Elevated Rates Research Articles

Combating antimicrobial resistance: the silent war.

Once hailed as miraculous solutions, antibiotics no longer hold that status. The excessive use of antibiotics across human healthcare, agriculture, and animal husbandry has given rise to a broad array of multidrug-resistant (MDR) pathogens, posing formidable treatment challenges. Antimicrobial resistance (AMR) has evolved into a pressing global health crisis, linked to elevated mortality rates in the modern medical era. Additionally, the absence of effective antibiotics introduces substantial risks to medical and surgical procedures. The dwindling interest of pharmaceutical industries in developing new antibiotics against MDR pathogens has aggravated the scarcity issue, resulting in an exceedingly limited pipeline of new antibiotics. Given these circumstances, the imperative to devise novel strategies to combat perilous MDR pathogens has become paramount. Contemporary research has unveiled several promising avenues for addressing this challenge. The article provides a comprehensive overview of these innovative therapeutic approaches, highlighting their mechanisms of action, benefits, and drawbacks.

Knowledge mapping of anaplastic thyroid cancer treatments: a bibliometric analysis (2000-2023).

Anaplastic thyroid cancer (ATC) is a relatively rare and extensively malignant kind of thyroid carcinoma. The poor prognosis and high mortality rate of ATC can be attributed to its invasive features and undifferentiated phenotype. At present, there is a lack of efficacious therapeutic options. In light of the elevated fatality rate, it is vital to possess a comprehensive comprehension of the scientific terrain pertaining to ATC. To gather the perspectives of different researchers about the topic of ATC treatment, we did a bibliometric network analysis, which offers a comprehensive view of the scholarly literature. A systematic search was conducted on the WoSCC database to identify publications pertaining to ATC treatment between the years 2000 and 2023. In this bibliometric investigation, the tools VOSviewers, CiteSpace, and the R package "bibliometrix" were employed to investigate the general attributes, developmental framework, and academic frontiers of the subject matter. 1223 publications in total, written by 6937 scholars from 53 areas and 1402 institutions and published in 358 scholarly journals, were analyzed. There has been a gradual increase in the quantity of publications pertaining to ATC treatment. The United States and China emerged as the most prominent nations. The University of Texas MD Anderson Cancer Center and Memorial Sloan Kettering Cancer Counseling Center are prominent research institutions in highly productive countries. The journal Thyroid holds a prominent position within its discipline, being widely recognized as both the most popular and highly co-cited publication. According to the available data, Maria Cabanillas has authored the highest number of published articles, while RC Smallridge has received the highest number of co-citations. It turned out that the prevailing keywords encompassed expression, therapy, apoptosis, survival, activation, proliferation, metastasis, and other related terms. Immunotherapy, targeted therapy, and prognostic factors are the emerging research hotspots and trends. This paper presents a complete overview of research trends and advancements in the treatment of ATC using bibliometric analysis. The acquisition of information will offer vital insights for funding and potential creative strategies in researching the treatment of ATC, which indicates the research frontiers as well as prevalent directions in recent years.

Positive selection and relaxed purifying selection contribute to rapid evolution of male-biased genes in a dioecious flowering plant.

Sex-biased genes offer insights into the evolution of sexual dimorphism. Sex-biased genes, especially those with male bias, show elevated evolutionary rates of protein sequences driven by positive selection and relaxed purifying selection in animals. Although rapid sequence evolution of sex-biased genes and evolutionary forces have been investigated in animals and brown algae, less is known about evolutionary forces in dioecious angiosperms. In this study, we separately compared the expression of sex-biased genes between female and male floral buds and between female and male flowers at anthesis in dioecious Trichosanthes pilosa (Cucurbitaceae). In floral buds, sex-biased gene expression was pervasive, and had significantly different roles in sexual dimorphism such as physiology. We observed higher rates of sequence evolution for male-biased genes in floral buds compared to female-biased and unbiased genes. Male-biased genes under positive selection were mainly associated with functions to abiotic stress and immune responses, suggesting that high evolutionary rates are driven by adaptive evolution. Additionally, relaxed purifying selection may contribute to accelerated evolution in male-biased genes generated by gene duplication. Our findings, for the first time in angiosperms, suggest evident rapid evolution of male-biased genes, advance our understanding of the patterns and forces driving the evolution of sexual dimorphism in dioecious plants.

