Early Career Scientists Research Articles

Interleukin-1β triggers muscle-derived extracellular superoxide dismutase expression and protects muscles from doxorubicin-induced atrophy

Oxidative stress plays an important role in skeletal muscle atrophy. Doxorubicin, a conventional chemotherapeutic agent prescribed for cancer, causes skeletal muscle atrophy and adversely affects mobility and strength. Since doxorubicin-induced muscle atrophy is primarily attributable to oxidative stress, its effects could be mitigated by antioxidant-focused therapies; however, these protective therapeutic targets remain ambiguous. This study aimed at demonstrating that doxorubicin triggered severe muscle atrophy via upregulation of oxidative stress (4-Hydroxynonenal and Malondialdehyde) and atrogenes (Atrogin-1/MAFbx and Muscle RING Finger-1) in association with decreased expression of the antioxidant enzyme, extracellular superoxide dismutase (EcSOD), in cultured C2C12 myotubes and mouse skeletal muscle. EcSOD recombinant protein supplementation elevated EcSOD levels on the cellular membrane of cultured myotubes, consequently inhibiting doxorubicin-induced oxidative stress and myotube atrophy. Furthermore, doxorubicin treatment reduced interleukin-1β (IL-1β) mRNA expression in cultured myotubes and skeletal muscle, while transient IL-1β treatment increased EcSOD protein expression on the myotube membrane. Notably, transient IL-1β treatment of cultured myotubes and local administration in mouse skeletal muscle attenuated doxorubicin-induced muscle atrophy, which is associated with increased EcSOD expression. Collectively, these findings reveal that the regulation of skeletal muscle EcSOD via maintenance of IL-1β signaling is a potential therapeutic approach against doxorubicin-and oxidative stress-mediated muscle atrophy. This study was supported by Grant-in-Aid for Scientific Research (B) (15H03080, 18H03153, 21H03326), Grant-in-Aid for Exploratory Research (20K21766), Suzuken Memorial Foundation, Toyoaki Scholarship Foundation, The Nakatomi Foundation, and The Uehara Memorial Foundation (to M.O.). This research was also supported by Grant-in-Aid for JSPS Fellows (20J15551), Grant-in-Aid for Early-Career Scientists (22K17733), Suzuken Memorial Foundation, The Nakatomi Foundation, and The Uehara Memorial Foundation (to M.Y.). This is the full abstract presented at the American Physiology Summit 2024 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process.

Muscle p62 stimulates the expression of antioxidant proteins alleviating cancer cachexia

Cancer cachexia is characterized by a significant reduction in body weight predominantly resulting from severe loss of skeletal muscle. Oxidative stress plays an important role in skeletal muscle atrophy during cancer cachexia, and more glycolytic muscles are preferentially affected. Sequestosome1/SQSTM1 (i.e., p62), particularly when phosphorylated at Ser 349 (Ser 351 in mice), competitively binds to the Kelch-like ECH-associated protein 1 (Keap1) activating Nuclear factor erythroid 2-related factor 2 (Nrf2). Nrf2 then stimulates the transcription of antioxidant/electrophile-responsive elements (ARE/EpRE) in target genes. However, a potential role for p62 in the protection of muscle wasting in cachexia remains to be determined. Here, using the well-established cachexia-inducing model of Lewis Lung Carcinoma (LLC) in mice we demonstrate higher expression of antioxidant proteins (i.e., NQO1, HO-1, GSTM1, CuZnSOD, MnSOD, and EcSOD) in the more oxidative and cachexia resistant soleus muscle than in the more glycolytic and cachexia prone extensor digitorum longus muscle. This was accompanied by higher p62 (total and phosphorylated) and nuclear Nrf2 levels in the soleus, which were paralleled by higher expression of proteins known to either phosphorylate or promote p62 phosphorylation (i.e., NBR1, CK1, PKCδ, and TAK1). Muscle-specific p62 gain-of-function (i.e., in p62 mTg mice) activated Nrf2 nuclear translocation and increased the expression of multiple antioxidant proteins (i.e., CuZnSOD, MnSOD, EcSOD, NQO1, and GSTM1) in glycolytic muscles. Interestingly, skeletal muscle Nrf2 haplodeficiency blunted the increases of most of these proteins (i.e., CuZnSOD, EcSOD, and NQO1) suggesting that muscle p62 stimulates antioxidant protein expression also via additional, yet to be determined mechanisms. Of note, p62 gain-of-function mitigated glycolytic muscle wasting in LLC-affected mice. Collectively, our findings identify skeletal muscle p62 as a potential therapeutic target for cancer cachexia. This research was supported by Grant-in-Aid for JSPS Fellows (20J15551), Grant-in-Aid for Early-Career Scientists (22K17733), Suzuken Memorial Foundation, The Nakatomi Foundation, and The Uehara Memorial Foundation (to M.Y.). This is the full abstract presented at the American Physiology Summit 2024 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process.

