Employing Feature Selection Research Articles

Classification Analysis of Transition Metal Compounds Using Quantum Machine Learning

AbstractQuantum machine learning (QML) leverages the potential of machine learning (ML) to explore the subtle patterns in huge datasets of complex nature with quantum advantages. QML accelerates materials research with active screening of chemical space, identifying novel materials for practical applications, and classifying structurally diverse materials given their measured properties. This study analyzes the performance of three efficient quantum machine learning algorithms viz., variational quantum classifier (VQC), quantum support vector classifier (QSVC), and quantum neural networks (QNN) for distinguishing transition metal chalcogenides (TMCs) from transitional metal oxides (TMOs). By employing feature selection, classical machine learning achieves 100% accuracy whereas QML achieves the highest performance of 99% and 98% for test and train data respectively on QSVC. Further, to extend the QML models for structural and functional analysis of materials that cannot be inferred directly from the formula, stability analysis, and magnetic nature analysis on 1000 and 500 materials are performed, respectively. The stability analysis achieves 78% accuracy with QSVC and the magnetic nature analysis achieves 88% with QNN establishing the competence of QML models. This study proves that QML models are remarkable in materials classification and analysis which fuels the task of materials discovery in the future.

COMPUTATIONALLY EFFICIENT DEEP FEDERATED LEARNING WITH OPTIMIZED FEATURE SELECTION FOR IOT BOTNET DETECTION

Internet of Things (IoT) is a technology that has revolutionized various fields, offering numerous benefits, such as remote patient monitoring, enhanced energy efficiency, and automation of routine tasks in homes. However, unsecured IoT devices are susceptible to botnet-based attacks such as distributed denial of Service (DDoS). Conventional machine learning models used for detecting these attacks compromise data privacy, prompting the adoption of federated learning (FL) to improve privacy. Yet, most FL-based cyberattack detection models proposed for IoT environments do not address computational complexity to suit their deployment on resource-constrained IoT edge devices. This paper introduces an FL model with low computational complexity, designed for detecting IoT botnet attacks. The study employs feature selection and dimensionality reduction to minimize computational complexity while maintaining high accuracy. First, an extreme gradient boosting model, trained with repeated stratified k-fold cross-validation, is used to select the optimal features of the botnet dataset based on feature importance. Principal component analysis is then used to reduce the dimensionality of these features. Finally, a differentially private multi-layer perceptron is trained locally by four FL clients and aggregated through federated averaging (FedAvg) to form a global Mirai botnet attack detection model. The model achieved an accuracy, precision, recall, and F1-score of 99.93%, an area under the curve of 1.0, and 8,612 floating-point operations, contributing to 87.34% reduction in computational complexity compared to the previous work. The proposed model is well-suited for detecting botnet attacks in smart homes, smart grids, and environments where resource-constrained IoT edge devices are deployed.

Advanced Transfer Learning Strategies for Improving Deep Learning Model Efficiency and Accuracy

Machine learning primarily focuses on supervised learning, which relies on labeled data, while unsupervised learning addresses data without labels. Reinforcement learning, on the other hand, develops agents that learn optimal actions based on past experiences. Transfer learning, distinctively, enhances learning in a target task by leveraging knowledge from related source tasks. In recent years, many machine learning models have remained single-task focused. This paper explores scenarios in which transfer learning can be applied effectively from a source domain to a target domain, employing feature selection, extraction, and construction techniques. These methods enable transformation into a new feature space by generating a refined subset of the original features.

