Effects Of Octacosanol Research Articles

Effects of octacosanol on HMG-CoA reductase and cyclooxygenase-2 activities in the HT-29 human colorectal cancer cell line

Effects of octacosanol on HMG-CoA reductase and cyclooxygenase-2 activities in the HT-29 human colorectal cancer cell line

Effects of Octacosanol, Wheat Germ Oil and Rice Oil Supplementation on Egg Quality Traits of Laying Quail

The study was carried out in the poultry field of the Animal Production Department of the Faculty of Agriculture at Tikrit University. The current study aimed to estimate the effects of adding different percentages of octacosanol, wheat germ oil and rice oil to the ration on egg quality traits. 96 laying quail (age 45 days), were used and divided into six treatments were included: adding the octacosanol/kg feedstuff (T1 without adding, T2=15 mg, T3=20 mg, T4=25 mg), (T5) was adding 5 ml of wheat germ oil/kg feedstuff and (T6) wasadding 5 ml of rice oil/kg feedstuff, which each treatment included four replicates. It used three female quails for each one male, during 90 days at the age of 16 weeks.The results showed the following: no significant effect (P<0.05) of dietary octacosanol, wheat germ oil and rice oil supplementation which was recorded on relative weights of shell, yolk and albumen, and shell thickness also yolk color, egg shape index, albumen index, yolk index, egg quality of laying quail. However, there was a significant increase (P<0.05) in hough unit for the two treatments that it included octacosanol powder (20 and 25 mg) compared to the control treatment, However, there was no significant difference between the addition treatments.

Effects of octacosanol extracted from rice bran on blood hormone levels and gene expressions of glucose transporter protein-4 and adenosine monophosphate protein kinase in weaning piglets.

The object of this study was to explore the regulatory mechanism of octacosanol to the body of animals and the effects of octacosanol on blood hormone levels and gene expressions of glucose transporter protein (GLUT-4) and adenosine monophosphate protein kinase (AMPK) in liver and muscle tissue of weaning piglets. A total of 105 crossbred piglets ([Yorkshire × Landrace] × Duroc) with an initial BW of 5.70 ± 1.41 kg (21 d of age) were used in a 6-wk trial to evaluate the effects of octacosanol and tiamulin supplementation on contents of triiodothyronine (T3), thyroxine (T4), growth hormone (GH), glucagon (GU) and adrenaline (AD) in blood and gene expressions of GLUT-4 and AMPK in liver and muscle. Piglets were randomly distributed into 3 dietary treatments on the basis of BW and sex. Each treatment had 7 replicate pens with 5 piglets per pen. Treatments were as followed: control group, tiamulin group and octacosanol group. The results showed that compared with control group and tiamulin group, octacosanol greatly promoted the secretion of T3, GH, GU and AD (P < 0.01) and significantly up-regulated the gene expressions of GLUT-4 and AMPK in muscle and liver tissues (P < 0.05). There was no significant difference between the control group and tiamulin group in T3, T4, GH, GU or AD (P > 0.05). Results of the present study has confirmed that octacosanol affects energy metabolism of body by regulating secretion of blood hormones and related gene expression in tissue of weaning piglets, which can reduce stress response and has an impact on performance.

Anti-parkinsonian effects of octacosanol in 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-treated mice.

Our previous research showed that octacosanol exerted its protective effects in 6-hydroxydopamine-induced Parkinsonian rats. The goal of this study was to investigate whether octacosanol would attenuate neurotoxicity in 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine (MPTP)-treated C57BL/6N mice and its potential mechanism. Behavioral tests, tyrosine hydroxylase immunohistochemistry and western blot were used to investigate the effects of octacosanol in a mouse model of Parkinson's disease. Oral administration of octacosanol (100 mg/kg) significantly improved behavioral impairments in mice treated by MPTP and markedly ameliorated morphological appearances of tyrosine hydroxylase-positive neuronal cells in the substantia nigra. Furthermore, octacosanol blocked MPTP-induced phosphorylation of p38MAPK and JNK, but not ERK1/2. These findings implicated that the protective effects afforded by octacosanol might be mediated by blocking the phosphorylation of p38MAPK and JNK on the signal transduction in vivo. Considering its excellent tolerability, octacosanol might be considered as a candidate agent for clinical application in treating Parkinson's disease.