Effect Of Zingiber Officinale Research Articles

Integrative Bioinformatics Analysis Reveals Potential Target Genes and PTEN Signaling in Breast Cancer and Effect of Zingiber officinale (Ginger) and Allium sativum (Garlic) extract on It.

Breast cancer is the most common type of cancer in women. The construction of a competing gene network is an important step in the identification of the role of hub genes in breast cancers. In the current research, we used a number of bioinformatics tools to construct this network in breast cancer and investigated the combined effect of garlic and ginger on mice model of breast cancer. We chose female mice weighing 18-20 g that were divided into 7 groups including; the cancer group receiving normal saline, different doses of ginger extract (100 and 500 mg/kg), different doses of garlic (50 and 100 mg/kg), tamoxifen (10 mg/ kg) and simultaneous garlic (100 mg/kg) and ginger (500 mg/kg) for 3 weeks intraperitoneal. Then we anesthetized the mice, isolated the tumor, and determined its size. Glutathione reductase and peroxidase levels and HER2, PTEN, and Cullin3 genes expression were measured. We identified 20 hub genes for breast cancer. In animal phase we found that tumor size in all mice receiving garlic and ginger showed a significant decrease compared to the control. Glutathione reductase showed a significant increase in all groups, especially in ginger 500 and combined groups. Glutathione peroxidase increased almost in all groups, especially in ginger 500. Expression of HER2 decreased in all treated groups. Expression of PTEN increased just in the combined group. Taken together, we introduce a number of novel promising diagnostic biomarkers for breast cancer. The use of garlic and ginger in the treatment of cancer can be useful. This action is probably through the antioxidant mechanism, and regulation of the expression of cancer related genes such as PTEN.

The Effects of Zingiber Officinale and Propolis supplementation on Hospitalized Covid-19 Patients' Oxygen Saturation

Antiviral, anti-inflammatory, and supportive therapy are required in the Covid-19 management, whilst there is no available specific antiviral for Covid-19 patients. Zingiber officinale and Propolis were reported to suppress the pro-inflammatory cytokines and their safety profiles were considered in several toxicity studies. However, their efficacy in hospitalized Covid-19 patients has not been clarified yet. This study explored the activity of Z. officinale and Propolis in modulating the clinical signs and hematology parameters in hospitalized Covid-19 patients. A total of 22 subjects were divided into a control group (standard therapy), and a treatment group (standard therapy and supplemented with the combination of Z. officinale 500 mg/day and Propolis 1000 mg/day). We analyzed the differences in demographic characteristics, clinical signs, and hematology parameters at pre and post-treatment in both groups. The increased oxygen saturation in control and treatment groups were 0.45 ± 0.45 and 3.45 ± 1.16, respectively (p = 0.011). Moreover, the high-fluorescent lymphocyte count (HFLC) and mean platelet volume (MPV) in the treatment group tend to be lower compared to the control, although it is not statistically significant. The supplementation of Z. officinale and Propolis has beneficial effects in alleviating clinical signs of Covid-19 disease, especially in the enhancement of oxygen saturation, and tend to restore the hematological parameters.

Nootropic Activity of Ethanolic Extract of Zingiber officinale and Centella asiatica on Stress Induced Rats

Nootropics, natural or synthetic substances that boost brain function and cognitive abilities, were investigated in this study. Specifically, the effects of Zingiber officinale and Centella asiatica extracts were compared to the standard nootropic piracetam. Both plant extracts demonstrated nootropic activity and contained phytochemicals like flavonoids, tannins, and saponins that protect the brain from oxidative damage. Sterols such as stigmasterol inhibiting acetyl CoA esterase activity were also present. Tests were conducted on rats given the extracts or piracetam daily for 7 to 21 days. High and low doses were used. Nootropic effects were measured using elevated plus maze and Morris water maze tests compared to controls. The results were promising: At higher doses, the extracts significantly reduced latency time to 21 ± 0.33 seconds compared to 33.33 ± 0.12 seconds for piracetam and 54 ± 0.08 seconds for controls. This suggests the plant extracts have considerable nootropic potential when administered at higher doses.