Artificial intelligence in cardiology: a machine learning model for supraventricular tachycardia discrimination

Abstract Background Distinguishing atrioventricular nodal reentrant tachycardia (AVNRT) from orthodromic atrioventricular reentrant tachycardia (AVRT) presents a diagnostic challenge, with clinical and electrocardiogram (ECG) features playing a crucial role in differential diagnosis. Purpose The aim of this study was to devise and validate a predictive algorithm that utilises basic clinical and ECG parameters to accurately classify AVNRT versus AVRT. Furthermore, this algorithm was integrated into a user-friendly, web-based tool to support clinical decision-making. Methods We conducted a prospective analysis of 704 patients (median age: 53.6 years; 59.7% female) with electrophysiologically confirmed AVNRT (n=535) or AVRT (n=169). A comprehensive evaluation was performed using a structured questionnaire tailored to arrhythmia-specific symptoms. The study utilised advanced machine learning techniques for classification, employing feature selection methods to enhance predictive accuracy. The analysis included 19 demographic, clinical, and ECG variables, adopting an 80-20% split for training and internal validation. The algorithm's performance was evaluated against a model comprising all variables (Full Model), expert ECG interpretations (ExpertECG), objective ECG criteria (ECG model), and a baseline dummy classifier, with efficacy assessed by the Area Under the Receiver Operating Characteristic curve (AUC) and the Area Under the Precision-Recall Curve (AUPRC). Results The optimised model, utilising the XGBoost algorithm with six critical variables (initial age at first episode, biological sex, presence of neck palpitations, pseudoR wave in lead V1/pseudoS wave in inferior leads, visibility of retrograde P-waves, and tachycardia cycle length), exhibited superior performance, achieving an AUC of 0.916 and an AUPRC of 0.823. This model significantly outperformed other comparative models in terms of predictive accuracy (Figure 1). Implementation of the model into a web-based interface was accomplished using Shiny, enhancing its accessibility for clinical application (Figure 2). Conclusions This study illustrates the efficacy of employing machine learning algorithms to utilise bedside clinical and ECG variables for accurately differentiating between AVNRT and AVRT. The creation of a web-based calculator marks a significant advancement, empowering clinicians, especially non-specialists, with a potent tool for providing personalised diagnostic insights. Future research should focus on external validation to ascertain the model's generalisability and its applicability in broader clinical settings.Figure 1Figure 2

Predicting House Prices Using Regression Model

This paper shows a study on the development of a predictive model for house prices. The model uses machine learning techniques to analyze a large dataset of of housing market data, including demographic information, real estate trends, and economic indicators. The goal of the model is to accurately predict the sale prices of a house given its features and traits. To achieve this target, the study employs feature selection and engineering methods to determine the most significant predictors of house prices [1]. The results of the model are evaluated using standard metrics, sucha as root mean squared error [RMSE] and mean absolute error [MAE]. The results show that the proposed model outperforms benchmark model and provides a reliable prediction of house prices. The model can be used by real estate professionals, policymakers, and homebuyers to gain insights into the housing market and make the right choice [3]. Keywords- Regression, prediction, house price, Machine Learning.

Computational modeling of air pollutants for aquatic risk: Prediction of ecological toxicity and exploring structural characteristics

Assessing the aquatic toxicity originating from air pollutants is essential in sustaining water resources and maintaining the ecosystem's safety. Quantitative structure-activity relationship (QSAR) models provide a computational tool for predicting pollutant toxicity, facilitating the identification/evaluation of the contaminants and identifying responsible structural fragments. One-vs-all (OvA) QSAR is a tailored approach to address multi-class QSAR problems. The study aims to determine five distinct levels of aquatic hazard categories for airborne pollutants using OvA-QSAR modeling containing 254 air contaminants. This QSAR analysis reveals the critical descriptors of air pollutants to target for molecular modification. Various factors, including the selection of relevant mechanistic descriptors, data quality, and outliers, determine the reliability of QSAR models. By employing feature selection and outlier identification approaches, the robustness and accuracy of our QSAR models were significantly increased, leading to more reliable predictions in chemical hazard assessment. The results revealed that models using the Random Forest algorithm performed the best based on the selected descriptors, with internal and external validation accuracy ranging from 71.90% to 97.53% and 76.47%–98.03%, respectively. This study indicated that the aquatic risk of air contaminants might be attributed predominantly to their sp3/sp2 carbon ratio, hydrogen-bond acceptor capability, hydrophilicity/lipophilicity, and van der Waals volumes. These structures can be critical in developing innovative strategies to mitigate or avoid the chemicals' harmful effects. Supporting air quality improvement, this study contributes to the rapid implementation of measures to protect aquatic ecosystems affected by air pollution.

