Dysphagia For Liquids Research Articles

Guillain-Barrè Syndrome-Retrospective Analysis of Data from a Cohort of Patients Referred to a Tertiary Care Pediatric Neuromuscular Center from 2000 to 2017: Electrophysiological Findings, Outcomes, and a Brief Literature Review.

Background and Objectives: Guillain-Barré syndrome (GBS) is the most frequent cause of acute flaccid paresis in children. The aim of this study was to describe the clinical and electrophysiological findings and outcomes of children with GBS diagnosed in our unit. Moreover, the literature on pediatric GBS cases from the past 5 years was reviewed. In this retrospective study, we reported data on 12 patients (9 male and 3 female patients; mean age: 5 y, 4 mo; range: 9 mo-11 y) clinically diagnosed at the Child Neurology Unit of the AUSL-IRCCS of Reggio Emilia, Italy, between 2000 and 2017 and a brief analysis/comparison with data from the literature. Materials and Methods: Data were collected from medical charts. Results: In our cohort, male patients were more frequent than female ones (9 vs. 3), and upper respiratory tract infection (n = 8, 66.7%) was the most frequent triggering factor. The main clinical symptoms on admission were distal lower limbs' weakness with gait difficulties (83.3%), pain (50%), upper limbs' weakness (50%), and dysphagia for liquids (25%). Peripheral neurophysiological studies revealed acute inflammatory demyelinating polyradiculoneuropathy (AIDP) in 66.6% of the children, acute motor and sensory axonal neuropathy (AMSAN) in 25%, and acute motor axonal neuropathy (AMAN) in 8.3%. Ten individuals (83.3%) received timely treatment with intravenous immunoglobulins (IVIG), and, out of these ten patients, 58% received concomitant treatment with IV methylprednisolone because of a progressive disease course. Complete remission was observed in the majority of individuals (91.6%) within 6 months of symptom onset. Conclusions: Different subtypes of GBS can affect children; however, the outcome is usually positive. Early treatment appears to be important for a favorable outcome.

Case Report and Therapeutic Approach for Achalasia Cardia

Achalasia cardia is an uncommon esophageal motility disorder characterized by the impaired relaxation of the lower esophageal sphincter (LES) and the absence of peristaltic contractions in the esophageal body. This report presents a case of a 42-year-old woman with a prolonged history of dysphagia and regurgitation of solids and liquids. The patient's clinical history included a 10-year history of neck swelling, hypothyroidism, and diabetes mellitus. Physical examination and laboratory investigations revealed normal findings, except for elevated blood glucose, thyroid hormone levels, and thyroid-stimulating hormone (TSH) levels. An esophagogram showed proximal dilation of the distal esophagus with a contrast fluid level, and endoscopy revealed a tight LES, which was difficult to pass through. Based on these findings, the diagnosis of achalasia cardia was established. Initial medical management with nitrates and proton pump inhibitors did not provide significant improvement. Subsequently, the patient underwent laparoscopic Heller's myotomy with fundoplication, which successfully resolved her dysphagia symptoms. This case report highlights the diagnostic challenges and the importance of a multidisciplinary approach in managing achalasia cardia. It emphasizes the role of surgical interventions, such as Heller's myotomy with fundoplication, in alleviating symptoms and restoring esophageal function when conservative medical management fails

Can esophageal symptoms be associated with sleep disorders in esophageal rare diseases?. A prospective case-control study across achalasia, eosinophilic esophagitis and gastroesophageal reflux disease.

The association between sleep disorders and gastroesophageal reflux disease (GERD) has been the subject of several studies; however, quality of sleep has been under investigated in adult patients with eosinophilic esophagitis (EoE) and achalasia (Ach). This study aims to evaluate the prevalence of sleep disturbances in patients with EoE and Ach compared to GERD patients and their associations with esophageal symptoms. Thirty Ach patients and 20 EoE patients were consecutively enrolled and compared to a control group of 46 GERD patients. All patients underwent a standardized questionnaire investigating the intensity-frequency scores (from 0 to 6) of esophageal symptoms, Pittsburgh Sleep Quality Index (PSQI) questionnaire to assess sleep quality, a SF-36 survey to investigate health-related quality of life (both physical (PCS) and mental (MCS) component scales), Beck Depression Inventory-II (BDI-II) and State Trait Anxiety Inventory (STAI) to assess the presence of depression and anxiety. The prevalence of sleep disturbances was 66.7% in Ach, 50% in EoE, and 60% in GERD patients (P=0.5). PCS and MCS significantly correlated with depression and anxiety levels. Ach patients showed significantly higher intensity-frequency scores of dysphagia for solids (Scheffè P<0.001) and liquids (Scheffè P<0.001) than EoE and GERD patients. No differences were found in the intensity-frequency scores of the esophageal symptoms among the three groups. There was a significant association between worst quality of sleep and higher intensity-frequency scores of regurgitation. Sleep disturbances are common with Ach and EoE, similar to GERD patients. Moreover, there is a significant association between regurgitation, a typical GERD symptom, and poor quality of sleep, independent from diagnosis.

