Effects Of Parent Gender Research Articles

Context and education affect the quality of parents' speech to children

The present study examined the influence of the context of interaction, parent education level, and parent gender on the quantity and language acquisition-supporting quality of parents' talk with their 3- to 5-year-old children. The conversations of 155 Danish parent-child dyads (41 fathers; 79 boys) in book sharing, reminiscing, and LEGO toy play were recorded, transcribed, and coded for indicators of linguistic and interactive quality. Book sharing and reminiscing elicited higher quality speech than toy play but did not diminish education-related differences in parent speech quality. Higher levels of parent education were associated with higher linguistic quality and linguistic contingency of parent speech. There were no effects of parent gender. The findings support the use of book sharing and reminiscing in parent-implemented interventions to enhance children's language experience, with the caveat that these interventions will not eliminate gaps in children's early language-learning experience associated with parent education.

Cognitively challenging talk during shared reading: Effects of parent gender, child gender and relations with story comprehension

Although research on the home literacy environment and its impact on early literacy has long focused on mothers, the past decade has seen a shift in scholarly attention to the role of fathers. Building on this shift, we examined whether the nature of parent–child interactions during shared storybook reading varies with parent gender, child gender and the interaction between the two, and we analysed whether possible differences in the nature of mother– and father–child interactions are related to story comprehension. We made video observations of mothers and fathers within 36 relatively highly educated families reading a storybook with their kindergartener (age 4 – 5) and registered the use of cognitively challenging (i.e. decontextualized) talk during these activities. After each shared reading session, we additionally administered a test assessing children’s understanding of the story being read. Two-way mixed ANOVA’s revealed no effects of parent gender or child gender on either the use of cognitively challenging talk or children’s story comprehension, nor did we find interaction effects of parent and child gender. The extent of cognitively challenging talk was significantly correlated to children’s comprehension scores for fathers, but not for mothers. This correlation seems to have masked another association, however: when correlations were computed separately for girls and boys, we found that the proportion of cognitively challenging utterances of both parents was correlated to comprehension scores for boys, but not for girls. The absence of parent gender effects provides further insights into the way mothers and fathers shape interactions during shared reading, but also stresses the need for studies with larger, more diverse samples. The observation that more frequent use of cognitively challenging talk was paralleled by better story comprehension for boys invites further research on the specific effects of shared reading for boys.

Child Sleep Problems Affect Mothers and Fathers Differently: How Infant and Young Child Sleep Affects Paternal and Maternal Sleep Quality, Emotion Regulation, and Sleep-Related Cognitions.

PurposeProblems in infant and young child sleep can represent a serious challenge to parental behavior of mother and father. However, most research about the effect of infant and young child sleep on parenting has focused on mothers. Therefore, the present study aimed to explore the perception and consequences of infant and young child sleep problems of both parents.Participants and MethodsParticipants were recruited via random sampling at, eg, kindergartens in North Rhine Westphalia. The sample includes data of heterosexual German-speaking couples with children without any medical or psychopathological problems. For this study, parents were asked to complete the test battery with regard to their youngest child. As sampling was via the kindergarten, the range of child age was 4–68 months. A survey assessed data of parents (N=196, 46% female). The test battery contained the following questionnaires: Children Sleep Habits Questionnaire (CSHQ), Pittsburgh Sleep Quality Index (PSQI), Self-Report Measure for the Assessment of Emotion Regulation Skills (SEK-27), and a German version of the Infant Sleep Vignettes Interpretation Scale (ISVIS). For the outcome variables of parental sleep as well as for parental emotional competence, the statistical tests of ANOVA were used, and for parental sleep-related cognitions with the grouping variables of infant and young child sleep as well as parental gender, a MANOVA was used. According to the analysis of group differences, the age of the child was also included additional to the grouping variable of parental gender and children’s sleep.ResultsMothers and fathers in this sample were equally aware of their children’s sleep problems and reported similar sleep quality and emotion regulation themselves (all p > 0.05). Mothers as well as fathers of children with sleep problems had lower parental sleep quality (F(1, 183) = 110.01, p < 0.001) and emotion regulation (F(1, 184) = 143.16, p < 0.001) compared to parents of children without sleep problems. In children under 26 months of age, the child’s age seemed to have less negative impact on the father’s sleep quality (F(1, 183) = 5.01, p < 0.001) and emotion regulation (F(1, 184) = 0.72, p < 0.05) than on the outcomes of the mother. With regard to sleep-related cognition, there were statistically significant effects of parental gender (F(2, 185) = 44.39, p < 0.001) and interaction effects of parental gender × child sleep problems observed (F(2, 185) = 31.91, p < 0.001).ConclusionThe conclusion from this survey refers to the role of the father. According to the results, an association between paternal emotional competence, sleep quality as well as their sleep-related cognitions and infants and toddlers sleep behavior could be assumed in addition to and independent of the results of mothers. We would highlight the urgent need of inclusion of fathers in infant and developmental sleep research. In the context of sleep intervention, both parents should be provided with ongoing support to improve their sleep quality and competence in emotion regulation.

