Effects Of Virgin Coconut Oil Research Articles

A Pilot Study on the Effect of Virgin Coconut Oil On Serum Lipid Profile and HS CRP Level Among Post Acute Coronary Syndrome Patients: A Randomized Controlled Trial

ABSTRACT Introduction: Acute coronary syndrome (ACS) is a leading cause of death in Malaysia and worldwide. Besides, teh current treatment which involves teh prescription of statins is found to TEMPhas several side TEMPeffects on ACS patients. Those side TEMPeffects TEMPhas guided teh author to introduce virgin coconut oil (VCO) as supplemental management of ACS. However, its benefits TEMPhas not been widely tested on humans. Methodology: dis study examines teh use of VCO among ACS patients via a crossover trial. It seeks to ascertain teh TEMPeffect of VCO on serum lipid profile and hs-CRP level among ACS patients. Result: VCO was found to be statistically significant in reducing serum lipid level and hs-CRP level (p<0.001). These findings measured from small to moderate Cohen’s d TEMPeffect size, thus proving teh results from dis study as statistically and clinically significant. Conclusion: These findings suggest dat dietary intake wif saturated fatty acid (C6 to C12) can improve health condition. Keywords: virgin coconut oil, acute coronary syndrome, saturated fatty acid, medium-chain triglycerides

The microbiological effect of virgin coconut oil on the morphological and volumetric dimensional changes of 3D printed surgical guides (in vitro study)

Background/objectivesDisinfection of surgical guides is mandatory for intraoperative use. Virgin Coconut Oil may be a potent alternative disinfectant; however, its effect has not been fully discussed in dentistry. The objectives of this study were to compare the morphological and the volumetric dimensional changes of 3D printed surgical guides after immersion in three disinfectants: 100%Virgin Coconut Oil, 2% Glutaraldehyde, and 70% Ethyl Alcohol and to assess the antimicrobial effectiveness of the tested disinfectants.Materials and methodsA surgical guide was designed using open platform software to print thirty guides and then cut them into two halves (N = 60). Pre-disinfection scans of the first half of the three study groups (n = 30) were performed using Cone-beam Computed Tomography, then immersed for 20 min in three disinfectants as follows: group VCO was immersed in 100% Virgin Coconut Oil, group GA was immersed in 2% Glutaraldehyde, and group EA was immersed in 70% Ethyl Alcohol. Post-disinfection scans of the first half of the three study groups (n = 30) were performed and then compared morphologically and volumetrically using an analyzing software program The second half of the three control groups (n* = 30) were soaked for 20 min in sterile distilled water as follows: group VCO*, group GA*, and group EA* for the assessment of the antimicrobial effectiveness of the three tested disinfectants.ResultsAt the morphological assessment of the dimensional changes, group VCO were the most accurate with the lowest mean deviation value of 0.12 ± 0.02 mm and root mean square value of 0.12 mm, group GA and group EA were less accurate with mean deviation value of = 0.22 ± 0.05 mm and = 0.19 ± 0.03 mm and root mean square value of 0.22 and 0.20 respectively (p < 0.001). At the volumetric assessment, group VCO showed lower volumetric changes with a mean deviation value of 0.17 ± 0.10 mm, root mean square value of 0.19 mm, than group GA with mean deviation value of 0.23 ± 0.10 mm, root mean square value of 0.25 mm and group EA with mean deviation value of 0.27 ± 0.11 mm, root mean square value of 0.29 mm, however, no statistically significant differences were found between the three study groups (p = 0.10). The antimicrobial effectiveness of the three tested disinfectants showed a hundred percent (100%) reduction in the total microbial count in the first half of the three study groups treated with the three disinfectants revealing no bacterial growth, however, statistically significant differences were found between the second half of the three control and the first half of the three study groups. (p < 0.001).ConclusionsVirgin Coconut Oil showed higher morphological dimensional accuracy of the tested surgical guides than Glutaraldehyde and Ethyl Alcohol without causing any volumetric dimensional changes in the 3D printed surgical guides after disinfection for 20 min and the antimicrobial effectiveness was the same between the three tested disinfectants without showing any microbial growth.

