Electrocatalytic Sensor Research Articles

An ethylvanillin electrocatalytic sensor based on perovskite La3+-doped barium stannate nanorods

Herein, a series of La3+-doped BaSnO3 nanorods (Ba1-xLaxSnO3) were prepared by sol-gel method and were developed as electrochemical sensor for the electrochemical detection of ethylvanillin (EVA). The Ba1-xLaxSnO3 sensor exhibited better electrocatalytic detection performance than that of GCE and BaSnO3, which is ascribed to the enhancement of conductivity and active sites after the introduction of La3+. The optimized Ba0.995La0.005SnO3 sensor exhibited a linear range from 0.05 μM to 130 μM and a low limit of detection (LOD) of 8.6 nM. Mechanistic study demonstrated that the electrochemical oxidation process of EVA is involved the diffusion control process of two electrons and the same number of protons. Additionally, the proposed sensor for EVA demonstrated good anti-interference ability, repeatability (RSD ∼2.70 %), reproducibility (RSD ∼2.99 %), and stability (RSD ∼2.44 %). Moreover, the Ba0.995La0.005SnO3 sensor has good recoveries (100.4 %–102.4 %) for the detection of EVA in real milk powder extraction sample. The as-fabricated Ba0.995La0.005SnO3 sensor provide the possibility to detect the EVA in the real sample.

A new multifunctional electrocatalyst based on PbS nanostructures decorated with graphene/polyaniline-modified glassy carbon electrode for selective detection of non-steroidal anti-inflammatory drug naproxen

Naproxen (NAP), a well-known anti-inflammatory drug, has also been considered for its antiviral prospective and acceptable potential for in vitro activity against serious respiratory syndrome-related coronavirus (SARS-CoV) and anti-influenza activity. However, designing a selective, sensitive and efficient electrocatalyst for the determination of NAP is still a great challenge. In this research, a new electrocatalytic sensor was constructed for the electrochemical recognition of NAP by a glassy carbon electrode modified with PbS nanostructures incorporated graphene/polyaniline nanocomposite. The synthesized samples were characterized by physicochemical analyses like EDS, XRD, FTIR, FESEM, and PL. Cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS) and differential pulse voltammetry (DPV) were carried out to examine the electrocatalytic behavior of the modified electrodes. The EIS plot obviously demonstrated rapid electron transport at low frequencies for the PbS/graphene/PANI/GC electrode. It was observed that the PbS/graphene/PANI/GC electrode exhibited better-defined oxidation peaks, and greater peak currents for NAP detection compared to other electrodes. Under the optimum conditions, the proposed PbS/graphene/PANI nanoplatform provided a reliable linear range of 1 to 100 µM with a detection limit as low as 0.08 μM. Meanwhile, the PbS/graphene/PANI electrode possessed acceptable selectivity, good repeatability with an RSD of about 2.6 %, and a reduction of about 3 % after two weeks, and long-term stability of about 97 % of its original response for the recognition of NAP. Furthermore, the constructed electrode demonstrated NAP detection in real samples, such as human plasma and urine with good recoveries ranging from 98.8 % to 99.9 %, suggesting its promising prospects in clinical diagnostics.

Nicotine sensing behavior of nickel(II) complexes catalyzed oxidation and coupling reactions

One of the main source of demise during the next ten years will be coronary heart disease and stroke, which are brought on by smoking (nicotine). To identify the percentage (%) of nicotine consumption by electrocatalytic sensor towards nicotine for target-specific prevent stroke, four uninuclear Ni2+ complexes of substituted butanimidamide Schiff base ligands [H2L1-4] was prepared. All the complexes were thoroughly analyzed by using several spectroscopic techniques such as CHNS analysis, FT-IR, NMR (1H &13C) UV–Vis and NMR. The analyses showed tetradentate binding mode of ligand around nickel(II) metal ion leads to the structure of square planar with N2X2 (X = O, S) donor fashion. In addition, the well-defined nickel(II) complexes were utilized for oxidation of various alcohols such as cyclohexanol, and benzyl alcohol were produced to the assorted oxidized products with high yield respectively using greener co-oxidant (molecular oxygen). In addition, Nickel(II) complexes was further utilized as catalyst for aryl-aryl coupling reaction via Suzuki-Mayura method to obtain biphenyl compound. Furthermore, nickel(II) complexes were exploited for electrochemical detection of nicotine sensing in μM concentration.