The effect of zingiber officinale on prooxidant-antioxidant balance and glycemic control in diabetic patients with ESRD undergoing hemodialysis: a double-blind randomized control trial

BackgroundDiabetes management in hemodialysis patients with end-stage renal disease needs precision to avoid complications. The study aimed to investigate the effect of ginger supplementation on prooxidant-antioxidant balance, glycemic management, and renal function in diabetic hemodialysis patients.Trial design and methodsForty-four patients were randomly allocated to either the ginger or the placebo group in this randomized, double blind, placebo-controlled study. Patients in the ginger group received 2000 mg/d ginger for eight weeks, whereas those in the placebo group received equivalent placebos. After a 12- to 14-h fast, serum levels of fasting blood glucose (FBG), insulin, urea, creatinine, and prooxidant-antioxidant balance (PAB) were measured at baseline and at the end of the study. The homeostatic model evaluation of insulin resistance was used to determine insulin resistance (HOMA-IR).ResultsSerum levels of FBG (p = 0.001), HOMA-IR (p = 0.001), and urea (p = 0.017) were considerably lower in the ginger group compared to baseline, and the difference was significant when compared to the placebo group (p < 0.05). Moreover, ginger supplementation decreased serum levels of creatinine (p = 0.034) and PAB (p = 0.013) within the group, but the effect was insignificant between groups (p > 0.05). On the other hand, insulin levels did not vary significantly across and among the groups (p > 0.05).ConclusionIn summary, this study indicated that in diabetic hemodialysis patients, ginger could result to lower blood glucose levels, enhanced insulin sensitivity, and lower serum urea levels. Further studies with a more extended intervention period and various doses and forms of ginger are needed.Trial registrationIRCT20191109045382N2. (06/07/2020), Retrospectively registered, https://www.irct.ir/trial/48467

Effect of Zingiber officinale on Lipid Profile and Some Inflammatory Markers in Diabetic Hemodialysis Patients: A Randomized Double-Blind Placebo-Controlled Clinical Trial.

Diabetes, inflammation, and abnormal lipid levels are the main risk factors for mortality in end-stage renal disease (ESRD). The present study aimed to investigate the effects of ginger supplementation on inflammatory markers and lipid profile in diabetic patients with ESRD undergoing hemodialysis. In this study, 44 patients were randomly assigned to either the ginger or the placebo group. The patients in the ginger group received 2000 mg/d ginger for eight weeks, while the control group received the placebo with the same protocol. The serum concentrations of triglyceride (TG), total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-c), high-density lipoprotein-cholesterol (HDL-c), albumin, and high-sensitivity C-reactive protein (hs-CRP) were measured after a 12- to 14-hours fast at the baseline and the end of the study, as along with the platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), and Glasgow prognostic score (GPS). Forty-one subjects were analyzed based on the intention-to-treat method of all included patients. Serum levels of TG (p=0.003), hs-CRP (p=0.022), and NLR (p=0.001) decreased significantly in the ginger group compared to the placebo group, while albumin concentration in serum was elevated (p=0.022). However, there were no significant differences in GPS, levels of TC, LDL-C, HDL-C, and PLR within and between the groups (p > 0.05). Ginger administration reduced NLR, hs-CRP, and TG serum levels and increased serum albumin levels in included patients. Thus, ginger can be considered an effective complementary treatment for these patients. This trail is registered with IRCT20191109045382N3.

Effects of Zingiber officinale as a feed additive on productive parameters, carcass quality, and meat quality in growing rabbits

The objective of this study was to evaluate the effects of ginger as an additive in the diet of fattening rabbits. Sixty weaned rabbits (35 days old) were randomly assigned to four groups (n = 15). Animals were fed ad libitum with a control diet or one of three experimental diets supplemented with 0.5, 1, and 2 g of ginger per 100 g of feed during 28 d. Weight gain in the final week of the experiment was significantly [...]