DYMUS-Hr self-assessment questionnaire (Croatian version) for dysphagia in multiple sclerosis-validity, reliability, and cross-cultural adaptation.

The prevalence of dysphagia in the early phases of multiple sclerosis is 30-40%, with an estimated of 30% of cases going undiagnosed cases. Such complications can lead to malnutrition, dehydration, and aspiration pneumonia and have a great impact on the quality of life and psychosocial status of a person with MS. The aim of this study was the validation of dysphagia in multiple sclerosis self-assessment questionnaire (DYMUS) in the Croatian language. The cross-cultural adaptation process included a back-forward translation technique of the English language version of DYMUS to the Croatian language, with pilot testing on 30 participants. The validity and reliability of the Croatian version of DYMUS (DYMUS-Hr) was applied to 106 MS patients, with comparison to the Eating Assessment Tool (EAT10), the Water Swallowing Test (WST), and a dichotomous self-assessment question. In the assessment of test-retest reliability, 99 MS patients were included. Internal consistency of DYMUS-Hr was very good (Cronbach's alpha-0.837); Cronbach's alpha was 0.819 for the "dysphagia for solids", and 0.562 for "dysphagia for liquids" subscale. A significant correlation (p < 0.001) was found between DYMUS-Hr and EAT10 (Spearman's rho-0.787), and WST (Spearman's rho-0.483). Construct validity was assessed with the self-assessment question and interpreted with the Mann-Whitney U test. Test-retest reliability showed moderate to substantial Cohen's Kappa reliability for each item. DYMUS-Hr is a valid and reliable screening assessment tool for patients with MS. There is a general lack of awareness about dysphagia symptoms among patients with MS; consequently, this disorder receives inadequate attention and often goes untreated.

Clinicopathological correlation of aspartate aminotransferase-to-platelet ratio (APRI) and aspartate aminotransferase-to-alanine aminotransferase ratio (AAR) with survival in esophageal carcinoma patients: a retrospective cohort analysis of 951 patients.

The objectives of the current study were to associate novel markers, including aspartate aminotransferase-to-platelet ratio (APRI) and aspartate aminotransferase-to-alanine aminotransferase ratio (AAR) with survival in esophageal malignancy. A retrospective study in a tertiary care hospital (single-center) included 951 patients having diagnosed esophageal carcinoma of any age group. The median (interquartile range) age of study participants were 50 (38-60) years, including 43% males and 57% female patients, while the median (interquartile range) levels of AAR and APRI were 0.97 (0.81-1.25) and 0.19 (0.13-0.29), respectively. AAR was found to be higher in dysphagia for solids only and dysphagia for both liquids and solids rather than liquids only (P=0.002), while other associations included well-differentiated tumor grade (P=0.011), finding of esophageal stricture on esophagogastroduodenoscopy (P=0.015), and characteristic of mass on computerized tomography scan being both circumferential and mural (P=0.005). APRI was found to be higher in adenocarcinoma (P=0.038), and finding of circumferential±ulcerated mass on esophagogastroduodenoscopy (P<0.001). On survival analysis, adenocarcinoma (P<0.001), luminal narrowing (P=0.002), AAR greater than 1.0 (P=0.006), and APRI greater than 0.2 (P=0.007) were found to be poor survival predictors. On Cox proportional hazards regression, APRI was found to be more associated with poor survival than AAR (Hazard ratio: 1.682, 1.208-2.340, P=0.002). This study correlated clinical and pathological features of esophageal malignancy with noninvasive markers of hepatic function.

