Efficient Sorbent Research Articles

Irradiated fig pomace pyrochar as a promising and sustainable sterilized sorbent for water pollutant removal

Irradiated fig pomace pyrochar (IrrPyrFP) is noteworthy as a novel sterilized low-cost sorbent of BTEX, pesticides, and Pb2+ ions. It was produced by applying pyrolysis treatment followed by gamma irradiation modification in order to obtain a highly efficient and sterile sorbent.The characterization of fig pomace before and after pyrolysis, as well as before and after irradiation of the obtained pyrochar, was done using SEM, FTIR, and elemental analysis, while its sorption ability was tested through the removal of examined pollutants by batch sorption experiments. The obtained results suggest that IrrPyrFP could play a significant role in the control of environmental pollutants, as indicated by the maximum adsorption capacities: 42 mg g−1 for BTEX, 0.625 mg g−1 for malathion, 0.495 mg g−1 for chlorpyrifos and 255 mg g−1 for Pb2+. A kinetic study showed that the removal process by IrrPyrFP mainly follows pseudo 2nd kinetics order, while the sorption equilibriums were estimated using the Langmuir and Freundlich model. Overall, the findings of this work suggest that pyrolysis and activation by irradiation of waste biomass is a promising way to produce sterile efficient sorbents for waste-water treatment based on green chemistry. Additionally, the demonstrated application of fig pomace promotes the potential of using this biomass for continual and economical waste management in the rising fig industry.

A new solid phase extraction sorbent developed based on cyanopropyl functionalized silica nanoparticles for organophosphorus pesticides determination

In this work, a simple sol-gel approach was used for the preparation of cyanopropyl (CNPr) functionalized silica nanoparticles (SiO2-CNPr) that tetraethoxysilane (TEOS) and cyanopropyltriethoxysilane (CNPrTEOS) used as precursors. This as-prepared SiO2-CNPr nanoparticle sorbent was first characterized using FESEM, EDX, FTIR, TGA, and BET techniques. Then, the SiO2-CNPr nanoparticle was applied as a new SPE sorbent for determining trace levels of OPPs in environmental water samples. To enhance the simultaneous extraction of non-polar or/and polar OPPs and to obtain the most efficient sorbent, several sol-gel synthesis parameters were studied. In addition, the effect of several effective parameters on SPE performance was investigated toward simultaneous extraction of non-polar or/and polar OPPs. Moreover, the figures of merit such as precision, linearity, LOQ, LOD, and recovery were evaluated for the sorbent. Finally, the designed SiO2-CNPr SPE was used to determine OPPs in real water samples, and its extraction performance was compared to commercial cartridges based on cyanopropyl.

Phosphonic Acid-Functionalized MIL-53(Al) As an Efficient Sorbent for Trace Rare Earth Elements Preconcentration, Storage and Their Determination by X-ray Fluorescence Spectrometry.

In this work, a simple and novel method coupling solid phase extraction (SPE) with X-ray fluorescence spectrometry (XRF) is proposed for the simultaneous determination of 15 kinds of trace rare earth elements (REEs) in water samples. A phosphonic acid functionalized metal-organic framework named BPG-MIL-53(Al) was prepared via postsynthetic modification and served as an efficient adsorbent for these REEs. The prepared BPG-MIL-53(Al) could almost completely adsorb REEs in 5 min under neutral conditions. After filtration, REEs-adsorbed BPG-MIL-53(Al) was deposited on a filter membrane to form a thin film, which was directly analyzed by XRF. The XRF intensities of the REEs-retained MOF disc remained almost unchanged after six months. Taking advantage of this strategy, XRF was able to quantitate ng mL-1 levels of REEs in water samples, achieving impressive limits of detection in the range of 0.4-4.7 ng mL-1. The proposed method was applied to the on-site collection and analysis of REEs in real water samples with desirable accuracy and spike recoveries obtained.