Optimizing Random Forest for Predicting Thoracic Surgery Success in Lung Cancer Using Recursive Feature Elimination and GridSearchCV

Abstract. Lung cancer is one of the deadliest forms of cancer, claiming numerous lives annually. Thoracic surgery is a strategy to manage lung cancer patients; however, it poses high risks, including potential nerve damage and fatal complications leading to mortality. Predicting the success rate of thoracic surgery for lung cancer patients can be accomplished using data mining techniques based on classification principles. Medical data mining involves employing mathematical, statistical, and computational methods. In this study, the prediction of thoracic surgery success employs the random forest algorithm with recursive feature elimination for feature selection. The feature selection process yields the top 8 features. The 8 best features include 'DGN', 'PRE4', 'PRE5', 'PRE6', 'PRE10', 'PRE14', 'PRE30', and 'AGE'. Hyperparameter using GridSearchCV is then applied to enhance classification accuracy. The results of this method implementation demonstrate a predictive accuracy of 91.41%. Purpose: The study aims to develop and evaluate a Random Forest model with a Recursive Feature Elimination feature selection and applies hyperparameter GridSearchCV for predicting thoracic surgery success rate. Methods: This study uses the thoracic surgery dataset and applies various data preprocessing techniques. The dataset is then used for classification using the Random Forest algorithm and applies the Recursive Feature Elimination feature selection to obtain the best features. GridSearchCV is used in this study for hyperparameter. Result: The accuracy using the Random Forest algorithm and Recursive Feature Elimination feature selection with hyperparameters tuning GridSearchCV resulted in an accuracy of 91,41%. The accuracy was obtained from the following parameters values: bootstrap set to false, criterion set to gini, n_estimator equal to 100, max_depth set to none, min_samples_split equal to 4, min_samples_leaf equal to 1, max_features set to auto, n_jobs set to -1, and verbose set to 2 with 10-fold cross validation. Novelty: This study comparison and analysis of various dataset preprocessing methods and different model configurations are conducted to find the best model for predicting the success rate of thoracic surgery. The study also employs feature selection to choose the best feature to be used in classification process, as well as hyperparameter tuning to achieve optimal accuracy and discover the optimal values for these hyperparameters.

Intelligent cardiovascular disease diagnosis using deep learning enhanced neural network with ant colony optimization

To identify patterns in big medical datasets and use Deep Learning and Machine Learning (ML) to reliably diagnose Cardio Vascular Disease (CVD), researchers are currently delving deeply into these fields. Training on large datasets and producing highly accurate validation results is exceedingly difficult. Furthermore, early and precise diagnosis is necessary due to the increased global prevalence of cardiovascular disease (CVD). However, the increasing complexity of healthcare datasets makes it challenging to detect feature connections and produce precise predictions. To address these issues, the Intelligent Cardiovascular Disease Diagnosis based on Ant Colony Optimisation with Enhanced Deep Learning (ICVD-ACOEDL) model was developed. This model employs feature selection (FS) and hyperparameter optimization to diagnose CVD. Applying a min–max scaler, medical data is first consistently prepared. The key feature that sets ICVD-ACOEDL apart is the use of Ant Colony Optimisation (ACO) to select an optimal feature subset, which in turn helps to upgrade the performance of the ensuring deep learning enhanced neural network (DLENN) classifier. The model reforms the hyperparameters of DLENN for CVD classification using Bayesian optimization. Comprehensive evaluations on benchmark medical datasets show that ICVD-ACOEDL exceeds existing techniques, indicating that it could have a significant impact on CVD diagnosis. The model furnishes a workable way to increase CVD classification efficiency and accuracy in real-world medical situations by incorporating ACO for feature selection, min–max scaling for data pre-processing, and Bayesian optimization for hyperparameter tweaking.