Implementation of a free water protocol at a long term acute care hospital

This feasibility study aimed to trial a Free Water Protocol (FWP) for patients with thin liquid dysphagia in the Long-Term Acute Care Hospital (LTACH) setting. Patients with dysphagia are often prescribed thickened liquids to avoid or mitigate aspiration. While this clinical intervention can minimize the risk of aspiration pneumonia (PNA), it is generally not well received by patients. As such, the goal of this study was to determine if patients who knowingly aspirate thin liquids can safely tolerate thin liquid water, and if so, to what degree of benefit. The study assessed for adverse events, fluid intake, hydration status, quality of life, and overall swallow function outcomes. These measurements were taken over a 7 day trial period using inventories, lab work, clinical judgment, and observation. Ten participants were enrolled in this study with 9 having sufficient data for analysis (n = 9). No adverse events related to the FWP were observed, and patients saw improved total fluid intake (P = 0.0074), swallow-related quality of life (P = 0.0273), and overall swallow function (P = 0.0002). The results in this feasibility study allowed for the hospital wide implementation of the FWP and laid out the groundwork for future studies looking at longitudinal effects of a FWP.

Achalasia in the emergency room: An infrequent disease with typical images

A 36 year old male with no medical history was referred to the Emergency Room (ER) with complaints of vomiting and progressive dysphagia for solids and liquids over a two week period. The patient denied other symptoms.

Atypically Gastric Tumor with Unexpected Evolution: A Case Report

We present the case of a 62 year old male with no relevant medical history, who for the last two months had been complaining of dysphagia for solids and liquids, marked physical fatigue, oliguria. Clinical examination revealed palor and dehydrated skin, as well as a tumoral mass of 10/10 cm palpable in the upper abdomen. Upper digestive endoscopy was performed, showing a vegetant lesion of 6 cm on the gastric angle, with a central ulcer of 4 cm. The oesophagus and duodenum were normal, and Helicobacter pylori test was negative. Histological exam from the gastric lesion revealed diffuse large-cell malignant lymphoid tumoral proliferation, with tumoral cells infiltrating the mucosa between the glands. Immunohistochemical analysis diagnosed B cell lymphoma. CT scan of the thorax, abdomen and pelvis was performed, revealing multiple tumors involving the gastric walls, the posterior parietal peritoneum, the intra-peritoneal fat, the pancreatic tissues and the right antero-inferior mediastinum, as well as multiple adenopathies on both sides of the diaphragm and ascites. We performed paracentesis, and malignant cells were detected in the peritoneal fluid. Bone marrow biopsy was normal. The patient was referred to the hematology department for treatment. He received chemotherapy including CHOP followed by RICE with the disappearance of the gastric tumor on upper endoscopy and the disappearance of peritoneal, mediastinal and pancreatic region tumors with the persistence of a circumferential thickening of the horizontal gastric region walls on CT reevaluation.

Using Downgaze Palsy Progression Rate to Model Survival in Progressive Supranuclear Palsy-Richardson Syndrome.

Rapid development of downgaze palsy, the most specific symptom of progressive supranuclear palsy (PSP), has been associated with shorter survival in small studies. We hypothesized that the progression rate of downgaze palsy and other disease features could predict survival if assessed soon after the onset of downgaze palsy in a large data set. We used a longitudinal database of 414 patients with probable PSP-Richardson syndrome from 1994 to 2020. The data set comprised demographics and, for each visit, 28 PSP Rating Scale (PSPRS) items and PSP stage scores. We calculated the rate of progression of each PSPRS item as its item score when the downgaze item first reached 1 or more (on a 0-4 scale) divided by disease duration at that point. Multivariate Cox regression was applied to identify variables independently associated with survival. We also explored the progression pattern of total PSPRS and downgaze palsy scores with disease course. Independently associated with shorter survival were older onset age and faster progression of downgaze palsy, dysphagia for liquids, difficulty in returning to seat, and PSP stage. Patients with survival duration within 1 year of the median survival (6.58 years) showed approximately linear progression of the PSPRS score and downgaze palsy score during years 2 through 6 of the disease course. Older onset age and faster progression of downgaze palsy and several axial features are associated with shorter survival. The disease typically progresses in approximately linear fashion during years 2 through 6. These results may aid study design and patient counseling. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Validation of the Czech Version of the Dysphagia in Multiple Sclerosis Questionnaire (DYMUS).

