Energy Balance Behaviors Research Articles

Promoting Energy-Balance Behaviors via the Choose Healthier Coach Hotline

Promoting Energy-Balance Behaviors via the Choose Healthier Coach Hotline

Perinatal deficiency in dietary omega-3 fatty acids potentiates sucrose reward and diet-induced obesity in mice

Insufficient dietary intake of essential omega-3 polyunsaturated fatty acids (N-3), especially during critical stages of development, is well-associated with negative neurological and metabolic consequences. The increased availability and intake of foods rich in saturated fat coincides with reduced N-3 consumption, yet how N-3 dietary deficiency during perinatal development modulates motivation for palatable food and interacts with a high-fat diet to affect body weight and emotional states is not clear. Pregnant C57Bl6 mice and pups were subjected to diets either deficient or adequate (control) in N-3 until postnatal day 21. Adult male N-3 deficient or control offspring were tested in a progressive ratio operant task for sucrose motivated behavior or given prolonged access to a saturated high-fat diet or chow followed by measures of energy balance and anxiety-like behavior in the elevated-plus maze and open field test. Brain fatty acid profiles were measured via gas chromatography mass spectrometry. Perinatal dietary N-3 deficiency lowered brain N-3 levels, augmented the rewarding effects of sucrose, heightened diet-induced weight gain and fat mass accumulation and diminished spontaneous physical activity. Finally, perinatal N-3 deficiency increased anxiety-like behaviour independent of diet in the open field but not in the elevated-plus maze test. Insufficient dietary N-3 during critical periods of developmental can amplify the obesogenic effects of saturated fat intake, enhance motivated behaviour for palatable foods and may elicit negative emotional states that can perpetuate overeating and obesity.

Ghrelin and hypothalamic NPY/AgRP expression in mice are affected by chronic early-life stress exposure in a sex-specific manner

Early-life stress (ES) is a risk factor for metabolic disorders (e.g. obesity) with a notoriously higher prevalence in women compared to men. However, mechanisms underlying these effects remain elusive. The development of the hypothalamic feeding and metabolic regulatory circuits occurs mostly in the early sensitive postnatal phase in rodents and is tightly regulated by the metabolic hormones leptin and ghrelin. We have previously demonstrated that chronic ES reduces circulating leptin and alters adipose tissue metabolism early and later in life similarly in both sexes. However, it is unknown whether chronic ES might also affect developmental ghrelin and insulin levels, and if it induces changes in hypothalamic feeding circuits, possibly in a sex-dependent manner. We here show that chronic ES, in the form of exposure to limited nesting and bedding material from postnatal day (P)2 to P9 in mice, affects ghrelin levels differently, depending on the form of ghrelin (acylated vs desacylated), on age (P9 vs P14) and on sex, while insulin levels were similarly increased in both sexes after ES at P9. Even though ghrelin levels were more strongly affected in ES-exposed females, hypothalamic neuropeptide Y (NPY) and agouti-related peptide (AgRP) fiber density at P14 were similarly altered in both sexes by ES. In the paraventricular nucleus of the hypothalamus, both NPY and AgRP fiber density were increased, while in the arcuate nucleus of the hypothalamus, NPY was increased and AgRP unaltered. Additionally, the hypothalamic mRNA expression of ghrelin’s receptor (i.e. growth hormone secretagogue receptor) was not affected by ES. Taken together, the specific alterations found in these important regulatory circuits after ES might contribute to an altered energy balance and feeding behavior in adulthood and thereby to an increased vulnerability to develop metabolic disorders.

Intervention effects on stage transitions for adolescent smoking and alcohol use acquisition.

