The orthorhombic pseudobrookites have served as model material systems for investigating the role of thermal expansion anisotropy on the microcracking behavior in single phase ceramics. Among those typically studied are MgTi_2O_5, Fe_2TiO_5 and Al_2TiO_5. Fe_2TiO_5 is anisotropic in both thermal expansion and paramagnetic susceptibility. Fe_2TiO_5 has an orthorhombic crystal structure and belongs to the Bbmm space group. It belongs to the class of titanates under investigation as second-phase toughness enhancers and as coatings for engine manifolds. The coefficient of thermal expansion of Fe_2TiO_5 is 10.1 × 10^(−6) K^(−1), 16.3 × 10^(−6) K^(−1) and 0.6 × 10^(−6) K^(−1) in the a, b and c directions, respectively. The goal of the present work is to examine residual stresses and study the effect of interface properties on fracture and propensity toward microcracking of Fe_2TiO_5 using finite element analysis.