Elevated Triglycerides Research Articles

Associations of endocrine-disrupting chemicals mixtures with serum lipid and glucose metabolism among overweight/obese and normal-weight children: A panel study.

Associations of endocrine-disrupting chemicals mixtures with serum lipid and glucose metabolism among overweight/obese and normal-weight children: A panel study.

Full-length 16S rRNA Sequencing Reveals Gut Microbiome Signatures Predictive of MASLD in children with obesity

BackgroundThe gut microbiota plays a crucial role in metabolic dysfunction-associated steatotic liver disease (MASLD). Next-generation sequencing technologies are essential for exploring the gut microbiome. While recent advancements in full-length 16S (FL16S) rRNA sequencing offer better taxonomic resolution, whether they establish stronger associations with the risk of MASLD remains to be determined.MethodThis study utilized long-read FL16S and short-read V3-V4 16S rRNA sequencing to profile gut microbiome compositions in age-, sex-, and BMI-matched case–control pairs of obese children with and without MASLD. A random forest predictive model was employed, using gut-microbiota features selected based on the top 35 most abundant taxa or a linear discriminant analysis score greater than 3. The model's performance was evaluated by comparing the area under the receiver operating characteristic curve (AUC) through a tenfold cross-validation method.ResultsSubjects with MASLD exhibited significantly elevated serum alanine aminotransferase, triglycerides, and homeostasis model assessment of insulin resistance levels compared to controls. At the genus level, the gut microbiome compositions detected by both FL16S and V3-V4 sequencing were similar, predominantly comprising Phocaeicola and Bacteroides, followed by Prevotella, Bifidobacterium, Parabacteroides, and Blautia. The AUC for the model based on FL16S sequencing data (86.98%) was significantly higher than that based on V3-V4 sequencing data (70.27%), as determined by DeLong's test (p = 0.008).ConclusionFL16S rRNA sequencing data demonstrates stronger associations with the risk of MASLD in obese children, highlighting its potential for real-world clinical applications.

Comprehensive assessment of patients with symptomatic hand osteoarthritis: Cross-sectional insights into links with other joints.

Symptomatic hand osteoarthritis (HOA) significantly affects daily activities and quality of life, but its associations with osteoarthritis (OA) in other joints and systemic factors remain unclear. This study aimed to comprehensively assess patients with symptomatic HOA by examining their laboratory findings and radiographic features across multiple joints. This cross-sectional study enrolled 53 patients with symptomatic HOA who initially presented to the outpatient clinic with hand pain and were subsequently diagnosed. Radiographic assessments of the hands, knees, hips, and spine were performed using the grading system of Kellgren-Lawrence (KL). The sum of the KL scores for all joints in both hands was calculated as the hand KL score. In total, 79.2% of patients had coexistent knee OA. Elevated triglyceride levels and erythrocyte sedimentation rates were observed in >50% of the cohort. Hand KL scores displayed weak positive correlations with C-reactive protein levels (r=0.34) and knee KL scores (r=0.35). This study highlights the frequent coexistence of knee OA in patients with symptomatic HOA and suggests potential links between HOA, systemic inflammation, and lipid metabolism. These findings provide insights into the multifactorial nature of HOA and underscore the importance of comprehensive evaluation in clinical practice.

Association between cardiometabolic index (CMI) and suicidal ideation: A cross-sectional analysis of NHANES 2005 to 2018 data.

With suicide ranking as a leading cause of death globally, identifying modifiable risk factors is crucial. Suicidal ideation (SI) is a significant precursor to suicide, and there is a growing interest in the role of cardiometabolic factors, particularly the cardiometabolic index (CMI), multiplying the triglyceride-to-high-density lipoprotein cholesterol ratio by the waist-to-height ratio, in mental health outcomes. Previous studies have shown a notable relationship among lipid abnormalities, elevated triglyceride levels, and depressive symptom severity, including SI. This research investigated the correlation between the CMI levels of adult Americans and SI, utilizing data from the National Health and Nutrition Examination Survey (NHANES) ranging from the years 2005 to 2018. After collecting data on demographics, physical examinations, and laboratory testing, multivariate logistic regression analysis was conducted to assess the relationship between CMI and SI while adjusting for relevant factors. The study, which enrolled 15,849 individuals exhibiting symptoms of SI, constituting 3.47% of the total, revealed a significant association between CMI levels and SI. A significant positive association was found between CMI and SI (adjusted OR = 1.07, 95% CI: 1.02-1.13, P = .0029). Moreover, a nonlinear relationship was identified between CMI and SI, characterized by an atypical inverted U-shaped curve with a breakpoint at approximately CMI = 2.08. Subgroup analysis revealed consistent findings across various demographic and clinical subpopulations. The findings of this study demonstrate a substantial correlation between elevated CMI levels and an increased incidence of SI within the US population. Early interventions targeted at individuals with elevated CMI levels, such as psychological support or lifestyle adjustments, may mitigate the risk of SI.