Preventive Effect of Combined Zingiber officinale and Terminalia chebula against DMBA-Induced Breast Cancer Rats via mTOR Inhibition

Zingiber officinale (ZO) and Terminalia chebula (TC) are plants used for the treatment of diverse illnesses in traditional medicine. The present study investigates the preventive effect of Zingiber officinale–Terminalia chebula extract (ZOTC) against DMBA-induced breast cancer in a rat model. Bioactive compounds from ZO (6-gingerol, 6-shogaol) and TC (gallic acid, ellagic acid, corilagin, chebulinic acid, and chebulagic acid) were detected using high-performance liquid chromatography. Mammary carcinogenesis was induced in rats with a single subcutaneous injection of 7,12-Dimethylbenz[a]anthracene (DMBA). Oral administration of ZOTC ameliorated the antioxidant status in mammary tissues, serum lipid levels, and serum cytokines. Histological analysis of the mammary tissue (normal and tumor) was carried out to obtain pathological alterations due to ZOTC treatment. The effect of ZOTC on the mechanistic target of rapamycin (mTOR) gene and accumulation of corresponding gene product was also investigated. mTOR plays a central role in cell metabolism and proliferation in normal and cancer cells. Transcriptional and immunohistochemical analysis showed the downregulation of mTOR expression in the mammary tissues of ZOTC-treated rats. In conclusion, the results obtained suggest that ZOTC can suppress tumor progression in DMBA-induced breast cancer rats via inhibition of the mTOR pathway.

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Effect of Zingiber officinale (Ginger) Extract on Acetaminophen- Induced Hepatotoxicity in Mice

Effect of Zingiber officinale (Ginger) Extract on Acetaminophen- Induced Hepatotoxicity in Mice

The Effect of Zingiber officinale on the Spleen Tissue and Antibody Titer of Broiler Chickens

Introduction Increasing the immune system's function of fighting infectious diseases is very important in the poultry industry. Ginger, scientifically known as Zingiber officinale, belongs to the Zingiberaceae family. The use of ginger in the diet of poultry increases serum levels of superoxide dismutase enzymes and glutathione peroxidase, which are considered to be important antioxidant enzymes. The main objective of the present study is to evaluate the effect of ginger on the spleen tissue of broiler chickens. Material and Methods The specimens comprised 2 groups of 20 Ross breed broiler chicks, for 42 days and were then, examined and tested. The diet was supplemented with 1 g/kg of ginger powder from the beginning of the rearing period. Blood samples of the chicks were randomly collected to measure the levels of hemagglutination (HI). The removed spleens were fixed with 10% formalin buffer. The specimens were cut in 5-micron diameters and stained with hematoxylin and eosin. Results and Conclusion There was a statistically significant difference in the mean of HI blood titers between the chicks in the growth period and final period groups (p &lt; 0.05). The white-pulp tissue samples were more clearly seen in the treatment group than in the control group, and also, it was observed that the wall of the central artery of the white pulp was thicker in the ginger-treated group as compared with the control group. The nutritional value of ginger may vary. Thus, it is necessary to investigate the effect of this plant final on weight gain; the serum factors associated with the metabolic chart, and the response of the immune system to this plant.