Principal causes of acute poisoning in an emergency service: experience between 2014 and 2021 at a University Hospital in Southwestern Colombia

Acute poisonings are a global public health problem, which implies costs and disease burden for society. In Colombia, there is a significant underreporting of data on acute poisoning and data gaps on the toxicological profile of the population. This study aims to identify the epidemiology of acute poisoning in a high-complexity hospital in southwestern Colombia. A descriptive study with retrospective data collection was performed. The variables were expressed through the measure of central tendency and dispersion. Categorical variables were described in proportions. A total of 406 patients were included. The median age was 31 years (IQR 23–48), 56.2% were male, and only 19.2% had a history of mental illness. Suicidal intent represented 58.8% of the cases, and the most frequent route of exposure was the oral route (81.6%). The most prevalent groups of substances were pesticides (34.2%) and medicines (32%). The most common etiological agent was organophosphates (16.5%). Cholinergic toxidrome was the most common. The average stay in the ICU was 4.5 days (± 4.8), and the mortality was 4.2%. The principal causes of acute poisoning were drugs and pesticides, with a predominant etiology of organophosphates and depressants of the central nervous system. There was a significant predominance of young male patients with suicidal intent, low mental disorders, elevated unemployment rate, and similar mortality reported in other studies. This study improves the knowledge about acute poisoning in southwestern Colombian to carry out multicenter analytic studies.

An infective endocarditis complicated by multiple septic emboli: case report

BackgroundOwing to challenges associated with heart failure and cardiac embolism, infectious endocarditis emerges as a critical pathology characterized by elevated mortality and morbidity rates. Our case stands out as a rare instance of endocarditis involving multisystem embolization, with a successful outcome.Case presentationWe present the case of an 81-year-old man whose admission was further complicated by various septic emboli affecting the brain (manifesting as a brain abscess and ischemic stroke), spleen (resulting in splenic infarction), and spinal cord. The patient received a diagnosis of infective endocarditis affecting the native mitral valve. Following prompt medical and surgical intervention, the overall progression was favorable despite encountering several challenges.ConclusionsThis case is notable for its detailed description and analysis of the multiple embolic events. More importantly, it underscores the significance of timely surgical intervention and the collaborative approach of a heart team in the face of complicated endocarditis marked by numerous septic emboli. Despite the typically grim prognosis associated with such cases, the outcomes emphasize the positive impact of timely surgery on prognosis.

Dual-modified surface encapsulation strategy for elevating rate performance and cycling stability of Ni-rich NCM811 cathode

LiNi0.8Co0.1Mn0.1O2 (NCM811) presents as a prevailing commercialized cathode material for lithium-ion batteries. Nevertheless, further restraint in the extensive application of NCM811 attributed to its intrinsic inferior ionic conductivity and sluggish diffusion kinetics necessitates ingenious strategies to alleviate the above deficiencies. Enlightened by experimental investigation coupled with theoretical calculation (density functional theory calculation), the Y3+-doped and LiYO2-coated (ionic conductor) interface is rationally created as an innovative surface engineering. The Y3+-doping contributes to reducing the diffusion barriers of Li+ (NCM with 0.78 eV, and NCM-Y with 0.62 eV), systemic energy (NCM with −1031.29 eV, and NCM-Y with −1041.32 eV), and lift Ni2+ irreversible migration energy barrier (NCM with 3.06 eV, and NCM-Y with 3.25 eV) so as to accelerate Li+ diffusion rate and effectively restrain the cationic mixing (NCM with 0.0202, and NCM-Y with 0.0198). Simultaneously, the ionic coating (LiYO2) can not only inhibit the occurrence of side reactions at the interface to improve the interfacial stability, but also as a fast ion-conductor to elevate the lithium-ion diffusion rate of the material. The pristine NCM represents a commonplace comprehensive electrochemical performance with unsatisfactory rate capacity (116.4 mAh·g−1 at 10 C), and poor long cycling stability (35.5 mAh·g−1 after 500 cycles at 5 C). Interestingly, the dual-modified NCM-Y exhibits distinguished electrochemical performance with fabulous rate capacity (144.5 mAh·g−1 even at 10 C), and preeminent long cycling stability (132.6 mAh·g−1 over 500 cycles at 5 C).