“How to Bridge the Gap”: Empowering Early-Career Scientists to Navigate the Science-Policy Interface—Conclusions from a Summer School

The “Science and Policy - How to Bridge the Gap” summer school, which took place in July 2023 in Switzerland, aimed to educate PhD students in natural science and engineering on engaging with policymakers effectively. Over the course of five days, the program covered various aspects of the Swiss and international science-policy interface, including the Science for Policy framework, concrete examples of evidence-based policy advice from scientists, and talks on the significance of Open Science (OS) and public engagement in fostering the dialogue between science and society. Additionally, multiple workshops illustrated science communication formats for different audiences, such as policymakers, stakeholders, and the general public. Organized by five PhD students with a natural science and/or engineering background, the event brought together thirty participants and featured twenty-eight speakers, creating a highly international and stimulating learning environment. This workshop review, written by the summer school organizers, summarizes the school’s outcomes and aims to provide valuable insights for early-career scientists and engineers taking their first steps in science-informed policymaking. The roles scientists may play at the science-policy interface, the various meeting points (physical and ideological) to interact with decision-makers, tools for more effective communication with non-expert audiences, and the importance of OS and Citizen Science (CS) in integrating scientific information more widely into society are discussed. Based on the participants’ feedback, suggestions are also offered for future events on science and policy, which early-career researchers can implement in their respective universities and countries. Given the strong commitment of participants and their desire to create a community, the authors believe such workshops are essential to give early-career scientists the tools and network to actively engage in the science-policy landscape.

Structures, aims and needs of early career scientists at the German Center for Mental Health

Early career scientists (ECS) are agents of change and driving forces in the promotion of mental health. The German Center for Mental Health (DZPG) is apowerful initiative to guide and support careers in the field of mental health. The DZPG aims to make investments to educate, engage, excite, and empower ECS in an interdisciplinary and interinstitutional scientific community. To achieve this, the ECS Board at the DZPG plays acentral role and consists of 18elected ECS representatives. The ECS culture gives members the right of voice and embraces bottom-to-top ideas and acknowledges autonomy and co-determination. The DZPG academy was developed to facilitate communication and networking and encourage collaboration among ECS members. The DZPG also navigates several key issues, such as equality, diversity, inclusion, family friendliness and work-life balance, which are essential for afunctioning research landscape. The DZPG also extends opportunities to ECS to develop skills and competencies that are essential for contemporary ECS. It complements nationwide support for ECS with funding opportunities, mental health support at work, careers advice and guidance activities. Importantly, the ECS Board is committed to patient and public involvement and engagement, scientific communication and knowledge transfer to multiple settings. The DZPG will contribute to fostering ECS training programs for student and academic exchanges, collaborative research, and pooling of resources to acquire grants and scholarships. It will also support the establishment of hubs for ECS networks and promote the expansion of international competence of ECS in Germany.

The prominent and heterogeneous gender disparities in scientific novelty: Evidence from biomedical doctoral theses

Scientific novelty is the essential driving force for research breakthroughs and innovation. However, little is known about how early-career scientists pursue novel research paths, and the gender disparities in this process. To address this research gap, this study investigates a comprehensive dataset of 277,288 doctoral theses in the biomedical sciences authored by US Ph.D. graduates. Spanning from 1980 to 2016, the data originates from the ProQuest Dissertations & Theses Database. This study aims to shed light on Ph.D. students’ pursuit of scientific novelty in their doctoral theses and assess gender-related differences in this process. Using a combinatorial approach and a pre-trained Bio-BERT model, we quantify the scientific novelty of doctoral theses based on bio-entities. Applying fractional logistic and quantile regression models, this study reveals a decreasing trend in scientific novelty over time and heterogeneous gender disparities in doctoral theses. Specifically, female students consistently exhibit lower scientific novelty levels than their male peers. Under the supervision of female advisors, students tend to produce doctoral theses that exhibit lower levels of novelty compared to those supervised by male advisors. The significant interaction effect of female students and female advisors suggests that female advisors may amplify gender disparities in scientific novelty. Moreover, heterogeneous gender disparities in scientific novelty are identified, with non-top-tier universities displaying more pronounced disparities, while the gender differences at higher percentile ranges of scientific novelty scores were comparatively more minor. These findings indicate a potential underrepresentation of early-career female scientists pursuing novel research. Notably, the outcomes of this study hold significant policy implications for advancing the careers of female scientists.

