Emotional Abuse Research Articles

Relationship between childhood trauma and risk-taking and self-harm behaviors among Eswatini adolescents.

Relationship between childhood trauma and risk-taking and self-harm behaviors among Eswatini adolescents.

Emotional maltreatment and adolescent friendship quality: Examining the divergent impacts of abuse and neglect on friendship development across gender.

Emotional maltreatment and adolescent friendship quality: Examining the divergent impacts of abuse and neglect on friendship development across gender.

Network analysis of adverse childhood experiences and problematic internet use among Chinese adolescents.

Network analysis of adverse childhood experiences and problematic internet use among Chinese adolescents.

The Relationship Between Parent-Adolescent Relationships and Emotional Abuse.

This study aimed to evaluate the relationship between parent-adolescent relationships and emotional abuse. The research was conducted with 400 adolescents between 25.11.2023 and 25.03.2024. Adolescents in one school were included in the study by simple random sampling method. Data were collected with AMFRI and EAQ and a questionnaire regarding the demographic structure of adolescents. ANOVA, t-test and correlation analysis were used to analyze the data of the study. The average score of the adolescents from the Emotional Abuse Questionnaire was 30.43 ± 23.11 and the total average score received from the Adolescent-Mother, Father Relationship Inventory was 126.22 ± 24.57 for their mothers and 133.38 ± 32.36 for their fathers. It was determined that there was a moderate negative relationship between EAQ and its sub-scales and AMFRI (mother) score averages. It was determined that there was a weak negative relationship between EAQ and its sub-scales and AMFRI (father) score averages. Emotional abuse scores of adolescents were found to be high and parental relationships were evaluated as inadequate. Adolescents' experiences of emotional abuse and parental relationships were found to be related to each other.

A prospective, randomized control trial of concurrent paclitaxel and carboplatin along with radiotherapy versus concurrent cisplatin along with radiotherapy in carcinoma cervix patients at a tertiary care hospital of central India.

TPS5620 Background: In India, cervical cancer accounted for 9.0% of all cancers and 18.3% (127,526) of new cases in 2022 as per GLOBOCAN. It is leading cause of cancer-related deaths in women in low and middle-income countries. Concurrent chemoradiotherapy (CCRT) with Cisplatin is standard for LACC but is often limited by nephrotoxicity & ototoxicity. Hence, the combination of paclitaxel and carboplatin has been explored for its potentially favorable toxicity profile and effectiveness. Thus comparative analysis of two concurrent chemoradiotherapy regimens examining their efficacy, toxicity profiles and suitability for patients. is assessed. The results can have significant implications for clinical practice, particularly in resource-limited settings where treatment- related toxicity and patient compliance are critical concerns. Methods: Simple randomization with open label study conducted to compare the efficacy and toxicity of concurrent radiotherapy with paclitaxel and carboplatin versus concurrent radiotherapy with cisplatin in patients with locally advanced cervical cancer. Conducted in Department of Radiation Oncology, GMC Nagpur from July 2024 to December 2026. Sample size 100 (50 each group assuming 10% dropout) Inclusion criteria: Age 18-70 years, histologically confirmed diagnosis, FIGO stage IB1 to IVA, ECOG 0-3, written informed consent, baseline audiometry. Exclusion criteria: Prior chemo-radiotherapy for cervical cancer, severe comorbid conditions, pregnant or breastfeeding women, and known hypersensitivity to study drugs. Intervention: Arm A: Concurrent Cisplatin with EBRT to pelvis with dose of 45-50 Gy/ 23-25 fractions followed by brachytherapy. Chemotherapy: Cisplatin 40 mg/m² IV weekly for up to 6 cycles. Arm B: Concurrent RT with Paclitaxel and Carboplatin. RT: Same as Arm A. Chemotherapy: Paclitaxel 50 mg/m² and carboplatin AUC 2 IV weekly for up to 6 cycles. Primary Outcomes: Locoregional control (RECIST criteria at 3,6,12 and 24 months post-treatment). Secondary Outcomes: Overall Survival, Progression-Free Survival, Disease-free survival, Toxicity, Quality of Life (EORTC QLQ-C30) questionnaire. Data Collection and Analysis: Baseline assessments-Medical history, physical examination, laboratory tests, imaging studies. During treatment- Weekly clinical assessments, laboratory tests and toxicity evaluations. Follow-up: Clinical assessments, Imaging studies and QoL at 0, 3, 6, 12 and 24 months post-treatment. Ethical Considerations: Ethical approval is obtained from relevant institutional review boards on 04/12/2024. Patients are under accrual.