Effect of garlic on sodium fluoride-induced hypertension and elevated cardiac enzymes in male albino rats

Introduction: Garlic, also known as Allium sativum, has been used for centuries to protect the heart and reduce blood pressure. Objectives: This study aims to evaluate the antihypertensive effects and cardioprotective effects of garlic against the effects of sodium fluoride (NaF) on the blood pressure and heart tissue. Materials and Methods: Thirty adult male Albino rats used in the study. Rats were assigned into three groups consisting of one control group, NaF, and NaF + garlic. After a week of acclimatization, the rats were sedated with ketamine and thoracotomy, blood samples were collected, and heart tissues were dissected. Heart specimens were taken from the left ventricle and stained with hematoxylin and eosin for histological examination. Masson’s trichrome was conducted to examine collagen fibers. Results: The study findings indicated that exposure to NaF leads to an increase in indicators of cellular demise and a decrease in markers of survival in cardiac tissue, suggesting the occurrence of apoptosis. This exposure also disrupts blood lipid profiles, resulting in elevated cholesterol and triglyceride levels and reduced high-density lipid (HDL) levels. Furthermore, it enhances the activity of oxidative stress enzymes while lowering the levels of glutathione (GSH). Conversely, garlic exposure is associated with decreased arterial blood pressure, improved histopathological structure, and reduced serum levels of oxidative stress biomarkers. Conclusion: After thorough evaluation, it has been determined that garlic therapy may hold potential as a treatment for various cardiovascular diseases.

The association between dyslipidemia and hand osteoarthritis: a systematic review and meta-analysis.

Hand osteoarthritis (HOA) is a prevalent degenerative joint disease, with emerging evidence suggesting metabolic factors, including dyslipidemia, play a role in its pathogenesis. Dyslipidemia components, including low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglycerides, may contribute to cartilage damage and inflammation in hand joints, though robust evidence is limited. A systematic review and meta-analysis were conducted using PubMed, Embase, and Web of Science to identify case-control and cohort studies examining the association between dyslipidemia and HOA. Dyslipidemia was assessed as a binary variable, while LDL, HDL, and triglycerides were analyzed as continuous variables. The quality of the included studies was assessed using the Newcastle-Ottawa Scale. Random effects model was used to calculate standardized mean differences (SMDs) and odds ratios (ORs). This study adhered to PRISMA guidelines for transparent reporting and was registered with the International Prospective Register of Systematic Reviews (CRD42024616873). For dyslipidemia (binary), the pooled OR was 1.40 (95% CI = 1.19-1.66, P < 0.0001) with negligible heterogeneity (I2 = 0%, P = 0.82). Triglycerides showed a mean difference of 14.48 (95% CI = 5.37 to 23.60, P = 0.002) with low heterogeneity (I2 = 0%, P = 0.46). HDL yielded a pooled SMD of 0.48 (95% CI = - 1.50 to 2.46, P = 0.63) with low heterogeneity (I2 = 9%, P = 0.35). For LDL, the SMD was 4.78 (95% CI = - 0.53 to 10.09, P = 0.08) with moderate-to-high heterogeneity (I2 = 68%, P = 0.02). This meta-analysis reveals a moderate association between dyslipidemia, especially elevated triglycerides, and HOA. While lipid abnormalities may play a role in HOA development, the evidence for LDL and HDL is less clear. Limitations in study definitions and populations suggest the need for further research to better understand these relationships and their implications for prevention and management strategies in HOA.

Neuropsychiatric Abnormalities in Metabolic Disturbances: Interplay of Adipokines and Neurotransmission.