Dysphagia is a common symptom of neurological disease, including multiple sclerosis (MS). The DYsphagia in MUltiple Sclerosis (DYMUS) questionnaire was developed as a screening tool for swallowing problems. The purpose of the present study was to validate the Czech version of the DYMUS questionnaire. We validated the questionnaire on a sample of 435 patients with MS and 135 healthy controls (HC) chosen by accidental sampling from larger, long-term studies conducted by the Prague MS Center. For the purposes of this study, we used both electronic (primary method of distribution) and paper-based (backup) versions of the questionnaire. The internal consistency of the whole scale was satisfactory (Cronbach’s α =0.833). The DYMUS mean score in HC was 0.215 (standard deviation [SD] = 0.776). Normative data suggested a cut-off value for dysphagia between 1 and 2 points. Principal component analysis (PCA) showed a two-factor structure of the adapted scale. However, the structure did not completely correspond to the originally proposed dimensions of dysphagia for solids and liquids; our data supported dropout of item Q10. Criterion validity was proved by the difference in dysphagia between HC and patients MS (U = 25,546, p < 0.001) and by a positive correlation with the EDSS (Kendall’s tau-b = 0.169, p < 0.001) and other patient-reported outcomes. The Czech version of the DYMUS questionnaire is a valid and reliable tool for evaluating swallowing impairment in Czech-speaking patients with MS. Moreover, the questionnaire can be administered electronically, with a paper-based backup.Supplementary InformationThe online version contains supplementary material available at 10.1007/s00455-022-10530-5.

S2279 Bisphosphonate-Induced Esophageal Stricture: A Situation of Unusual Severity

Introduction: Pill-induced esophageal stricture is a rare but well-documented condition associated with various causative agents. Potassium chloride and quinine are the most common causes and are more likely to produce stricture than other agents (such as Bisphosphonates and Tetracyclines). Predisposing factors include older age, male gender, sustained release medication formulation and prior esophageal structural abnormality. Case Description/Methods: An 80-year-old female with history of osteoporosis taking Alendronate presented with 3 weeks history of progressive solid and liquid dysphagia and endorsed 20 lbs weight loss. The patient reported inability to keep any food down for 3 days prior to presentation and had begun requiring the use of oral suction at bedside due to inability to swallow her own saliva. She appeared clinically stable on exam. He laboratory study showed profound electrolytes abnormality. Esophagogastroduodenoscopy (EGD) showed circumferential mid esophageal ulceration that progressed to a narrow stricture that could not be traversed even with a stricture scope (5.9 mm diameter). Alendronate was discontinued and the patient was treated with liquid formulation omeprazole twice daily. Her diet was slowly advanced from clear liquid to mince. Her hospitalization was prolonged because she developed refeeding syndrome after reinitiating her diet. She was discharged after her electrolytes normalized. Two months after her initial presentation, her dysphagia had completely resolved. A repeat EGD revealed a tapered benign-appearing stricture in the distal esophagus, which was traversed without resistance with a standard gastroscope. Balloon dilation was performed to a diameter of 13 mm without creation of a mucosal rent (Figure). Discussion: This case highlights the severity and potential rapid progression of pill-induced esophageal damage caused by Bisphosphonate therapy. Esophagitis or esophageal mucosa ulceration are common. The mucosal damage is caused by direct contact of the drug with the esophageal mucosa. Reports of stricture formation from Alendronate use are rare. Stricture formation may be caused by chronic inflammation from long-term use. Clinicians should have a low index suspicion in a high-risk patient presenting with classic symptoms of dysphagia. In addition, patients should receive counseling on proper pill ingestion technique to prevent potential damage.Figure 1.: See attachment.

DIFFUSE LEIOMYOMATOSIS OF THE ESOPHAGUS – A RARE CAUSE OF PEDIATRIC PSEUDOACHALASIA.

Achalasia is an esophageal motility disorder with progressive dysphagia for liquids and solids. It occurs due to absence or degeneration of myenteric plexus of nerves in the distal esophagus. The term pseudoachalasia refers to achalasia like symptoms and imaging manifestations caused by diseases other than aganglionosis [1]. It can be due to stricture, extrinsic compression, malignant neoplasm or proliferation of smooth muscle cells as in leiomyomatosis. Diffuse leiomyomatosis of the esophagus is a very rare cause of pseudoachalasia and requires total esophagectomy with gastric pull through surgery. We present a rare case of a seven year old boy with diffuse leiomyomatosis of esophagus presenting with pseudoachalasia, aspiration pneumonitis and bronchiectasis secondary to recurrent aspirations.