Peanut shell-derived activated biochar as a convenient, low-cost, ecofriendly and efficient sorbent in rotating disk sorptive extraction of emerging contaminants from environmental water samples

Peanut shell-derived activated biochar as a convenient, low-cost, ecofriendly and efficient sorbent in rotating disk sorptive extraction of emerging contaminants from environmental water samples

Copper sulfide nanosheet arrays constructed on copper skeleton for efficient elemental mercury immobilization from flue gas

The major challenge to use metal sulfide for elemental mercury (Hg0) immobilization from coal-fired flue gas is exploiting a facile and feasible pathway to achieve its fixed-bed application. In this work, copper sulfide (Cu7S4) nanosheet arrays anchored on copper skeleton as an efficient Hg0 trap with outstanding Hg0 sequestration performance was rapidly fabricated via a facile room-temperature chemical bath deposition method. After being impregnated in the polysulfide solution, the surface of copper foam was quickly oxidized and then converted into Cu7S4 nanosheet, which tightly adhered to the macro-porous copper foam. Benefitted from well arrayed Cu7S4 nanosheet, high-permeability structure, and uniform dispersion of active sites, the as-obtained Cu7S4/Copper foam favors for its application in Hg0 immobilization under a fixed-bed circumstance. These superiorities contribute to its outstanding Hg0 removal capacity of 38.32 mg g-1and adsorption rate of 6.06 μg g−1 min−1, far transcending that of commercial granular S impregnated activated carbon by magnitudes. This study not only developed an efficient Hg0 sorbent used in fix-bed scenarios but also illustrated a versatile strategy to rapidly functionalize metal skeletons with metal sulfides for vapor Hg0 immobilization from coal-fired flue gas.

Synthesis of imidazothiazole Schiff base functionalized silica as an adsorbent for efficient and selective removal of Cu(II) from wastewater: a combined experimental and theoretical investigation

Today's world faces a serious problem of heavy metal contamination in water, which can lead to serious health and environmental problems. In this work, an efficient and selective sorbent is synthesized, characterized, and reported to be used for adsorption of Cu(II) from aqueous solution. The obtained hybrid material was systematically characterized by Fourier-transform infrared spectroscopy, scanning electron microscope, and thermogravimetric analysis were confirmed that the imidazothiazole Schiff base was successfully functionalized the silica surface. Parameters influencing adsorption performance such as pH, time, initial concentration, and temperature were studied in the batch method. The results show that the excellent adsorption capacity of the adsorbent for Cu(II) ions was 110.33 mg/g at 30 min and pH = 6. Furthermore, the Cu(II) adsorption process exhibits a pseudo-second-order kinetic model and a Langmuir adsorption isotherm. Thermodynamic studies confirmed that the reaction was spontaneous and endothermic. Moreover, the adsorbent presents the better adsorption selectivity toward Cu(II). The coexisting cations did not show any competing effect on Cu(II) adsorption, and the adsorption performance did not decline appreciably after 5 cycles. The high adsorption efficiency of the sorbent provides potential applications for copper removal from wastewater. Theoretical methods using density functional theory, quantum theory of atoms in molecules (QTAIM), electron localization function (ELF), and localized orbital locator (LOL) confirm the experimentally discovered results. This study suggests that this adsorbent is an attractive material for the selective removal of Cu(II) from wastewater.

Aluminum soap nanoparticles-lignin powder form phase-selective gelator as an efficient sorbent for oils/water separation

Rapid and efficient recovery of oil spill is the key link for oil spill remediation, and also a great challenge. Here, the organogelator-polymerized porous matrix composed of adsorbents and organogelators can provide a new strategy for solving this problem. The gelling mechanism of aluminum 12-hydroxystearate (Al HSA) to form spherical nano micelles in solvents was investigated via UV–vis, FT-IR, and XRD. A creative method for aluminum soap-lignin gelator (OTS-AL/Al HSA) syntheses was put forward through the saponification of 12-hydroxystearic acid (HSA) and lignin via epichlorohydrin (ECH) crosslinking. By adjusting the ECH content, the growth of Al HSA nanoparticles (15–40 nm) on lignin can be realized, and the accordingly increased roughness endowed gelator with better hydrophobicity (WCA of 134.6°) before octadecyltrichlorosilane (OTS) modification. Thanks to the porous structures, the gelator powder exhibited a high sorption capacity in the range of 3.5–5.2 g g−1 for oils and organic solvents. Rheological studies demonstrated high mechanical strength of gels (>1.6 × 105 pa) and the gelator still retained 70% sorption capacity after 6 gelation-distillation cycles. The gelation characteristics of OTS-AL/Al HSA were attributed to the rapid sorption of oils by lignin and the self-assembly of Al HSA nano micelles on lignin to form an aggregated network structure trapping oils, thus realizing the synergistic effect of oil sorption-gelation.