Ponceau polymer film for electrocatalytic sensing of levodopa in human serum, urine, and pharmaceutical formulation

An exceptional, affordable, and disposable electrocatalytic sensor (403% increase in peak height compared to activated pencil graphite electrode) with a one-step preparation process, ponceau-based polymer film, was utilized for levodopa determination in human serum, urine, and pharmaceutical formulation. The analytical response for levodopa was determined by measuring its oxidation signal at 180 mV in a phosphate buffer solution with a pH of 6. Characterization of the sensing platform was carried out using various techniques including cyclic voltammetry, electrochemical impedance spectroscopy, scanning electron microscopy, energy dispersive X-ray spectroscopy, and X-ray photoelectron spectroscopy. The developed sensor exhibited the capability to detect levodopa at a low concentration of 20 nM, spanning a wide dynamic range from 0.06 to 160 µM. Additionally, a comparative analysis was performed between the produced poly ponceau modified activated pencil graphite electrode and a potentiometric automatic titration system. The statistical evaluation revealed no significant difference between the results obtained from both methods confirming their consistency within a 95% confidence level.

Ni-P nanosheets derived from a metal–organic framework containing triptycene ligand: A high-performance electrochemical sensor for glucose determination

The synthesis of hierarchical nanostructures using transition metal phosphides (TMPs) derived from metal-organic frameworks (MOFs) has shown good potential in the design of electrochemical sensors. Trypticenes have become attractive organic ligands in the synthesis of MOFs due to their favorable properties. In this study, first, a new MOF using nickel and 2,3,6,7,14,15-hexahydroxy triptycene (Ni-HHTT) has been synthesized through a simple hydrothermal method on nickel foam (NF). Then, during the phosphidation process in an N2 atmosphere, the Ni-HHTT precursor synthesized on nickel foam (Ni-HHTT/NF) was converted into MOFs-derived Ni-P/NF and used as an electrocatalytic sensor in glucose sensing. The fabricated non-enzymatic glucose sensor has a wide concentration range including 0.5–1700 µM and 1700–4100 μM with a low detection limit (0.15 µM). This sensor has advantages such as high sensitivity, accuracy, fast response time (Δt<1.5s), stability, and cost-effectiveness. In addition, the performance of the proposed sensor for measuring glucose in human blood serum samples was evaluated as satisfactory. The proposed strategy provides a new idea for the development of MOF materials based on trypticenes scaffolds and their transition metal phosphide derivatives.

Highly anti-interference electrocatalytic sensing for dopamine with nitrogen-doped graphdiyne directly in biofluids

Nitrogen-doped graphdiyne (N-GDY) nanostructures are attracting increasing attention in electrochemical sensing field owing to its peculiar chemical structure, high structure defects, good electrical conductivity, favorable biocompatibility and hydrophilicity. A highly anti-interference electrocatalytic sensor based on N-GDY for the detection of dopamine (DA), a crucial neurotransmitter and chemical substance for numerous physiological processes, was demonstrated. The highly anti-interference ability was endowed by the abundant existing sp-N interactive sites on synthesized N-GDY surface that not only offered the very high-efficiency interactions between target DA molecules and developed interface but also effectively excluded other interferential component combinations which further powerfully boosted the high selectivity of fabricated sensor. Density functional theory (DFT) calculations were used to explore, verify and reveal both the best-matched sp-N interactive sites for DA molecules on N-GDY surface and the correlative mechanism for electrocatalytic process towards DA. Electrocatalytic sensitivity was also enhanced due to the large electroactive surface area, more active sites, superior conductivity, and improved interfacial charge transfer of as-prepared N-GDY nanostructure. Such developed sensor achieved highly selective and sensitive DA detection with a very wide linear ranging from 1 to 550 µM and a low limit of detection (LOD) of 0.46 µM, even in the real complex biofluids, where a good deal of biological components are co-existing. The superior performance towards target was principally attributed to its outstanding anti-interference ability and the analysis results in biofluids markedly declared its powerful potential for practical applications of such DA sensor.

Facile Gram-Scale Synthesis of NiO Nanoflowers for Highly Selective and Sensitive Electrocatalytic Detection of Hydrazine.

