While air conditioner is running, opening doors and windows is a great way to reduce operating efficiency and undermine the air conditioning system’s ability to bring the indoor to a comfortable temperature. The purpose of this study is to evaluate the heat loss and thermal environment through the door open while air conditioner running. To achieve this goal, using full-scale measurement with the commercial store during the cooling period, the infiltration rate, thermal environment and energy consumption of air conditioners with door opened and door closed state were measured. The measured results show that the infiltration rate at the door opened state was increased by about 21.3 times compared to the door closed state. When the set temperature of the air conditioner was 24 °C, the room temperature in the opening gate cooling was measured to be about 5 °C higher than the closing gate cooling. However, the energy consumption was measured approximately 12 kWh/day and there was no difference with door state. This means that the energy consumption is not increased if the indoor air temperature would not reach the set point temperature of air conditioner.