Parental Factors Related to Adolescent Girls' Suicide Attempts: A Cross-Sectional Study from 2015 to 2018.

Adolescent suicide is a serious global health concern. Although familial transmission of suicidal behaviors has been identified in previous research, the effects of parental gender remain unknown. This study identified the influence of parental suicidal behaviors on suicide attempts among adolescent girls. We collected data through a cross-sectional, nationwide, population-based survey in South Korea and evaluated data from 890 adolescent girls (aged 12–18 years) who had attempted suicide and their parents. Hierarchical logistic regression was used to analyze the risk factors related to suicide attempts among adolescent girls. The final model indicated that mothers’ suicidal plans and attempts (OR = 6.39, OR = 12.38, respectively) were important risk factors for suicide attempts in adolescent girls. Future studies should identify specific methods for effective prevention and treatment through path analysis of the related factors affecting suicidal behavior of adolescents according to their parents’ gender.

How Chatty Are Daddies? An Exploratory Study of Infants' Language Environments.

Purpose Fathers play a critical but underresearched role in their children's cognitive and linguistic development. Focusing on two-parent families with a mother and a father, the present longitudinal study explores the amount of paternal input infants hear during the first 2 years of life, how this input changes over time, and how it relates to child volubility. We devote special attention to parentese, a near-universal style of infant-directed speech, distinguished by its higher pitch, slower tempo, and exaggerated intonation. Method We examined the daylong recordings of the same 23 infants at ages 6, 10, 14, 18, and 24 months, given English-speaking families. The infants were recorded in the presence of their parents (mother-father dyads), who were predominantly White and ranged from mid to high socioeconomic status (SES). We analyzed the effects of parent gender and child age on adult word counts and parentese, as well as the effects of maternal and paternal word counts and parentese on child vocalizations. Results On average, the infants were exposed to 46.8% fewer words and 51.9% less parentese from fathers than from mothers, even though paternal parentese grew at a 2.8-times faster rate as the infants aged. An asymmetry emerged where maternal word counts and paternal parentese predicted child vocalizations, but paternal word counts and maternal parentese did not. Conclusions While infants may hear less input from their fathers than their mothers in predominantly White, mid-to-high SES, English-speaking households, paternal parentese still plays a unique role in their linguistic development. Future research on sources of variability in child language outcomes should thus control for parental differences since parents' language can differ substantially and differentially predict child language.

The More Similar, the Healthier: The Effect of Perceived Parent-Child Facial Resemblance on Parental Physical Health.

Parent-child facial resemblance (PCFR) is one of the direct cues used to assess the genetic relationship between two individuals. Due to the inner fertilization of humans, fathers are liable to suffer from paternal uncertainty. When a father perceives low father-child facial resemblance, he would become anxious, which is detrimental to his immune system and physical health. For a mother, however, she can assure her genetic relationship to her children and does not need any external cues to verify her maternity. Thus, the mother-child facial resemblance does not influence the mothers’ physical health. To test these hypotheses, we examined the moderating effect of parental gender and the mediating effect of trait anxiety on the relationship between PCFR and physical health of parents. The results showed that fathers’ PCFR positively predicted their physical health, whereas the mothers’ PCFR failed to show any predicting effect on mothers’ physical health. Furthermore, trait anxiety mediated the relationship between fathers’ PCFR and their physical health. The implications for paternal uncertainty, gender difference, and public policy were discussed.

Emotion regulation and its relation to symptoms of anxiety and depression in children aged 8\u201312\xa0years: does parental gender play a differentiating role?