A deep reservoir for hydrogen drives intense degassing in the Bulqizë ophiolite

Deep crustal production of hydrogen (H 2 ) is a potential source of primary energy if recoverable accumulations in geological formations are sufficiently large. We report direct measurements of an elevated outgassing rate of 84% (by volume) of H 2 from the deep underground Bulqizë chromite mine in Albania. A minimum of 200 tons of H 2 is vented annually from the mine’s galleries, making it one of the largest recorded H 2 flow rates to date. We cannot attribute the flux solely to the release of paleo-fluids trapped within the rocks or to present-day active and pervasive serpentinization of ultramafic rocks; rather, our results demonstrate the presence of a faulted reservoir deeply rooted in the Jurassic ophiolite massif. This discovery suggests that certain ophiolites may host economically useful accumulations of H 2 gas.

Convergent genomic signatures associated with vertebrate viviparity

BackgroundViviparity—live birth—is a complex and innovative mode of reproduction that has evolved repeatedly across the vertebrate Tree of Life. Viviparous species exhibit remarkable levels of reproductive diversity, both in the amount of care provided by the parent during gestation, and the ways in which that care is delivered. The genetic basis of viviparity has garnered increasing interest over recent years; however, such studies are often undertaken on small evolutionary timelines, and thus are not able to address changes occurring on a broader scale. Using whole genome data, we investigated the molecular basis of this innovation across the diversity of vertebrates to answer a long held question in evolutionary biology: is the evolution of convergent traits driven by convergent genomic changes?ResultsWe reveal convergent changes in protein family sizes, protein-coding regions, introns, and untranslated regions (UTRs) in a number of distantly related viviparous lineages. Specifically, we identify 15 protein families showing evidence of contraction or expansion associated with viviparity. We additionally identify elevated substitution rates in both coding and noncoding sequences in several viviparous lineages. However, we did not find any convergent changes—be it at the nucleotide or protein level—common to all viviparous lineages.ConclusionsOur results highlight the value of macroevolutionary comparative genomics in determining the genomic basis of complex evolutionary transitions. While we identify a number of convergent genomic changes that may be associated with the evolution of viviparity in vertebrates, there does not appear to be a convergent molecular signature shared by all viviparous vertebrates. Ultimately, our findings indicate that a complex trait such as viviparity likely evolves with changes occurring in multiple different pathways.

Evaluation of telehealth administration of MMPI symptom validity scales

ABSTRACT Introduction Telehealth assessment (TA) is a quickly emerging practice, offered with increasing frequency across many different clinical contexts. TA is also well-received by most patients, and there are numerous guidelines and training opportunities which can support effective telehealth practice. Although there are extensive recommended practices, these guidelines have rarely been evaluated empirically, particularly on personality measures. While existing research is limited, it does generally support the idea that TA and in-person assessment (IA) produce fairly equitable test scores. The MMPI-3, a recently released and highly popular personality and psychopathology measure has been the subject of several of those experimental or student (non-client) based studies; however, no study to date has evaluated these trends within a clinical sample. This study empirically tests for differences in TA and IA test scores on the MMPI-3 validity scores when following recommended administration procedures. Method Data were from a retrospective chart review. Veterans (n = 550) who underwent psychological assessment in a Veterans Affairs Medical Center ADHD evaluation clinic were contrasted between in person and telehealth assessment modalities on the MMPI-2-RF and MMPI-3. Groups were compared using t tests, chi square, and base rates. Results Results suggest that there were minimal differences in elevation rates or mean scores across modality, supporting the use of TA. Conclusions This study’s findings support the use of the MMPI via TA with ADHD evaluations, Veterans, and in neuro/psychological evaluation settings more generally. Observed elevation rates and mean scores of this study were notably different from those seen in other VA service clinics sampled nationally, which is an area of future investigation.