Favorable Effects of Virgin Coconut Oil on Neuronal Damage and Mortality after a Stroke Incidence in the Stroke-Prone Spontaneously Hypertensive Rat.

Stroke is consistently one of the top ten causes of morbidity and mortality globally, whose outcomes are quite variable, necessitating case-specific management. Prophylactic diets before the onset of stroke have been implicated to work. In this research, the effects of virgin coconut oil (VCO) on stroke were evaluated using a stroke-prone spontaneously hypertensive rat (SHRSP) model. Eight-week-old SHRSPs were subjected to the repeated oral administration (5 mL/kg/day) of either 1% Tween 80 (group A) or VCO (group B). An early stroke onset was observed due to hypertension that was aggravation by the administration of 1% NaCl in water ad libitum. The following data were collected: the days until stroke occurred, the survival rate until the animal died, and blood pressure (BP) every two weeks using the tail-cuff method. After necropsy, the organs were harvested, and the brain was processed for a routine histopathological analysis. VCO delayed the incidence of it and prolonged their survival. Compared to group A, group B showed a significantly lowered BP by 20 mmHg at four weeks after the start of VCO treatment. Lastly, the brain histopathology showed that the structurally damaged areas were smaller in group B than they were in group A. The VCO could have protective effects on the brain before and even after stroke incidence.

Co-morbidity of alzheimer-like dementia and type-2 diabetics mellitus: possible therapeutic effect of virgin coconut oil

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Protective Effect of Virgin Coconut Oil on Osteopenia Induced by High Refined Carbohydrate-Containing Diet in Mice.

Background: Obesity leads to chronic low-grade inflammation, promoting detrimental effects on bone. The consumption of virgin coconut oil (VCO) is associated with benefits related to meta-inflammation. We evaluated the effect of VCO supplementation on osteopenia promoted by diet-induced obesity in mice. Methods: Male BALB/c mice were fed a control (C) or highly refined carbohydrate-containing (HC) diet for eight weeks. After that, the HC diet group was supplemented with three doses of VCO for four weeks. Results: The HC diet increased the adiposity and leptin levels associated with augmented systemic inflammatory cells improved with VCO supplementation. The HC diet reduced the trabecular bone in the tibia, lumbar vertebrae, distal and proximal femur, as well as the bone mineral density of the femur and alveolar bone. The VCO supplementation reverted bone osteopenia by increasing the trabecular bone in different sites and improving femur and alveolar bone microarchitecture. Although the reduced number of osteoblasts in the alveolar bone of the HC diet group was not significantly enhanced by VCO supplementation, the reduced Alp expression in the HC diet group was enhanced in the VCO group. These beneficial effects were associated with lowering the Rankl/Opg ratio. Conclusion: VCO supplementation might be an effective strategy to attenuate bone osteopenic effects induced by obesity.

Effects of Coconut Oil on Weight Loss and Blood Lipids

Hindistan cevizi yağı tropikal ülkelerde binlerce yıldır kullanılan, Cocos nucifera adlı ağaçtan elde edilen yenilebilir bir yağdır. Saf hindistan cevizi yağı, hindistan cevizinin taze, olgun çekirdeğinden, mekanik veya doğal yollarla, ısı kullanılarak veya kullanılmadan kimyasal rafinasyon işlemi yapılmadan elde edilir. Hindistan cevizi yağı esas olarak 6-12 karbon atomundan oluşan orta zincirli yağ asitlerinden (MCT) oluşur. Hindistan cevizi yağının ağırlık kaybı üzerindeki etkilerinin termogenezi ve doygunluk yanıtını artırmasından kaynaklı olduğu bildirilmektedir. Sızma hindistan cevizi yağının kan lipidleri ve LDL oksidasyonu üzerindeki potansiyel yararlı etkilerinin ise, içerdiği biyoaktif polifenol bileşenlerden kaynaklandığı düşünülmektedir. Bu derleme, son yıllarda sağlık faydaları ile ön plana çıkan hindistan cevizi yağının ağırlık kaybı ve kan lipidleri üzerindeki etkilerine güncel bir bakış sunmaktadır.