BackgroundSymptoms of anxiety and depression are prevalent and highly comorbid in children, contributing to considerable impairment even at a subclinical level. Difficulties with emotion regulation are potentially related to both anxious and depressive symptoms. Research looking at maternal contributions to children’s mental health dominates the literature but ignores the potentially important contributions of fathers.MethodThe present study is part of the Coping Kids study in Norway, a randomized controlled study of a new indicated preventive intervention for children, EMOTION. EMOTION aims to reduce levels of anxious and depressive symptoms in children aged 8–12 years. Using cross sectional data and multiple regression analyses, we investigated the relations between anxious and depressive symptoms and emotion regulation in n = 602 children. Symptoms were reported by the child, mothers and fathers. Emotion regulation was reported by mothers and fathers.ResultsSymptoms of anxiety, as reported by parents, were associated with poorer emotion regulation. This association was also demonstrated for depressive symptoms as reported by both parents and children. When analyzing same gender reports, parental gender did not differentiate the relationship between anxiety symptoms and emotion regulation. For depressive symptoms, we did find a differentiating effect of parental gender, as the association with dysregulation of emotion was stronger in paternal reports, and the association with adaptive emotion regulation was stronger in maternal reports. When using reports from the opposite parent, the emotion regulation difficulties were still associated with depressive and anxiety symptoms, however exhibiting somewhat different emotional regulation profiles.ConclusionProblems with emotion regulation probably coexists with elevated levels of internalizing symptoms in children. In future research, both caregivers should be included.Trial registrationThe regional ethics committee (REC) of Norway approved the study. Registration number: 2013/1909; Project title: Coping Kids: a randomized controlled study of a new indicated preventive intervention for children with symptoms of anxiety and depression. ClinicalTrials.gov; Protocol ID 228846/H10.

Using the Health Belief Model to Explain Mothers\u2019 and Fathers\u2019 Intention to Participate in Universal Parenting Programs

Using the Health Belief Model (HBM) as a theoretical framework, we studied factors related to parental intention to participate in parenting programs and examined the moderating effects of parent gender on these factors. Participants were a community sample of 290 mothers and 290 fathers of 5- to 10-year-old children. Parents completed a set of questionnaires assessing child emotional and behavioral difficulties and the HBM constructs concerning perceived program benefits and barriers, perceived child problem susceptibility and severity, and perceived self-efficacy. The hypothesized model was evaluated using structural equation modeling. The results showed that, for both mothers and fathers, perceived program benefits were associated with higher intention to participate in parenting programs. In addition, higher intention to participate was associated with lower perceived barriers only in the sample of mothers and with higher perceived self-efficacy only in the sample of fathers. No significant relations were found between intention to participate and perceived child problem susceptibility and severity. Mediation analyses indicated that, for both mothers and fathers, child emotional and behavioral problems had an indirect effect on parents’ intention to participate by increasing the level of perceived benefits of the program. As a whole, the proposed model explained about 45 % of the variance in parental intention to participate. The current study suggests that mothers and fathers may be motivated by different factors when making their decision to participate in a parenting program. This finding can inform future parent engagement strategies intended to increase both mothers’ and fathers’ participation rates in parenting programs.

Effects of parental gender and level of education on the quality of life and general health of pediatric patients with epilepsy: An outpatient cross-sectional survey.

The quality of life (QOL) of children with epilepsy has been widely studied, and several problems related to cognition, behavior, social lives, and physical activity among these children have been reported. Family life and parental care are important aspects of the lives of these patients. The impact of parental education on the QOL of pediatric patients with epilepsy is an understudied topic, especially in developing countries. In this study, we investigated the QOL and general health (GH) of patients with epilepsy presenting at the pediatric neurology clinic at Baqiyatallah Hospital and a private clinic. The Quality of Life in Childhood Epilepsy (QOLCE) questionnaire, which is a 92-item epilepsy-specific questionnaire covering physical activity, well-being, cognition, behavior, social activity, overall QOL, and GH, was used for interviewing parents. A total of 106 patients (m=61, 57.5% and f=45, 42.5%) aged 5-17years (mean: 10.31±2.91) participated in the study. Overall, there was no significant difference between the QOL and GH results of male and female patients. However, the maternal education level had a significant impact on the overall QOL (high school: 3.02±0.85 vs. B.Sc.: 3.67±0.61, p<0.05) and GH (high school: 2.81±0.79 vs. B.Sc.: 3.8±0.94, p<0.05) of male patients, while paternal education had no significant effect. A multiple linear regression showed that the maternal education level had an independently significant association with the physical activity of the patients (p=0.02, CI: 1.4-6.25), and the paternal education level had an independently significant association with the well-being of the patients (p=0.02, CI: 0.43-5.36). In addition, the maternal education level (high school vs. B.Sc.) had a significant effect on physical activity, well-being, cognition, and behavior for all of the patients (p<0.05), while the paternal education level (high school vs. B.Sc.) had no significant impact. However, in a comparison of high school vs. higher education, paternal education had a significant effect on patients' physical activity and well-being (p<0.05). We conclude that parental levels of education play a significant role in various aspects of the lives and GH of children with epilepsy. Maternal education, in particular, plays a significant role in GH and the overall QOL of male patients. Further research is suggested to identify the socioeconomic and cultural factors responsible for these findings.