Effect of Zingiber officinale on some biochemical parameters and cytogenic analysis in lead-induced toxicity in experimental rats

Exposure to toxic elements is greatly unavoidable in our daily activities due to several routes of coming in contact with these elements. Thus lead (Pb), is one of the major causes of health hazard in human. In this study, evaluation of Zingiber officinale as mitigating measure against Pb induced biochemical and cytogenic toxicity in albino rats was investigated. Experimental rats were grouped into five with five animals per group, group I serves as control and groups 2–5 were induced intraperitoneal with lead acetate dissolved in distilled water at 3 mg/kg body weight whereas group 3–5 were orally administered with 200 mg/kg vitamin C, 200 mg/kg, and 100 mg/kg of Z. officinale, respectively for 7 d. The obtained results show that aspartate aminotransferase (AST), alkaline phosphatase (ALP), lipid peroxidation, urea, creatinine, bilirubin, and gamma-glutamyl transferase (GGT) were significantly increased (p < 0.05) and catalase (CAT) were reduced progressively in Pb alone induced rats. Hematological parameters showed a progressive reduction (p < 0.05) in lead acetate alone rats. There were significant changes in micronuclei (MN), chromosomal aberrations (CA) frequency, and oxidative damages in the bone marrow cells from lead acetate alone induced rats, although, mitotic index scores in these cells were reduced gradually (p < 0.05). The altered parameters were significantly reversed toward the levels observed in normal control rats administered with vitamin C and aqueous extract of Z. officinale. Hence, these results suggest that Z. officinale roots might contain therapeutic potential that can ameliorate the hazard effect of lead acetate poison.

EFFECT OF ZINGIBER OFFICINALE ON MORTALITY PERCENTAGE AND COCOON SHELL RATIO OF THE SILKWORM, BOMBYX MORI L.

The effect of Zingiber officinale was studied on mortalitypercentages and cocoon shell ratio of silkworm, Bombyx mori duringspring season of 2015 at Plant Protec. Dept. Fac. of Agric., El FayoumUniv. The powder of Z. officinale was dissolved in distilled water toprepare different concentrations (10, 20, 30, 40 and 50 mg/ml.). In thepresent study, results showed that, the concentration 20 mg/ml. of Z.officinale occupied the first category to reduce 1st , 2nd and 3rd instarsmortality percentages. While 40 mg/ml. of Z. officinale occupied thefirst category for reducing 4th & 5th instars mortality percentages andimproving cocoon shell ratio.

The effect and safety of highly standardized Ginger (Zingiber officinale) and Echinacea (Echinacea angustifolia) extract supplementation on inflammation and chronic pain in NSAIDs poor responders. A pilot study in subjects with knee arthrosis

The study aimed to evaluate the effect of Zingiber officinale and Echinacea angustifolia extract supplementation (25 mg of ginger and 5 mg of Echinacea) for 30 days on inflammation and chronic pain in knee osteoarthritis (OA). Consecutive nonsteroidal anti-inflammatory-drugs (NSAIDs) poor responders with chronic inflammation and pain due to knee arthrosis were assessed (15 subjects, age: 67.2 ± 7.9, body mass index: 30.6 ± 7.1, men/women:2/13). The primary endpoint was to determine pain improvement from baseline to Day 30 by Tegner Lysholm Knee Scoring. The secondary endpoints were the assessment of Visual Analog Scale for Pain, health-related quality of life, by the ShortForm36 (SF-36), anthropometric parameters, hydration. After supplementation, a significant improvement of 12.27 points was observed for Lysholm scale score (p < 0.05), SF-36 (p < 0.05), and a decrease in −0.52 cm in knee circumference (left) (p < 0.01). This pilot study provides feasibility and safety data for the use of highly standardised ginger and Echinacea extract supplementation in people with knee OA.

Effect of Zingiber Officinale (Ginger Rhizomes) Hydroethanolic Extract on Hyoscine-Induced Memory Impairment in Adult Male Rats