Sulfidation performance of unsupported and SBA 15-supported Ca-based mixed metal oxides

Coal is the most widely used fossil fuel resource, and clean coal technologies allow an increase in the efficiency of clean energy production. Gasification-based combined cycle power generation systems, for example, aim to produce a mixture of CO and H2 (syngas) formed from coal and biomass. However, H2S is an undesired gasification product of fossil fuels with their high sulfur content. Hot gas desulfurization (HGD) reduces the sulfur contents of the gasification products by eliminating thermal losses of endothermic syngas formation processes. This study aims to develop efficient sorbents to remove H2S from hot flue gas. Unsupported and SBA 15-supported Ca-based binary mixed metal oxides (CuO, FeO, MnO, ZnO) were synthesized as sulfur sorbents by the wet impregnation method. The crystal structure of the sorbents was determined by X-ray diffraction (XRD), while BET analysis was used to determine the surface area and pore size distribution of the sorbents. The results of the XRD and BET analyses revealed mixed metal oxide formation and a high surface area of SBA 15-supported sorbents, respectively. Mixed metal oxide formation was also confirmed by Fourier transform infrared radiation (FTIR) spectroscopy. The desulfurization performance of the sorbents was examined by a simulated gas mixture at 800 °C. A gas chromatography analyzer equipped with a flame photometric detector was used to follow the H2S concentration. SBA 15-supported CaO–MnO exhibited the best desulfurization performance at 800 °C with a breakthrough sulfur capacity (BSC) of 43.38 g S/100 g sorbent in the longest breakthrough time of 1077 min.

The Al2O3 and Mn/Al2O3 sorbents highly utilized in destructive sorption of NF3

NF3 is commonly used as an etching and cleaning gas in semiconductor industry, however it is a strongly greenhouse gas. Therefore, the destruction of disposal NF3 is an urgent task to migrate the greenhouse effect. Among the technologies for NF3 abatement, the destructive sorption of NF3 over metal oxides sorbents is an effective way. Thus, the search for a highly reactive and utilized sorbent for NF3 destruction is in great demand. In this work, AlOOH supported on carbon-sphere (AlOOH/CS) as precursors were synthesized hydrothermally and heat-treated to prepare the Al2O3 sorbents. The influence of AlOOH/CS hydrothermal temperatures on the reactivity of derived Al2O3 sorbents for NF3 destruction was investigated, and it is shown that the Al2O3 from AlOOH/CS hydro-thermalized at 120 °C is superior to others. Subsequently, the optimized Al2O3 was covered by Mn(OH)x to prepare Mn/Al2O3 sorbents via changing hydrothermal temperatures and Mn loadings. The results show that the Mn/Al2O3 sorbents are more utilized than bare Al2O3 in NF3 destructive sorption due to the promotional effect of Mn2O3 as surface layer on the fluorination of Al2O3 as substrate, especially the optimal 5%Mn/Al2O3(160 °C) exhibits a utilization percentage as high as 90.4%, and remarkably exceeds all the sorbents reported so far. These findings are beneficial to develop more efficient sorbents for the destruction of NF3.

Synergistic mechanisms for the superior sorptive removal of aquatic pollutants via functionalized biochar-clay composite

This study investigated the successful synthesis of functionalized algal biochar-clay composite (FBKC). Subsequently, the sorption performance of FBKC towards norfloxacin (NFX) antibiotic and crystal violet dye (CVD) from water was extensively assessed in both batch and continuous flow systems. A series of characterization techniques were carried out for FBKC and the utilized precursors, indicating that the surface area of FBKC was increased thirty-fold with a well-developed pore structure compared to the original precursors. FBKC demonstrated a maximum sorption capacity of 192.80 and 281.24 mg/g for NFX and CVD, respectively. The suited fitting of the experimental data to Freundlich and Clark models suggested multi-layer sorption of NFX/CVD molecules. The mechanistic studies of NFX/CVD sorption onto FBKC unveiled multiple mechanisms, including π-π interaction, hydrogen bonding, electrostatic attraction, and surface/pore filling effect. The estimated cost of 5.72 €/kg and superior sorption capacity makes FBKC an efficient low-cost sorbent for emergent water pollutants.