Knowledge and Practices of Nurses Regarding the Management of Elderly Patient with Dysphagia at Tertiary Care Hospital Lahore

Introduction: Dysphagia is the subjective sensation of difficulty swallowing and there are many potential etiologies. It also negatively impacts quality of life and decreases work productivity, and it is the 10th leading cause of ambulatory care visits in the United States among gastrointestinal (GI) symptoms, with more than 600,000 visits annually. Method: Quantitative cross-sectional study design was used to determine the knowledge and practices of nurses regarding the management of elderly patient with dysphagia at tertiary care hospital. 111 nurses working at gastro, medical and surgical wards were selected as sample. Data was collected through the standardized well adopted 14 item questionnaires. Results: Results revealed that only (52) 47 % nurses have good knowledge and majority (59) 53% nurses have poor knowledge. Further the practices of nurses regarding dysphagia management analysis revealed that 41 % nurses have adequate practices and majority 59% nurses have inadequate practices. Conclusions: The results of the present study showed that the participants had a moderate/low knowledge practice of the definition, diagnosis, and clinical management of liquid dysphagia and inadequate. So necessary tools must be provided for their training in this field. This training must be multidisciplinary and should be directed to all professionals who provide healthcare to patients with liquid dysphagia. Keywords: knowledge, practices, dysphagia, management, elderly DOI: 10.7176/JHMN/100-04 Publication date: May 31 st 2022

S2073 Dedifferentiated Liposarcoma Presenting as Dysphagia and Weight Loss: Common Symptoms of an Uncommon Diagnosis

Introduction: Liposarcoma is a malignant soft-tissue tumor that frequently occurs in extremities and retroperitoneum but rarely affects the GI tract. We report a case of dedifferentiated liposarcoma manifesting as dysphagia and early satiety. Case Description/Methods: A 76 year old woman was referred for progressively worsening dysphagia for solids and liquids, early satiety and unintentional weight loss. She denied acid reflux symptoms, regurgitation, odynophagia or chest pain. She never smoked cigarettes nor consumed alcohol. Physical examination did not show cervical, supraclavicular or axillary lymphadenopathy. Esophagogastroduodenoscopy (EGD) showed an area of moderate to severe extrinsic compression in the lower esophagus from 31 cm to 38 cm from the incisors (Figure 1A). Contrast enhanced computed tomography (CT) scan of the chest revealed a 6 × 7 cm solid homogeneous mass in the lower middle/posterior mediastinum, laterally displacing the esophagus and the descending thoracic aorta, with anterior displacement of the heart (Figure 1B). No pathological lymphadenopathy was seen. Endoscopic ultrasound (EUS) showed a hypoechoic and homogenous mass with smooth borders. Fine needle aspiration (FNA) was performed (Figure 1C) for pathological diagnosis. Histopathology of the mass demonstrated a hypocellular infiltrate of pleomorphic cells in a loose collagenous matrix. There was no overt evidence of lipogenic differentiation, and mitotic activity was inconspicuous (Figure 1D). By immunohistochemistry, neoplastic cells were negative for epithelial, vascular, neural, and melanocytic markers. Fluorescent in-situ hybridization (FISH) detected MDM2 amplification in the formalin-fixed, paraffin-embedded tumor sample (Figure E), compatible with a diagnosis of dedifferentiated liposarcoma (DDL). Metastatic lesions were subsequently identified (AJCC stage IV). Discussion: Dedifferentiated liposarcoma (DDL) is one of the four major subtypes of liposarcomas. DDL typically has the appearance of undifferentiated pleomorphic or spindle cell sarcoma, and is associated with more aggressive clinical behavior and with a greater propensity for local recurrence and metastasis. The lack of specific symptoms can lead to delay in diagnosis. Systemic therapy with doxorubicin or other anthracyclines remains the treatment mainstay. The patient is currently receiving doxorubicin-based systemic therapy and under close clinical surveillance. This case highlights potential rare presentations of liposarcomas affecting the GI tract.Figure 1.: CT scan chest showing soft tissue mass in the anterior mediastinum.