Children's books for research-based outreach and science communication pedagogy

Abstract. Academics are encouraged to integrate scientific research with the public, but methods of doing so are often transient and insubstantial. Students and future scientists also require training and exposure to the importance of public outreach and science communication within STEM fields. Here, I describe two projects that provide a template for using children's books as an efficient and impactful means of science communication. The first part describes an international research project that culminates in the writing, illustration, and distribution of a children's book. Farzana’s Journey is a children's book based on multidisciplinary research on the pairing of the physical and human systems in coastal Bangladesh. Written, illustrated, and freely distributed in the Bengali language, the book is a place-based tool to teach rural Bangladesh communities about the natural world and our scientific findings. Through the development and distribution of the book, we encouraged collaboration and public outreach with scientists, artists, and students concerned with enhancing educational and social opportunities in rural communities. We also ensure a physical tie to the community after the project's culmination. The book sparks children’s curiosity in the local environment while also demonstrating a means for sustainable educational outreach with impoverished, remote communities. The second part of the paper provides an overview of how this type of science communication can be taught to early-career scientists. Students in an intensive learning undergraduate course produce children's books about a scientific concept or process. I describe the curricular context and layout of the course, the assessment of deliverables, and the impacts of the science storytelling process as a model for teaching communication literacy. Together, these efforts demonstrate the potential impact of children's books on science communication efforts among students, early-career scientists, and local communities.

Inclusive Science Communication Approaches Through an Equity, Diversity, Inclusion, and Social Justice (EDISJ) Lens

Science communication has taken center stage in Science, Technology, Engineering, and Math (STEM) disciplines in the context of public outreach and citizen science. Developing practical communication skills is imperative for all scientists to be highly successful in their careers and more so for underrepresented and Black, Indigenous, and People of Color (BIPOC) professionals in STEM. The program, led by the Engineering and Science Librarian at the University of Victoria (UVic) Libraries, aimed to equip students and early career scientists with critical communication skills by leveraging the unique voices and lived experiences of BIPOC speakers in STEM disciplines. Through this program, a unique toolkit with engaging modules consisting of 30 short videos, each three minutes long (30 x 3) by BIPOC speakers was created to provide broad foundational skills in verbal and visual communication, using an Equity, Diversity, Inclusion, and Social Justice (EDISJ) lens. A two-day conference offered networking and communication development opportunities to students and early-career scientists in STEM disciplines by connecting them with BIPOC STEM leaders and visionaries who promote STEM advocacy. This paper will discuss the methods used in the creation of the toolkit and conference using an EDISJ lens.

Analysis of justification for author order and gender bias in author order among those contributing equally.

First-author publications are important for early career scientists to secure funding and educational opportunities. However, an analysis published in eLife in 2019 noted that female authors are more likely to be placed second even when both authors report they have contributed equally. American Society for Microbiology announced in response that they would require submissions to include a written justification of author order. In this paper, we analyze the resultant data and show that laboratories are most likely to use some combination of alphabetical order, seniority, and chance to determine author order. However, the prevalence of these methods varies based on the research team's geographic location. These findings highlight the importance of equal contributor statements to provide clarity for readers, funding agencies, and tenure committees. Furthermore, this work is critically important for understanding how these decisions are made and provides a glimpse of the sociology of science.

Report on the Marine Imaging Workshop 2022

Imaging is increasingly used to capture information on the marine environment thanks to the improvements in imaging equipment, devices for carrying cameras and data storage in recent years. In that context, biologists, geologists, computer specialists and end-users must gather to discuss the methods and procedures for optimising the quality and quantity of data collected from images. The 4th Marine Imaging Workshop was organised from 3-6 October 2022 in Brest (France) in a hybrid mode. More than a hundred participants were welcomed in person and about 80 people attended the online sessions. The workshop was organised in a single plenary session of presentations followed by discussion sessions. These were based on dynamic polls and open questions that allowed recording of the imaging community’s current and future ideas. In addition, a whole day was dedicated to practical sessions on image analysis, data standardisation and communication tools. The format of this edition allowed the participation of a wider community, including lower-income countries, early career scientists, all working on laboratory, benthic and pelagic imaging. This article summarises the topics addressed during the workshop, particularly the outcomes of the discussion sessions for future reference and to make the workshop results available to the open public.