The Sport Concussion Assessment Tool: A multidimensional symptom model for detecting elevated post-concussion symptoms

Objective: Investigate whether a four-factor model of post-concussion symptoms (i.e. cognitive, physical, affective, and sleep-arousal) aids in identifying student-athletes with persistent concerns not reflected by a total symptom score. Method: Collegiate student-athletes (N = 32,066) from the Concussion Assessment Research and Education consortium completed the Sport Concussion Assessment Tool, 3rd edition Symptom Evaluation at baseline and two post-injury follow-ups (i.e. beginning RTP and 6-month). Confirmatory factor analysis was used to compare a one- and four-factor model of post-concussion symptoms. Normative reference data were compared across stratifications (e.g. sex, prior concussions, and number of pre-existing conditions) using Mann-Whitney U tests, and elevation rates (i.e. ≥ 84th percentile) for subscales and the total score were recorded. Results: The four-factor model fit well before and after injury (CFIs > .95). Greater symptom severity on the subscale and total scores was associated with female sex (ps<.001, r range: .07 to .14) and more pre-existing conditions (ps<.001, η 2 range: .01 to .04), while having more prior concussions was only related to total symptom scores (ps<.001, η 2<.01). After a concussion, a sizeable portion of student-athletes (i.e., RTP = 11.8%; 6-month = 8.3%) had subscale elevations despite no total score elevation. Physical subscale elevations at RTP were the most common (i.e., 11.9%), driven by head and neck pain. Conclusion: After a sport-related concussion, a four-factor symptom model can be used to assess persistent symptoms in collegiate student-athletes. Identifying athletes with domain-specific elevations may help clinicians identify areas for further assessment and, in some cases, personalized rehabilitation plans.

A Novel Serum Exosomal miRNA Signature in the Early Prediction of Persistent Organ Failure in Patients with Acute Pancreatitis.

Current study aims to investigate whether serum exosomal microRNAs (miRNAs) could be potential biomarkers in predicting APs with POF at early phase. Novel biomarkers are sorely needed for early prediction of persistent organ failure (POF) in acute pancreatitis (AP) patients. In the discovery stage, exosomal miRNAs were profiled in sera from APs with or without POF (5 vs. 5) using microarrays. POF-associated miRNA signatures then were assessed in training cohort (n=227) and further validated in three independent cohorts (n=516), including one nested case-control cohort. A total of 743 APs were recruited in this large-scale biomarker identification study with a nested case-control study. Data from the discovery cohort demonstrated that 90 exosomal miRNAs were significantly dysregulated in APs with POF compared with controls. One miRNA classifier (Cmi) comprising 3 miRNAs (miR-4265, 1208, 3127-5p) was identified in the training cohort, and was further evaluated in two validation cohorts for their predictive value for POF. AUCs for Cmi ranged from 0.88 to 0.90, which was statistically superior to AUCs of APACHE-II and BISAP, and outperformed BUN and creatinine in POF prediction across all cohorts (P<.05). Higher levels of Cmi indicated increased need for ICU admission, prolonged hospitalization, and elevated mortality rate, thus poor prognosis. In the nested case-control study, Cmi could help identify prediagnostic POF in post-ERCP pancreatitis cases within "golden hours" after ERCP with high efficacy. Serum exosomal Cmi may be an early predictor for POF in AP, even within "golden hours" after AP onset. ClinicalTrials.gov (NCT02602808).

Analysis of 1999–2017 NHANES Data: Minimal Increase and Racial Disparities in U.S. Fiber Consumption Over 18 Years

Low dietary fiber consumption is associated with an increased risk of colorectal cancer, a leading cause of cancer-related mortality in the United States. The average daily fiber intake has declined over recent decades. Notably, Black Americans exhibit lower fiber consumption than other racial/ethnic groups, possibly influencing their elevated colorectal cancer rates. We hypothesize that there has been a significant increase in dietary fiber consumption in the United States from 1999 to 2017. The study encompassed 59,204 adult NHANES participants and observed variations in caloric intake over survey years. Although there was a slight overall increase in dietary fiber intake compared to 1999, the most substantial increment occurred among individuals classified as Hispanic (AD: +2.86 g, P < 0.001), followed by non-Hispanic Black (AD: +1.64 g, P < 0.001), and finally non-Hispanic White showed a decrease in fiber intake (AD: −0.86 g, P < 0.001). The findings suggest a modest rise in fiber consumption from 1999 to 2017, but disparities persist, particularly with non-Hispanic Black individuals consuming the least fiber. This emphasizes the need for interventions to promote fiber intake and address racial/ethnic inequalities in dietary habits.