652 LAPAROSCOPIC FUNDOPLICATION IS EFFECTIVE TREATMENT FOR PATIENTS WITH GASTROESOPHAGEAL REFLUX AND ABSENT ESOPHAGEAL CONTRACTILITY

Abstract Anti-reflux surgery in the setting of preoperative esophageal dysmotility is contentious due to fear of persistent long-term dysphagia, particularly in individuals with an aperistaltic esophagus (absent esophageal contractility). Emerging evidence suggests fundoplication is safe and effective in patients with esophageal dysmotility. This study aimed to determine the long-term postoperative outcomes following fundoplication in patients with absent esophageal contractility versus normal motility. Methods A case control study was performed, using a prospectively maintained database to identify all (40) patients with absent esophageal contractility on preoperative manometry who subsequently underwent fundoplication (36 anterior partial, 4 Nissen). Cases were propensity matched based on age, gender, and fundoplication type with another 708 patients who all had normal motility. Groups were assessed using prospective symptom assessment questionnaires to assess heartburn, dysphagia for solids and liquids, regurgitation, and satisfaction with surgery. Outcomes were compared at baseline and at 1, 5 and 10 years follow-up. Results Across follow-up to 10 years, no significant differences were found between the two groups for any of the assessed postoperative symptoms. Multivariate analysis found that patients with absent contractility had worse preoperative dysphagia (adjusted mean difference 1.09, p = 0.048), but postoperatively there were no significant differences in dysphagia scores at 5 and 10 year follow-up. No differences in overall patient satisfaction were identified across the follow-up period. Conclusion Laparoscopic anterior partial fundoplication in patients with absent esophageal contractility achieves acceptable symptom control without significantly worse dysphagia compared to patients with normal contractility. Patients with medically refractory reflux who have absent contractility should still be considered for surgical intervention.

Laparoscopic Fundoplication Is Effective Treatment for Patients with Gastroesophageal Reflux and Absent Esophageal Contractility

BackgroundAnti-reflux surgery in the setting of preoperative esophageal dysmotility is contentious due to fear of persistent long-term dysphagia, particularly in individuals with an aperistaltic esophagus (absent esophageal contractility). This study determined the long-term postoperative outcomes following fundoplication in patients with absent esophageal contractility versus normal motility. MethodsA prospective database was used to identify all (40) patients with absent esophageal contractility who subsequently underwent fundoplication (36 anterior partial, 4 Nissen). Cases were propensity matched based on age, gender, and fundoplication type with another 708 patients who all had normal motility. Groups were assessed using prospective symptom assessment questionnaires to assess heartburn, dysphagia for solids and liquids, regurgitation, and satisfaction with surgery, and outcomes were compared. ResultsAcross follow-up to 10 years, no significant differences were found between the two groups for any of the assessed postoperative symptoms. Multivariate analysis found that patients with absent contractility had worse preoperative dysphagia (adjusted mean difference 1.09, p = 0.048), but postoperatively there were no significant differences in dysphagia scores at 5- and 10-year follow-up. No differences in overall patient satisfaction were identified across the follow-up period. ConclusionLaparoscopic partial fundoplication in patients with absent esophageal contractility achieves acceptable symptom control without significantly worse dysphagia compared with patients with normal contractility. Patients with absent contractility should still be considered for surgery.

Knowledge and Practice of Health Professionals in the Management of Dysphagia.

The aim of this study was to determine healthcare providers’ knowledge and practices about dysphagia. A descriptive cross-sectional study was carried out based on a self-administered and anonymous questionnaire addressed to healthcare providers in Spain. A total of 396 healthcare providers participated in the study. Of these, 62.3% knew the definition of dysphagia as a swallowing disorder. In addition, up to 39.2% of the participants reported that they did not know whether the EatingAssessmentTool (EAT-10) dysphagia screening test was usedin their own clinical settings. Similarly, up to 49.1% of them did not know the ClinicalExaminationVolume-Viscosity (MECV-V) method. Nearly all participants (98.8%) reported that thickeners must be used forall liquids administered to patients. A higher percentage of respondents based the choice of texture on patient’s tolerance (78.2%) rather than on the MECV-V result (17.3%). In addition,76.4% of the professionals had witnessed a bronchoaspiration; after it, 44.4% (n = 175) of them reported the appearance of pneumonia, and 14.5% (n = 57) the death of the patient (p = 0.005). The participants revealeda moderate/low knowledge ofthe definition, diagnosis, and clinical management of liquid dysphagia, which indicates some room for improvements.

