Elimination Of Leakage Research Articles

FinFET-Based Feedback Control Assisted Near-Threshold SRAM Cell

This paper presents a single-ended 12-transistor SRAM cell capable of operating at near-threshold voltage in FinFET technology. This cell employs Schmitt trigger-based inverters and feedback cut write assist technique to improve performance properties. The simulations have been done through HSPICE using 10 nm FinFET technology at a supply voltage of 0.45 V and a temperature of 25°C under 5000 Monte Carlo tests. The proposed cell improves the read static noise margin by at least 1.01 times. The write static noise margin is also increased by at least 1.07. The proposed single-ended cell leads to a reduction of α BL by 50% and offers low dynamic write power. The leakage power is also reduced by 1.03 times due to the use of single bitline in the cell structure, stack transistors in the write path and elimination of leakage in the read path.

Elimination of bile leakage in liver injuries

Aim. To study the causes and consequences of bile leakage in liver injury and determine the potential ways for its elimination. Materials and methods. The study involved a retrospective analysis of 204 liver injuries of various types. 26 % of cases were detected with isolated abdominal trauma, 74 % – with concomitant abdominal injury. According to the AAST grading scale, 15.7 % of patients got grade II liver injuries, 44.6 % – grade III, 34.3 % – grade IV, and 5.4 % – grade V. Since concomitant injuries predominated, surgical treatment was initially performed in the overwhelming number of cases. 14 % of cases received non-operative management. Results. The incidence of bile leakage amounted to 28.4 % for all liver injuries and reached 54.9 % for III–V grade injuries (AAST). Small bile leakage prevailed, while active leaking was observed in 36.2 %. Damage to peripheral parts of the biliary tract was noted in most cases (68 %). Conservative management of patients with small bile leakage associated with damage to peripheral parts of the biliary tract appeared successful in 48.5 % of cases. Endoscopic biliary drainage of bile ducts proved effective in case of active bile leakage and (or) injuries of the central bile ducts. Conclusion. Endoscopic biliary drainage of bile ducts is considered the most effective for elimination of active biliary leakage in the absence of biliary peritonitis and communication of biliary tract with pleural cavity.

Exploring advanced 2D acquisitions in breast tomosynthesis: T-shaped and Pentagon geometries.

In this study, we investigate the performance of advanced 2D acquisition geometries - Pentagon and T-shaped - in digital breast tomosynthesis (DBT) and compare them against the conventional 1D geometry. Unlike the conventional approach, our proposed 2D geometries also incorporate anterior projections away from the chest wall. Implemented on the Next-Generation Tomosynthesis (NGT) prototype developed by X-ray Physics Lab (XPL), UPenn, we utilized various phantoms to compare three geometries: a Defrise slab phantom with alternating plastic slabs to study low-frequency modulation; a Checkerboard breast phantom (a 2D adaptation of the Defrise phantom design) to study the ability to reconstruct the fine features of the checkerboard squares; and the 360° Star-pattern phantom to assess aliasing and compute the Fourier-spectral distortion (FSD) metric that assesses spectral leakage and the contrast transfer function. We find that both Pentagon and T-shaped scans provide greater modulation amplitude of the Defrise phantom slabs and better resolve the squares of the Checkerboard phantom against the conventional scan. Notably, the Pentagon geometry exhibited a significant reduction in aliasing of spatial frequencies oriented in the right-left (RL) medio-lateral direction, which was corroborated by a near complete elimination of spectral leakage in the FSD plot. Conversely T-shaped scan redistributes the aliasing between both posteroanterior (PA) and RL directions thus maintaining non-inferiority against the conventional scan which is predominantly affected by PA aliasing. The results of this study underscore the potential of incorporating advanced 2D geometries in DBT systems, offering marked improvements in imaging performance over the conventional 1D approach.

An Iterative IpDFT Method for Frequency Estimation with Elimination of the Spectral Leakage

An Iterative IpDFT Method for Frequency Estimation with Elimination of the Spectral Leakage

Intraoperative and Postoperative Outcomes of Modified Bidirectional Intra-Umbilical Incision versus Infra-Umbilical Incision for Direct Trocar Insertion in Gynaecological Laparoscopy

