Background and Objective: Leukemia is one of the top five cancers in Iran. Aside from physical issues, the disease causes a variety of social and psychological issues for patients. In this regard, one aspect that cancer may affect is quality of life, which can lead to anxiety. The collaborative care model is a novel nursing model that improves treatment outcomes through collaboration. As a result, the purpose of this study is to look into the impact of a collaborative care model on quality of life and anxiety in leukemia patients.Methods: The current non-randomized clinical trial, which included a control group, was conducted on 60 leukemia patients at Firoozgar and Rasoul Akram hospitals in Tehran (affiliated to Iran University of Medical Sciences). The hospitals were randomly divided into two groups: control and intervention, and patients were chosen at random from each hospital using a convenience sampling method. The collaborative care model was implemented in the intervention group, while no specific measures were taken in the control group. Patients in both groups' quality of life was measured using the Quality-of-Life Questionnaire in Oncology Patients before, one, and two months after the intervention, and their anxiety was measured using the Beck Anxiety Inventory. Both groups completed their questionnaires using a self-report method.Results: In terms of demographic characteristics, there was no statistically significant difference between the two groups (p>0.05). Prior to the intervention, no statistically significant difference in mean anxiety, quality of life, and its dimensions was observed between the two groups (p>0.05). Following the intervention, a statistically significant difference in mean anxiety and quality of life scores was observed between the two groups (p<0.05), indicating a decrease in anxiety and an increase in quality of life among patients in the intervention group.Conclusion: Based on the findings, it appears that the collaborative care model has a positive effect on reducing anxiety and improving quality of life in leukemia patients, and it is preferable to use this model when caring for this group of patients.
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