Effect of Virgin Coconut Oil on Prolactin Levels and Breast Milk Production in Postpartum Mothers

Background and Aim: Breastfeeding is a natural process for a mother to support and prosper her child after giving birth. Lack of perception about breast milk production is one of the factors causing failure in exclusive breastfeeding. Nutritional and hormonal factors (prolactin and oxytocin) are the main factors that affect breast milk production. The purpose of this study was to determine the effect of giving virgin coconut oil to prolactin levels and milk production. Material and Method: This type of research is experimental with Posttest Only Group Design. The sample was selected by purposive sampling technique so as to get a sample of 33 pregnant women in the group and 33 pregnant women in the control group. Examination of prolactin levels were measured using the ELISA method. Data were analyzed by Kolmogorov Smirnov and Independent T test. Result: The results of the average prolactin level of each group, namely the control group was 50.69 ng/ml and the treatment group was 72.98 ng/ml. The average milk production obtained in the control group was 325.73 ml and the treatment group was 432.80 ml. The results of the analysis using the Independent T test concluded that there were significant differences, between VCO, prolactin levels (p = 0.00) and VCO on breast milk production (p = 0.00). Conclution: The conclusion of this study is that giving Virgin Coconut Oil has an effect on increasing prolactin and breast milk production in postpartum mothers. Keywords: VCO, Prolactin, Breast Milk .

Effect of virgin coconut oil, lauric acid and myristic acid on serum and prostatic markers of benign prostatic hyperplasia

Purpose: To investigate the effect of virgin coconut oil, lauric acid and myristic acid on serum and prostatic androgens in testosterone-induced prostatic hyperplasia.Methods: Benign prostatic hyperplasia (BPH) was induced in the animals by repeated subcutaneous injection of testosterone propionate (5 mg/kg) at the inguinal region once a day for 28 days. Thereafter, BPH was treated for 56 days by oral administration of virgin coconut oil, lauric acid and myristic acid. Following the treatment period, the rats were sacrificed and blood samples were collected through cardiac puncture for biochemical analysis.Results: Virgin coconut oil, lauric acid and myristic acid led to a significant reduction (p &lt; 0.05) in serum prostatic acid phosphatase (PAcP), prostate specific antigen (PSA) and dihydrotestosterone (DHT) levels, and also in prostatic DHT level.Conclusion: This study provides evidence that virgin coconut oil, lauric acid and myristic acid may be useful in the management of BPH because they exerted some anti-proliferative effects in the development and progression of BPH. Therefore, coconut may be a potential functional food for the management of BPH patients because it is rich in both lauric and myristic acid. However, further investigations, including clinical trials are required to buttress this.

PHOTOCHEMICAL TEST AND REPELLENT VIRGIN COCONUT OIL (VCO) TEST WITH SUPLEMENTATION OF Citronella Oil

Background: Repellents are chemicals or non-chemicals that can prevent insect activity from approaching humans. The development of repellent products needs to be done so as not to cause skin irritation and provide skin health. The purpose of this study was to carry out phytochemical and repellent tests to determine the active content and effectiveness of virgin coconut oil (VCO) supplementation with Citronella oil (CO) repellent essential oil against Aedes aegypti mosquitoes. Method: The research method used was true experiment with Posttest Only Control Group Design with experimental group namely VCO, VCO supplementation with 10% and 20% CO. Results: VCO supplementation with CO contained flavonoids, alkaloids, tannins, terpenoids, and saponins. VCO has a repellant power of 68.47%, supplementation with a combination of VCO with CO 10% is 97.55% and a concentration of 20% is 100%. Conclusion: VCO and CO supplementation of 10% and 20% were effective as repellants against Aedes aegypti mosquitoes. These two concentrations did not have a significant difference, so the 10% concentration could be used as the basis for further research. The presence of active ingredients in VCO supplementation with CO provides potential as a repellant and skin health care.. Suggestion: Organoleptic testing on this supplementation repellent product needs to be done so that it can be used by the community..