Objectives: This study aimed to describe a modified, curved, deep, bidirectional, intra-umbilical, vertical incision for primary trocar insertion and prospectively compare its intraoperative and postoperative outcomes with an infra-umbilical incision in gynaecologic laparoscopy. Methods: Between August 2019 and March 2021, 110 patients subjected to the direct trocar insertion technique for laparoscopic intervention were classified into two groups. Group A comprised 55 cases of infra-umbilical incision, whereas group B comprised 55 cases of a modified, curved, longitudinal, deep, bidirectional, intra-umbilical incision. Afterwards, intraoperative and postoperative assessments were performed. Results: The increase in the numbers of parity, gravidity and previous caesarean sections was found to be statistically significant; a smaller number of infertility complaints were observed in group B. Similarly, group B expressed a statistically significant less peri-trocar CO2 leakage (46 [83.6%] patients versus 28 [50.9%] patients) and more tightness of the primary portal entry (45 [81.8%] patients versus 30 [54.5%] patients) when compared to group A throughout the whole operation. After a one-month follow-up, a statistically significant (P = 0.029) decrease in the Observer Scar Assessment Scale and Patient Scar Assessment Scale scores in group B (10.4 ± 4.2 and 11.8 ± 4.3, respectively), demonstrating better cosmoses when compared to group A (13.3 ± 5.7 and 16.0 ± 6.8, respectively). Conclusion: Performing a modified, curved, deep, bidirectional, intra-umbilical, vertical incision for the insertion of a primary laparoscopic trocar (i.e. Darwish laparoscopic entry) is a simple and fast step that results in the elimination of intraoperative gas leakage and trocar slippage without the need for any additional sutures. Aesthetically, it results in a better scar with satisfactory cosmoses when compared to an infra-umbilical incision. Keywords: Laparoscopy; Trocar; Egypt.

Optical compensation schemes for elimination of off-axis color difference in a light control film based on dichroic dyes

We report optical compensation schemes for eliminating off-axis light leakage and color differences when a dichroic dye-based light control film is applied to a display panel. When a vertically aligned dichroic dye (VA-Dye) film without an optical compensation film is applied to the display panel, the light emitted from the display panel can be completely blocked on the upward and downward sides because the absorption axes of the dichroic dye molecules and top polarizer are perpendicular to each other. However, light leakage occurred in the diagonal direction because of the deviation in the angle between the absorption axes. To eliminate off-axis light leakage and off-axis color differences, we present three approaches for optical compensation. First, we optimized the positive biaxial + B plate by controlling its Nz value such that the off-axis color difference could be significantly reduced. Next, we employed optical compensation films using + B/negative C (-C) and positive A (+A)/positive C (+C) configurations. These designed configurations using commercially available films exhibited a significant reduced off-axis color difference as well as the elimination of light leakage in oblique directions when the VA-Dye film was applied to the display panel.

Strengthening Intraframework Interaction within Flexible MOFs Demonstrates Simultaneous Sieving Acetylene from Ethylene and Carbon Dioxide.

Efficient separation of acetylene (C2 H2 )/ethylene (C2 H4 ) and acetylene/carbon dioxide (CO2 ) by adsorption is an industrially promising process, but adsorbents capable of simultaneously capturing trace acetylene from ethylene and carbon dioxide are scarce. Herein, a gate-opening effect on three isomorphous flexible metal-organic frameworks (MOFs) named Co(4-DPDS)2 MO4 (M = Cr, Mo, W; 4-DPDS =4,4-dipyridyldisulfide) is modulated by anion pillars substitution. The shortest CrO4 2- strengthens intraframework hydrogen bonding and thus blocks structural transformation after activation, striking a good balance among working capacity, separation selectivity, and trace impurity removal of flexible MOFs out of nearly C2 H2 /C2 H4 and C2 H2 /CO2 molecular sieving. The exceptional separation performance of Co(4-DPDS)2 CrO4 is confirmed by dynamic breakthrough experiments. It reveals the specific threshold pressures control in anion-pillared flexible materials enabled elimination of the impurity leakage to realize high purity products through precise control of the intraframework interaction. The adsorption mechanism and multimode structural transformation property are revealed by both calculations and crystallography studies. This work demonstrates the feasibility of modulating flexibility for controlling gate-opening effect, especially for some cases of significant aperture shrinkage after activation.

Functionalized Metallic 2D Transition Metal Dichalcogenide-Based Solid-State Electrolyte for Flexible All-Solid-State Supercapacitors.