The design and development of efficient and electrocatalytic sensitive nickel oxide nanomaterials have attracted attention as they are considered cost-effective, stable, and abundant electrocatalytic sensors. However, although innumerable electrocatalysts have been reported, their large-scale production with the same activity and sensitivity remains challenging. In this study, we report a simple protocol for the gram-scale synthesis of uniform NiO nanoflowers (approximately 1.75 g) via a hydrothermal method for highly selective and sensitive electrocatalytic detection of hydrazine. The resultant material was characterized by scanning electron microscopy, X-ray photoelectron spectroscopy, and X-ray diffraction. For the production of the modified electrode, NiO nanoflowers were dispersed in Nafion and drop-cast onto the surface of a glassy carbon electrode (NiO NF/GCE). By cyclic voltammetry, it was possible to observe the excellent performance of the modified electrode toward hydrazine oxidation in alkaline media, providing an oxidation overpotential of only +0.08 V vs Ag/AgCl. In these conditions, the peak current response increased linearly with hydrazine concentration ranging from 0.99 to 98.13 μmol L-1. The electrocatalytic sensor showed a high sensitivity value of 0.10866 μA L μmol-1. The limits of detection and quantification were 0.026 and 0.0898 μmol L-1, respectively. Considering these results, NiO nanoflowers can be regarded as promising surfaces for the electrochemical determination of hydrazine, providing interesting features to explore in the electrocatalytic sensor field.

Disposable electrocatalytic sensor for whole blood NADH monitoring

Monitoring nicotinamide adenine dinucleotide (NADH) is important because NADH is involved in cellular redox reactions and cellular energy production. Currently, few biosensors quantify NADH in whole blood. However, they still have limitations due to several defects, including poor repeatability, long analysis time, and their requirement of extra sample pretreatment. In this study, we developed electrocatalytic sensors using screen-printed electrodes with a redox-active monolayer 4′-mercapto-N-phenylquinone diamine formed by a self-assembled monolayer of a 4-aminothiophenol (4-ATP). We exhibited their behavior as electrocatalysts toward the oxidation of NADH in whole blood. Finally, the electrocatalytic sensors maintained stability and exhibited 3.5 µM limit of detection, with 0.0076 ± 0.0006 µM/µA sensitivity in a mouse’s whole blood. As proof of concept, a polyhexamethylene guanidine phosphate–treated mouse model was used to induce inflammatory and fibrotic responses, and NADH level was measured for 45 days. This work demonstrates the potential of electrocatalytic sensors to analyze NADH in whole blood and to be developed for extensive applications.

(Digital Presentation) Electrocatalytic Cortisol Tracing Smart Patch

Rapid and continuous tracking of the stress hormone cortisol's circadian rhythm is vital for diagnosing diseases related to chronic stress and adrenal gland disorders [1]. Commercial cortisol sensors relying on labeled enzyme and antibodies suffer from limited stability, lengthy reaction time, and cross-reactivity with analogous molecules [2]. To address these issues, we developed an electrocatalytic sensor using phthalocyanine (Pc) doped molecularly imprinted polymer (MIP) modified screen-printed electrodes for label-free, reagentless, sensitive, and selective electrochemical detection of cortisol. The sensor was constructed via one-step electropolymerization of conductive prepolymer in the presence of Pc and template cortisol. The controlled release of cortisol templates resulted in an MIP network embedded with Pc catalysts in the vicinity of the cortisol-specific binding cavities. The sensor directly measures the cortisol level by catalysing the reduction reaction of the cortisol captured by the cavities of the MIP. Proof of studies was performed to detect cortisol over a wide concentration range varying from 500 pM to 10 µM with high selectivity against structurally similar hormones. The facile label-free and antibody-free cortisol sensor on a wearable smart patch offers an appealing approach for selective steroid hormone detection at point-of-care testing.

A kind of complex-based electrocatalytic sensor for monitoring the reduction of Cr(Ⅵ) by organic/inorganic reductants

In order to monitor the reduction of Cr(Ⅵ) by organic/inorganic reductants, three transition metal ions of Co2+/Ni2+/Cu2+ were selected to combine with a semi-rigid amide ligand [N, N'-bis-pyridin-3-ylmethyl-terephthalamide (L)]. As a result, [Co(L)(HIPA)](H2O)2]∙H2O (1) [Ni(L)(HIPA)](H2O)2]∙H2O (2) [Cu(L)(HIPA)]∙4H2O (3) were obtained by hydrothermal method (H2HIPA = 5-Hydroxyisophthalic acid). Complexes 1 and 2 are similar 2D cellular networks, while complex 3 has 4-connected 3D structure with semicircle 1D channel. The title complexes can act as electrochemical sensors to detect Cr(Ⅵ) by cyclic voltammetry and differential pulse method. The corresponding detection limits are 5.9 × 10−6 (1), 1.6 × 10−5 (2), 9.1 × 10−6 (3) for Cr(Ⅵ) anion, respectively. In addition, the title complexes 1–3 modified carbon paste electrode (1–3-CPEs) provide a kind of generalizable sensor for the electrochemical monitor the reduction of Cr(Ⅵ) by organic/inorganic reductants [Ascorbic acid (AA), H2O2 and Na2S2O3]. The effect of metal ions on the structures and electrochemical properties of 1–3 were discussed.