Effect of Metacid on toxicity, behaviour and dose-response relationship in fingerlings of Channa gachua (Ham).

In the present work an attempt has been made to evaluate the effect of Metacid (an organophosphate pesticide) on toxicity, behavior and dose-response relationship in the fingerlings of a freshwater air breathing snake headed murrel fish, Channa gachua (Ham). The safe concentration value of Metacid was calculated to be 4.12 ppm at 29.0 ± 1.0 degree C. The behavioral response of the fish (fingerlings) towards toxicant was grossly dependent on concentration and length of exposure with unit increase in the concentration of Metacid, the opercular beating decreased by a power of -3.891 (b value or repression coefficient) at 29.0 ± 1.0°C. The co-relation coefficients were very high.. KEYWORDS :Toxicity, Behavior, Metacid, Fish.

Effectiveness of mindfulness-based cognitive therapy for treating generalized anxiety disorder and the moderating influence of abuse during childhood: A randomized controlled trial.

Effectiveness of mindfulness-based cognitive therapy for treating generalized anxiety disorder and the moderating influence of abuse during childhood: A randomized controlled trial.

Childhood adversity and empathy in eating disorders: Exploring transdiagnostic profiles and socio-emotional functioning.

Childhood adversity and empathy in eating disorders: Exploring transdiagnostic profiles and socio-emotional functioning.

The effects of sexual orientation and adverse childhood experiences on short sleep duration: Evidence from the behavioral risk factor surveillance system (BRFSS).

The effects of sexual orientation and adverse childhood experiences on short sleep duration: Evidence from the behavioral risk factor surveillance system (BRFSS).

Child Torture Perpetrated by a Caregiver: Identification, Evaluation, and Management.

Child Torture Perpetrated by a Caregiver: Identification, Evaluation, and Management.

Immune related kidney toxicity, management, and outcomes in ICI treated patients with advanced or metastatic cancers.

2601 Background: The impact of kidney immune-related adverse events (KirAEs) and their management (mgmt) on clinical outcomes in patients receiving immune checkpoint inhibitors (ICI) has not been fully examined. We aimed to evaluate the association between KirAEs, their mgmt, and progression-free survival (PFS) and overall survival (OS) in ICI-treated cancer patients. Methods: Data were drawn from the Flatiron Health Research Database, an EHR-based database representing 280+ U.S. oncology practices. Adults with advanced non-small cell lung cancer (aNSCLC), advanced melanoma (aMel), or metastatic renal cell carcinoma (mRCC) who initiated ICI between 1/1/16 - 12/31/20 were included and followed from ICI initiation to death, loss to follow-up, or end of the study period (12/31/21). CTCAE Grade 2 or higher KirAEs and mgmt actions (immunosuppression using corticosteroids or other immunosuppressants, ICI-regimen holds, ICI-regimen discontinuations) and hospitalizations were curated from unstructured data. Cox regression was used to evaluate the association between KirAEs, their mgmt (both as time-varying covariates) and PFS and OS adjusting for baseline characteristics such as line of therapy and corticosteroid use. The earliest KirAE per patient was examined in survival analyses. Results: The study included 513 aNSCLC, 463 aMel, and 451 mRCC patients. For aNSCLC, aMel, and mRCC, respectively, 21.1%, 29.6%, and 33.9% experienced at least one KirAE, with a median time to onset of 70, 84, and 128 days. Nephritis ranged from 2.1% of KirAEs in aNSCLC to 4.6% in aMel. Elevated creatinine was the most common KirAE (23.6% in mRCC to 29.1% in aNSCLC), followed by acute kidney injury (20.5% in mRCC to 28.4% in aNSCLC). Immunosuppression was used to treat KirAEs in 67.6%, 80.3%, and 67.3% of aNSCLC, aMel, and mRCC patients with KirAEs. In aNSCLC, aMel, and mRCC, respectively, median OS was 17.1, 58.6, and 33.7 months, median PFS was 7.8, 8.9, and 9.5 months, and patients with KirAEs had longer PFS than those without KirAEs [HR (95%CI): 0.65 (0.51-0.83); 0.74 (0.57-0.97); 0.67 (0.53-0.84)]. In aNSCLC, KirAEs were associated with shorter OS [1.31 (0.98-1.74); P = 0.06]. In all cancers, KirAEs that occurred during hospitalization or led to hospitalization were associated with shorter OS (HR≥2.84; P < 0.02). KirAE mgmt was not associated with OS or PFS. Conclusions: Results suggest that while KirAEs might indicate an intensified immune response, their management and impact on survival vary across cancer types and call for cancer-specific strategies for early identification and management of KirAEs in the ambulatory care setting.