Highly efficient and durable flexible solid-state supercapacitors (FSSSCs) are emerging as low-cost devices for portable and wearable electronics due to the elimination of leakage of toxic/corrosive liquid electrolytes and their capability to withstand elevated mechanical stresses. Nevertheless, the spread of FSSSCs requires the development of durable and highly conductive solid-state electrolytes, whose electrochemical characteristics must be competitive with those of traditional liquid electrolytes. Here, we propose an innovative composite solid-state electrolyte prepared by incorporating metallic two-dimensional group-5 transition metal dichalcogenides, namely, liquid-phase exfoliated functionalized niobium disulfide (f-NbS2) nanoflakes, into a sulfonated poly(ether ether ketone) (SPEEK) polymeric matrix. The terminal sulfonate groups in f-NbS2 nanoflakes interact with the sulfonic acid groups of SPEEK by forming a robust hydrogen bonding network. Consequently, the composite solid-state electrolyte is mechanically/dimensionally stable even at a degree of sulfonation of SPEEK as high as 70.2%. At this degree of sulfonation, the mechanical strength is 38.3 MPa, and thanks to an efficient proton transport through the Grotthuss mechanism, the proton conductivity is as high as 94.4 mS cm-1 at room temperature. To elucidate the importance of the interaction between the electrode materials (including active materials and binders) and the solid-state electrolyte, solid-state supercapacitors were produced using SPEEK and poly(vinylidene fluoride) as proton conducting and nonconducting binders, respectively. The use of our solid-state electrolyte in combination with proton-conducting SPEEK binder and carbonaceous electrode materials (mixture of activated carbon, single/few-layer graphene, and carbon black) results in a solid-state supercapacitor with a specific capacitance of 116 F g-1 at 0.02 A g-1, optimal rate capability (76 F g-1 at 10 A g-1), and electrochemical stability during galvanostatic charge/discharge cycling and folding/bending stresses.

Solution-processed green and blue quantum-dot light-emitting diodes with eliminated charge leakage

Quantum-dot light-emitting diodes (QD-LEDs) promise a new generation of efficient, low-cost, large-area and flexible electroluminescent devices. However, the inferior performance of green and blue QD-LEDs compared with their red counterpart is hindering the commercialization of QD-LEDs in display and solid-state lighting applications. Here we demonstrate green and blue QD-LEDs with ~100% conversion of the injected charge carriers into emissive excitons. The key to success is the elimination of electron leakage at the organic/inorganic interface by using hole-transport polymers with simultaneous low electron affinity and reduced energetic disorder. Our devices exhibit high external quantum efficiencies over a wide range of luminance values (peak external quantum efficiencies of 28.7% for green and 21.9% for blue) and excellent stability (extrapolated T95 lifetime is 580,000 h for green and 4,400 h for blue QD-LEDs). We expect our work to provide a general strategy for eliminating charge leakage in solution-processed LEDs featuring organic/inorganic interfaces.

Regression analysis of the operational parameters and energy-saving potential of industrial compressed air systems

The electricity consumption of compressed air (CA) production and utilisation systems is high, due to an absence of suitable recovery methods and proper measurements in most industrial plants. This situation results in high costs of production and reduced profits. In our study, we therefore investigate the energy-saving potential of a CA system with the aim of reducing electricity consumption in an industrial facility. Our study consists of two parts: in the first stage, we evaluate the applicability of methods such as elimination of leakage in distribution lines, loaded-unloaded operation of compressors, and the use of waste heat recovery system methods, both physically and economically, while in the second, we examine the correlations between leakage airflow rate, noise, and system pressure in a general CA system and carry out regression analyses, using the SPSS (Statistical Package for Social Sciences) software program, for the first time. Our results suggest that optimised and improved CA systems are energy-saving solutions when applied in industrial plants. We demonstrate that there are strong correlations between the system pressure, air leakage diameter, noise, and annual leakage cost in industrial CA systems. The relationships between these variables can be expressed as a power model (Y=β×Xn).

DNA methylation-based predictors of health: applications and statistical considerations.

DNA methylation data have become a valuable source of information for biomarker development, because, unlike static genetic risk estimates, DNA methylation varies dynamically in relation to diverse exogenous and endogenous factors, including environmental risk factors and complex disease pathology. Reliable methods for genome-wide measurement at scale have led to the proliferation of epigenome-wide association studies and subsequently to the development of DNA methylation-based predictors across a wide range of health-related applications, from the identification of risk factors or exposures, such as age and smoking, to early detection of disease or progression in cancer, cardiovascular and neurological disease. This Review evaluates the progress of existing DNA methylation-based predictors, including the contribution of machine learning techniques, and assesses the uptake of key statistical best practices needed to ensure their reliable performance, such as data-driven feature selection, elimination of data leakage in performance estimates and use of generalizable, adequately powered training samples.