"Important Enough to Show the World": Using Authentic Research Opportunities and Micropublications to Build Students' Science Identities.

Primarily undergraduate institutions (PUI) often struggle to provide authentic research opportunities that culminate in peer-reviewed publications due to "recipe-driven" lab courses and the comprehensive body of work necessary for traditional scientific publication. However, the advent of short-form, single-figure "micropublications" has created novel opportunities for early-career scientists to make and publish authentic scientific contributions on a scale and in a timespan compatible with their training periods. The purpose of this qualitative case study is to explore the benefits accrued by eight undergraduate and master's students who participated in authentic, small-scale research projects and disseminated their work as coauthors of peer-reviewed micropublications at a PUI. In these interviews, students reported that through the process of conducting and publishing their research, they developed specific competencies: reading scientific literature, proposing experiments, and collecting/interpreting publication-worthy data. Further, they reported this process enabled them to identify as contributing members of the greater scientific community.

PyRTlib: an educational Python-based library for non-scattering atmospheric microwave radiative transfer computations

Abstract. This article introduces PyRTlib, a new standalone Python package for non-scattering line-by-line microwave radiative transfer simulations. PyRTlib is a flexible and user-friendly tool for computing down- and upwelling brightness temperatures and related quantities (e.g., atmospheric absorption, optical depth, opacity, mean radiating temperature) written in Python, a language commonly used nowadays for scientific software development, especially by students and early-career scientists. PyRTlib allows for simulating observations from ground-based, airborne, and satellite microwave sensors in clear-sky and in cloudy conditions (under non-scattering Rayleigh approximation). The intention for PyRTlib is not to be a competitor to state-of-the-art atmospheric radiative transfer codes that excel in speed and/or versatility (e.g., ARTS, Atmospheric Radiative Transfer Simulator; RTTOV, Radiative Transfer for TOVS (Television Infrared Observation Satellite (TIROS) Operational Vertical Sounder)). The intention is to provide an educational tool, completely written in Python, to readily simulate atmospheric microwave radiative transfer from a variety of input profiles, including predefined climatologies, global radiosonde archives, and model reanalysis. The paper presents quick examples for the built-in modules to access popular open data archives. The paper also presents examples for computing the simulated brightness temperature for different platforms (ground-based, airborne, and satellite), using various input profiles, showing how to easily modify other relevant parameters, such as the observing angle (zenith, nadir, slant), surface emissivity, and gas absorption model. PyRTlib can be easily embedded in other Python codes needing atmospheric microwave radiative transfer (e.g., surface emissivity models and retrievals). Despite its simplicity, PyRTlib can be readily used to produce present-day scientific results, as demonstrated by two examples showing (i) an absorption model comparison and validation with ground-based radiometric observations and (ii) uncertainty propagation of spectroscopic parameters through the radiative transfer calculations following a rigorous approach. To our knowledge, the uncertainty estimate is not provided by any other currently available microwave radiative transfer code, making PyRTlib unique for this aspect in the atmospheric microwave radiative transfer code scenario.

A temporal-agential lens on the reintegration experiences of Chinese early career STEM returnees

ABSTRACT Recently, there has been a massive trend of Chinese international PhD graduates returning to China’s research-intensive universities that are undergoing systemic reforms and aspire to flourish in the global higher education field. Taking into account this changing academic environment and field-specific mobility patterns, the study examines the case of 14 early career science, technology, engineering, and mathematics (STEM) returnees employed in one of such institutions. Informed by a temporal perspective on agency, we present their academic reintegration experiences negotiated on national/local and institutional levels and unfolding in multiple realms of their post-return lives. Findings derive three prominent themes concerning their encounter with Chinese work culture encompassing entrenched and emerging features, embeddedness into local academic communities of exchange, and navigation of transformative possibilities within the institutional framework of career excellence. Importantly, the study underscores that structures internal to the university can profoundly shape the way returnees leverage their cosmopolitan assets and the direction they take in envisioning their transnationally viable career paths.