Virgin Coconut Oil Emulgel: Effect of VCO and Carbopol 940 Concentration on Characterization and Antibacterial Activity

Virgin coconut oil (VCO) is mostly produced from Cocos nucifera L. Kopyor coconut from Cocos nucifera L.is a coconut that has fruit flesh apart from its shell with mainly consist of lauric acid, vitamin C and α-tocopherol as antioxidants. Kopyor coconut has high lauric acid content in the flesh or VCO and has been found effective against Propionibacterium acnes bacteria. To increase its acceptability as anti-acne or skin diseases, VCO of kopyor coconut was formulated into emulgel. VCO concentration as the active agent was used of 20% and 30%. A selected gelling agent was Carbopol 940 at concentration of 1% and 2%. The emulgel then evaluated for physical characterization such as viscosity, pH, spreadability, particle size, particle size distribution, and zeta potential. The emulgel was also tested for antibacterial activity against Propionibacterium acnes and stability tests using thermal cycling method. The selected formula was formula 4 that had good zeta potential, suitable with skin pH, had a good particle size and distribution and was effective against Propionibacterium acnes bacteria.

Virgin coconut oil protected the diameter and the epithelium thickness of seminiferous tubules of mice (Mus musculus) from oral ethanol induction

This study investigated the preventive effect of virgin coconut oil (VCO) on the epithelium thickness and the diameter of the seminiferous tubules induced by ethanol in mice (Mus musculus). This study used 20 male mice as the experimental animal which were divided into five groups with four mice in each group. Negative control (C-) was given 2% Tween and aquadest, while positive control (C+) was given 2% Tween and 33% ethanol. T1, T2, and T3 were respectively given 0.09, 0.19, and 0.37 mL/kg bw VCO and 33% ethanol (0.2 mL/kg bw). VCO was given orally for 39 days, and ethanol was given orally seven days later for 32 days. Ethanol was administered two hours after the VCO administration. Analysis of variance followed by Tukey’s range test on the epithelium thickness and the diameter of the seminiferous tubules showed significant differences (p &lt;0.05) of C+ group from the other groups. Whereas, there was no significant difference (p &gt;0.05) was found among C-, T1, T2 and T3 group. The result concluded that VCO could protect the testis of mice from the damage caused by ethanol.

A narrative review on use of virgin coconut oil in dermatology

Background: Coconut oil is of two varieties: virgin and refined oil. Virgin coconut oil (VCO) is made by cold-pressing the liquid from the fresh part of coconut meat. It has a milky appearance. This oil extraction method prevents the loss of vitamin E, pro-vitamin A, and polyphenols. It has various properties such as analgesic, anti-inflammatory, and anti-cancer. Skin is the general structure of the body. It is the first line of protection against traumatic injuries and microorganisms. Aim: This review is focussed on the existing data on the effect of VCO on the skin. Materials and Methods: PubMed and Google Scholar were searched for citations for keywords “virgin coconut oil and dermatology” and “virgin coconut oil and skin.” In search of the various databases, 13 articles were found on VCO related to skin. Result: Virgin coconut oil is used as antioxidant, anti-inflammatory, as skin protector, in Alzheimer's disease, in wound healing and as moisturizer. Conclusion: From this review, it can be concluded that VCO is beneficial for various dermatological disorders. It is antifungal and antibacterial and also acts as an immunomodulator. It also has anti-inflammatory, angiogenic, wound-healing, and skin protective properties.