Conduction of a Laboratory Experiment with the Goal of Researching Submerged Flow Peculiarities

In connection with the decreasing hydrocarbon reserves on land, the interest of researchers in new alternative methods of hydrocarbon production is growing. One of the actively developing areas is the production of hydrocarbons from deep-water deposits, in connection with which the share of developed deposits in the water area of the World Ocean is growing every year. However, this production method is not completely safe, since any damage to the production structure can lead to leakage of hydrocarbons. In this case, hydrocarbons are distributed in the form of a submerged jet. Predicting the behavior of submerged jets, calculating their trajectories and thermophysical parameters is important in the elimination of leakage. The article discusses an experimental study of a submerged jet. The results of the experiment will make it possible to verify the mathematical model describing the propagation of a submerged jet. The experiment was carried out to study the trajectory of the jet and its temperature. This paper presents the results on the analysis of the jet trajectory. In the experiment, gasoline or diesel fuel was used as a liquid, air was used as a gas. The work shows a diagram of the experimental setup, describes the process of the experiment, and also shows a photograph of the experiment and a comparison with the results of calculations.

Post-Resection Biliar Complications

As a result of the analysis of modern Russian and foreign literature, it was found that in the structure of postoperative complications after liver resections, biliary complications are the leading ones today. The main risk factors for the development of biliary complications and predictors of prognosis were determined at the different stages (preoperative, during the operation and postoperative period). The necessity to apply a complex of instrumental investigation methods in the postoperative period for early detection of bile leakage, clarification of its causes and forms of manifestation is determined; their importance for choosing a method of elimination is emphasized. The ways of improving the results of liver resections due to the prevention and effective elimination of bile leakage are outlined.Possibilities of prognosis of biliar complications after liver resections were analyzed. The available assessment systems can be considered uninformative, which demands development and implementation of more modern and more effective programs for predicting biliary complications after liver resections.

Research and Development of Essentials for Silage Preparation, Transport and Storage in Flexible Containers of Optimal Volume

Abstract The research purpose was to develop the basics for silage preparation by vacuuming with the use of flexible polymer containers and estimating silage quality. The analysis of modern systems used for silage preparation and storage showed that the main disadvantages include the high storage and preparation costs, and losses of silage weight and nutrients by 3–25% after opening of storage facilities. To eliminate these disadvantages, the basics for preparing the silage by vacuuming in flexible polymer containers that can be transported and stored with optimum volume have been studied and developed. The study pursuits its goals by observing the changes in density and degree of silage compaction caused by the vacuum pressure and deadweight. A comparative estimation of silage quality indices was conducted by means of chemical analysis of silage specimens. The results show graphical dependencies of changes in silage volume and density at vacuum pressure up to 60 kPa. Moreover, a comparative assessment of quality indices of silage specimens prepared by vacuuming in soft containers, and traditional method using trenches was conducted. The reliability of results for silage storing quality in a vacuum container was achieved by fivefold test repetition within 2 years. Comparison of silage quality indices obtained using vacuum technology and traditional method showed improvement in favour of the proposed method: dry matter by 2.05%; protein by a factor of 1.47; nitrogenous substances by 1.37; starch by 1.56; calcium by 1.83; phosphorus by 2; digestible protein by 1.24; feed unit by 1.31; exchange energy by 1.16, which was achieved thanks to the elimination of succus leakage.

Rapid, Nitric Oxide Synthesis-Dependent Activation of MMP-9 at Pericyte Somata During Capillary Ischemia in vivo

Nitric oxide serves essential roles in normal vascular physiology, but paradoxically contributes to vascular pathology in disease. During brain ischemia, aberrant nitric oxide levels can cause cellular injury through induction of nitrosative/oxidative stress and post-translational activation of matrix-metalloproteinase-9 (MMP-9). We recently demonstrated that brain pericyte somata were associated with very early and localized MMP-9 activation along capillaries during cerebral ischemia, leading to focal blood-brain barrier disruption. Here, we tested whether this effect was dependent upon nitric oxide production. In vivo two-photon imaging was used to directly visualize MMP9 activity using a FITC-gelatin probe and leakage of intravenous dye during photothrombotically induced capillary ischemia. Results showed that the NOS inhibitor, L-NIL, at concentrations affecting both iNOS and constitutive NOS isoforms, attenuated capillary leakage at pericyte soma-specific locations and substantially reduced FITC-gelatin cleavage. We also found that combined administration of L-NIL and anisomycin, an inhibitor of protein synthesis, led to near complete elimination of FITC-gelatin cleavage and vascular leakage. These results indicate that both nitric oxide synthase and new protein synthesis are involved in the rapid activation of MMP-9 at somata of capillary pericytes during ischemia.

