policymakers to refine the Watershed Sustainability Index methodology and enhance its relevance and robustness. Future research should focus on refining indicator frameworks, developing spatially explicit modeling approaches, and integrating emerging technologies like remote sensing and machine learning. Efforts to enhance scalability and transferability across different scales and contexts are crucial for supporting more effective watershed management strategies. This study provides a concise overview of the Watershed Sustainability Index by considering its conceptual framework, main applications and future perspectives.

Purpose Therefore, our goal is to understand the possibilities and potentialities of articulation between environmental education and health education from the perception of older individuals. We evaluated this group’s perspectives due to their life experiences and health concerns. This research employed walking ethnography, a qualitative methodology based on sensory ethnography for data production. The methodology recognizes lived experiences, perceptions and construction of knowledge through location and social context. Design/methodology/approach Environmental education and health education are fields of study and practice with different origins, approaches and theoretical frameworks. Environmental education includes authors working in ecological epistemologies, which are defined by the need to overcome modern dualities and dichotomies between human-world-environment. When working on socioecological, formative and pedagogical aspects, health education provides an opportunity to be a protagonist in understanding and transforming their own reality, covering cultural, social, economic, environmental and other aspects. Despite their interdisciplinary perspectives and the fact that both are initiatives that integrate health and the environment, there are few attempts to bring environmental education and health education into dialogue. Findings The data indicated the emergence of three categories: attentionalities, ethics and presence, which demonstrate the potential of the Buen Vivir philosophy for articulating health education and environmental education. Originality/value Dialogues between these research fields can facilitate educational practices that emphasize sensations and emotions, are motivated by embodiment and offer new perspectives on environmental education and health education.

India's municipal solid waste (MSW) management system is predominantly characterized by unsegregated mixed waste streams, comprising heterogeneous organic and inorganic fractions such as food waste, plastics, and paper. The lack of source-level segregation presents significant challenges for conventional waste treatment pathways and highlights the need for context-specific waste-to-energy (WTE) processes. This study applies a hybrid multi-criteria decision analysis (MCDA) framework, integrating the Fuzzy Analytic Hierarchy Process (FAHP) and the Fuzzy Technique for Order Preference by Similarity to Ideal Solution (FTOPSIS), to systematically evaluate five WTE processes: incineration, anaerobic digestion (AD), pyrolysis, gasification, and hydrothermal liquefaction (HTL). Eighteen evaluation criteria covering elemental, environmental, energy, economic, and socio-economic aspects were identified and weighted using Fuzzy AHP, with environmental impacts emerging as the highest priority (∼34%), followed by elemental and energy recovery efficiency (∼30%), economic feasibility (∼19%), and socio-economic considerations (∼7%). The weighted criteria were then used within the Fuzzy TOPSIS model to rank the technological alternatives. The results indicate that HTL is the most promising WTE process for India's mixed MSW, followed by gasification, pyrolysis, incineration, and AD. The hybrid MCDA framework employed provides a robust and adaptable decision-making process for policymakers and stakeholders to identify optimal WTE process options in regions facing high waste heterogeneity and inadequate waste segregation infrastructure.

Climate change and environmental degradation require the financial sector to play an active role in supporting sustainability. Islamic finance has significant potential due to its foundational values that align with the principles of sustainable development. Contemporary Islamic accounting practices remain largely focused on formal compliance and have not yet comprehensively integrated environmental aspects. This study aims to analyze the integration of Green Accounting with the principles of Maqashid Syariah and Islamic environmental ethics, and to develop a conceptual framework for Islamic Green Accounting. This research adopts a qualitative approach through a systematic literature review of 32 selected articles sourced from Google Scholar (2015-2025) with the keywords Green Accounting, Maqashid Syariah, Islamic Finance, and ESG. The analysis employs content analysis and concept mapping, grounded in the Maqashid Syariah framework. The findings indicate strong alignment between Green Accounting and Maqashid Syariah, particularly in protecting life, progeny, and wealth. This study proposes a conceptual framework of Islamic Green Accounting that positions Maqashid Syariah as the value foundation, Green Accounting as the technical instrument, and sustainability as the ultimate objective.

Urban planning of cities according to modern, comprehensive designs is an important and kay factor in maintaining security in cities and the quality of life in them .preventing crime is considered one of the primary aspects of and urban planning has a large and clear role in linking the various components of the city with each other a balanced environment for these components , and the extent of the clear impact on economic, environmental aspects .this study aims to clarify the relationship between spatial environmental, social and economic factors in reducing crime within cities.

Social dimensions of Managed Aquifer Recharge: A scoping review.

ObjectiveDepressive symptoms are a common disorder influenced by various factors, including genetic, environmental, and psychosocial aspects. This study aimed to explore the association between depressive symptoms and the number of close friends.MethodsThis cross-sectional study employed data from the 2005-2008 National Health and Nutrition Examination Survey. Weighted logistic regression was used to analyze the relationship between the number of close friends and depressive symptoms, and restricted cubic spline plots were constructed. Subgroup and sensitivity analyses were also performed.ResultsThis study included 5564 participants. After grouping participants based on the number of close friends into tertiles, a negative association was found between the number of close friends and depressive symptoms. After adjustment, the group with a higher number of close friends exhibited a 48% lower risk of depressive symptoms. An approximately L-shaped relationship was observed (nonlinear P = 0.001). Depressive symptoms decreased with an increasing number of close friends up to 10, beyond which the association plateaued.ConclusionAn approximately L-shaped relationship exists between the number of close friends and depressive symptoms. When the number of close friends was ≤10, a higher number of close friends was associated with a lower level of depressive symptoms.