The health impacts of smoking and alcohol abuse have been long established with smoking representing one of the most preventable causes of disease and alcohol use the most popular psychoactive substance among adolescents. The current study evaluated stage of change progression in a large (N = 4,158) school-based, computer-delivered, transtheoretical model (TTM)-tailored multiple behavior intervention focused on preventing acquisition of smoking and alcohol use in adolescents. Assessments began in sixth grade and continued yearly until eighth grade, with a follow-up in ninth grade. Markov modeling was used to (a) characterize the best pattern of stage movement (e.g., no stage change, stage-sequential change, stages skipped), (b) test whether the identified pattern was stable over time (e.g., between assessments and after intervention completion), and (c) to determine whether the substance use prevention (SP) intervention effectively kept adolescents in acquisition stages (e.g., prevents stage movement toward substance use), relative to the comparison intervention. Major findings supported positive effects for both the intervention and comparison condition, which focused on energy balance (EB) behaviors and provided no direct intervention on substance use behaviors. Substantial differences in stage membership and transitions across intervention conditions highlighted the process of smoking and alcohol use acquisition in middle school students across each intervention condition. (PsycINFO Database Record

A systematic review of mediators of physical activity, nutrition, and screen time in adolescents: Implications for future research and clinical practice

BackgroundAdolescents are not meeting current recommendations for daily physical activity, nutrition, and screentime which has been associated with overweight and obesity. Understanding the mediators that facilitate teens in improving their healthy lifestyle behaviors may be helpful in halting this crisis. PurposeThe purpose of this systematic review was to assess published findings regarding mediators of adolescent energy balance behaviors. MethodWe followed the Institute of Medicine guidelines for completing a systematic review. DiscussionFourteen analyses from 12 studies were included with mediating variables tested for nutrition, physical activity, and screen time. Mediators were identified for all three behaviors and were primarily on the individual level of the social ecological model. ConclusionsCombining findings from this and other reviews of mediators can help guide researchers in choosing mediating factors for specific target behaviors.

Intervention Effects on Stage of Change Membership and Transitions among Adolescent Energy Balance Behaviors

ABSTRACTThe transition from childhood to adolescence is a crucial period for the development of healthy behaviors to be sustained later in life. With obesity a leading public health problem, the promotion of healthy behaviors has the potential to make a huge impact. The current study evaluated Stage of Change progression in a large (N = 4158) computer-delivered, Transtheoretical Model-tailored intervention focusing on physical activity and fruit and vegetable consumption (FV). Markov models were used to explore stage transitions and patterns of discrete change from sixth to ninth grade. Nested model comparisons examined the consistency of these patterns across time and intervention condition. Major findings supported models in which participants were free to transition forward and backward to any of the stages, but higher probabilities were observed for remaining in the same stage or for transitioning one or two stages forward. Participants in the intervention group had higher probabilities of transitioning toward Maintenance, with more change occurring relative to the comparison group during transitions from grades six to eight but not for grades eight to nine.

Loss of Action via Neurotensin-Leptin Receptor Neurons Disrupts Leptin and Ghrelin-Mediated Control of Energy Balance.

The hormones ghrelin and leptin act via the lateral hypothalamic area (LHA) to modify energy balance, but the underlying neural mechanisms remain unclear. We investigated how leptin and ghrelin engage LHA neurons to modify energy balance behaviors and whether there is any crosstalk between leptin and ghrelin-responsive circuits. We demonstrate that ghrelin activates LHA neurons expressing hypocretin/orexin (OX) to increase food intake. Leptin mediates anorectic actions via separate neurons expressing the long form of the leptin receptor (LepRb), many of which coexpress the neuropeptide neurotensin (Nts); we refer to these as NtsLepRb neurons. Because NtsLepRb neurons inhibit OX neurons, we hypothesized that disruption of the NtsLepRb neuronal circuit would impair both NtsLepRb and OX neurons from responding to their respective hormonal cues, thus compromising adaptive energy balance. Indeed, mice with developmental deletion of LepRb specifically from NtsLepRb neurons exhibit blunted adaptive responses to leptin and ghrelin that discoordinate the mesolimbic dopamine system and ingestive and locomotor behaviors, leading to weight gain. Collectively, these data reveal a crucial role for LepRb in the proper formation of LHA circuits, and that NtsLepRb neurons are important neuronal hubs within the LHA for hormone-mediated control of ingestive and locomotor behaviors.

