Effect Of Danhong Injection Research Articles

GW25-e1671 The Relaxation effect of Danhong Injection in Vascular smooth muscle cells and its mechanism

Danhong injection (DHI) is composed of two herbs Savia miltiorrhiza and Carthamus tinctorius L., it is used for the treatment of cardiovascular related diseases, such as stroke, coronary heart disease and angina pectoris in clinical therapy in Chinese. We have confirmed that DHI could stimulate the

The curative effect observation of Danhong injection combined with atorvastatin calcium in the treatment of lacunar cerebral infarction of the elderly

Objective To observe the clinical curative effect of Danhong injection combined with atorvastatin calcium in the treatment of lacunar cerebral infarction of the elderly.. Methods 125 elderly patients with lacunar cerebral infarction were randomly recruited into two groups, a control group（n=60 cases） was treated with atorvastatin calcium on the basis of conventional symptomatic treatment, and an observation group （n=65 cases） was treated with Danhong injection combined with atorvastatin calcium on the basis of conventional symptomatic treatment, the courses of two groups were 14 d. The clinical curative effect, the degree of nerve function defect score, the changes of hemorheology of two groups before and after the treatment were compared. Results The total effective rate of the observation group（89.2%）was significantly higher than that of the control group（71.7%）（P〈0.05）. The degree of nerve function defect score（16.24±4.63）of observation group after treatment improved significantly better than that of control group（22.17±7.38）, P〈0.05, and the whole blood viscosity（high）, whole blood viscosity（low）, plasma viscosity and fibrinogen [（3.62±0.64）mPa·s,（8.07±2.45）mPa·s, （1.61±0.30）mPa·s, （2.76±0.28）g/L]decreased significantly than that of the control group[（4.73±0.85）mPa·s, （9.86±3.26）mPa·s, （2.05±0.33）mPa·s,（3.94±0.35）g/L], P〈0.05. Conclusion The treatment of Danhong injection combined with atorvastatin calcium for elderly lacunar cerebral infarction had a good therapeutic effect. It could improve nerve function defect degree and blood rheology indexes. Key words: Lacunar cerebral infarction; Danhong injection; Atorvastatin calcium

The clinical effect of Danhong injection in treatmant unstable angina and its effect on the endothelial function

Objective To investigate the clinical effect of Danhong injection to treat unstable angina and its effect on the endothelial function.Methods 100 cases with unstable angina were randomly divided into control group and treatment group,each group had 50 cases.All patients were hospitalized for routine treatment,the control group was given Isosorbide mononitrate and 5％ glucose solution or saline,while the treatment group was given Danhong injection and 5％ glucose solution or saline on the basis of the routine treatment.Results After treatment,the efficacy of ECG and angina in the treatment group were better than the control group( all P ＜ 0.05) ; the NO level of post-treatment was higher than pre-treatment,ET and CRP levels were lower than pre-treatment( all P ＜0.05 ) ;the NO level in the treatment group was higher than the control group,the ET and CRP levels were lower than the control group( all P ＜ 0.05 ).Conclusion Danhong injection for the treatment of patients with unstable angina could effectively relieve the angina and improve the endothelial function. Key words: Danhong; Angina unstable; Endothelium, vascular

Danhong Inhibits Oxidized Low-Density Lipoprotein–Induced Immune Maturation of Dentritic Cells via a Peroxisome Proliferator Activated Receptor γ–Mediated Pathway

Danhong injection (DHI), a Chinese Materia Medica standardized product extracted from Radix Salviae miltiorrhizae and Flos Carthami tinctorii, is effective in the treatment of atherosclerosis (AS)-related diseases. It is widely recognized that AS is a complex inflammatory disease of the arterial wall and the dendritic cells (DCs) is a major player in the pathogenesis of AS via mediating atherosclerotic antigen presenting and T lymphocytes. Here, we determined the effect and possible mechanism of DHI on oxidized low-density lipoprotein (ox-LDL)-induced maturation and immune function of DCs. Human monocyte-derived DCs were incubated with DHI or ciglitazone and were subsequently stimulated with ox-LDL to induce maturation. Similar to ciglitazone, a peroxisome proliferator activated receptor (PPAR) γ agonist, DHI, could significantly reduce ox-LDL-induced expressions of mature markers, enhance the endocytotic function, and inhibit secretions of cytokine on DCs. These effects of DHI could be partly reversed by silencing the PPARγ. In conclusion, DHI could inhibit ox-LDL-induced maturation of DCs partly through activating a PPARγ-mediated signaling pathway.[Supplementary Methods and Figures: available only at http://dx.doi.org/10.1254/jphs.11226FP]

Protective effects of Danhong injection against heart injury in rats with severe acute pancreatitis

Protective effects of Danhong injection against heart injury in rats with severe acute pancreatitis