Gender and parenting: Effects of parenting failures on evaluations of mothers and fathers

Stereotypes may function as standards, such that individuals are judged relative to within-category expectations. Subjective judgments may mask stereotyping effects, whereas objective judgments may reveal stereotype-consistent patterns. We examined whether gender stereotypes about parenting lead judges to rate women and men as equally “good” parents while objective judgments favor women and whether parenting performance moderates this pattern. Participants evaluated a mother or father who successfully or unsuccessfully performed a parenting task. Subjective judgments of parent quality (“s/he is a good parent”) revealed no parent gender effects, but objective estimates of parenting performance favored mothers. In a hypothetical divorce scenario, participants also favored mothers in custody decisions. However, this pro-mother bias decreased when the mother failed at the parenting task (through her own fault). Performance did not affect custody decisions for fathers. We suggest parenting quality matters more for evaluations of mothers than for fathers because negative performance violates stereotyped expectations.

Parenting clinically anxious versus healthy control children aged 4–12 years

This study investigated whether parenting behaviors differed between parents of 68 clinically anxious children and 106 healthy control children aged 4–12 years. The effects of parent gender, child gender and child age on parenting were explored. Mothers and fathers completed a questionnaire to assess parenting behaviors in for children hypothetically anxious situations. Results showed that parents of clinically anxious children reported more anxiety-enhancing parenting (reinforcement of dependency and punishment) as well as more positive parenting (positive reinforcement). For the clinical sample, fathers reported using more modeling/reassurance than mothers, and parents reported using more force with their 4–7-year-olds than with their 8–12-year-olds. No interaction effects were found for child gender with child anxiety status on parenting. Results indicate that for intervention, it is important to measure parenting behaviors, and to take into account father and mother differences and the age of the child.

Parental correlates in child and adolescent physical activity: a meta-analysis.

ObjectivePhysical activity (PA) has a profound impact on health and development in children. Parental behaviors (i.e., modeling and support) represent an obvious important factor in child PA. The purpose of this paper was to provide a comprehensive meta-analysis that overcomes the limitations of prior narrative reviews and quantitative reviews with small samples.MethodsTen major databases were used in the literature search. One-hundred and fifteen studies passed the eligibility criteria. Both fixed and random effects models with correction for sampling and measurement error were examined in the analysis. Moderator analyses investigating the effects of child’s developmental age, study design, parental gender, measurement of child PA, and quality rating were performed.ResultsBased on the random effects model, the results showed that parental modeling was weakly associated with child PA (summary r = .16, 95% CI .09-.24) and none of the proposed moderators were significant. Separate analyses examining the moderating effects of parental gender and boys’ PA found that that father-son PA modeling (r = .29, 95% CI .21-.36) was significantly higher compared to mother-son PA (r = .19, 95% CI .14-.23; p < .05). However, parental gender did not moderate the relationship between parental modeling and girls’ PA (p > .05). The random effects model indicated an overall moderate effect size for the parental support and child PA relationship (summary r = .38, 95% CI .30-.46). Here, the only significant moderating variable was the measurement of child PA (objective: r = .20, 95% CI .13-.26; reported: r = .46, 95% CI .37-.55; p < .01).ConclusionsParental support and modeling relate to child PA, yet our results revealed a significant degree of heterogeneity among the studies that could not be explained well by our proposed moderators.