Metabolic syndrome, with a high global incidence, is characterized by central obesity, elevated fasting blood glucose, high blood pressure, and abnormal lipid levels, including reduced high-density lipoprotein cholesterol and elevated triglycerides. These metabolic dysfunctions can lead to neurotransmitter alterations and dysregulation of the hypothalamic-pituitary-adrenal axis. These changes, in turn, contribute to mental disorders such as depression and anxiety. Adipokines, secreted from adipose tissue, modulate various metabolic processes, neurotransmission, and immune responses. The interplay between adipokines and neurotransmitters may be a critical component underlying the interaction between metabolic abnormalities and mental disorders. This review aims to discuss the brain-metabolism axis, focusing on altered levels of adipokines and neurotransmitters in metabolic and mental disorders.

Effect of alirocumab on postprandial hyperlipidaemia in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled, cross-over trial.

Postprandial hyperlipidaemia (PPL), characterized by elevated triglyceride (TG) concentrations after a meal, is common in type 2 diabetes (T2D) and is often recognized as an independent cardiovascular risk factor. Here, we aimed to assess the effect of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition by alirocumab on PPL in patients with T2D. EUTERPE is a randomized, double-blind, placebo-controlled cross-over trial conducted in male patients with T2D. Participants received sequentially two sequences of 10-week treatment (alirocumab 75 mg Q2W or placebo s/c) with a wash-out period of 10 weeks. The primary end-point was the percentage reduction in plasma TG response after an oral fat load (incremental area under the curve [iAUC]0-8h TG). Secondary end-points included mass spectrometry-based apolipoprotein measurements and nuclear magnetic resonance (NMR)-based lipoprotein profiling. Fourteen participants were included: age 59 ± 9 years, BMI 32.8 ± 5.5 kg/m2, HbA1C 6.7 ± 0.5%. Compared to placebo, alirocumab did not reduce PPL (iAUC0-8h TG: -5% [CI 95%: -28, +25], p = 0.68). Alirocumab decreased fasting non-HDL cholesterol (-38.5 ± 5.6%, p = 0.0003), remnant cholesterol (-20.0 ± 13.3%, p = 0.04), apoB100 (-21.2 ± 6.4%, p = 0.004) and apoE (-15.3 ± 6.6%, p = 0.02) concentrations. NMR analyses showed that alirocumab decreased both postprandial VLDL2 cholesterol (-42% [-55, -25], p < 0.001) and IDL cholesterol (-26% [-38, -12], p = 0.0007), without effect on VLDL1 cholesterol or TG concentrations. Inhibition of PCSK9 by alirocumab did not reduce PPL in T2D, confirming that PCSK9 controls remnant cholesterol catabolism rather than intestinal chylomicron production.

RNF213 Variant and Infectious Burden Associated With Intracranial Artery Stenosis in Moyamoya Disease.

The mechanisms driving the progression of moyamoya disease (MMD) remain unrecognized. There is evidence suggesting that genetic and environmental factors may be associated with intracranial artery stenosis. Here, we aimed to investigate the characteristics of infectious exposure and the association of the RNF213 (RING finger protein 213) variant and infectious burden (IB) with intracranial artery stenosis of MMD. We prospectively recruited 275 patients with MMD. Participants underwent RNF213p.R4810K sequencing. Serum antibody titers of herpes simplex virus, cytomegalovirus, toxoplasma, rubella virus, and Epstein-Barr virus were assessed and combined into an IB score. The degree of intracranial artery stenosis was measured by using the Willis narrowing score (WNS), which was then dichotomized as mild and severe. Multivariate regression analyses were performed to analyze variables associated with severe WNS. Patients with the RNF213 variant had a higher risk of severe WNS than wild-type individuals (P=0.003). Patients with MMD with severe WNS showed an increased level of IB score (P<0.001). The RNF213 variant (odds ratio [OR], 2.832 [95% CI, 1.347-5.955]; P=0.006) and IB score (OR, 1.771 [95% CI, 1.286-2.439]; P<0.001) were significantly associated with severe WNS after adjusting for covariates. Furthermore, the associations between IB score and severe WNS were more prominent among patients with modifiable risk factors of elevated body mass index (Pinteraction<0.001), triglycerides (Pinteraction=0.011), and homocysteine (Pinteraction=0.016). This study outlined a perspective of the genetic-environmental interactions in the progression of MMD. The RNF213 variant and increased IB were associated with intracranial artery stenosis in MMD. The study will provide novel insights into the mechanism of disease progression, which may offer opportunities for early intervention of infectious exposure in MMD.

