Introduction: Lithium-sulfur (Li-S) batteries represent a pioneering technology with the potential to revolutionize energy storage due to their high theoretical energy density and cost-effectiveness. Nevertheless, their practical implementation encounters various challenges, hindering widespread commercialization. This abstract aims to explore the critical hurdles facing Li-S batteries and proposes strategies to advance their development into a sustainable and efficient energy storage solution. The primary obstacles for Li-S batteries encompass issues related to the polysulfide shuttle effect, sulfur's poor conductivity, limited cycle life, and significant volume changes during charge-discharge cycles. Moreover, achieving stable and efficient sulfur cathodes and electrolytes remains a crucial concern for ensuring prolonged battery performance. This review focuses on a range of strategies and innovations addressing these challenges, including advanced material design, conductive additives, novel electrolytes, and modified separator designs, all aimed at enhancing electrochemical performance. Advanced techniques such as computational modeling and machine learning play a pivotal role in accelerating the discovery and optimization of materials and architectures for Li-S batteries. These methodologies enable precise prediction, design, and evaluation of materials, expediting breakthroughs in overcoming limitations. The future of Li-S batteries relies on multidisciplinary research encompassing material science, electrochemistry, engineering, and computational methodologies.Keywords: Li – S batteries, Energy density, Cycle life, electrolyte design, cost-effectiveness