Background: The spice Zingiber officinale or ginger possesses antioxidant activity andneuroprotective effects. In this study we hypothesized that treatment with hydroethanolicextract of ginger (50, 100 and 200 mg/kg, p.o) would effect on the hyoscine-induced memoryimpairment in rats.Methods: In this experimental study 64 male Wistar rats were divided into eight groups (8 ratsin each group): normal saline, hyoscine (1 mg/kg), ginger extract (50, 100 and 200 mg/kg),or hyoscine (1 mg/kg) plus ginger extract (50, 100 and 200 mg/kg). Memory impairment wasinduced by a single injection of hyoscine (1 mg/kg, i.p). Cognitive functions were evaluatedusing passive avoidance learning (PAL) task. Retention test was carried out 24 h after training,and the latency of entering the dark compartment [step-through latency (STL)] and the totaltime in the dark compartment (TDC) were recorded. All statistical analysis was carried out at5% level of significance using SPSS version 21. The data were analyzed by ANOVA followedby Tukey’s test.Results: The time latency in hyoscine-treated group was lower than control (133.87±14.60vs. 242.12±10.58; p<0.001, respectively). Treatment of the animals by 100 and 200 mg/kg ofginger extract before the training trial increased the time latency at 24 h after the training trial(277±4.67 and 280.37±7.68; p<0.01, respectively). Administration of both 100 and 200 mg/kgdoses of the extract in hyoscine received animal groups before retention trials also increasedthe time latency than the hyoscine-treated groups (247.37±7.62 and 271.87±9.11; p<0.001,respectively).Conclusion: The results revealed that the ginger hydroethanolic extract attenuated hyoscineinducedmemory impairment.

Immunomodulatory and Antioxidant Protective Effect of Zingiber officinale, in Lead Intoxicated Rat

Immunomodulatory and Antioxidant Protective Effect of Zingiber officinale, in Lead Intoxicated Rat Zingiber officinale (ZO) is commonly used as one of natural food additives. This study was designed to evaluate immunomodulatory and antioxidant effect of Zingiber officinale extract (ZO) against lead toxicity in rats.

Zingiber officinale(Ginger): A Future Outlook on Its Potential in Prevention and Treatment of Diabetes and Prediabetic States

Diabetes is reaching pandemic levels in both developing and developed countries and requires safe, affordable, and effective therapies. This report summarises work in our laboratory on the effects ofZingiber officinale(ginger) and its components in diabetes models and provides a future outlook on the potential for their use in type 2 diabetes. A high fat diet rat model showed modulation of body weight gain and normalisation of glucose and lipid metabolic disturbances, with reduction of insulin resistance in a high fat-high carbohydrate diet model. Ginger extract inhibits enhanced NF-κB in liver of high fat-fed rats through inhibition of the IKK/IκBα/NF-κB classical pathway. The major active component(S)-[6]-gingerol inhibited elevated cytokines in inflamed HuH7 cells through suppression of COX2 expression and protection against the ROS pathway. Ginger extract and gingerols enhanced glucose uptake in L6 myotubes, by enhancing translocation of GLUT4 to the surface membrane and activation of AMPKα1 through a Ca2+/calmodulin-dependent protein kinase kinase pathway.(S)-[6]-Gingerol also enhanced energy metabolism through marked increment of peroxisome proliferator-activated receptor-γcoactivator-1α(PGC-1α) gene expression and mitochondrial content in L6 skeletal muscle cells. Future studies will require well designed clinical trials on ginger preparations of defined chemical composition.

The effect of Zingiber officinale R. rhizomes (ginger) on plasma pro-inflammatory cytokine levels in well-trained male endurance runners.

The aim of this study was to investigate the effect of ginger on the concentrations of plasma interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in welltrained male endurance runners. To this end, twenty-eight high-level endurance runners were randomly assigned to two groups (control and experimental). They performed the same weekly training volume for 12 weeks. The Bruce treadmill test was used three days before the start of the 12-week training period and after weeks 6 and 12 to evaluate the physiological effects of training and ginger administration. After completing the first 6-week period of exercise training protocol, two groups received 500 mg capsules of ginger powder and placebo, respectively, three times a day for the second 6-week period. Blood samples were collected before (resting blood sample) and after the Bruce treadmill test. IL-1β, IL-6 and TNF-α were assayed using standard commercial ELISA kits. Two-way repeated measures analysis of variance (ANOVA) was used to determine significant differences between control and experimental plasma IL-6, IL-1β and TNF-α concentration means of pre- and post-test periods. The IL-1β, IL-6 and TNF-α concentrations at the end of week 12/weeks 6 and 12 between two training groups were significantly different (p = 0.01, p = 0.01, and p = 0.01). In the experimental group alone, there were also significant differences in the mean IL-1β, IL-6 and TNF-α concentrations at the end of weeks 6 and 12 (p = 0.01, p = 0.01, and p = 0.01). Our findings indicated that post-exercise plasma elevations of several pro-inflammatory cytokines can be attenuated by a six-week ginger administration period.