Negative Associations between Minority Stressors and Self-Reported Health Status among Sexual Minority Adults Living in Colombia.

Colombia has extensive laws prohibiting discrimination against sexual minority people. However, violence and discrimination toward sexual minorities are still frequent. While a growing body of research shows that sexual minority people experience elevated rates of discrimination and domestic abuse globally, little research has been conducted on these issues affecting sexual minorities in Colombia specifically. Using minority stress theory as a conceptual framework, this paper aims to fill this gap by examining the prevalence of experiencing intimate partner violence (IPV) and witnessed discrimination and the relationship of these stressors to self-reported health among a national sample of sexual minority Colombians. We found that bisexual individuals experienced higher rates of physical and sexual IPV, compared to lesbian and gay individuals. Additionally, sexual minority Colombians who experienced IPV and witnessed discrimination were more likely to report having poorer health, compared to those who had not. We discuss the implications of our findings for future research and clinicians working with sexual minority clients.

Practical Lessons on Antimicrobial Therapy for Critically Ill Patients.

Sepsis stands as a formidable global health challenge, with persistently elevated mortality rates in recent decades. Each year, sepsis not only contributes to heightened morbidity but also imposes substantial healthcare costs on survivors. This narrative review aims to highlight the targeted measures that can be instituted to alleviate the incidence and impact of sepsis in intensive care. Here we discuss measures to reduce nosocomial infections and the prevention of equipment and patient colonisation by resilient pathogens. The overarching global crisis of bacterial resistance to newly developed antimicrobial agents intensifies the imperative for antimicrobial stewardship and de-escalation. This urgency has been accentuated in recent years, notably during the COVID-19 pandemic, as high-dose steroids and opportunistic infections presented escalating challenges. Ongoing research into airway colonisation's role in influencing disease outcomes among critically ill patients underscores the importance of tailoring treatments to disease endotypes within heterogeneous populations, which are important lessons for intensivists in training. Looking ahead, the significance of novel antimicrobial delivery systems and drug monitoring is poised to increase. This narrative review delves into the multifaceted barriers and facilitators inherent in effectively treating critically ill patients vulnerable to nosocomial infections. The future trajectory of intensive care medicine hinges on the meticulous implementation of vigilant stewardship programs, robust infection control measures, and the continued exploration of innovative and efficient technological solutions within this demanding healthcare landscape.

Population Dynamics of Gudusia chapra (Hamilton, 1822) from Lake Kaptai, Bangladesh

Aims: This study aimed to assess the population dynamics of Gudusia chapra in Lake Kaptai, Bangladesh, utilizing FiSAT II software for comprehensive analysis. The key objective was to determine growth parameters, mortality rates, exploitation status, and length-weight relationships to inform policy.&#x0D; Study Design: The study employed a quantitative approach, utilizing length frequency data collected from Lake Kaptai. FiSAT II software facilitated the estimation of population dynamics parameters, employing the Von Bertalanffy growth equation and other relevant analyses.&#x0D; Place and Duration of Study: The research was conducted in Lake Kaptai, Bangladesh, focusing on the intricate aquatic ecosystem from November 2003 to October 2004. Data collection and analysis spanned an extensive duration, providing a robust understanding of the population dynamics of G. chapra.&#x0D; Methodology: FiSAT II software was utilized for population dynamics estimation, with a particular focus on growth parameters, mortality rates, and exploitation status using Von Bertalanffy growth equation. Length-weight relationships were also determined. Recruitment patterns were observed, and key indices, including the growth performance index calculated.&#x0D; Results: The estimated asymptotic length (L∞) and growth coefficient (K) of G. chapra were found to be 19.95 cm and 0.89 year-1 respectively. Natural mortality (M), fishing mortality (F) and total mortality (Z) rates were 1.85, 2.21 and 4.06 year-1 respectively. The exploitation rate (E) indicated overfishing, with a value of 0.54, which exceeded the optimum E (E=0.5). The growth performance index (φ´) of 2.54 was recorded, and the recruitment pattern occurred between April and July.&#x0D; Conclusion: The study concludes that G. chapra in Lake Kaptai is experiencing overfishing, as indicated by the elevated exploitation rate. Understanding the growth parameters and mortality rates is vital for sustainable fisheries management in the region.&#x0D; Implication: The findings have significant implications for fisheries management, highlighting the urgent need for measures to mitigate overfishing of G. chapra in Lake Kaptai. Implementing conservation strategies and monitoring recruitment patterns are crucial for ensuring the long-term sustainability of this important fish species.