A First Resilient DC-Dominated Microgrid for Mission-Critical Space Applications

The advanced electrical power system (AEPS) is the first remote, resilient dc microgrid for mission-critical space applications. This structured microgrid features resiliency, energy balancing, autonomy, standard interface, fault tolerance, fault isolation, modularity, and scalability. The basic standard building modules are first described. Typical system configurations are then presented to illustrate its versatility and its ability to reduce cost. Fault-tolerant design principles are discussed. A-minute-day simulation is then presented to demonstrate the system-level energy balance and smooth dynamic behaviors when entering and exiting the lunar eclipse. Fuse clearing transient capability is also discussed. A dead-bus recovery circuitry is presented, which ensures self-resiliency. The test results are presented to validate the system design and to demonstrate self-recovery with a dead bus. The measured peak power tracking accuracy and current sharing accuracy among multiple batteries are also presented.

What Strategies do Registered Dietitian Nutritionists Use to Assess a Patient’s/Client’s Weight Loss Readiness?

What Strategies do Registered Dietitian Nutritionists Use to Assess a Patient’s/Client’s Weight Loss Readiness?

Energy balance education in schools

Obesity prevention and control have been identified as top public health priorities in modern societies. Sport and exercise science researchers from multiple perspectives (e.g. behavioral, pedagogical, psychological, and physiological) have been active contributors addressing this topic. This paper examines the importance of energy balance (EB) knowledge in enabling behaviors associated with weight management in youth (e.g. physical activity and dietary behaviors). Relevant research studies were searched using ERIC, Proquest, PubMed, and Scopus. A total of 48 articles that met the inclusion criteria were identified and retrieved. The research findings of the included articles were summarized after being thoroughly reviewed. The paper reveals mixed findings about the association between EB knowledge and behaviors, reinforcing the importance of developing knowledge through education. The literature review further identifies that there is inadequate knowledge about EB among youth, coinciding with a national call for action to enhance EB education in schools. The knowledge inadequacy is related to two plausible reasons: the science of EB is still evolving and systematic EB education is lacking in schools. In addition, while some school-based EB education programmes are available, many of these programmes are expensive and lack generalizability and sustainability over time. The paper concludes with a proposal to enhance EB education using concept-based physical education.

Multiphase isenthalpic flash integrated with stability analysis

Isobaric, isenthalpic (PH) flash is challenging for multiphase non-isothermal flow simulation using an equation of state (EOS). This is because the number of equilibrium phases is unknown in temperature and composition space, and because the system of equations in PH flash becomes nearly degenerate for narrow-boiling fluids. The term “narrow-boiling” is used in the literature to refer to enthalpy that is sensitive to temperature.The primary objective of this research is to develop the multiphase PH-flash algorithm integrated with stability analysis that resolves the two technical challenges mentioned above. The secondary objective is to present a new analysis of narrow-boiling behavior by coupling energy and phase behavior equations through the temperature dependency of K values. The thermodynamic model used is the Peng-Robinson EOS with the van der Waals mixing rules.PH flash in this research is formulated by use of the tangent-plane-distance function, in which phase-split computation is integrated with phase-stability analysis. The formulated PH flash is solved by the direct-substitution algorithm with an arbitrary number of sampling compositions (NS), at which phase stability is measured during the iteration. The number of equilibrium phases is not required to be fixed in the new algorithm.Results in case studies show that the new algorithm can robustly handle phase appearance/disappearance with narrow-boiling behavior, including the case of one degree of freedom. The algorithm becomes more robust with increasing NS because the possibility of finding all stationary points of the tangent-plane-distance function increases. However, the number of iterations required tends to increase with increasing NS because the algorithm with more sampling compositions may take more iterations for merging and adding some of the sampling compositions.The general condition presented for narrow-boiling behavior is that the interplay between energy balance and phase behavior is significant. Two subsets of the condition are derived by analyzing the convex function whose gradient vectors consist of the Rachford-Rice equations; (i) the overall composition is near an edge of composition space, and (ii) the solution conditions (temperature, pressure, and overall composition) are near a critical point, including a critical endpoint. A special case of the first specific condition is the fluids with one degree of freedom. These conditions for narrow-boiling behavior are demonstrated in case studies.