Sentinel protist taxa of the McMurdo Dry Valley lakes, Antarctica: a review

High-latitude meromictic lakes such as those in the Antarctic McMurdo Dry Valleys (MDV) harbor aquatic ecosystems dominated by the microbial loop. Within this habitat, which is limited year-round by light and nutrients, protists, or single celled eukaryotes, play outsized roles in the food web as the dominant primary producers and the apex predators. Thus, the MDV lake ecosystem represents an ideal system to study the role of sentinel protist taxa in carbon and nutrient cycling. The perennially ice-covered lakes are part of the McMurdo Long Term Ecological Research (McM LTER; mcmlter.org) established in 1993. In this review we will highlight the diversity and trophic roles of the MDV lake protist community and compare environmental factors driving spatiotemporal patterns in key protist taxa in two lakes within the McM LTER, Lakes Bonney and Fryxell. We will then discuss lessons learned from manipulated experiments on the impact of current and future climate-driven environmental change on sensitive protist taxa. Last, we will integrate knowledge gained from 25 years of lab-controlled experiments on key photosynthetic protists to extend our understanding of the function of these extremophiles within the MDV aquatic food webs. Our research group has studied the distribution and function of the MDV microbial community for nearly two decades, training the next generation of scientists to tackle future problems of these globally significant microbes. This review article will also highlight early career scientists who have contributed to this body of work and represent the future of scientific understanding in the Anthropocene.

Chapter 11: Astrobiology Education, Engagement, and Resources.

Although astrobiology is a relatively new field of science, the questions it seeks to answer (e.g., "What is life?" "What does life require?") have been investigated for millennia. In recent decades, formal programs dedicated specifically to the science of astrobiology have been organized at academic, governmental, and institutional scales. Constructing educational programs around this emerging science relies on input from broad expertise and backgrounds. Because of the interdisciplinary nature of this field, career pathways in astrobiology often begin in more specific fields such as astronomy, geology, or biology, and unlike many other sciences, typically involve substantial training outside one's primary discipline. The recent origin of astrobiology as a field of science has led to strong collaborations with education research in the development of astrobiology courses and offers a unique instructional laboratory for further pedagogical studies. This chapter is intended to support students, educators, and early career scientists by connecting them to materials and opportunities that the authors and colleagues have found advantageous. Annotated lists of relevant programs and resources are included as a series of appendices in the supplementary material.

How the EU Soil Observatory contributes to a stronger soil erosion community

New policy developments have emerged in relation to soil conservation after 2020. The Common Agricultural Policy (CAP) 2023–2027, the proposal for a Soil Monitoring Law and the mission ‘A Soil Deal for Europe’ have shaped a new policy framework at EU level, which requires updated assessments on soil erosion and land degradation. The EU Soil Observatory (EUSO) successfully organised a scientific workshop on ‘Soil erosion for the EU’ in June 2022. The event has seen the participation of more than 330 people from 63 countries, addressing important topics such as (i) management practices, (ii) large scale modelling, (iii) the importance of sediments in nutrient cycle, (vi) the role of landslides and (v) laying the foundations for early career scientists. As a follow up, among the 120 abstracts submitted in the workshop, we received fifteen manuscripts, out of which nine were selected for publication in the present special issue. In this editorial, we summarize the major challenges that the soil erosion research community faces in relation to supporting the increasing role of soils in the EU Green Deal.

In Berlin we met again, The YM Leadership Meeting glamoring the EPS forum of 2024!

The Young Minds project of the European Physical Society is committed to its foundation as a global connecting hub for physicists and early career scientists from every country in Europe and its surroundings. Therefore, and as every year, the Young Minds project hosts the annual leadership meeting where representatives from every student-run chapter (section) are invited to join us for two outstanding days of scientific research skills and career development in addition to priceless networking opportunities.

Research trend on marine zooplankton in Indonesian Waters: A systematic review

Research on marine zooplankton in Indonesian waters was conducted in the 19th century. However, there is limited information regarding evaluating the research trends and notable scientists involved in this area. This study aims to know the research trend on marine zooplankton research in Indonesian waters. This study analyzed publications that were included in the Scopus database from 1900 to 2021. A systematic review was undertaken using a three-stage procedure including identification, screening, and final following PRISMA chart. The final list was analysed in terms of topics of research, keywoards, location, time of publication, and authorship.. We found that the research trend was changed. During the early stages of the study, there was a prevalent focus on studying both taxonomy copepods and parasite Copepods. However, in recent times, there has been a shift towards favoring the plankton ecology. Despite being a hotspot for marine biodiversity, Indonesia only had a few taxonomists, therefore it was overlooked when marine zooplankton was discovered in its seas. We also found that most of the new finding species come from copepods whereas the other taxa of zooplankton remain undescribed or misidentification. Additionally, young scientists pay less attention to the study of taxonomy. To address these problems, priority is given to intensive training for early-career scientists. Comprehensive approaches using morphological traits and genetic tools will solve this issue.