Histological and immunohistochemical study of the protective effect of virgin coconut oil on cyclophosphamide-induced immunotoxicity of the spleen and peyer’s patches

Introduction: Virgin coconut oil (VCO) is an edible oil extracted from the meat of mature coconuts. It is also known for its health and therapeutic benefits, mainly attributed to its polyphenols and medium-chain fatty acid contents The immunomodulatory effects of VCO have not been extensively investigated. The aim of the present study was to investigate the effects of VCO on cyclophosphamide (CY)-induced immunotoxicity of peripheral lymphoid tissues. Methods: Forty Wistar rats were divided into five groups of eight rats each. Group 1 served as the normal control, while the other groups were all given 10 mg/kg of CY orally once daily for 4 weeks. Group 2 received CY served as the negative control. Group 3 rats were treated with levamisole (LMS) for 6 weeks, while Groups 4A and 4B were given VCO at 10 mL/kg and 15 mL/kg, respectively, for 6 weeks. The spleen and ileum sections were subjected to routine histological examination and immunohistochemical evaluation for T and B lymphocytes. Results: Histologically, the spleen and Peyer’s patches (PPs) of the ileum exhibited a significant reduction in the lymphoid cellularity following daily administration of 10 mg/kg CY for 4 weeks.

Protective Effects of Virgin Coconut Oil on Acetaminophen-Induced Hepatotoxicity in Wistar Rats

Protective Effects of Virgin Coconut Oil on Acetaminophen-Induced Hepatotoxicity in Wistar Rats

Properties of film-forming emulsions and films based on corn starch/sodium alginate/gum Arabic as affected by virgin coconut oil content

The effects of virgin coconut oil (VCO) contents (10%, 30%, 50%, and 70%, based on the mass of gum Arabic) on the properties of the emulsions and the films of corn starch/sodium alginate/gum Arabic composite were investigated. Results showed that increased VCO content led to larger droplet size and weakened emulsion stability, as evidenced by the microscopic images. Regarding the film properties, the higher the VCO content, the lower the water vapor permeability (WVP), oxygen permeability, and water adsorption. The incorporation of VCO decreased the tensile strength but effectively increased the elongation at break of the films. Moreover, high linearity against VCO content was observed for WVP, water adsorption, and water contact angle. This study contributes to the understanding of modulating the properties of the emulsion and the resultant film by altering the oil content.

THE EFFECT OF DIFFERENT FREE FATTY ACID FRACTIONS FROM HYDROLYZED VIRGIN COCONUT OIL ON CHANGES OF LIPID PROFILE AND LIVER MORPHOLOGY INDUCED BY HIGH FAT DIET: AN IN VIVO STUDY

This study investigated effect of virgin coconut oil (VCO)-derived fatty acids on the alteration of lipid profiles and liver tissues of high fat diet (HFD) fed mice. The initial fatty acids mixture was successfully obtained via hydrolysis process using Candida rugosa lipase (CRL). Enrichment of medium chain fatty acids (MCFA) from the initial fatty acid mixture using distillation process was developed to achieve 3 fractions of fatty acids mixture including Fraction I (MCFA mainly from C8 to C10), Fraction II of lauric acid (C12), and Fraction III (long chain fatty acids from C14 to C20). Among these agents, VCO only diminished ALT level but the initial FFA mixture decreased both ALT and AST levels compared with HFD-induced mice. Moreover, Fraction I and Fraction II showed an obvious difference in decreasing ALT, AST, total cholesterol, and LDL cholesterol levels as well as increasing HDL cholesterol level compared to other agents. It was observed a microvesicular steatosis and mild inflammation in liver section of mice fed with HFD whereas VCO, initial fatty acids, and Fraction II showed the beneficial effect on liver damage.