The latitudinal dependence of the oceanic barotropic eddy kinetic energy and macroturbulence energy transport

AbstractGeostrophic turbulence theory predicted already a few decades ago an inverse energy cascade in the barotropic mode, yet there has been limited evidence for it in the ocean. In this study, the latitudinal behavior of the oceanic barotropic energy balance and macroturbulent scales is studied using the ECCO2 (Estimating the Circulation and Climate of the Ocean) state estimate, which synthesizes satellite data and in situ measurements with a high‐resolution general circulation model containing realistic bathymetry and wind forcing. It is found that inverse energy cascade occurs at high latitudes, as eddy‐eddy interactions spread the conversion of eddy kinetic energy from the baroclinic to the barotropic mode, both upscale and downscale. At these latitudes, the conversion scale of baroclinic eddy kinetic energy and the energy‐containing scale follow the most unstable and Rhines scales, respectively. Even though an inverse energy cascade occurs at high latitudes, the energy spectrum follows a steeper slope than the −5/3 slope. Different than classic arguments, the Rossby deformation radius does not follow the baroclinic conversion and most unstable scales.

The extended Infant Feeding, Activity and Nutrition Trial (InFANT Extend) Program: a cluster-randomized controlled trial of an early intervention to prevent childhood obesity.

BackgroundUnderstanding how we can prevent childhood obesity in scalable and sustainable ways is imperative. Early RCT interventions focused on the first two years of life have shown promise however, differences in Body Mass Index between intervention and control groups diminish once the interventions cease. Innovative and cost-effective strategies seeking to continue to support parents to engender appropriate energy balance behaviours in young children need to be explored.Methods/DesignThe Infant Feeding Activity and Nutrition Trial (InFANT) Extend Program builds on the early outcomes of the Melbourne InFANT Program. This cluster randomized controlled trial will test the efficacy of an extended (33 versus 15 month) and enhanced (use of web-based materials, and Facebook® engagement), version of the original Melbourne InFANT Program intervention in a new cohort. Outcomes at 36 months of age will be compared against the control group.DiscussionThis trial will provide important information regarding capacity and opportunities to maximize early childhood intervention effectiveness over the first three years of life. This study continues to build the evidence base regarding the design of cost-effective, scalable interventions to promote protective energy balance behaviors in early childhood, and in turn, promote improved child weight and health across the life course.Trial registrationACTRN12611000386932. Registered 13 April 2011.

The independent prospective associations of activity intensity and dietary energy density with adiposity in young adolescents.

There is limited evidence on the prospective association of time spent in activity intensity (sedentary (SED), moderate (MPA) or vigorous (VPA) physical activity) and dietary intake with adiposity indicators in young people. This study aimed to assess associations between (1) baseline objectively measured activity intensity, dietary energy density (DED) and 4-year change in adiposity and (2) 4-year change in activity intensity/DED and adiposity at follow-up. We conducted cohort analyses including 367 participants (10 years at baseline, 14 years at follow-up) with valid data for objectively measured activity (Actigraph), DED (4-d food diary), anthropometry (waist circumference (WC), %body fat (%BF), fat mass index (FMI), weight status) and covariates. Linear and logistic regression models were fit, including adjustment for DED and moderate-to-vigorous physical activity. Results showed that baseline DED was associated with change in WC (β for 1kJ/g difference: 0·71; 95% CI 0·26, 1·17), particularly in boys (1·26; 95% CI 0·41, 2·16 v. girls: 0·26; 95% CI -0·34, 0·87), but not with %BF, FMI or weight status. In contrast, baseline SED, MPA or VPA were not associated with any of the outcomes. Change in DED was negatively associated with FMI (β for 1kJ/g increase: -0·86; 95% CI -1·59, -0·12) and %BF (-0·86; 95% CI -1·25, -0·11) but not WC (-0·27; 95% CI -1·02, 0·48). Change in SED, MPA and VPA did not predict adiposity at follow-up. In conclusion, activity intensity was not prospectively associated with adiposity, whereas the directions of associations with DED were inconsistent. To inform public health efforts, future studies should continue to analyse longitudinal data to further understand the independent role of different energy-balance behaviours in changes in adiposity in early adolescence.

The Role of Hypothalamic Neuropeptides in Neurogenesis and Neuritogenesis.

The hypothalamus is a source of neural progenitor cells which give rise to different populations of specialized and differentiated cells during brain development. Newly formed neurons in the hypothalamus can synthesize and release various neuropeptides. Although term neuropeptide recently undergoes redefinition, small-size hypothalamic neuropeptides remain major signaling molecules mediating short- and long-term effects on brain development. They represent important factors in neurite growth and formation of neural circuits. There is evidence suggesting that the newly generated hypothalamic neurons may be involved in regulation of metabolism, energy balance, body weight, and social behavior as well. Here we review recent data on the role of hypothalamic neuropeptides in adult neurogenesis and neuritogenesis with special emphasis on the development of food intake and social behavior related brain circuits.