Feature selection technique on convolutional neural network – multilabel classification task

Automated text-based recommendation, an artificial intelligence development, finds application in document analysis like job resumes. The classification of job resumes poses challenges due to the ambiguity in categorizing multiple potential jobs in a single application file, termed multi-label classification, deep learning, particularly convolutional neural networks (CNN), offers flexibility in enhancing feature representations. Despite its robust learning capabilities, the black-box design of deep learning lacks interpretability and demands a substantial number of parameters, requiring significant computational resources. The primary challenge in multilabel learning is the ambiguity of labels not fully explained by traditional equivalence relations. To address this, the research employs feature selection techniques, specifically the Chi-square method. The goal is to reduce features in deep learning models while considering label relevance in multi-label text classification, easing computational workload while preserving model performance. Experimental tests, both with and without the Chi-square feature selection technique on the dataset, underscore its substantial impact on the classification model's ability. The conclusion emphasizes the influence of the Chi-square feature selection technique on performance and computational time. In summary, the research underscores the importance of balancing computational efficiency and model interpretability, especially in complex multi-label classification tasks like job applications.

Estimating the severity of obstructive sleep apnea during wakefulness using speech: A review

Obstructive sleep apnea (OSA) is a chronic breathing disorder during sleep that affects 10-30% of adults in North America. The gold standard for diagnosing OSA is polysomnography (PSG). However, PSG has several drawbacks, for example, it is a cumbersome and expensive procedure, which can be quite inconvenient for patients. Additionally, patients often have to endure long waitlists before they can undergo PSG. As a result, other alternatives for screening OSA have gained attention. Speech, as an accessible modality, is generated by variations in the pharyngeal airway, vocal tract, and soft tissues in the pharynx, which shares similar anatomical structures that contribute to OSA. Consequently, in this study, we aim to provide a comprehensive review of the existing research on the use of speech for estimating the severity of OSA. In this regard, a total of 851 papers were initially identified from the PubMed database using a specified set of keywords defined by population, intervention, comparison and outcome (PICO) criteria, along with a concatenated graph of the 5 most cited papers in the field extracted from ConnectedPapers platform. Following a rigorous filtering process that considered the preferred reporting items for systematic reviews and meta-analyses (PRISMA) approach, 32 papers were ultimately included in this review. Among these, 28 papers primarily focused on developing methodology, while the remaining 4 papers delved into the clinical perspective of the association between OSA and speech. In the next step, we investigate the physiological similarities between OSA and speech. Subsequently, we highlight the features extracted from speech, the employed feature selection techniques, and the details of the developed models to predict OSA severity. By thoroughly discussing the current findings and limitations of studies in the field, we provide valuable insights into the gaps that need to be addressed in future research directions.

Phishing Website Detection Using Bidirectional Gated Recurrent Unit Model and Feature Selection

Phishing attacks continue to be a significant threat to internet users, necessitating the development of advanced detection systems. This study explores the efficacy of a Bidirectional Gated Recurrent Unit (BiGRU) model combined with feature selection techniques for detecting phishing websites. The dataset used for this research is sourced from the UCI Machine Learning Repository, specifically the Phishing Websites dataset. This approach involves cleaning and preprocessing the data, then normalizing features and employing feature selection to identify the most relevant attributes for classification. The BiGRU model, known for its ability to capture temporal dependencies in data, is then applied. To ensure robust evaluation, we utilized cross-validation, dividing the data into five folds. The experimental results are highly promising, demonstrating a Mean Accuracy, Mean Precision, Mean Recall, Mean F1 Score, and Mean AUC of 1.0. These results indicate the model's exceptional performance distinguishing between phishing and legitimate websites. This study highlights the potential of combining BiGRU models with feature selection and cross-validation to create highly accurate phishing detection systems, providing a reliable solution to enhance cybersecurity measures.