Designing of surface engineered Ytterbium oxide nanoparticles as effective electrochemical sensing platform for dopamine

The simple and well framed sensing podium for Dopamine (DA) is holding significant importance in early analysis of neurodegenerative syndromes. Here, a facile electrochemical biosensor of Ytterbium oxide nanoparticles (Yb2O3 NPs) functionalized with (3-mercaptopropyl)trimethoxysilane (MPTMS) were prepared for efficient and selective quantification of DA. The developed electrocatalytic sensor overcome the associated confronts related to selectivity, sensitivity and interference from co-existing bio-components. The fabrication of MPTMS@Yb2O3 NPs was carried out by hydrothermal route. The physiochemical, morphological and structural characterization of chosen electrocatalyst was performed HRTEM, FE-SEM, XRD, SAXS, Raman, FTIR, TGA-DTA, XPS and DSC techniques. The electrochemical investigation suggests the superior performance of MPTMS@Yb2O3 NPs modified gold electrode as compared to the individual MPTMS or Yb2O3 modified electrodes towards DA sensing. The formed sensor displayed wide linear ranges from 1 to 40 µM with lowest detection limit (LOD) of 41 nM for DA. The calculated diffusion coefficient value is 8.57 × 10−5 cm2s−1 for DA. The usability of Au/ MPTMS@Yb2O3 NPs for DA estimation was successfully checked in real samples for practical applications. The developed sensor offers a great signal recovery and reproducibility and showed enhanced prospective in clinical samples.

One-dimensional self-assembled Co2SnO4 nanosphere to nanocubes intertwined in two-dimensional reduced graphene oxide: an intriguing electrocatalytic sensor toward mesalamine detection

The present work deals with the preparation of hybridized electrode material with electrostatic self-assembly strategy for mesalamine (MES) detection. Grabbing significant abilities between the one-dimensional bimetallic oxides and two-dimensional nanosheets network, a nanohybrid was designed. The developed cobalt stannate/reduced graphene oxide (Co2SnO4/rGO)-1D/2D heterostructure will possess improvised anisotropic electron transport, earth abundant, highly conducting, multiple actives site, and higher surface area. The 1D/2D nanostructured architecture will enhance faster electron and mass transport during the electrochemical analysis, which is more significant for MES detection. Progressive testing of Co2SnO4/rGO for structural analysis was done, and highly crystalline nature was proved. The self-assembled nanospheres to form nanocube such as Co2SnO4 strongly attached over the rGO matrix was confirmed with field emission scanning microscope, and nanocube structure is more visible with high-resolution transmission electron microscopy. The hierarchical highly electroactive material establishes lower detection limit at 4.9 nM with sensitivity of about 8.57 μA/μM/cm2. The interfacial area of nanocomposite with higher conducting channels to improve the interactions with MES resulted in enhanced selectivity. The practical analysis in environmental, pharmaceutical, and biological fluids (human urine and serum) showed good recovery. The Co2SnO4/rGO will be more prominent and significant as electrode material in electrochemical sensing.

Nitrogen, phosphorus co-doped hollow porous carbon microspheres as an oxidase-like electrochemical sensor for baicalin

Nitrogen, phosphorus co-doped hollow porous carbon microspheres as an oxidase-like electrocatalytic sensor for baicalin were successfully developed by two-stage activation.

Au@Carbon quantum Dots-MXene nanocomposite as an electrochemical sensor for sensitive detection of nitrite

A highly sensitive electrochemical sensor was developed through a one-pot green synthesis method for nitrite detection based on the electrochemical technique. Xylan-based carbon quantum dots (CQDs) were used as green in situ reducing agent to prepare CQDs capped gold nanoparticles (Au@CQDs). MXene of good electrical conductivity was used as the immobilized matrix to fabricate Au@CQDs-MXene nanocomposites with the advantages of good electrical conductivity and electrocatalysis. An electrochemical sensor for nitrite monitor was obtained by loading the Au@CQDs-MXene on a glassy carbon electrode. The sensor presents high sensitivity, good stability, wide linear range, and excellent selectivity due to the high catalytic activity of AuNPs and CQDs, the large specific surface area of MXene, and exceptional electrical conductivity of AuNPs and MXene. Under the optimal condition, the linear detection range of the sensor was from 1 μM to 3200 μM with a detection limit of 0.078 μM (S/N = 3), which was superior to most reported sensors using differential pulse voltammetry (DPV) method. Furthermore, this sensor was successfully applied to detect nitrite in tap water and salted vegetables with satisfactory recoveries. This modified electrocatalytic sensor shows a new pathway to fabricate nitrite detection sensor with feasibility for practical application.