"Eppur si muove" - Clinical case: evolutionary "saga" during the last 6 years: posttraumatic subdural hematoma, decompressive craniectomy, right hemiplegia and aphasia, cranioplasty, hydrocephalus and porencephaly, post-traumatic encephalopathy - in remission

The case reports a 59-year-old male patient who suffered a severe head injury (affirmative by accidental fall from 3 m) with multiple hemorrhagic lesions (bifrontal, bioccipital, biparieto-temporal) and left cerebral subdural hematoma, requiring a large fronto- temporo-parietal decompressive craniotomy for the mass lesion evacuation. Cranioplasty was performed after 6 months. The paper synthesizes the evolution over six years of follow-up (12 in-patient admissions and 4 out-patient evaluations), like in a neurorehabilitation cinematographic “saga”. The posttraumatic encephalopathy had a peculiar evolution, sugestively compared with the humps of a camel: the brain injury (determined coma, right hemiplegia and mixed aphasia, intense psycho-motor agitation, severe dysphagia for solids and liquids, neurogenic bladder, anemia), was followed by a slowly progressive favorable neuro-psychological evolution (after the decompressive craniectomy). A brutal neurological fall-down was noticed after the cranioplasty, and finally a gradually favorable ascending trend, towards a global neuro-psichological stabilization (with an almost imperceptible sequelary ataxic hemiparesis). The paper discusses the pathophisiological aspects focused on the decompressive craniectomy and cranioplasty, correlated to the patient’s evolution. Complications of each neurosurgical procedures are succinctly depicted. The traumatic encephalopathy was complicated with post-traumatic seizures (therapeutically controlled) and active internal hydrocephalus with interstitial edema and an ischemic lesion. Finally it was a "happyend", with favorable clinical evolution, towards a stable and stationary normotensive asymmetric hydrocephalus, with a gigantic and deforming porencephaly. The paper advocates for a carefully follow-up and prompt intervention in order to prevent recurrences and/ or complications (secondary and tertiary prophylaxis). Keywords: traumatic brain injury, subdural hematoma, decompressive craniectomy; cranioplasty; internal hydrocephalus; post-traumatic encephalopathy; seizures; neurorehabilitation,

S1982 Life-Threatening Massive Upper Gastrointestinal (GI) Bleed and Airway Obstruction in a Patient With Megaesophagus From Longstanding Achalasia

INTRODUCTION: In 10% of patients, untreated or poorly managed Achalasia can cause progressive esophageal dilation and loss of functionality, forming a sigmoidolichomegaesopahagus, with less than 5% of cases requiring an esophagectomy. In extremely rare situations, this megaesopahagus can cause airway obstruction from the regurgitation of food and life-threatening esophageal bleeding from underlying pressure mucosal ulcers from the retained food debris. CASE DESCRIPTION/METHODS: A 65 year-old female with a past medical history of Achalasia, presented to the emergency department (ED) with complaints of worsening shortness of breath, chest pain, nausea, non-bilious hematemesis with regurgitated food and water since one day. These symptoms were accompanied by diaphoresis, fatigue and chronic intermittent dysphagia for both solid foods and liquids. In the ED, she experienced another massive episode of bright red hematemesis accompanied by severe dizziness with an acute drop in hemoglobin, resulting in a blood transfusion. Her chest x-ray showed a dilated megaesophagus occupying most of the right hemithorax and CTangiography displayed significant distention of the esophagus with intraluminal Solid material and fluid containing a small amount of gas as well partially obstructing the Right mainstem Bronchi (Image 1,2). Emergent Esophagogastroduodenoscopy was conducted, which revealed a large amount of food debris with areas of esophageal necrosis and dark red blood seen throughout, preventing visualization of the bleeding source (Image 3). The bleeding was likely from an ulcer caused by pressure necrosis from retained food. The patient was then transferred for an emergent esophagectomy to another Health care facility. DISCUSSION: Upper GI bleeding in Achalasia is usually associated with underlying mucosal ulcers caused by pill and infectious esophagitis, malignancies, excessive ingestion of tannins. Pressure ulcers from retained food debris is a rare but lethal etiology of Upper GI bleed in patient with Achalasia. The three factors that play an important role in the pathogenesis of this pressure ulcer formation in Achalasia are immobility from esophageal aperistalsis, non-uniform shearing forces induced from the regurgitation of food and the increased tendency of self-vomiting in these patients, and lastly, mucosal barrier disruption from gastric acid reflux and malnutrition. We hope to contribute to the current understanding of this topic and increase awareness among physicians about it by presenting this rare case.Figure 1.: Computed tomography Angiogram of Chest, Axial Scout (Left) with corresponding Coronal section (Right) showing dilated megaesophagus occupying most of the right hemithorax with intraluminal Solid and fluid material containing a small amount of gas partially obstructing the Right main Bronchi (Arrow).Figure 2.: Again Computed tomography Angiogram of Chest at lower level, Axial Scout (Left) with corresponding Coronal section (Right) showing severely dilated esophagus occupying most of the right hemithorax, with intraluminal Solid and fluid material containing a small amount of gas.Figure 3.: Esophagogastroduodenoscopy showing areas of esophageal necrosis and dark red blood seen throughout, preventing visualization of the exact bleeding source.