Enhancing machine learning algorithm performance through feature selection for driver behavior classification

Machine learning (ML) techniques empower computers to learn from data and make predictions or decisions in various domains, while preprocessing methods assist in cleaning and transforming data before it can be effectively utilized by ML. Feature selection in ML is a critical process that significantly influences the performance and effectiveness of models. By carefully choosing the most relevant and informative attributes from the dataset, feature selection enhances model accuracy, reduces overfitting, and minimizes computational complexity. In this study, we leverage the UAH-DriveSet dataset to classify driver behavior, employing Filter, embedded, and wrapper methods encompassing 10 distinct feature selection techniques. Through the utilization of diverse ML algorithms, we effectively categorize driver behavior into normal, drowsy, and aggressive classes. The second objective is to employ feature selection techniques to pinpoint the most influential features impacting driver behavior. As a results, random forest emerges as the top-performing classifier, achieving an impressive accuracy of 96.4% and an F1-score of 96.36% using backward feature selection in 7.43 s, while K-nearest neighbour (K-NN) attains an accuracy of 96.29% with forward feature selection in 0.05 s. Following our comprehensive results, we deduce that the primary influential features for studying driver behavior include speed (km/h), course, yaw, impact time, road width, distance to the ahead vehicle, vehicle position, and number of detected vehicles.

Parsimonious Random-Forest-Based Land-Use Regression Model Using Particulate Matter Sensors in Berlin, Germany.

Machine learning (ML) methods are widely used in particulate matter prediction modelling, especially through use of air quality sensor data. Despite their advantages, these methods' black-box nature obscures the understanding of how a prediction has been made. Major issues with these types of models include the data quality and computational intensity. In this study, we employed feature selection methods using recursive feature elimination and global sensitivity analysis for a random-forest (RF)-based land-use regression model developed for the city of Berlin, Germany. Land-use-based predictors, including local climate zones, leaf area index, daily traffic volume, population density, building types, building heights, and street types were used to create a baseline RF model. Five additional models, three using recursive feature elimination method and two using a Sobol-based global sensitivity analysis (GSA), were implemented, and their performance was compared against that of the baseline RF model. The predictors that had a large effect on the prediction as determined using both the methods are discussed. Through feature elimination, the number of predictors were reduced from 220 in the baseline model to eight in the parsimonious models without sacrificing model performance. The model metrics were compared, which showed that the parsimonious_GSA-based model performs better than does the baseline model and reduces the mean absolute error (MAE) from 8.69 µg/m3 to 3.6 µg/m3 and the root mean squared error (RMSE) from 9.86 µg/m3 to 4.23 µg/m3 when applying the trained model to reference station data. The better performance of the GSA_parsimonious model is made possible by the curtailment of the uncertainties propagated through the model via the reduction of multicollinear and redundant predictors. The parsimonious model validated against reference stations was able to predict the PM2.5 concentrations with an MAE of less than 5 µg/m3 for 10 out of 12 locations. The GSA_parsimonious performed best in all model metrics and improved the R2 from 3% in the baseline model to 17%. However, the predictions exhibited a degree of uncertainty, making it unreliable for regional scale modelling. The GSA_parsimonious model can nevertheless be adapted to local scales to highlight the land-use parameters that are indicative of PM2.5 concentrations in Berlin. Overall, population density, leaf area index, and traffic volume are the major predictors of PM2.5, while building type and local climate zones are the less significant predictors. Feature selection based on sensitivity analysis has a large impact on the model performance. Optimising models through sensitivity analysis can enhance the interpretability of the model dynamics and potentially reduce computational costs and time when modelling is performed for larger areas.

Detecting tumors in medical images using segmentation and feature extraction techniques

Tumors rank among the most prevalent and lethal diseases worldwide, emphasizing the paramount importance of early detection in mitigating mortality rates. There has been a tremendous growth in medical image segmentation and classification for diagnosing cancer. This led to the various developments in medical research that help in diagnosing types of cancers and other human medical problems. This work focuses on performing effective segmentation procedures and feature extraction by a proposed hybrid intelligent technique for detecting tumors in the medical images. Additionally, the research addresses the design aspects of feature extraction, image classification, and texture features. These features are reduced by employing feature selection. Finally, experiments were conducted to compare tumor detection in medical images using the proposed algorithm with other existing algorithms. The results demonstrated promising achievements in terms of their evaluation metrics.