Neuroprotective Effects of Virgin Coconut Oil Solubilized Curcumin in Diabetic Peripheral Neuropathy

Neuroprotective Effects of Virgin Coconut Oil Solubilized Curcumin in Diabetic Peripheral Neuropathy

Effect of Virgin Coconut Oil Administration to Increase HDL, Decrease LDL and IL-6 in Hypercholesterol Male Wistar Rats

Background: Hypercholesterol is a change in blood lipid profile levels, from rising cholesterol levels that can be triggered by frequent consumption of fatty foods. Hypercholesterol causes adipose tissue and macrophages to release inflammatory cytokines, then adipose cells release IL-6 and spur the formation of CRP. This study aimed to determine the effect of Virgin coconut oil (VCO) on changes in HDL, LDL, and IL-6 levels in hyper cholesterol mice. Subjects and Method: This randomized controlled trial was carried out at the PSPG UGM Nutrition Laboratory in August 2021. The total number of samples used was 20 tails and 4 spare tails, namely 24 male Wistar strain rats. Sampling using simple random sampling. The independent variables in this study were the dose of VCO 0.9 ml/200g BW/day, and 0.45 ml/200g BW/day. The dependent variables in this study were HDL, LDL, and IL-6 cholesterol levels in male Wistar rats. The data in the analysis used a normality test with the Shapiro-Wilk test and a data homogeneity test with the Levane test. HDL dan LDL levels were measured using a lysis reagent, while IL-6 was measured using the ELISA method. Results: Average LDL and HDL levels are highest in the P1 group compared to the P2, K0, and K1 groups. The One Way Anova test on HDL levels showed a significant difference between groups with p&lt;0.001. One Way Anova test results on LDL and IL-6 levels showed significant differences between the groups (p&lt;0.001) and (p= 0.004). Conclusion: Administering VCO at a dose of 0.9 mL/ 200 g BB/day 0.45 mL/200 g BB/day, and 86.4 mg/200 g can increase HDL and IL-6 levels in male rats Wistar strain with hyper cholesterol and lowered LDL levels by the same dose in male mice with hyper cholesterol. Keywords: hyper cholesterol, HDL, LDL, IL-6 Correspondence: Meli Maulidia, Magister Ilmu Biomedik, Universitas Islam Sultan Agung Semarang. Jl. Raya Kaligawe Km.04 Semarang 50112, Central Jawa, Indonesia. Email: maulidia.dr@gmail.com. Mobile: +6285740003464. Indonesian Journal of Medicine (2022), 07(04): 471-478 https://doi.org/10.26911/theijmed.2022.07.04.12

Effect of Virgin Coconut Oil on Feeding Problems of the Autistic Children: A Randomized Clinical Trial

Effect of Virgin Coconut Oil on Feeding Problems of the Autistic Children: A Randomized Clinical Trial

A Randomized Controlled Trial on the Effect of VCO in Reducing Glucose and Body Weight in Post-Acute Coronary Syndrome Patients: A Pilot Study

The aims of this paper were to determine the effect of virgin coconut oil (VCO) on bodyweight and serum glucose level among acute coronary syndrome (ACS) patients. Various clinical trials on animal studies have found that the VCO has many beneficial effects on health. However, there have been limited published human studies on the pharmacological properties of VCO. Investigation on human subjects is extremely required in order to provide more empirical evidence to show the effect of VCO for ACS patients. Randomised single blind study conducted between March 2018 and April 2018. RCT was conducted among 70 ACS patients for 30 days. Participants in group A received their bottles containing 100 pieces of virgin coconut oil soft gels and were required to ingest 10 capsules per day (5 mL/5 gm) and continue routine treatment (diabetic diet and diabetic medication). Group B participants continued receiving routine treatment. Changes in serum fating blood sugar and body weight were identified using a paired t-test and independent t-test. A total of 70 patients participated with ages of 51 years old and older and were mostly male. The serum FBS and body weight of the intervention group that received VCO were reduced about 13.6% on day 30, from the baseline on day 1. They also had body weight reduction of about 2% with p value of less than 0.05. In contrast, the control group that only received routine treatment showed an increment of 12.1% in their serum FBS and had no changes in body weight. These reductions were noted within 30 days of consuming a daily dose of VCO (5 g every day). The properties of lauric acid and antioxidants present in the VCO composition were key players in the reduction of serum glucose levels and body weight. VCO can reduce serum glucose levels and body weight with 5 mL (5 g) of VCO per day for 30 days. Also, VCO may have a positive effect towards the glucose level and other cardiovascular risk factors.