A systematic review of the effectiveness of whole-of-community interventions by socioeconomic position.

Whole-of-community (WOC) interventions have led to modest reductions in population weight gain. Whether they exhibit differential effectiveness by socioeconomic position (SEP) remains unknown. We aimed to summarize evidence of differential effectiveness of WOC interventions by SEP. Electronic databases and grey literature were searched to identify studies that evaluated the effectiveness of a WOC intervention on behavioural change measures, energy balance behaviours and/or anthropometric outcomes according to any measure of SEP. Interventions were assessed for the following characteristics: structural changes to the environment, number of settings the intervention acted in, presence of community engagement and whether equity was considered in its design. Ten studies were included. Nine reported a greater or equal effect among low SEP groups compared with high SEP groups. These studies commonly featured interventions that incorporated structural changes to the environment, acted across more than three settings and/or employed community engagement. Conclusions did not change when excluding low-quality studies (n = 4). WOC interventions represent an effective and equitable approach for the reduction of population weight. Structural components, a larger number of settings and community engagement were common in equitable WOC interventions and should be considered in the design of future WOC interventions.

The Early Childhood Obesity Prevention Program (ECHO): an ecologically-based intervention delivered by home visitors for newborns and their mothers.

BackgroundObesity is a major problem in the United States, particularly among socio-economically disadvantaged Latino and Black children. Effective interventions that can be disseminated to large numbers of at-risk children and their families are needed. The goals of the Early Childhood Obesity Prevention Program (ECHO) are to examine the 12-month efficacy of a primary obesity prevention program targeting the first year of life that is delivered by home visitors and that engages mothers as agents of change to modify their own behavior and their infant’s behavior through education and skill-building around nutrition, physical activity, and wellness, and then “echoes” her training with linkages to neighborhood programs and resources.Methods/DesignSix family centers located in low-income neighborhoods in Hartford, CT were randomized into control and intervention neighborhoods. Fifty-seven mothers were recruited either prenatally or shortly after delivery into the Nurturing Families Network home visitation program; 27 lived in a control neighborhood and received the standard home visitation program and 30 lived in an intervention neighborhood and received both the standard home visitation program and the ECHO intervention. The intervention increases maternal skills in goal-setting, stimulus control and problem-solving, engages family members to support changes, links mothers to neighborhood resources and is embedded in the standard home visitation program. ECHO targets include breastfeeding, solids, juice and sugar-sweetened beverages, routines for sleep and responding to infant cues, television/screen time, and maternal diet and physical activity. We hypothesize that infants in ECHO will have been breastfed longer and exclusively, will have delayed introduction of solids and juice, have longer sleep duration, decreased television/screen time and a lower weight for length z-score at 12 months, and their mothers will have greater fruit and vegetable consumption and higher levels of physical activity.DiscussionECHO will provide important information about whether an enhanced behavior change curriculum integrated into an existing home visitation program, focused on the mother as the agent of change and linked to neighborhood resources is effective in changing energy balance behaviors in the infant and in the mother. If effective, the intervention could be widely disseminated to prevent obesity in young children.Trial RegistrationClinicalTrials.gov NCT02052518 January 30, 2014.

Food, Health & Choices (FHC): How Perceptions of Maternal and Peer Energy Balance Behaviors Relate to Students’ Own Behaviors