Improving Credit Card Fraud Detection with Data Reduction Approaches

Detecting fraudulent activities in credit card transactions can be challenging due to issues like high dimensionality and class imbalance that are often present in the datasets. To address these challenges, data reduction techniques such as data sampling and feature selection have become essential. In this study, we compare four approaches for data reduction: using data sampling alone, employing feature selection alone, applying data sampling followed by feature selection, and using feature selection followed by data sampling. Additionally, we include results using all features. We build classification models using five Decision Tree-based classifiers and Logistic Regression, and evaluate their performance using two performance metrics: the Area Under the Receiver Operating Characteristic Curve (AUC) and the Area under the Precision–Recall Curve (AUPRC). In this work, we adopt ensemble supervised feature selection (SFS) techniques and Random Undersampling (RUS) for data reduction. The experimental results demonstrate that all four data reduction techniques have the potential to improve the performance of classifiers. These results are valuable since the classifiers available are dependent upon application domains, computing environments, and licensing agreements. However, these techniques can be applied independently of all these dependencies. We recommend utilizing the ensemble SFS followed by RUS (SFS–RUS) approach as the preferred data reduction method due to its ability to run feature selection and data sampling in parallel. Additionally, we find that XGBoost and CatBoost outperform other classifiers.

Enhancing a machine learning model for predicting agricultural drought through feature selection techniques

This study aims to determine the crucial variables for predicting agricultural drought in various climates of Iran by employing feature selection methods. To achieve this, two databases were used, one consisting of ground-based measurements and the other containing six reanalysis products for temperature (T), root zone soil moisture (SM), potential evapotranspiration (PET), and precipitation (P) variables during the 1987–2019 period. The accuracy of the global database data was assessed using statistical criteria in both single- and multi-product approaches for the aforementioned four variables. In addition, five different feature selection methods were employed to select the best single condition indices (SCIs) as input for the support vector regression (SVR) model. The superior multi-products based on time series (SMT) showed increased accuracy for P, T, PET, and SM variables, with an average 47%, 41%, 42%, and 52% reduction in mean absolute error compared to SSP. In hyperarid climate regions, PET condition index was found to have high relative importance with 40% and 36% contributions to SPEI-3 and SPEI-6, respectively. This suggests that PET plays a key role in agricultural drought in hyperarid regions because of very low precipitation. Additionally, the accuracy results of different feature selection methods show that ReliefF outperformed other feature selection methods in agricultural drought modeling. The characteristics of agricultural drought indicate the occurrence of drought in 2017 and 2018 in various climates in Iran, particularly arid and semi-arid climates, with five instances and an average duration of 12 months of drought in humid climates.

Development of Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy Coupled with Multivariate Classification Chemometric Model for Routine Screening of Paracetamol, Ibuprofen, and Aspirin Adulteration in Herbal Products

Objective: The objective of this study is to develop and validate a routine screening test for the determination of three common antipyretic-analgesic synthetic drugs (paracetamol, ibuprofen, and aspirin) adulteration in herbal products using Attenuated Total Reflectance Fourier Transform Infrared (ATR-FTIR) coupled with chemometric method. Methods: ATR-FTIR spectra of sixteen testing sets of herbal product samples for pain and fever indications were used for multivariate chemometrics model construction. Linear Discriminant Analysis (LDA) was selected as a method for model construction with IBM SPSS for statistical analysis. Model development employed feature selection, such as the stepwise method for variable selection. The model with a high %correct classification and cross-validation was selected and was then validated with an independent testing data set with an auto-prediction test, confusion matrix, and Receiver Operating Characteristic (ROC) curve. To validate the developed test for routine use, the result from ATR-FTIR method was compared with the standard HPLC and TLC analyses used for adulteration screening. Results: The selected model's overall %correct classification result was 97.7%, with a cross-validation of 93.8% rate in training set samples. External validation with an independent testing dataset gave an overall correct classification of 93.8%, with an area under the curve of ROC at 0.979. Comparative testing revealed that model performance was comparable with the HPLC and TLC methods, which routinely detect the presence of paracetamol, aspirin, and ibuprofen. The results of testing set samples classification were consistent with training set samples. Conclusion: Against the standard chromatographic methods, the multivariate chemometric model based on ATR-FTIR demonstrates comparable detection capability to determine adulteration of paracetamol, ibuprofen, and aspirin in herbal products.