Cross-sectional associations between healthy and unhealthy plant-based diets and metabolic syndrome in three distinct French populations, a meta-analysis.

Prior studies have shown that plant-based diets are associated with lower cardiovascular risk. However, these diets encompass a large diversity of foods with contrasted nutritional quality that may differentially impact health. We aimed to investigate the pooled cross-sectional association between metabolic syndrome (MetS), its components, and healthy and unhealthy plant-based diet indices (hPDI and uPDI), using data from two French cohorts and one representative study from the French population. This study included 16,358 participants from the NutriNet-Santé study, 1,769 participants from the Esteban study and 1,565 participants from the STANISLAS study who underwent a clinical visit. The MetS was defined according to the International Diabetes Federation definition. The associations between these plant-based diet indices and MetS were estimated by multivariable Poisson and logistic regression models, stratified by gender. Meta-analysis enabled the computation of a pooled Prevalence Ratio. A higher contribution of healthy plant foods (higher hPDI) was associated with a lower probability of having MetS (PRmen: 0.85; 95% CI: 0.75-0.94, PRwomen: 0.72; 95% CI: 0.67-0.77), elevated waist circumferences and elevated blood pressure. In women, a higher hPDI was associated with a lower probability of having elevated triglycerides, low HDL-cholesterolemia and hyperglycemia; and a higher contribution of unhealthy plant foods was associated with a higher prevalence of MetS (PRwomen: 1.13; 95% CI: 1.01-1.26) and elevated triglycerides. A greater contribution of healthy plant floods was associated with protective effects on metabolic syndrome, especially in women. Gender differences should be further investigated in relation to the current sustainable nutrition transition.

Multilayer regulation of postprandial triglyceride metabolism in response to acute cold exposure.

Multilayer regulation of postprandial triglyceride metabolism in response to acute cold exposure.

Metabolic syndrome is associated with more pain in hand osteoarthritis: Results from the DIGICOD cohort.

Metabolic syndrome is associated with more pain in hand osteoarthritis: Results from the DIGICOD cohort.

Olezarsen in Patients with Hypertriglyceridemia at High Cardiovascular Risk: Rationale and Design of the Essence-TIMI 73b Trial.

Olezarsen in Patients with Hypertriglyceridemia at High Cardiovascular Risk: Rationale and Design of the Essence-TIMI 73b Trial.

Assessing the predictive value of elevated triglycerides, triglyceride-glucose index (TyG), and TG/HDL ratios for cardiovascular disease and mortality during 20 years of follow-up: Tehran lipid and glucose study.

Assessing the predictive value of elevated triglycerides, triglyceride-glucose index (TyG), and TG/HDL ratios for cardiovascular disease and mortality during 20 years of follow-up: Tehran lipid and glucose study.

Sedentary Leisure Behaviour, Physical Activity, and Gastroesophageal Reflux Disease: Evidence From a Mendelian Randomization Analysis.

Gastroesophageal reflux disease (GERD) is common worldwide. Although associations between sedentary behaviour (LSBs), physical activity (PAs), and GERD have been reported, their causal relationships remain unclear. This study uses Mendelian randomization (MR) to examine these associations with GERD. Genetic instruments from the UK Biobank and other consortia were utilized to assess the causal relationship between LSBs, PAs, and GERD. Causal analyses employed inverse variance weighted (IVW), weighted-median (WM), and MR-Egger regression. Sensitivity analyses included Cochran's Q test, MR-Egger intercept test, leave-one-out analysis, and funnel plot assessment. Outliers were detected using MR-PRESSO and Radial MR. A risk factor analysis explored potential causal links. Genetically predicted leisure television (TV) watching (OR = 2.29, 95% CI 2.12-2.48; p < 0.001) and self-reported moderate physical activity (MPAs) (OR = 2.45, 95% CI 1.46-4.13; p < 0.001) were associated with an higher risk of GERD. In contrast, leisure computer use (OR = 0.62, 95% CI 0.53-0.73; p < 0.001) and accelerometer-measured fractional accelerations > 425 milligravities (OR = 0.68, 95% CI 0.52-0.88; p = 0.003) were associated with a lower risk of GERD. No causal relationship was observed between driving, self-reported vigorous physical activities (VPAs), and accelerometer-measured "average acceleration" with GERD. Risk factor analyses suggested that metabolic risk factors, such as smoking, high body mass index, elevated serum triglyceride levels, insulin resistance, and type 2 diabetes might mediate the observed causal links. Leisure TV watching and self-reported MPA are associated with an higher risk of GERD, whereas leisure computer use and accelerometer-measured fractional acceleration > 425 milligravities may serve as protective factors against GERD. These findings highlight the necessity of differentiating various LSBs and PAs in GERD research.

