An aqueous extract of <em>Ocimum sanctum</em> (Tulsi) and <em>Elettaria cardamomum</em> (Cardamom) was administered to elderly subjects suffering from depression living in selected old age home. Geriatric Depression Assessment Scale was used to assess the level of depression; based on the scale, 40 subjects were selected for the study. The subjects were divided into two groups of twenty each. Experimental group received aqueous extracts of<em> Ocimum sanctum</em> and <em>cardamom</em> for eight weeks, similarly, control group received aqueous extract of <em>green tea leaves.</em> Post assessment was done after eight weeks of treatment in both the control and experimental groups. Aqueous extracts of <em>Ocimum sanctum</em> and <em>cardamom</em> were found to have a significant anti depressive effect on experimental group after 8 weeks, while control group did not show any significant change. Preliminary data of the study showed a significant antidepressive activity of <em>Ocimum sanctum</em> and <em>cardamom</em> extracts.