Intrusion Detection System on Cloud Computing using Ensemble SVM

This study introduces a specialized Intrusion Detection System (IDS) designed specifically for cloud computing environments. By leveraging the UNSW_NB15 dataset, it employs feature selection techniques such as SelectKBest and ANOVA to extract relevant features, thereby improving the overall performance of the model. The IDS framework encompasses data preprocessing, Ensemble SVM model training, and performance evaluation utilizing standard metrics. The key methodology revolves around training SVM models using bagging and boosting techniques on preprocessed data, resulting in resilient intrusion detection models. These models are subsequently utilized to determine whether a given set of input features signifies a network intrusion. Through experimental analysis, the research demonstrates the system's efficacy in accurately detecting network intrusions, shedding light on its robustness and dependability.

Employing Feature Selection Algorithms to Determine the Immune State of Mice Model of Rheumatoid Arthritis.

The immune response is a dynamic process by which the body determines whether an antigen is self or nonself. The state of this dynamic process is defined by the relative balance and population of inflammatory and regulatory actors which comprise this decision making process. The goal of immunotherapy as applied to, e.g. Rheumatoid Arthritis (RA), then, is to bias the immune state in favor of the regulatory actors - thereby shutting down autoimmune pathways in the response. While there are several known approaches to immunotherapy, the effectiveness of the therapy will depend on how this intervention alters the evolution of this state. Unfortunately, this process is determined not only by the dynamics of the process, but the state of the system at the time of intervention - a state which is difficult if not impossible to determine prior to application of the therapy. To identify such states we consider a mouse model of RA (Collagen-Induced Arthritis (CIA)) immunotherapy; collect high dimensional data on T cell markers and populations of mice after treatment with a recently developed immunotherapy for CIA; and use feature selection algorithms in order to select a lower dimensional subset of this data which can be used to predict both the full set of T cell markers and populations, along with the efficacy of immunotherapy treatment.

ADHD-AID: Aiding Tool for Detecting Children's Attention Deficit Hyperactivity Disorder via EEG-Based Multi-Resolution Analysis and Feature Selection.

The severe effects of attention deficit hyperactivity disorder (ADHD) among adolescents can be prevented by timely identification and prompt therapeutic intervention. Traditional diagnostic techniques are complicated and time-consuming because they are subjective-based assessments. Machine learning (ML) techniques can automate this process and prevent the limitations of manual evaluation. However, most of the ML-based models extract few features from a single domain. Furthermore, most ML-based studies have not examined the most effective electrode placement on the skull, which affects the identification process, while others have not employed feature selection approaches to reduce the feature space dimension and consequently the complexity of the training models. This study presents an ML-based tool for automatically identifying ADHD entitled "ADHD-AID". The present study uses several multi-resolution analysis techniques including variational mode decomposition, discrete wavelet transform, and empirical wavelet decomposition. ADHD-AID extracts thirty features from the time and time-frequency domains to identify ADHD, including nonlinear features, band-power features, entropy-based features, and statistical features. The present study also looks at the best EEG electrode placement for detecting ADHD. Additionally, it looks into the location combinations that have the most significant impact on identification accuracy. Additionally, it uses a variety of feature selection methods to choose those features that have the greatest influence on the diagnosis of ADHD, reducing the classification's complexity and training time. The results show that ADHD-AID has provided scores for accuracy, sensitivity, specificity, F1-score, and Mathew correlation coefficients of 0.991, 0.989, 0.992, 0.989, and 0.982, respectively, in identifying ADHD with 10-fold cross-validation. Also, the area under the curve has reached 0.9958. ADHD-AID's results are significantly higher than those of all earlier studies for the detection of ADHD in adolescents. These notable and trustworthy findings support the use of such an automated tool as a means of assistance for doctors in the prompt identification of ADHD in youngsters.