Electrocatalytic Sensor for Hydrogen Peroxide Based on Immobilized Benzoquinone

AbstractAn amperometric chemosensor for the detection of hydrogen peroxide is reported. The sensor is based on 1,4‐benzoquinone immobilized on the gold electrode using self‐assembled monolayer of short chain symmetrical dithiol as an anchor layer. Sensor analysis was performed by cyclic voltammetry at the potential range from −0.6 V till +0.9 V as well as in the anodic or cathodic potential ranges only. The results indicate oxidative electrochemical decomposition of hydrogen peroxide at the potential of ∼+0.4 V leading to the formation of oxygen while at cathodic potentials a reduction of the formed oxygen as well as of the hydrogen peroxide occur. A decrease in the oxidation potential of hydrogen peroxide on the gold electrode coated by self‐assembled monolayer with 1,4‐benzoquinone in comparison with that measured on the electrodes coated by the same self‐assembled monolayer without 1,4‐benzoquinone, indicates electrocatalytic effect of this moiety on oxidative decomposition of hydrogen peroxide. Analytical evaluation of the sensor performance was done in the voltammetric as well as in the chronoamperometric mode. The sensor exhibited linear response over the concentration range till 2.5 mM with a limit of detection ∼4 μM.

2D MoS2 nanosheets and hematein complexes deposited on screen-printed graphene electrodes as an efficient electrocatalytic sensor for detecting hydrazine

A new strategy to modify screen-printed graphene electrodes (SPGrEs) with two-dimensional molybdenum disulfide (2D-MoS2) nanosheets is described. The nanomaterial confined on the electrode surface is further modified forming a ternary complex with the redox mediator hematein (HM), using Al3+ salts as mordant. The formation of this ternary complex, HM-Al3+-(2D-MoS2), gives rise to new nanostructures that can be visualized by scanning electron microscopy (SEM). The resulting nanostructured platform has been characterized by electrochemical techniques. It exhibits a strong electrocatalytic activity towards hydrazine oxidation mainly due to the presence of quinone/hydroquinone moieties from the hematein and a good stability. The large value calculated for the electrocatalytic kinetic constant, (8.1 ± 0.1) x104 M−1 s−1, suggests that the presence of 2D-MoS2 nanosheets significantly improves the properties of hematein as an electron donor/acceptor. The catalytic current showed a linear dependence with the hydrazine concentration, which has allowed the development of a hydrazine sensor based on HM-Al3+-(2D-MoS2)/SPGrEs with detection and quantification limits of 1.05 μM and 3.48 μM, respectively. The presence of different interfering compounds such as glucose, urea and others did not significantly affect the response of the proposed hydrazine sensor. This sensor has been used for the determination of hydrazine in tap and river waters.

Synthesizing Electrodes Into Electrochemical Sensor Systems.

Electrochemical sensors that can determine single/multiple analytes remain a key challenge in miniaturized analytical systems and devices. In this study, we present in situ synthesis and modification of gold nanodendrite electrodes to create an electrochemical system for the analysis of hydrogen peroxide. The sensor system consisted of the reference and counter electrodes as well as the working electrode. Electrochemical reduction of graphene oxide, ErGO, on the thin-film gold and gold nanodendrite working electrodes was used to achieve an efficient sensor interface for the adsorption of a biomimetic electrocatalytic sensor material, Mn(III) meso-tetra(N-methyl-4-pyridyl) porphyrin complex, with as high as 10–10 mol cm−2 surface coverage. The sensor system demonstrated a detection limit of 0.3 µM H2O2 in the presence of oxygen. Electrochemical determination of hydrogen peroxide in plant material in the concentration range from 0.09 to 0.4 µmol (gFW)−1 using the electrochemical sensor system was shown as well as in vivo real-time monitoring of the hydrogen peroxide dynamics as a sign of abiotic stress (intense sunlight). Results of the electrochemical determination were in good agreement with the results of biochemical analysis with the spectrophotometric detection. We anticipate that this method can be extended for the synthesis and integration of multisensor arrays in analytical microsystems and devices for the quantification and real-time in vivo monitoring of other analytes and biomarkers.