Sibling Cooperative and Externalizing Behaviors in Families Raising Children With Disabilities

Raising a child with a disability (CWD) in the home is increasing across the globe. Because of caregiver burden and the complexity of care, there is growing concern for typically developing sibling (TDS) outcomes. The aim of the study was to examine whether caregiver burden, parenting style, and sibling relationships in families raising a CWD are associated with cooperative and externalizing behaviors in TDS. This correlational study included 189 families raising both a CWD and a TDS. Multilevel modeling was used to identify which variables were most predictive of TDS outcomes and if there were parent gender effects. Authoritative parenting was positively associated with cooperative behaviors. Authoritarian parenting was positively associated with externalizing behaviors. Multilevel modeling revealed caregiver burden was a significant predictor of sibling behaviors in the first model. When parenting style was added as a predictor, it was also significant. When sibling relationships were added as predictors, they were significant predictors for both cooperative and externalizing TDS behaviors; however, caregiver burden was no longer significant. Authoritarian parenting significantly predicted externalizing behaviors, and authoritative parenting was significantly related to cooperative behaviors. In families raising a CWD, positive sibling relationships may help negate the effects of caregiver burden and are more predictive of TDS outcomes than some parenting practices.

Children and Adolescents With Same-Gender Parents: A Meta-Analytic Approach in Assessing Outcomes

Given the societal, political, and cultural divide on the topic of same-gender parenting, there is a need for a stronger body of evidence that accurately identifies outcomes for children and adolescents of gay and lesbian parents. In addition, attention should be paid to the validity of the argument that parenting capabilities are gender-exclusive and children need both a mother and a father. The present study was a quantitative synthesis of the available literature to investigate the effects of parental gender and sexual identity on child and adolescent outcomes. An electronic search of relevant databases resulted in 33 unpublished and published studies (N of children = 5,272) that included a comparison of same-gender or different-gender parents and their children. Results indicated several significant findings for the parent-child relationship and child gender role behavior outcomes. Other outcomes, including child sexual orientation, cognitive abilities, psychological adjustment, and gender identity, were not moderated by parent gender or sexual orientation. Implications for future research are discussed.

Perceptions of Parenting Style Among College Students in India and the United States

Although a growing body of psychological literature has examined the influence of culture on parenting style, relatively less attention has been paid to gender differences in parenting style across cultures. The present study examined perceptions of parenting style as a function of participant’s culture, participant’s gender, and parent gender in college students in India and the United States. Using a new vignette-based self-report measure that characterizes each of Baumrind’s three parenting styles, participants rated perceptions of effectiveness, helpfulness, caring, and normativeness of each style. Contrary to expectation, results showed that Indian college students considered the parent demonstrating permissive parenting to be more effective and helpful than US college students. In contrast, US college students considered the parents demonstrating authoritative and authoritarian parenting to be more effective, helpful, and caring than Indian college students. A majority of Indian and US college students selected the parent demonstrating authoritative parenting as most similar to their own parents, and the type of parent they wish to be in the future. Females considered the parent demonstrating authoritative parenting to be more effective and helpful than males. Relatively few effects of parent gender were found.

Parents who catastrophize about their child’s pain prioritize attempts to control pain

How parents respond to their child in pain is critically important to how both parent and child attempt to cope with pain. We examined the influence of parental catastrophic thinking about child pain on their prioritization for pain control. Using a vignette methodology, parents reported, in response to different pain scenarios, on their imagined motivation for 2 competing goals: to control their child’s pain (ie, pain control) or to encourage their child’s participation in daily activities (ie, activity engagement). The effects of parent gender, pain intensity, and duration on parental goal priority were also explored. Findings indicated that higher levels of parental catastrophic thoughts were associated with the parents prioritizing child pain control over activity engagement. This effect was significantly moderated by pain duration. Specifically, pain control was more of a priority for those high in catastrophic thinking when the pain was more acute. In contrast, parental catastrophic thoughts had no effect on the pain control strategy favored by parents in situations with longer-lasting pain. Furthermore, independently of parental catastrophic thoughts, heightened priority for pain control was observed in highly intense and chronic pain situations. Moreover, in highly intense pain, priority for pain control was stronger for mothers compared with fathers. Theoretical and clinical implications and directions for future research are discussed.