Metabolic factors modulate effort-based decision-making in major depressive disorder.

Metabolic factors modulate effort-based decision-making in major depressive disorder.

A Phase I Study to Evaluate the Safety, Tolerability, Pharmacokinetics of BGT-002, a Novel ATP-Citrate Lyase Inhibitor, in Healthy Chinese Subjects.

This Phase I study evaluated the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of BGT-002, a novel ATP-citrate lyase (ACLY) inhibitor, in healthy Chinese adults. This study included three parts: Part I (single-ascending-dose study), Part II (multiple-ascending-dose study), and Part III (food effect study). A total of 104healthy subjects were enrolled in the study and were given BGT-002 tablet or placebo per protocol requirements. Blood samples were collected for pharmacokinetic and pharmacodynamic analysis. Safety was assessed by clinical examinations and adverse events. In Part I, BGT-002 demonstrated rapid absorption with a Tmax of 0.67 to 1.75hours, and slow elimination with a T1/2 of 24.53 to 72.86hours, prolonged with increased dosages. Cmax and AUC0-∞ ranged from 1.55 to 48.39μg/mL, and 31.09 to 2930.69h·μg/mL, respectively. In Part II, the accumulation index (Rac) of Cmax and AUCtau following 14 days of consecutive administration were 3.53 to 3.62 and 5.29 to 5.59, respectively, with a dose-proportionality PK profile. The levels of total cholesterol (TC), non-high-density lipoprotein cholesterol (non-HDL-C), and low-density lipoprotein cholesterol (LDL-C) were maximally decreased by 15.80%, 18.50%, and 22.37%, respectively. In Part III, the geometric mean ratio (90% CI) of fed to fasting condition in Cmax and AUC0-∞ of BGT-002 were 73.11% and 98.36%, respectively, indicating a minor food effect on the absorption rate. Across the study, two cases of Grade 3 adverse events (elevated blood triglycerides) were reported, both of which were assessed as not related to BGT-002. No serious adverse events were observed. BGT-002 demonstrated favorable safety, tolerability, and lipid-lowering effects, supporting its potential for further clinical development. ChiCTR2200057793(https://www.chictr.org.cn/showproj.html?proj=160210); ChiCTR2300067474(https://www.chictr.org.cn/showproj.html?proj=182183); ChiCTR2300067472(https://www.chictr.org.cn/showproj.html?proj=184079).

Qatar's Silent Epidemic: A Comprehensive Meta-analysis on the Prevalence of Metabolic Syndrome.

Metabolic syndrome comprises various conditions like abdominal obesity, insulin resistance, elevated triglyceride levels, reduced HDL, and high blood pressure, which pose significant health challenges globally. It's imperative to determine its prevalence in specific populations to formulate effective preventive measures. This systematic review and meta-analysis aimed to determine the prevalence of metabolic syndrome in the Qatari population. Using the PRISMA guidelines, a systematic search was executed on PubMed until July 2023 with keywords "Metabolic syndrome" and "Qatar." Eligibility criteria included human subjects, studies assessing metabolic syndrome components, and research conducted in Qatar or on Qatari subjects. The quality of the studies was evaluated using the Newcastle-Ottawa Scale (NOS). Pooled prevalence rates were calculated using the inverse variance weighting metaanalysis. Out of 237 studies, 14 met our inclusion criteria, with a combined sample size of 14,772 from the Qatari population. The overall pooled prevalence of metabolic syndrome was 26%. The ATP III and IDF criteria exhibited significant differences in prevalence rates, with the IDF criteria showing a higher prevalence. Patients in the age of 40 or older demonstrated a higher prevalence compared to the younger group. Studies post-2018 reported a decreasing trend in metabolic syndrome prevalence. The prevalence of metabolic syndrome in the Qatari population is comparable to rates in the Middle East. The study underscores the need for tailored interventions and strategies, especially targeting the older age group. Continuous research and monitoring are essential to track and understand the disease's progression in Qatar.