A Temperature Stable Amplifier Characteristics of AlGaN/GaN HEMTs on 3C-SiC/Si

A high temperature stable amplifier characteristics for L-band or 2 GHz was studied using AlGaN/GaN high electron mobility transistors (HEMTs) on 3C-SiC/Si substrate. A crack free, high quality AlGaN/GaN heterostructure on a 6-inch Czochralski (Cz)-Si substrate was realized by metal oxide chemical vapor deposition (MOCVD). The epitaxial structure comprises an $8~\mu \text{m}$ thick nitride layer and a $1~\mu \text{m}$ thick 3C-SiC intermediate layer. The fabricated AlGaN/GaN HEMT achieved excellent electron transport characteristics along with a comparable cutoff frequency ( ${f}~_{\text {T}}$ ) of 4.8 GHz for $2~\mu \text{m}$ gate length device. Temperature dependent S-parameter measurement of open pad structures achieved outstanding temperature stability up to $125~^\circ \text{C}$ . Continuous wave power measurements showed a 2 GHz continuous wave power density of 2 W/mm, a maximum power added efficiency (PAE) of 47% along with a linear gain of 17.2 dB for class A amplifier operation. Moreover, at elevated temperature of up to $125~^\circ \text{C}$ , the minimal power performance degradation was mainly attributed to the intrinsic property of the device, thus elimination of RF leakage from the buffer or epitaxial layers at high temperatures was confirmed.

Elimination of leakage in the head-stationary tubesheet connection of the shell and tube heat exchanger: a case study

Elimination of leakage in the head-stationary tubesheet connection of the shell and tube heat exchanger: a case study

Port site recurrence of esophageal adenocarcinoma after minimally invasive esophagectomy: a case report

BackgroundPort site recurrence has been observed after a variety of oncologic resection procedures. However, few have reported port site recurrence of esophageal cancer.Case presentationA 51-year-old man underwent minimally invasive esophagectomy for pT3(AD)N3M0 adenocarcinoma of the esophagus. One year after surgery, he presented with a rapidly growing tumor on the right thoracic wall. Contrast computed tomography demonstrated an enhancing tumor with uptake on positron emission tomography. We performed resection of the thoracic wall, including the skin and subcutis. The pathologic diagnosis was poorly differentiated adenocarcinoma, consistent with metastasis of esophageal origin.ConclusionThis was the first report on thoracic port site recurrence of esophageal adenocarcinoma. We recommend elimination of leakage around the thoracoscopic ports to prevent such recurrence. We should provide prudent postoperative clinical surveillance.

Highly Efficient and Water‐Insensitive Self‐Healing Elastomer for Wet and Underwater Electronics

AbstractIntegrating self‐healing capabilities into soft electronic devices increases their durability and long‐term reliability. Although some advances have been made, the use of self‐healing electronics in wet and/or (under)water environments has proven to be quite challenging, and has not yet been fully realized. Herein, a new highly water insensitive self‐healing elastomer with high stretchability and mechanical strength that can reach 1100% and ≈6.5 MPa, respectively, is reported. The elastomer exhibits a high (>80%) self‐healing efficiency (after ≈ 24 h) in high humidity and/or different (under)water conditions without the assistance of an external physical and/or chemical triggers. Soft electronic devices made from this elastomer are shown to be highly robust and able to recover their electrical properties after damages in both ambient and aqueous conditions. Moreover, once operated in extreme wet or underwater conditions (e.g., salty sea water), the self‐healing capability leads to the elimination of significant electrical leakage that would be caused by structural damages. This highly efficient self‐healing elastomer can help extend the use of soft electronics outside of the laboratory and allow a wide variety of wet and submarine applications.

Engineering high-robustness DNA molecular circuits by utilizing nucleases.

Toehold-mediated strand displacement (TMSD) as an important player in DNA nanotechnology has been widely utilized for engineering non-enzymatic molecular circuits. However, these circuits suffer from uncontrollable leakage and unsatisfactory response speed. We utilized site-specific and sequence-independent nucleases to engineer high- robustness DNA molecular circuits. First, we found that the kinetics of the APE1-catalyzed reaction is highly dependent on substrate stability, allowing for the elimination of asymptotic leakage of DNA split circuits. Second, we obtained strict substrate preference of λ exonuclease (λexo) by optimizing the reaction conditions. Robust single-layer and cascade gates with leak resistance were established by using λ exo. Owing to the remarkably fast kinetics of these nucleases, all the circuits yield a high speed of computation. Compared to TMSD-based approaches, nuclease-powered circuits render advanced features such as leakage resistance, hundreds of times higher speed, and simplified structures, representing a class of promising artificial molecule systems.