Relations Between Parent Psychopathology, Family Functioning, and Adolescent Problems In Substance-Abusing Families: Disaggregating the Effects of Parent Gender

The present study: (1) examined relations between parent psychopathology and adolescent internalizing problems, externalizing problems, and substance use in substance-abusing families; and (2) tested family functioning problems as mediators of these relations. Structural equation modeling was used to estimate the independent effects of parent psychopathology and family functioning problems by parent gender. Participants included 242 parents in treatment for substance abuse and/or dependence and 59 of their coparents (16.9% in treatment for substance-abuse/dependence) from middle income households (SES: M = 4.7; SD = 2.1). Ratings were obtained for 325 adolescents (48% female; 27.8% non-Caucasian) between the ages of 10 and 18 years (M = 13.5 years; SD = 2.5 years). Parent psychopathology, family functioning problems, and adolescent problems were assessed with parent and coparent ratings on the Symptom Checklist (SCL-90)/Brief Symptom Inventory (BSI), the Family Relationship Measure, and the Child Behavior Checklist, respectively. Results indicated that maternal psychopathology was directly related to adolescent internalizing problems and substance use, but maternal perceptions of family functioning problems failed to mediate relations between maternal psychopathology and adolescent problems. By contrast, paternal perceptions of family functioning problems uniquely mediated relations between paternal psychopathology and adolescent externalizing problems. Findings underscore the importance of examining how mothers and fathers may differentially impact adolescent problems in substance-abusing families.

Mothers' and Fathers' Parenting Quality and Toddlers' Interactive Behaviours in Dyadic and Triadic Family Contexts

AbstractBased on a family systems perspective, this research examined the role of parental gender and family play context in parent–toddler interactions and how behaviours of family members influence each other. Sixty‐seven mostly White, middle‐class families consisting of a mother, father and toddler were videotaped in three separate sessions: mother–child, father–child and both parents–child at a university laboratory setting. The results indicated that there were significant main effects of both parent gender (mother versus father) and context (dyadic versus triadic) on parents' positive and negative parenting and children's engagement and negativity toward parents. Higher levels of mutual engagement between mothers and toddlers were associated with lower levels of fathers' positive parenting and children's engagement with fathers, when moving from the dyadic to the triadic play context. However, fathers' mutual engagement with toddlers was not associated with mothers' parenting quality and child interactive behaviours with mothers. There were also interaction effects of parent gender and context on parents' negative parenting and children's engagement and negativity toward parents. This study adds unique insights to the differences and similarities of parent–child dyadic and triadic interactions during toddlerhood. Copyright © 2012 John Wiley &amp; Sons, Ltd.

Attributions and Attitudes of Mothers and Fathers in the Philippines

SYNOPSIS Objective. This article investigates the mean level and within-family similarities and differences in Filipino mothers' and fathers' attributions about success and failure in caregiving situations, and their progressive and authoritarian parenting attitudes. Design. Mothers and fathers in 95 families in metropolitan Manila in the Philippines completed interviews. Results. Controlling for parents' age, education, and possible social desirability bias, there was a significant gender difference in modernity of attitudes, with mothers exhibiting higher levels of modernity than fathers. There was a strong correlation in mothers' and fathers' authoritarian attitudes and moderate correlations in modernity of attitudes. There were neither parent gender effects nor concordance in the attributions of mothers and fathers. Conclusions. Cultural explanations are presented to account for the findings, specifically the sociocultural values that foster traditional attitudes favoring parental authority and child obedience, and the differences in gender and family roles of Filipino mothers and fathers.

Friedreich's Ataxia Induced Pluripotent Stem Cells Model Intergenerational GAA⋅TTC Triplet Repeat Instability

The inherited neurodegenerative disease Friedreich's ataxia (FRDA) is caused by GAA⋅TTC triplet repeat hyperexpansions within the first intron of the FXN gene, encoding the mitochondrial protein frataxin. Long GAA⋅TTC repeats cause heterochromatin-mediated gene silencing and loss of frataxin in affected individuals. We report the derivation of induced pluripotent stem cells (iPSCs) from FRDA patient fibroblasts by transcription factor reprogramming. FXN gene repression is maintained in the iPSCs, as are the global gene expression signatures reflecting the human disease. GAA⋅TTC repeats uniquely in FXN in the iPSCs exhibit repeat instability similar to patient families, where they expand and/or contract with discrete changes in length between generations. The mismatch repair enzyme MSH2, implicated in repeat instability in other triplet repeat diseases, is highly expressed in pluripotent cells and occupies FXN intron 1, and shRNA silencing ofMSH2 impedes repeat expansion, providing a possible molecular explanation for repeat expansion in FRDA.