The crucial role of lateral root angle in enhancing drought resilience in cotton.

Plant responses to drought stress are influenced by various factors, including the lateral root angle (LRA), stomatal regulation, canopy temperature, transpiration rate and yield. However, there is a lack of research that quantifies their interactions, especially among different cotton varieties. This experiment included two water treatments: well-watered (75 ± 5% soil relative water content) and drought stress (50 ± 5% soil relative water content) starting from the three-leaf growth stage. The results revealed that different LRA varieties show genetic variation under drought stress. Among them, varieties with smaller root angles show greater drought tolerance. Varieties with smaller LRAs had significantly increased stomatal opening by 15% to 43%, transpiration rate by 61.24% and 62.00%, aboveground biomass by 54% to 64%, and increased seed cotton yield by 76% to 79%, and decreased canopy temperature by 9% to 12% under drought stress compared to the larger LRAs. Varieties with smaller LRAs had less yield loss under drought stress, which may be due to enhanced access to deeper soil water, compensating for heightened stomatal opening and elevated transpiration rates. The increase in transpiration rate promotes heat dissipation from leaves, thereby reducing leaf temperature and protecting leaves from damage. Demonstrating the advantages conferred by the development of a smaller LRA under drought stress conditions holds value in enhancing cotton's resilience and promoting its sustainable adaptation to abiotic stressors.

Comparison of Protective Effect of Tri-circulator and Coenzyme Q10 on Myocardial Injury and the Mechanism Study by Zebrafish Model.

Tri-Circulator (TC) is a product comprising coenzyme Q10 (CoQ10), Salvia miltiorrhiza, and Panax notoginseng. Individually, each of these constituents has demonstrated protective effects on myocardial injury. The purpose of this study is to evaluate the protective efficacy of TC on heart function and compare the differential effects between CoQ10 and TC. Two myocardial injury models of zebrafish, the hypoxia-reoxygenation model (H/R) and the isoproterenol (ISO, a β-receptor agonist) model, were used in this experiment. The zebrafish subjects were divided into 4 groups: control, H/R, TC, and CoQ10. Heart rate, stroke volume (SV), cardiac output (CO), ejection fraction (EF), fractional area change (FAC), and pericardial height were monitored to assess changes in heart function. The gene expression of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) was studied as markers of injury/stress. TC significantly suppresses elevated heart rate induced by H/R and prevents the decrease of heart rate induced by ISO. It alleviates the pericardial infusion induced by ISO, whereas CoQ10 does not possess a similar effect. Both TC and CoQ10 significantly inhibit the decline in SV, CO, EF, and FAC induced by H/R and ISO, and suppress the expression of ANP and BNP in cardiomyocytes induced by ISO. It is noteworthy that TC demonstrates a more pronounced effect on EF, FAC, ANP, and BNP gene expression compared to CoQ10. Both TC and CoQ10 have a protective effect on myocardial injury of zebrafish. However, TC exhibits a greater efficacy compared to CoQ10 alone in mitigating myocardial injury.