The Effect of Zingiber Officinale (Ginger) Extract on Blood Pressure and Heart Rate in Healthy Humans

Zingiber officinale (ZO) has a long history of traditional use. It contains several constituents such as gingerol, gingerdiol, gingerdione, beta-carotene, capsaicin, caffeic acid and curumin. The present study was undertaken to investigate the effect of consumption of ZO on the heart rate and blood pressure (BP). Subjects for the study comprised of 22 males and 38 females making a total of 60 subjects. The subjects were in 3 groups of 20 each; a Control group (distilled water) and 2 experimental groups (100mg/kg bodyweight and 50mg/kg bodyweight of oral consumption of ZO extract). For each group, three readings were obtained per subject- one before administration, and the other two readings at intervals of 2hrs and 4hrs after consumption of water or ZO. The readings taken comprise of systolic BP, diastolic BP, and the heart rate. Results showed a significant (p<0.05) decrease in all measured parameters 2hrs after ZO administration and a significant (p<0.05) increase in only the systolic BP, 4hrs after ZO administration. It can be concluded that consumption of ZO at doses employed in this study, has a blood pressure lowering effect and this effect is dose-dependent.

Zingiber officinale alters 3,4-methylenedioxymethamphetamine-/INS;induced neurotoxicity in rat brain

Objective: The effects of this traditional herbal medicine on 3,4-methylenedioxymethamphetamine (MDMA) induced neurotoxicity have not yet been studied. The present study considers the effects of Zingiber officinale on MDMA-induced spatial memory impairment and apoptosis in the hippocampus of male rats. The spice Z. /INS;officinale or ginger possesses antioxidant activity and neuroprotective.

Effects of Zingiber officinale on the plasma pharmacokinetics and lung penetrations of ciprofloxacin and isoniazid.

The study was carried out to determine the effect of ginger on the plasma pharmacokinetics of ciprofloxacin and Isoniazid in a rat model in phase 1. The effects of the herb on the penetration of ciproflacin and Isoniazid into the lung tissues were also determined in phase 2. In phase 1, Albino rats of both sexes (n = 20) were divided into 4 groups of 5 rats per group. Two groups received oral ciprofloxacin (20 mg/kg) and isoniazid (15 mg/kg). Other groups were fed with ginger (5 mg/kg) for 10 days followed by the drug administration on the 11th day. Blood samples were collected from each group at 0-, 0.5-, 1-, 2-, 5-, 8-, 12-, and 24-hour intervals. Plasma concentrations of the drugs were determined by a spectrophotometric method and the pharmacokinetic parameters determined using noncompartmental method as implemented in the winNonlin program. In phase 2, where the effects of the herb on the penetration of the drugs were determined, the concentrations of ciprofloxacin and isoniazid attained in the lung fluid of rats in the presence and absence of the herb were compared after a single oral dose of the drugs used in the same dose range as in phase 1. In the first phase, treatment with ginger significantly increased the area under the concentration-time curve of ciprofloxacin, whereas Vz and Cl were decreased. Ginger significantly decreased the area under the concentration-time curve of isoniazid, whereas Vz and Cl were increased. Ginger enhanced the penetration of ciprofloxacin and Isoniazid into the lung tissues; however, their rates of penetration were delayed.