The association between occupational noise exposure, hearing loss, and metabolic syndrome among workers in a textile factory: A cross-sectional study

Rationale: Previous studies have examined the relationship between noise exposure and hearing loss with metabolic syndrome (MetS), but the results have been inconsistent. Aim: To assess an association between noise exposure, hearing loss, and the status of MetS. Methods: This cross-sectional study was carried out in 950 employees of a textile factory in 2023. Participants were categorized into two groups based on their noise exposure: under 85 dB versus 85–90 dB. Hearing loss was defined as a mean hearing threshold exceeding 25 dB in either or both ears within the relevant frequency ranges. MetS was diagnosed with the National Cholesterol Education Program Expert Panel and Adult Treatment Panel III criteria. Demographic, medical, and occupational data were collected during periodic examinations. Then, the relationship between MetS and its components with noise exposure and hearing loss was examined. Results: The median age of the study population was 33 years (IQR 28 to 38 years) and the median work experience was 3 years (IQR 2 to 9 years). 864 (90.9%) of the subjects were male, 774 (81.5%) were married, and 848 (89.3%) had shift work. 10.8% (n = 103) of the participants were diagnosed with MetS, and 72% (n = 684) had exposure to noise levels greater than 85 dB. Increased waist circumference (odds ratio (OR) = 1.61; 95% confidence interval (CI) 1.20–2.17, p = 0.002), elevated triglycerides (OR = 2.03; 95% CI 1.36–3.02, p 0.001), and reduced high-density lipoprotein (HDL) levels (OR = 1.71; 95% CI 1.28–2.29, p 0.001) were significantly associated with the noise exposure. There was also a significant relationship between MetS components and high-frequency hearing thresholds. Specifically, hearing loss at higher frequencies in both ears was linked to elevated fasting blood sugar, diastolic blood pressure, triglycerides, and low HDL. Conclusion: Our study showed a significant association between noise exposure and components of MetS including increased waist circumference, high triglycerides, and low HDL cholesterol. In addition, based on initial analysis, there was a significant association between MetS and its components, including dysregulated glucose and lipids, and elevated diastolic blood pressure, with the median hearing threshold at higher frequencies.

Evaluating the Effects of a 1000kcal Low Carbohydrate Diet and Panchakarma on Cardiovascular Risk Factors in Hypertriglyceridemia

Background: Elevated triglyceride (TG) levels are a significant risk factor for cardiovascular disease. This retrospective study investigates the impact of a 1000kcal/day low-carbohydrate diet, combined with Panchakarma, on TG levels in individuals with hypertriglyceridemia. Purpose: To evaluate the effectiveness of a 12-week intervention combining a 1000kcal/day low-carbohydrate diet and Panchakarma therapy in reducing triglyceride (TG) levels and improving other cardiometabolic parameters with hypertriglyceridemia. Methods: A retrospective, Multicentric, observational study was conducted from January 2024 to September 2024. A total of 52 patients aged 30-80 years with TG levels &gt;150mg/dL and followed a 1000kcal low-carbohydrate diet for 12 weeks, with Panchakarma were included in this study. The primary endpoint was improvement in Cholesterol Levels from baseline to the 90-day follow-up. Secondary endpoints were improvement in weight, ABG (Abdominal Girth), Heart Rate and reduction in dependency on allopathic medication from baseline to the 90-day follow-up. Results: Mean age of the study was 53.37±14.17 years. Primary finding (Mean ± SD, Baseline Vs. 90-days): TG improved from 246.56±82.14 to 230.35±90.55, p=0.0 at the 90-day follow-up. Secondary endpoints of Weight (day 1: 75.60±13.64% and day 90: 72.78±13.01%, p=0.00), ABG (day 1: 101.02±10.66 and day 90: 97.46±9.22, p=0.00), Heart Rate (day 1: 81.98±12.56 and day 90: 77.87±11.46, p=0.03), and BMI parameters also improved at the 90-day follow-up. Reduction in allopathic medication doses was also observed. Conclusions: A 12-week intervention with a 1000kcal/day low-carbohydrate diet and Panchakarma displayed positive impact on reduced TG levels and various health parameters. Keywords: Hypertriglyceridemia, Low-Carbohydrate Diet, Triglycerides, Panchakarma, Ayurveda