Nano graphite platelets/Cu (BDC) MOF coating on polyurethane sponge: A superhydrophobic self-extinguishing adsorbent for static and continuous oil/water separation

The discharge of toxic organic solvents and industrial oil into water is one of the major problems that threaten marine ecology and human health. In this work, a flexible superhydrophobic/superoleophilic polyurethane (PU) sponge was modified by decorating Cu-benzene dicarboxylic acid metal-organic framework (Cu (BDC) MOF) as a flame retardant and nano graphite platelets (NGPs) as a superhydrophobic agent. These materials were attached to the sponge skeleton by poly (styrene-co-butyl acrylate). The PU-Cu (BDC)-NGPs sponge showed high thermal, mechanical, and chemical stability. Moreover, this composite possessed excellent oil/water separation efficiency. The prepared composite showed excellent superhydrophobicity with a water contact angle of 154° and possessed self-extinguishing properties with a limiting oxygen index (LOI) of 24.46%. The oil adsorption capacity at a static state and oil separation efficiency at a continuous oil/water separation process for PU-Cu (BDC)-NGPs sponge were 43.5–132 g/g and 96%, respectively. Moreover, PU-Cu (BDC)-NGPs sponge had excellent stability in harsh conditions and exhibited good compressibility and reusability. Overall, the Cu (BDC) MOF-NGPs coated PU sponge can be a highly efficient sorbent with durability and flame retardancy.

Application of bio-metal-organic framework-based magnetic dispersive solid phase extraction for the extraction of polycyclic aromatic hydrocarbons from pasteurized milk

This work describes the development of a magnetic dispersive solid phase extraction method based on using bio–metal–organic framework (prepared from vitamin B3 and cobalt salt in water medium) as an efficient sorbent for the extraction of polycyclic aromatic hydrocarbons from milk samples. Briefly, the synthesized sorbent at mg–level is added to the supernatant phase after precipitating the proteins of milk sample and the mixture is vortexed. In the presence of magnetic field, the supernatant is removed and the sorbent particles containing the adsorbed analytes are eluted by using an appropriate organic solvent. The eluted analytes are more enriched using a magnetic ionic liquid–based dispersive liquid–liquid microextraction. After back–extraction of the analytes into n–hexane, the analytes are determined using gas chromatography–mass spectrometry. The experimental variables influencing the suggested method efficiency such as zinc sulfate solution concentration and volume, and vortexing time in proteins precipitating step, sorbent amount, adsorption time, ionic strength, elution solvent type and volume, desorption time, extraction solvent type and volume, and back–extraction solvent type, volume and time in extraction procedure were optimized by one parameter at a time strategy. Under the optimum conditions, low limits of detection (38–78 ng L−1) and quantification (130–260 ng L−1), high extraction recoveries (58–82%) and enrichment factors (145–205), and good precision (relative standard deviations ≤6.1%) were obtained. Finally, the developed method was effectively employed for quantification of polycyclic aromatic hydrocarbons in pasteurized milk samples.

Electrospun PVC/EVA/CS/Str nanofibers: an efficient sorbent for extraction of trace level of Atrazine and Ametryn in food samples

Electrospun PVC/EVA/CS/Str nanofibers: an efficient sorbent for extraction of trace level of Atrazine and Ametryn in food samples

NEW SORBENTS BASED ON INDUSTRIAL WASTE FOR WASTEWATER TREATMENT FROM PETROLEUM PRODUCTS

One of the most common types of ecotoxicants are petroleum products - an unidentified group of petroleum hydrocarbons and products of its processing. In this regard, the development of technology for obtaining new highly efficient and inexpensive sorbents for wastewater treatment from petroleum products (including those based on industrial waste) is an urgent problem. In this paper, a method of wastewater treatment from petroleum products using composite sorbents based on waste-tailings of Uchalinsky (SU), Buribaevsky (SB), Sibaysky (SS) mining and processing (GOK), and clay of the Talalaevsky deposit (G) and sodium humates (GN) obtained from the waste of the Tyulgan brown coal. The efficiency plants of purification was investigated using these sorbents of model wastewater contaminated with oil from the Vozeyskoye field of Usinsk Neftegaz LLC and real wastewater from the Ufa refinery of ANC Bashneft. It is shown that the efficiency of purification and the rate of adsorption of model wastewater containing petroleum products (8-50 mg/dm3) increases in a number of sorbents BAU - A < CC + G < SB ++ G < SU + G SU + G + GN (where BAU - A sorbent of comparison, activated carbon) and are maximal for GOK covered with GN. For real wastewater containing petroleum products of the Ufa refinery (3-625 mg/dm3), the adsorption activity increases in the series CC + G < SB ++ G < SU + G. Thus, the most effective sorbents for real and model wastewater containing oil and petroleum products are sorbents based on Uchalinsky GOK waste in a composition with clay (degree of purification 96.1 %), as well as SU modified GN (98.2 %).

