Systematic evaluation of the efficacy and safety of endoscopic electrocoagulation of gastrointestinal bleeding has been thwarted by the inability to quantify or control energy delivered to tissue. An analogue computer has been developed which can be inserted in the circuit between a commercial electrosurgical generator and the active electrode. It can record the actual energy delivered to the tissue at any arbitrary generator setting. Additionally, it can deliver a predetermined amount of energy by continuously adjusting the voltage of the generator to compensate for changes in the tissue impedance during electrocoagulation (power leveling). A special electrode has been devised to assure the reproducibility of the area of tissue contact. By using a force gauge at laparotomy with a predetermined energy of 20 joules, the effect of electrode pressure on the depth of injury was measured. Light pressure (1.3 newtons per cm2) injured a mean of 36% and moderate pressure (6.4 newtons per cm32) a mean of 87% of gastric wall thickness. Electrocoagulation applied in the clinical manner, or predetermined by power leveling, stopped all bleeding from experimental gastric ulcers with the same amount of energy for each method. Similarly, chronic studies of the depth of injury with each method of electrocoagulation showed no difference. Furthermore, the whole thickness of the gastric wall was injured in 4% of ulcers treated, and there was no significant difference between the two methods of applying the electrocoagulation. Thus, despite our ability to control energy delivered during monopolar electrocoagulation of experimental gastric ulcers, the depth of injury to the gastric wall was unpredictable and, at times, excessive. Further studies of other types of electrocoagulation are needed and will be facilitated by the availability of this computer-controlled electrosurgical generator.
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