Swallowing Disorder in Multiple Sclerosis: Modified Version of the Screening Tool

Objective: Dysphagia is commonly encountered in Multiple Sclerosis (MS). It can consequently cause severe complications such as the increased risk of dehydration, malnutrition and aspiration pneumonia that associated with an increased risk of death in the late stages of the disease. These complications can be prevented with an effective screening protocol. The Dysphagia in Multiple Sclerosis (DYMUS) is the only questionnaire developed specifically for patients with MS. The aim of the present study was translation and cross-culturally adaptation of DYMUS for the Persian population and estimation of the questionnairechr('39')s reliability and validity. Also, we investigated the frequency and severity of dysphagia in the patients referring to the Tehran MS Society and its association with the course of MS, disease duration, and Expanded Disability Status Scale (EDSS). Materials &amp; Methods: This is a methodological and descriptive-analytic study. The statistical populations consist of the patients with MS referring to the Tehran Multiple Sclerosis Society in 2018. The study sample consisted of 108 patients who were selected through a convenient sampling method. The research instruments consisted of 10-items DYMUS questionnaire (in the first part of the study, translated and its psychometric properties examined), Dysphagia Handicap Index and a demographic information questionnaire. In methodological section, translation and cross-cultural adaptation were fulfilled and the Confirmatory Factor Analysis (CFA) was used to assess the construct validity and to test the goodness-of-fit of the presented model. The association between the DYMUS and Dysphagia Handicap Index (DHI) scores investigated to convergent validity. ‏ The inter-item correlation matrix was calculated to assess the homogeneity of the questionnaire items. Kuder - Richardson (KR-20) was measured to assess the internal consistency of the questionnaire. Also, the test-retest procedure was conducted on the 19 subjects understudy to assess the reliability. Finally, the frequency and severity of dysphagia and its association with the course of MS, disease duration, and EDSS was investigated. KR-20 reliability coefficient, Intraclass Correlation Coefficient (ICC), inter-item correlation matrix, Mann-Whitney U test and rank correlation coefficient or Spearmanchr('39')s were used to inferential statistical analysis. Results: Analysis of the inter-item correlations matrix indicated a positive correlation between all items, exception item 10. Based on the results of the inter-item correlation, item 10 had the lowest correlation coefficient that was deleted from the questionnaire. CFA results confirmed the two-factor model of DYMUS, “dysphagia for solids” and “dysphagia for liquids”, and revealed that the item 10 was minimally contributing to the measurement of "dysphagia of solids" and internal consistency increased after the deletion of this item. Also, the solution of the 9-item Model was the best goodness-of-fit indicator for the sample. The obtained results from the convergent validity indicated a positive significant correlation between the DYMUS and DHI (rs=0.693, P&lt;0.001). A KR-20 reliability coefficient of the DYMUS was 0.856, indicating high internal consistency of the Persian translation of the questionnaire items. Test-retest reliability was excellent with 0.965 value. The results also showed that 65.7% of multiple sclerosis patients had a swallowing disorder. In terms of the dysphagia severity, 25.9% of participants had mild dysphagia, and 39.8% of participants had alarming dysphagia. DYMUS values were significantly correlated with disease duration (rs=0.198, P= 0.040), and EDSS (rs=0.235, P= 0.014) and significantly higher mean scores were observed in the patients with secondary progressive than the other subgroups of multiple sclerosis. Conclusion: The Persian adjusted 9-item questionnaire was demonstrated to be a simple, consistent, valid and reliable tool for the detection of patients who need more specific instrumental evaluations of swallowing. Also, about the dysphagia is very frequent in these patients, it is important that clinicians monitor these patients carefully even in early stages of the disease‏ for early detection and planning a rehabilitation program to the prevention of serious subsequence complications.