Hybrid learning/numerical framework for fast and robust electric field simulation in irreversible electroporation.

Linking electric field pattern to clinical efficacy of transcranial electrical stimulation in substance use disorder: A modeling-based meta-analysis.

Dendritic cells (DCs) are central to the initiation of anti-tumour immunity, yet the direct effects of electrochemotherapy (ECT) on DC biology remain poorly defined. We investigated how varying electric field strengths (800, 1000, and 1300V/cm) modulate murine DC viability, phenotype, Toll-like receptor (TLR) expression and functional responses in vitro. ECT induced predominantly necrotic cell death in a voltage-dependent manner, with higher voltages markedly reducing viability. Despite this decline, surviving DCs exposed to 1000V/cm and 1300V/cm upregulated MHC II and CD80, indicating activation of the remaining population. ECT also altered TLR expression, significantly increasing TLR6 and TLR9 while reducing TLR4, TLR7 and TLR8 levels. Functionally, ECT impaired DC cytokine responses to TLR4 and TLR7/8 stimulation but preserved or enhanced responsiveness to the TLR9 agonist CpG, suggesting selective disruption of downstream TLR pathways. Together, these findings demonstrate that ECT differentially shapes DC survival and function depending on electric field intensity, with low-voltage ECT better preserving DC competence and higher voltages inducing activation but impairing responsiveness. These data highlight opportunities to optimise ECT protocols and rationally combine ECT with immune adjuvants to enhance therapeutic immunogenicity.

Bifurcation and quasiperiodic chaos in microtubule energy transport with mass impurities and electric fields

Broadband metamaterial absorber based on photon-assisted tunneling diode for solar power generation

Electroporation-based death of bacteria on assembled piezoelectric nanoenzyme-tips for implant disinfection.

Synergistic regulation of microbial metabolism and quality features in liver products using combined ultrasound-pulsed electric field assisted co-fermentation.

Improving the efficiency of tumor treating fields delivery in tumor cell proliferation inhibition through conductive electrodes.

Outdoor sunlight driven CO2 capture and cycloaddition from flowing simulated industrial flue gas using amino functionalized bismuth catalysts

Regeneration of the gradient structure at the tendon-bone interface: Biomimetic design strategies of biomaterials and translational challenges.

Droplet impact on substrate with an improved dynamic contact angle hysteresis model in the presence of electric field

Pulsed-field ablation (PFA) is an emerging technique for cardiac arrhythmia treatment, but the effects of varying microsecond pulsed electric fields (μsPEFs) parameters on cardiomyocyte metabolic activity and survival remain incompletely understood. To systematically investigate how voltage intensity, pulse packet number, and the number of applications influence metabolic activity and viability. AC16 human cardiomyocytes were exposed to μsPEFs with varying voltages, pulse packets, and application numbers. Metabolic activity was assessed by CCK-8 assays at multiple time points post-intervention. Cell death was analyzed by Annexin V-FITC/PI flow cytometry. Low-voltage μsPEFs (≤ 1400V) induced minimal metabolic suppression with partial recovery at 24h. Higher voltages (≥ 1600V) caused biphasic metabolic responses, peaking at 6h then sharply declining by 24h. Increasing pulse packets and applications led to progressive metabolic suppression, especially at higher voltages. Flow cytometry revealed voltage-dependent increases in apoptotic and necrotic cardiomyocytes, with significant viability loss at ≥ 1600V. Cardiomyocyte metabolic activity and survival exhibit clear dose-dependent sensitivity to μsPEFs parameters, with distinct voltage and energy thresholds for irreversible injury. Precise modulation of μsPEFs settings is crucial to optimize therapeutic efficacy and safety. These findings inform future preclinical and clinical μsPEFs ablation protocols.

BiFeO 3 -BaTiO 3 (BF-BT) ceramics are important lead-free ferroelectric materials, which are attracting attention due to their high Curie temperatures. In the present study, the effects of annealing at intermediate temperatures on the structure and ferroelectric hardening effects in Ti-doped BF-BT ceramics are investigated. It is shown that enhanced ferroelectric and piezoelectric properties are obtained by air-quenching. After subsequent annealing for 200 hours at temperatures in the range from 500 to 600 °C, the ferroelectric hysteresis loops became constricted due to a strong domain stabilisation effect. The ferroelectric internal bias field increased to an outstanding value of 5 kV mm -1 in a poled-annealed specimen. Analysis of the extrinsic (domain switching) and intrinsic (lattice strain) contributions to electro-strain by in-situ x-ray diffraction indicated that domain switching is dominant in the quenched BF-BT ceramic, but the domain orientation fraction under high electric field was reduced dramatically, from approximately 80% to 25%, after annealing.

Spatial and chemical confinement catalysis of Ni single atoms on graphdiyne: Dual confinement electric fields precisely regulate reaction-path barriers for large-scale photocatalytic hydrogen evolution

Microstructured electrode coupled with electrochemical deposition enrichment laser-induced breakdown spectroscopy for ppb-level sensitive detection of Pb2+ and Cr3+ in water.

Cysteine exerts surface polarization effect on BiOCOOH for photoelectrochemical detection of small molecules.

Prefrontal tDCS modulates behavioural and neural signatures associated with consciousness.

Tailoring water networks for anisotropic proton transport and hydroxyl-induced hopping in electrocatalytic hydrogen evolution.

Simultaneous leaching of Li, Rb, Cs from lepidolite via external electric field enhanced alkali leaching

Impact of prick alternating electric field durations on protein degradation in refrigerated Lateolabrax maculatus fillets: Focusing on myofibrillar proteins and endogenous proteases