MXene nanosheets woven in polyacrylonitrile nanofiber yarns aligned spider web as a highly efficient sorbent for in-tube solid phase microextraction of beta-blockers from biofluids

The use of electrospinning has received much attention in the production of nanofiber webs due to its advantages such as flexibility and simplicity. The direct electrospinning of nanofibers in an aligned or twisted form and the production of nanofiber yarns can turn nanofibers into woven fabrics, which leads to an increase in the diversity of nanofiber applications and improves their end-use possibilities. In this work, a victorious nanofiber yarn spinning system was used with the help of a rotating funnel. Yarn formation was studied using a composited polyacrylonitrile (PAN)/MXene polymer solution ejected from two oppositely charged nozzles. Finaly their application for packed-in-tube solid-phase microextraction of β-blocker drugs from biofluids was demonstrated. The separation and quantification of analytes were performed by HPLC-UV instrument. The 3D-yarn PAN/MXene sorbent exhibited high flexibility, porosity, sorbent loading, mechanical stability, and a long lifetime. The characterization of the final nanofiber was carried out utilizing Fourier-transform infrared spectroscopy, field emission scanning electron microscope, energy-dispersive X-ray mapping, transmission electron microscope and X-ray diffraction analysis. Various parameters that affect the extraction efficiency, such as extraction time, pH, ionic strength and flow rate of sample solution, and type, volume and flow rate of eluent, were investigated and optimized. Under optimized conditions, the limits of detection were obtained in the range of 1.5–3.0 μg L−1. This method demonstrated appropriate linearity for β-blockers in the range of 5.0–1000.0 μg L−1, with coefficients of determination greater than 0.990. The inter- and intra-assay precisions (RSDs, for n = 3) are in the range of 2.5–3.5%, and 4.5–5.2%, respectively. Finally, the validated method was put in an application for the analysis of atenolol, propranolol and betaxolol in human urine and saliva samples at different hours and acceptable relative recoveries were obtained in the range of 89.5% to 110.4%.

A magnetic sorbent based on Zn-NiFe2O4@Ni-Al layered double hydroxide nanocomposite for the pre-concentration and quantification of mefenamic acid by differential pulse voltammetry

A novel magnetic sorbent was introduced involving a zinc–nickel ferrite@nickel–aluminum layered double hydroxide (Zn-NiFe2O4@Ni-Al LDH) nanocomposite. The Zn-NiFe2O4@Ni–Al LDH was synthesized through a co-precipitation method, and characterized using several techniques. The nanocomposite was shown to be an efficient sorbent for the pre-concentration of mefenamic acid prior to its detection by differential pulse voltammetry using a glassy carbon electrode modified with carbon nanotubes. To achieve the best extraction efficiency, the effects of various parameters such as pH, the sorbent dosage, extraction time, elution conditions, and sample volume were studied and optimized. Under the optimized experimental conditions, the calibration plot was linear in two concentration ranges from 50 to 100 nM (R2 = 0.9944) and 100–700 nM (R2 = 0.9913). The limit of detection was calculated to be 6.3 nM, and the precision of the method in the terms of intra-day and inter-day relative standard deviations (n = 5; mefenamic acid concentration = 100 nM) were 1.4% and 2.4%, respectively. The accuracy of the method was assessed by analyzing a pharmaceutical dosage form of the analyte, and comparing the results with those obtained from a standard method. To evaluate the applicability of the method, it was applied for trace determination of mefenamic acid in tablet, human plasma, urine, and pharmaceutical wastewater samples, and the satisfactory relative recovery values (96.0–103.1%) were attained for the spiked samples. The easy separation from the solution by applying an external magnet, high surface area, high stability in the strong alkaline solutions, and high reusability (more than 60 adsorption/desorption cycles) are some advantages of the synthesized nanosorbent.

Green hydrophobic maltodextrin nanosponges for magnetic solid-phase extraction of hypothalamic peptides from plasma samples