Childhood psychological maltreatment and addictive social media use in Chinese adolescents: A path model of sense of control and negative affect as mediators.

Childhood psychological maltreatment and addictive social media use in Chinese adolescents: A path model of sense of control and negative affect as mediators.

Retrospective Childhood Emotional Maltreatment and Adolescent Problem Behaviors Trajectories: The Mediating Roles of Neuroticism and Self-Compassion

Retrospective Childhood Emotional Maltreatment and Adolescent Problem Behaviors Trajectories: The Mediating Roles of Neuroticism and Self-Compassion

Gender differences in the associations of adverse childhood experiences with depression and anxiety: A systematic review and meta-analysis.

Gender differences in the associations of adverse childhood experiences with depression and anxiety: A systematic review and meta-analysis.

Efficacy and safety of triple oral metronomic chemotherapy in patients with advanced esophageal squamous cell carcinoma.

e16043 Background: Patients with advanced esophageal squamous cell carcinoma (ESCC) have dismal survival outcomes post-progression on standard first-line chemoimmunotherapy. The median overall survival (OS) is usually less than a year. Patients receiving subsequent line treatment options experience significant treatment related toxicities (> 50-60% develop > grade 3 toxicities), are frail, and have a poor ECOG Performance Status (> 30% have ECOG-PS >2). Triple oral metronomic chemotherapy (triple-OMCT) is an efficacious and cost-effective treatment option in patients with locally advanced head and neck SCC. We aimed to explore the role of triple-OMCT in patients of advanced ESCC treated at our institute. Methods: This was a retrospective observational study conducted at our institute between 28.05.2019 to 09.01.2025 Patients of advanced esophageal SCC who had progressed on prior lines of systemic treatment were treated with triple-OMCT (tablet methotrexate 9mg/m 2 per week, tablet erlotinib 150mg once daily, capsule celecoxib 200mg twice daily). The addition of immunotherapy was permitted with this regimen. We assessed treatment efficacy [objective response rate (ORR)], safety, and survival outcomes [progression-free (PFS), OS] in these patients. Results: The data of 57 consecutively evaluated patients was analyzed. Median age was 59 years (IQR, 52.5-63.0), 54.4% (n = 31) were females, and 86.0% (n = 49) had an ECOG-PS of 0-1. Prior treatment in the curative or palliative setting was received by 64.9% (n = 37) patients, and the median number of prior lines of treatment was 2 (IQR, 1-2). At OMCT initiation, 68.4% (n = 39) patients had metastatic disease, with 54.4% (n = 31) patients having metastasis to non-regional lymph nodes. Immunotherapy was added to triple-OMCT in 47.4% (n = 27) patients. Amongst response evaluable patients (59.6%, n = 34/57), the objective response was 14.7% (five partial response), and disease control rate was 47.1% (n = 16/34, eleven stable disease). > Grade 3 toxicity was seen in 17.5% (n = 10) patients. Median follow-up of the cohort was 28.8 months (95%CI, 18.7-39.1). The median PFS and OS with the use of triple-OMCT was 3.4 months (95%CI, 2.8-3.9) and 9.7 months (95%CI, 6.6-12.8) respectively. With the addition of immunotherapy, the median PFS and OS was 3.4 months (95%CI, 2.4–4.5) and 11.4 months (95%CI, 8.8-14.0) respectively, compared to 3.0 months (95%CI, 2.5-3.6, p = 0.618) and 7.6 months (95%CI, 4.1-11.2, p = 0.386) without immunotherapy. Conclusions: Triple-OMCT is safe and has activity in patients with advanced esophageal SCC. This regimen is worthy of exploration in resource-limited settings. Best Overall Response, n (%) Patients, n (%)N=34 Complete Response (CR) 0 (0.0) Partial Response (PR) 5 (14.7) Stable Disease (SD) 11 (32.3) Progressive Disease (PD) 18 (52.9) Objective Response Rate (ORR) 14.7% Disease Control Rate (DCR) 47.1%