Creative quality matters: Teaching early-career scientists to think in multiple directions

Divergent thinking (DT) is an essential cognitive ability to nurture creativity and is often used as an indicator of creative potential. This study examined early-career scientists’ ability to generate ideas in multiple directions during a 10-week creativity course. Three alternate-form exercises of two formats (“Many uses” and “What is”) – conducted at the beginning, middle, and end of the course – were used to assess DT evolution of biology PhD students (n = 21). Responses to these exercises were analyzed qualitatively and quantitatively using traditional DT scores, and theory-driven dimensions representing the ideational hyperspace. Results showed that PhD students’ fluency, originality, and peak originality greatly increased from Exercise 1 to Exercise 2, however, in Exercise 3, which involved the “What is” task, growth was not statistically significant in any of the three DT scores. Although overall fluency increased, correlations with originality and peak originality became weaker as the course advanced and not significant in the last exercise. The ideational hyperspace analysis revealed that PhD students generated ideas mostly on six conceptual categories: Practical, Serious, Non-Synthetic, NEMBL, Feasible, and Domain-General; five of which had been negatively correlated with originality. Findings suggested that DT should be supported with the practice of cognitive flexibility and deliberately thinking about specific cognitive processes to improve early-career scientists’ ability to generate both more and highly original ideas. Considerations for teaching creativity to scientists are discussed.

A review of the oceanographic structure and biological productivity in the southern Okhotsk Sea

The southern Okhotsk Sea is one of the best fishing grounds in Japan, and the biogeochemistry, primary productivity, and physical aspects of this region have been heavily researched. However, a comprehensive review of the literature has not been written since that by doctor Takatoshi Takizawa more than 40 years ago (1982). This review actualizes the share–ground knowledge of the influence of oceanographic conditions on the primary productivity of the area. This review includes topics from physical/chemical oceanography and hydrobiology, focusing on the complex oceanological structures that support the high primary productivity of the southern Okhotsk Sea. It is known that the formation of all water masses is ultimately a consequence of the seasonal interchange of the Soya Warm Current and the East Sakhalin Current. However, it was revealed that there may be over- or under-estimations in different material and heat fluxes among water masses, especially regarding the dense Soya Warm Current. Recent studies have investigated the formation mechanisms of different water masses using chemical tracers, particularly radionuclides. Although promising if properly combined with traditional techniques, more isotopes or compounds are required to derive further conclusions. In terms of biological aspects, the high seeding potential of Thalassiosira after sea ice melting has been featured by many authors, and it was considered as the reason for its highest abundance in spring. The total carbon mass flux, which is essential for scallop farming, is highest in April–June, normally 120–160 mg C m−2day−1. The total carbon mass flux is maximum (up to 1165 mg C m−2day−1) after the spring bloom peak, and the spring bloom is strongly linked to sea ice retreatment. It was identified that the routes of 134Cs towards the Intermediate Cold Water, the formation mechanism of the Cold Water Belt, and the solubilization process of sea ice-carried particulate Fe require further research. Three major potential threats were identified, including the appearance of alien toxic species, a decrease in sea ice production in the northern parts of the Okhotsk Sea, and offshore gas and oil drilling northeastern of the Sakhalin Island. Publicly available scientific knowledge about the biogeochemistry of the southern Okhotsk Sea and its relationship with its rich primary productivity was actualized to 2022, anticipating that this work will become the starting line for many early career scientists endeavoring in interdisciplinary studies.

BUILDING BRIDGES, CATALYZING RESEARCH, EMPOWERING ALL AGES: NIA SESSION FOR EARLY-CAREER RESEARCHERS

Abstract The National Institute on Aging (NIA) at the National Institutes of Health, Department of Health and Human Services, supports biomedical and behavioral research with a lifespan focus. NIA research seeks to understand the basic processes of aging, improve prevention and treatment of diseases in later life, and improve the health of older persons, in addition to an emphasis on Alzheimer’s disease and related dementias. NIA supports a variety of training and career development opportunities for students, junior faculty, early-career investigators, and emerging scholars. In this session, we will provide an overview of NIA-funded research, followed by a presentation on funding mechanisms and strategies to consider when applying for extramural grants, particularly for early-career scientists at multiple career stages. Finally, attendees will be able to join any number of breakout group discussions (led by extramural NIA training staff and program officials) to discuss programs, initiatives, mechanisms, and/or policies specific to various career paths.