In this work, for the first time, magnetic-phthalated maltodextrin nanosponges (M-PAMDNSs) were synthetized and introduced as efficient and green sorbents. The integration of phthaloyl groups as hydrophobic moieties into networks of maltodextrin nanosponges provided good enrichment for hypothalamic-related peptides (HRPs). The synthesized materials were characterized by 1H nuclear magnetic resonance spectroscopy, water contact angle, attenuated total reflection-Fourier transform infrared spectroscopy, dynamic light scattering, zeta potential, pH point of zero charge, acid-base titration, field-emission scanning electron microscopy, Brunauer-Emmett-Teller, and vibrating sample magnetometer. Under the optimized conditions (sorbent amount: 5.0 mg, desorption solvent volume and type: 300 µL of methanol: H2O: trifluoroacetic acid, extraction time: 15 min, and desorption time: 10 min), the developed magnetic solid-phase extraction (MSPE) method in combination with HPLC-UV was used as a novel and sensitive analytical method for the determination of HRPs in plasma samples. The proposed MSPE-HPLC-UV method provided good linearity (1.5–500 ng mL−1 R2 ≥ 0.9988), low limits of detection (0.1–0.2 ng mL−1) and quantification (0.4–0.8 ng mL−1), desirable precision (RSD ≤ 8.8%, n ₌ 5), satisfactory enrichment factor (EFs ≥ 66.0), and well relative recoveries (92.8–108.8%). Overall, the established method effectively expanded the analytical potential of MSPE approach for the quantification of HRPs in biological samples.

Complex Agent for Phosphate Sequestration from Digested Sludge Liquor: Performances and Economic Cost Analysis

Phosphorus (P) management in the “water-energy-resource-nexus” in wastewater treatment plants (WWTPs) remains a longstanding challenge. P adsorption from the P-enriched digested sludge liquor (DSL) is a comparatively more practical and economically viable approach for P recovery in WWTPs. However, high concentrations of impurities in DSL might pose a negative and interferential effect on P adsorption, hindering the application of sorbents or precipitation methods. Given such a situation, highly efficient and cost-effective sorbent towards P reclamation from DSL is highly needed. Therefore, this study aims to develop a novel complex agent containing aluminum coagulant and superparamagnetic nano-sorbent (SNS) that can be used in magnetic seeding coagulation for P recovery. The complex agents with different PACl: SNS ratios showed varied turbidity removal rates and P recovery efficiencies and the optimal ratio was 15 mg PACl: 15 g SNS. PAC and SNS showed significant interaction because PAC could enhance P adsorption by shielding the interferential effect of colloidal impurities. In addition, the complex is highly regenerative, with turbidity and P removal rate stably maintained at 70–80% after 10 adsorption/regeneration cycles. The cost–benefit analysis of the dosing complex agent showed a dosing cost of 0.154 EUR/m3, admittedly much higher than the conventional magnetic seeding coagulation, which could probably be covered by the profit if the expensive and rare P product is reclaimed. This work indicated that the complex agent was superior due to its high adsorption capacity, easy separation, and repeated dosing, and therefore had the potential for P recovery from DSL.

MXene: An efficient hemoperfusion sorbent for the removal of uremic toxins

MXene, a family of two-dimensional (2D) transition metal carbides and nitrides have attracted extensive interests for many biochemical applications, including tumour elimination, biosensors, and magnetic resonance imaging (MRI). In this article, we firstly discovered that Ti3C2Tx MXene exhibited a highly efficient adsorption capability as hemoperfusion absorbent towards middle-molecular mass and protein bound uremic toxins in the end stage of renal disease (ESRD) treatment. Molecular scale investigations reveal that the high efficiency of MXene for the removal of uremic toxins could be attributed to synergistic effects of physical/chemical adsorption, electrostatic interaction surface of 2D MXene, and transformation of protein secondary structure. 2D MXene materials could be used as a new hemoperfusion sorbent with ultrahigh efficiency for removing uremic toxins during the treatment of kidney disease.

Selective extraction of apixaban from plasma by dispersive solid-phase microextraction using magnetic metal organic framework combined with molecularly imprinted polymer nanocomposite.

This research aims to synthesize a specific and efficient sorbent to use in the extraction of apixaban from human plasma samples and its determination by high-performance liquid chromatography-tandem mass spectrometry. High specific surface area of metal-organic framework, magnetic property of iron oxide nanoparticles, selectively of molecular imprinted polymer toward the analyte, and the combination of dispersive solid-phase extraction method with a sensitive analysis system provided an efficient analytical method. In this study, first, a molecularly imprinted polymer combined with magnetic metal organic framework nanocomposite was prepared and then characterized using different techniques. Then the sorbent particles were used for selective extraction of the analyte from plasma samples. The efficiency of the method was improved by optimizing effective parameters. According to the validation results, wide linear range (1.02-200ng mL-1 ), acceptable coefficient of determination (0.9938), low limit of detection (0.32ng mL-1 ) and limit of quantification (1.02ng mL-1 ), high extraction recovery (78%), and good precision (relative standard deviations ≤ 2.9% for intra- (n=6) and interday (n=6) precisions) were obtainable using the proposed method. These outcomes showed the high potential of the proposed method for screening apixaban in the human plasma samples.