Stereotactic body radiation therapy (SBRT) for prostate-specific membrane antigen positron emission tomography (PSMA-PET)–detected oligometastatic prostate cancer: A real world analysis of patients treated in a reference center.

e17156 Background: Stereotactic body radiation therapy (SBRT) is a useful therapy for patients with oligometastatic prostate cancer (OPC). SBRT benefits patients by delaying androgen deprivation therapy (ADT) and thus avoiding its side effects and preserving quality of life. The aim of this study is to investigate real-world outcomes of applying SBRT to patients with OPC, who were pre-selected by PSMA-PET and did not receive concomitant ADT. Methods: A retrospective analysis of medical records was conducted at a reference oncology center in Brazil with the primary objective of evaluating androgen deprivation therapy free-survival (ADTFS). Secondary objectives included the assessment of radiologic progression free survival (PFS), PSA response, local control rate (LCR) and treatment related toxicity. All patients were oligometastatic by PSMA-PET (up to 5 lesions) and underwent SBRT without concomitant ADT. Patients were excluded if they received ADT with SBRT or started ADT within 30 days of completing SBRT. Toxicity was measured according to the Radiation Therapy Oncology Group (RTOG) score system. Results: Between 2017 and 2024, 86 prostate cancer patients received a total of 137 SBRT treatments. 50 patients were excluded due to concomitant ADT, 4 due to unmet inclusion criteria and 4 due to insufficient medical information. Our final analysis included 28 patients, 7 retreated with SBRT once, and 1 patient twice, totalling 37treatments.The average number of fractions and total dose delivered were 3 fractions (3-5) and 34,8 Gy (30-45), respectively. Median age at treatment initiation was 71 years (55-93). The total number of treated lesions was 69, with 62.3% being bone metastasis, 29.0% in lymph nodes, 7.3% lung lesions and one case (or 1.4%) in the penile bulb. SBRT was used in up to 3 metastases in 91.9% of cases, and in 4 or 5 in the remaining 8,1%. Metachronous disease represented 81% of cases, while 19% were considered synchronous disease. The median follow-up time was 27.1 months. Median ADTFS and PFS were 8,9 and 13,3 months, respectively. LCR was 62.1% in 12 months. Regarding PSA response, 21.6% of patients achieved undetectable rates, 40.6% maintained stable values, 35.1% showed PSA progression, and 2.7% lacked PSA information. RTOG grade 3 toxicity was observed in 5.4% of cases. Conclusions: SBRT is an effective and low toxicity therapeutic option for PSMA-PET selected OPC patients, who are then able to delay ADT.

Electronic patient reported outcomes in breast cancer patients receiving adjuvant chemotherapy with doxorubicin/cyclophosphamide combined with paclitaxel compared to patients receiving docetaxel/cyclophosphamide.

e12519 Background: Doxorubicin/cyclophosphamide combined with paclitaxel (ACT) and docetaxel/cyclophosphamide (TC) are two of the NCCN preferred regimens for the adjuvant treatment of Her2 neu negative early stage breast cancer. Physicians often choose one regimen over the other due to the relative toxicities of each regimen. We report on the electronic patient reported outcomes (ePROs) submitted by patients during treatment with each of these regimens. Methods: Patients treated at four community oncology sites from 2022-2024 were enrolled on a proprietary ePRO system. ePRO reporting commenced with the first cycle of chemotherapy and concluded with the last cycle of chemotherapy. Results: Over the study period 325 patients receiving ACT and 310 patients receiving TC submitted an ePRO report. The median number of reports submitted was 8 (IQR: 3, 14) for ACT and 6 (IQR: 3, 9) for TC. Median age of the ACT patients was 53 (IQR 44, 61) and median age of the TC patients was 61 (IQR: 49, 69). The most common symptoms reported by all patients were fatigue, pain, and nausea. Patients receiving ACT were more likely to report nausea (52% ACT vs 45% TC), skin/nail problems (29% ACT vs 19% TC) and numbness/tingling (35% ACT vs 17%TC) and patients receiving TC were more likely to report pain (57% TC vs 49% ACT), diarrhea (36% TC vs 26% ACT), and low grade fever (13% TC vs 8% ACT). Importantly, there were no major differences in the following symptoms: appetite, physical appearance, or performance status. As expected, cardiac symptoms were more common in the ACT group (23% ACT vs 16% TC). Conclusions: Patients report a significant number of symptoms during adjuvant chemotherapy. Avoidance of doxorubicin containing regimens does not lead to elimination of significant short term treatment related symptoms. As oncologists formulate treatment plans for patients with early stage breast cancer these differences in the symptoms experienced by patients should be considered.

