Background: The Covid-19 pandemic created a complex impact on the load of maxillofacial trauma cases worldwide. The exact effects of lockdown measures on the burden of maxillofacial trauma cases in India remain unknown. Aims and Objectives: The aim of this study was to assess the impact of Covid-19 lockdown measures on the burden of maxillofacial trauma cases reporting to the emergency department of Government Medical College, Kozhikode. Materials and Methods: A record-based comparative study was performed to assess the maxillofacial trauma cases among patients reported to the emergency department of Government Medical College, Kozhikode, Kerala from 25 March 2020 to 31 May 2020 (Lockdown group/Study group). This was compared with two control groups (pre-lockdown groups). Results: A total of 170 (10.4%) maxillofacial trauma cases were presented in the lockdown period, 723 (44.1%) cases during the pre-lockdown period, and 745 (45.5%) cases in the previous year (2019 period). There was a reduction of 35.1% and 33.7% in the number of maxillofacial trauma cases during lockdown period when compared with the respective counterparts. Conclusion: This study result will serve as a record for planning and implementing alternate protocols, identifying areas for improvement as well as re-distributing resources and manpower in times of future epidemics/pandemics.