Rapid Electrochemical Monitoring of Tyrosine by Poly (Riboflavin) Modified Carbon Nanotube Paste Electrode as a Sensitive Sensor and its Applications in Pharmaceutical Samples

A poly(riboflavin) modified carbon nanotube paste electrode (PRFMCNTPE) is employed as a compatible and electrocatalytic sensor for the determination of Tyrosine (TYR). The analysis and assessment are carried out through differential pulse voltammetry (DPV) and Cyclic Voltammetry (CV). The surface of the intended sensor is examined through Field Emission Scanning Electron Microscopy (FE-SEM). The modified electrode shows the outstanding electrocatalytic effect for TYR with high selectivity and sensitivity as compared to carbon nanotube paste electrode (CNTPE). The electro-oxidation peak current of TYR and its concentration is found linear from 2 µM to 10 µM with a detection limit (LOD) of 0.45 µM. The developed sensor is productively applied for the determination of TYR in pharmaceutical samples like Tyrosine capsules. The adapted electrode shows good stability, excellent reproducibility, and remarkable sensitivity.

An Ochratoxin A Electrocatalytic Sensor Based on Electron Mediator Decorated Nanoalloy Biomimetic Enzyme Coupling with Label-Free Hair Aptamer

An electrocatalytic sensor based on electron mediator toluidine blue (Tb) decorated PtPd nanoalloys (PtPdNAs) biomimetic enzyme coupling with label-free hair aptamer (HA) for OTA detection was successfully constructed. In this work, label-free HA was designed containing anti-OTA aptamer sequence (APT) and complementary sequence (cDNA) of report DNA (rDNA). rDNA and Tb joint decorated PtPdNAs (Tb-PtPd-rDNA) was used as a signal probe. The peroxidase-like activity of the PtPdNAs combined with the synergistic catalysis of the Poly 3,4-ethoxylene dioxy thiophene-AuNPs (PEDOT-AuNPs) coated glass-carbon electrode (PE-Au/GCE) resulted in strong catalytic current of Tb and eventually significantly improved the sensitivity of the sensor. The response current had a good metrological-signal relationship with OTA concentration from 0.1 pg ml-1 to 0.1 ng ml-1, and the low detection limit of 0.05 pg ml-1 was obtained. Meanwhile, the proposed sensor exhibited a good correlation with HPLC when it was applied for OTA detection in red wine samples. The strategy broadens the design of catalytic sensor and can be applied to the detection of other small molecules.

Facile sonochemical synthesis of silver nanoparticle and graphene oxide deposition on bismuth doped manganese oxide nanotube composites for electro-catalytic sensor and oxygen reduction reaction (ORR) applications

Pristine silver nanoparticles and silver-graphene oxide nanoparticles have incorporated in Bismuth doped manganese oxide (Bi-MnOx) nanotubes by an ultra-sonication deposition method. Pristine Bismuth doped porous MnO2 has prepared by a non-ionic surfactant (Triton-X-100) assisted co-precipitation and heat treatment process. In the second stage, the biogenic method prepared very fine Ag nanoparticles with a quantum dot size of particles (below 10 nm). They have further deposited on the dried powder of Bi-MnOx by ultra-sonication fabricate the composite material for electrode application. The pure nanotube formation obtained for silver nanoparticle deposited Bi-MnOx (Ag-BiMnOx) and silver/GO nanoparticle(Ag-BiMnOx/GO) nanocomposites have clearly confirmed by high resolution transmission electron micrographs (HR-TEM). The nanotube diameter obtained in the range of 10–25 nm and length of nanotube obtained in the rage of 40–50 nm. Enhanced thermal stability has achieved for Ag-BiMnOx and Ag-BiMnOx/GO composite compared to pristine manganese oxide. Band gap values of prepared compoiste is calculated from Diffuse reflectance spectral data provide the bandgap values of Ag–Bi-MnOx/GO (1.93 eV) and Bi-MnOx (2.47 eV). As prepared graphene oxide modified Bi-MnOx composite modified electrode have further analyzed for hydrogen peroxide sensor and Oxygen reduction reactions (ORR). Silver nanoparticle-graphene oxide modified Bi-MnOx composite shows an enhanced electrochemical capacitance activity of 2.61 mF and improved electrochemical surface area of 65.25 cm2 towards clean energy technology application.