Completion Rates for Patients Undergoing Concurrent Chemoradiotherapy for Stage III Nonsmall Cell Lung Cancer and its Importance in the Era of Consolidation Immunotherapy: A Cohort Study.

Completion Rates for Patients Undergoing Concurrent Chemoradiotherapy for Stage III Nonsmall Cell Lung Cancer and its Importance in the Era of Consolidation Immunotherapy: A Cohort Study.

Developmental Neurotoxicity (DNT) Studies for Chemical Safety Assessments: Basic Concepts, Experimental Strategies, and Future Directions

The 21st ESTP’s (European Society of Toxicology Pathology) Annual Congress (2024) included a 3-hour scientific session on developmental neurotoxicity (DNT) as applied to chemical safety assessments. Key concepts of this session were to provide an introduction to public concerns around this endpoint, a status update on practical aspects of DNT studies, insights into the use of DNT studies within a regulatory context, as well as some pointers on how to evaluate specific parameters. Understanding the biological and technical variability in performing neuropathology examinations (such as morphometric evaluation) is critical during the course of DNT evaluation. Using thyroid hormone disruption as an example, challenges and pitfalls impacting data interpretation were discussed. Results from the European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC) Thyroid Task Force regarding thyroid hormone–related neurodevelopmental toxicity in humans and rodents were presented. Histopathological findings in the brain and potential changes in the cochlea of pups associated with thyroid hormone imbalance in dams during pregnancy were shown. A case presentation from an Extended One-Generation Reproductive Toxicity Study (EOGRTS) showing histopathological findings in the absence of changes with morphometric endpoints was included. In conclusion, all session participants underscored the need for integrated data evaluation for DNT risk assessment.

Sexual problems among a representative sample of Australian men who have experienced physical and emotional intimate partner abuse

Abstract Background The experiences of being emotionally and physically abused by a romantic partner are associated with several deleterious outcomes including poor mental health, being sexually assaulted, and partner homicide. Aim To explore the roles of emotional and physical abuse in relation to men’s sexual functioning. Methods The sample comprised 5642 Australian men (Mage = 45.87 years, SD = 12.36) who completed Wave 4 (2022) of the Australian Longitudinal Study on Male Health: Ten to Men (T2M). As part of the T2M survey, participants completed questions relating to physical and emotional intimate partner abuse, and the National Survey of Sexual Attitudes and Lifestyles – Sexual Function subscale (Natsal-SF). Hierarchical binary logistic regression analyses were conducted to explore whether experiences of abuse in romantic relationships predicted the likelihood of sexual dysfunction in Australian men. Outcomes The variance in sexual dysfunction explained by men’s experiences of physical and emotional abuse over and above the variance explained by relevant covariates. Results The analyses showed that, after controlling for several covariates, physical abuse was not associated with any physio-psychological aspects of sexual dysfunction. However, emotional abuse was significantly associated with all aspects of physio-psychological functioning except for reaching climax more quickly than the man would have liked and experiencing pain as a result of sex. Clinical Implications The results have important implications for relationship therapy and intimacy counselling, with greater awareness of how emotional abuse impacts sexual functioning providing valuable insight for men and their partners. Strengths and Limitations The study used data from the Australian Longitudinal Study on Male Health, which sourced data from a nationally representative sample of Australian men. A potential limitation is that individual Natsal-SF items were used in lieu of the total score, and thus the same variance may be explained in multiple analyses. Conclusion The results suggest that emotional abuse is more damaging to male sexual functioning than physical abuse.