The natAg(n, xn)106m,g,104m,g,105gAg reaction cross-sections within the neutron energies of 14–37 MeV were determined by using an activation and off-line γ-ray spectrometric technique. The quasi-mono energetic neutron beams were produced from the 9Be(p, xn)9B reaction by using the proton beams of 25, 35, and 45 MeV at the Korean Institute of Radiological and Medical Sciences, Korea. Monte Carlo simulation code MCNPX was used to simulate the neutron energy spectra, whereas the theoretical cross-sections were calculated using the TALYS 1.8 code. The experimental and theoretical reaction cross-sections show similar trends from lower to higher neutron energy. The isomeric cross-section ratios of 104m,gAg and 106m,gAg for the natAg(n, xn) reactions were also obtained from the experimental values of present work and compared with the literature data.