FREQUENCY OF ACUTE KIDNEY INJURY IN PATIENTS POST-CORONARY ARTERY BYPASS GRAFTING AT TERTIARY CARE HOSPITAL, KARACHI

A descriptive study was conducted at the Department of Medicine and Cardiothoracic Surgery, Aga Khan University Hospital, Karachi, from May 27, 2019, to November 27, 2019, to determine the frequency of acute kidney injury in patients after coronary artery bypass grafting. A total of 174 patients who underwent coronary artery bypass graft surgery were enrolled in the study. Postoperatively, all patients were closely observed for acute kidney injury up to 48 hours post-surgery. The demographic characteristics of the participants revealed a mean age of 54.14±9.49 years, with 108 (62.1%) being males and 66 (37.9%) females. Out of the total participants, 25 (14.4%) experienced acute kidney injuries, while 149 (85.6%) did not show any signs of acute kidney injuries. The findings suggest that acute kidney injury is a common complication following isolated coronary artery bypass graft (CABG) surgery. This observation holds significant clinical importance, as it is associated with unfavourable postoperative outcomes, prolonged stays in the intensive care unit (ICU), and elevated fatality rates. These insights underscore the need for careful monitoring and management of renal function in patients undergoing CABG surgery to mitigate the impact of acute kidney injury on overall postoperative well-being.

Hyperparameter optimization strategy for Multi-Armed Bandits: Genre recommendation in MovieLens dataset

Due to the challenge of balancing exploration and exploitation in Multi-Armed Bandits (MAB) problems, it is rather challenging to determine the optimal exploration length for diverse datasets. This paper presents an in-depth investigation of the hyperparameter setting for the Explore-Then-Commit (ETC) algorithm, emphasizing an enforced exploration strategy to guarantee adequate exploration of each arm. This investigation will be realized in the context of movie recommendation systems, specifically utilizing the MovieLens 1M dataset. Two key hyperparameters are scrutinized: the horizon, which sets the overall timeframe of the algorithm's execution, and the number of times each arm is explored. The study systematically varies these parameters to study their influence on cumulative regret, a measure of the opportunity cost each time a non-optimal arm is sampled. The empirical examination of the ETC algorithm, conducted employing the MovieLens 1M dataset, has yielded significant discernments pertaining to the dynamic configuration of exploration lengths tailored to particular datasets. The empirical findings underscore that judicious fine-tuning of the ETC algorithm's hyperparameters, under a defined horizon of 50,000 and an exploration length of 500, engenders commendable competitive performance. This optimized configuration notably excels in the domain of genre recommendations, particularly manifesting enhanced proficiency in suggesting genres characterized by the most elevated average ratings. This research accentuates and reinforces the comprehension of hyperparameters under the exploration and exploitation dilemma, thereby providing a structured pathway for the forthcoming applicability of MAB in the wider realm of recommendation systems.

Text mining and sentiment analysis: A new lens to explore the emotion dynamics of mother‐child interactions

AbstractEmotions are highly dynamic and social in nature. Traditional approaches to studying emotion expression face obstacles such as substantial time investments, susceptibility to human biases, and limited capacity to capture nuanced emotional patterns. To address these challenges, this research leveraged text mining and sentiment analysis to explore the dynamic patterns of emotion expression within the context of mother‐child interactions. We analyzed 8,841 conversation transcripts involving 1,462 mother‐child dyads, sourced from the Child Language Data Exchange System. Polarity scores were calculated and analyzed to uncover the temporal patterns of mother and child emotional sentiment. Our findings revealed that mothers tended to exhibit heightened levels of positive emotion at the beginning and conclusion of conversations, whereas children displayed a more linear positive trend. Using model‐based cluster analysis, we identified two distinct clusters of mothers characterized by varying degrees of emotion expression variation and two clusters of children showing different rates of elevation in positive emotion. At the dyadic level, the differences between mother and child polarity scores varied as a function of time, with an increase of difference from the beginning to the 20th percentile point, a decrease until the 90th percentile, and then an increase again towards the end of the conversation. This study demonstrates the utility of text mining and sentiment analysis in developmental studies, particularly in the context of parent‐child interactions. The findings hold informative implications for interventions that focus on fostering healthy parent‐child relationships.