Many health behavior theories implement social determinants, yet exactly how social factors influence energy balance-related behaviors (EBRBs) remains unclear. This study examines how children’s perceptions of others’ EBRBs compare to their own. Fifth grade students (n=215; 10.8y; 49.8% male) in four urban public schools participated in the delayed control FHC childhood obesity prevention curriculum and wellness policy intervention during the 2013-14 school year. Students completed an audience response system questionnaire pre- and post-intervention which measured their EBRBs and those perceived of their peers and mothers. General linear models were constructed (SPSS v20) to examine how children’s post-behaviors were explained by mothers’ and peers’ pre-behaviors, controlling for children’s own pre-behaviors and gender. Students’ higher perceptions of mothers’ vegetable intake was related to increased vegetable frequency post intervention (F=4.586, P=0.034). Also, perceptions of lower sweetened beverage intake by mothers resulted in lower post intervention intake of sweetened beverage (F=5.980, P=0.016). Similarly, positive perceptions of mothers’ behaviors led to longer bouts of moderate-vigorous activity (F=6.122, P=0.014) and less recreational screen time (F=8.689, P=0.004). Peers positively influenced fast food intake only (F=4.141, P=0.044). Children’s perceptions of mothers’ behaviors seemed to strongly influence both positive and negative EBRBs; those who were influenced by their mothers’ behaviors experienced an amplified effect of the FHC intervention. Upper elementary school children, while likely experiencing increased effects of peer pressure, still seem to be heavily influenced by perceptions of mothers’ EBRBs. Highlighting maternal influences is warranted in future obesity prevention studies.

Perinatal undernutrition increases meal size and neuronal activation of the nucleus of the solitary tract in response to feeding stimulation in adult rats

During the early periods of development, i.e., gestation and lactation, the influences of stimulus such as undernutrition can lead to several behavioural and morphofunctional damages to organs and systems in general, including pathways and structures that control energy balance and feeding behaviour. Although a large body of evidences have shown the effects of this stimulus on structures such as hypothalamus, only few studies have directed their attention to the long-term effects of undernutrition on the nucleus of the solitary tract (NTS). The aim of this study was to investigate the effects of early undernutrition on the NTS and control of food intake in adulthood. Male Wistar rats were divided into two groups according to the diet offered to the dams during gestation and lactation: control group (C, diet containing 17% casein) or isocaloric low-protein group (LP, diet containing 8% casein). On 35 or 180 days, we evaluated the rats’ body weight, food intake, behavioural satiety sequence and c-Fos protein expression in the NTS in response to food stimulus. Based on these assessments, it was found that perinatal undernutrition promoted an increase in food intake and the number of activated cells in rostral and, mainly, medial NTS in response to food stimulation in adulthood. These results indicated that the NTS is a structure particularly vulnerable to the influences of nutritional manipulation in the early stages of development with effects on food control in adulthood.

Better postdiagnosis diet quality is associated with less cancer-related fatigue in breast cancer survivors.

A comprehensive understanding of the role of modifiable health behaviors in effective management of cancer-related fatigue is needed. Among breast cancer survivors, we examined how postdiagnosis diet quality, independently and jointly with physical activity, is related to fatigue, and the potential mediating role of inflammation. Seven hundred seventy women diagnosed with stage 0-IIIA breast cancer in the Health, Eating, Activity, and Lifestyle study completed food frequency and physical activity questionnaires 30 months postdiagnosis. We scored diet quality using the Healthy Eating Index 2010 (HEI-2010). Serum concentrations of C-reactive protein (CRP) were measured in fasting 30-ml blood samples. Multidimensional fatigue was measured 41 months postdiagnosis using the 22-item revised Piper Fatigue Scale. In multivariate linear models, we determined whether fatigue was associated HEI-2010 quartiles (Q1-Q4), and a variable jointly reflecting HEI quartiles and physical activity levels. Survivors with better-quality diets (Q4 vs. Q1) had lower total fatigue (4.1 vs. 4.8, p-contrast = 0.003) and subscale scores (behavioral severity 3.4 vs. 4.2, p-contrast = 0.003; affective meaning 3.9 vs. 4.8, p-contrast = 0.007; sensory 4.4 vs. 5.2, p-contrast = 0.003; cognitive 4.6 vs. 5.0, p-contrast = 0.046). Least squares estimates of fatigue were similar in models including CRP. Compared to survivors with poor-quality diets and no physical activity, survivors with better-quality diets and meeting physical activity recommendations had significantly lower behavioral severity (3.2 vs. 4.7, p-contrast = 0.002) and sensory (3.8 vs. 4.8. p-contrast = 0.006) fatigue scores. In this large breast cancer survivor cohort, postdiagnosis diet quality was inversely and independently associated with fatigue. Future interventions designed to improve multiple energy balance behaviors can provide insight into their associations with fatigue.