Dynamic scale position embedding for cross-modal representation learning.

A dynamic position and orientation deviation computational framework for adhesive-bonded assemblies under time-dependent thermal and mechanical loads

Interference in ballistic task learning: refining the notion of specificity.

Pseudomonas aeruginosa is considered a priority pathogen by the World Health Organization due to its resistance to antibiotics. Isolates resistant to ciprofloxacin (CPFX), a bactericide commonly used against P. aeruginosa, usually carry the mutations T83I or D87N in the GyrA subunit of the DNA gyrase. Yet, the molecular mechanisms by which these mutations confer CPFX-resistance to P. aeruginosa are unknown. Here we solved the crystal structure of the P. aeruginosa gyrase catalytic cleavage core and used it to carry out molecular dynamic (MD) simulations of CPFX-gyrase binding in the wild-type as well as the T83I and the D87N mutant systems. Our results show that DNA plays the most prominent role in maintaining the CPFX-bound conformation, with no appreciable contributions from Thr83 or Asp87. Interestingly, we found a solvent cavity adjacent to these residues that may provide CPFX access to the active site. Interaction energy analysis using Umbrella Sampling indicates that Thr83 and Asp87 may influence CPFX trajectory during binding. In the mutant systems, the attractive potential decreases, which may hinder CPFX accessing the binding site. These results shed light on P. aeruginosa resistance to CPFX and may help provide a methodology to identify new therapeutic agents to target fluoroquinolone resistant bacteria.

The Baltic Sea region presents challenging environmental and operational conditions for search and rescue (SAR) and oil spill recovery activities, including strong winds, high waves, seasonal ice, and low water temperatures. The current Lithuanian search and rescue and oil pollution response capabilities, particularly the existing vessel “Šakiai”, are insufficient to meet modern operational and safety requirements. This study aims to determine the optimal concept and technical characteristics of a new vessel capable of operating effectively in Lithuanian maritime responsibility area. The research combines hydrometeorological data analysis, review of international regulatory frameworks, evaluation of equipment requirements, and bridge simulator modelling of two reference vessel concepts: patrol-type and supply-type. Additional oil spill dispersion modelling was performed using the simulation tool. Findings show that search and rescue tasks prioritize speed, while spill response operations require stability and maneuverability. Simulations indicate that patrol-type vessels reach search and rescue zones faster, while supply-type vessels provide superior station maintenance and equipment deployment in adverse conditions. The optimal vessel concept should be based on a supply-type hull with dynamic positioning, ≥15 kn speed, ≥113 t bollard pull, ≥6-day endurance and oil recovery arms with ≥40 m sweep width.

SUMMARYBacteroides fragilis occupies a dynamic position within the human gut. Though it comprises a relatively minor fraction of the gut microbiota, it is disproportionately enriched at extraintestinal sites of infection. This ability to survive in contrasting host environments pivots on a regulatory framework that is both modular and highly plastic. Rather than deploying a suite of hierarchical global regulators, B. fragilis employs numerous operon-embedded transcriptional switches, including site-specific DNA inversions, phase-variable epigenetic systems, extracytoplasmic function sigma/anti-sigma factor pairs, and hybrid two-component systems. These networks are further complemented by cis-regulatory elongation checkpoints and post-transcriptional control by small RNAs. This review explores the full spectrum of these regulatory mechanisms, highlighting how they facilitate niche adaptation, surface variation, immune evasion, and metabolic prioritization. It also explores intraspecies variation focusing on glycan metabolism, antibiotic resistance, and virulence. Additionally, it outlines recombination-driven regulation, alongside extracytoplasmic function sigma factor diversification, flexible promoter architecture, and elongation checkpoints, each contributing to the evolution of transcriptional control in B. fragilis. Finally, it outlines unanswered questions, including the largely unexplored sRNA regulon, the coordination of DNA inversions, elongation control, and phase-variable methylation, and proposes experimental strategies to investigate the integration of these regulatory systems during environmental transitions. Taken together, B. fragilis emerges as a model bacterium for studying decentralized gene regulation in complex microbial ecosystems, with implications for both microbial ecology and therapeutic targeting of the gut microbiota.

In the actual engineering, the dynamic positioning of offshore platform is carried out by arranging different thrusters in different positions and adjusting propeller rotational speed and spatial azimuth angle to provide various thrust and torque, or changing the direction of thrust and torque. A special study on the dynamic positioning performance of the offshore platform should be conducted if it is necessary to obtain not only the final resultant forces and resultant moments on the offshore platform, but also the magnitude of each component force provided by each thruster and the spatial azimuth angle of each azimuth thruster. In this study, a dynamic positioning two-dimensional (2-D) simulation evaluation software DPTSE is designed and developed. Combined with the specific parameters of Offshore Platform 981, the thrust allocation strategy and the detailed layout of eight azimuth thrusters, the dynamic positioning process of the offshore platform in the South China sea under different environment loads are simulated and evaluated. The study demonstrates that second order wave drift forces, despite their complexity, enable faster positioning convergence (6 min) compared to steady current forces (110 min) due to their oscillatory nature and lower mean values. Under combined environmental loading, the DPTSE software successfully maintains platform positioning within acceptable limits while providing detailed thruster-level analysis that enables operators to optimize energy consumption and prevent individual thruster overloading. This research provides offshore engineers with a practical tool for preliminary DP system evaluation and thruster allocation optimization, offering significant value for platform design verification and operator training in realistic South China Sea environmental conditions.

This research aims to study the influence of throwing exercises on balance in third-grade pupils. To this end, a comparative study was conducted between two groups of pupils, applying an intervention program to the experimental group. The program included drills focused on all types of throws, performed from various static and dynamic positions, over a period of 13 weeks. The assessments generated results that led to significant conclusions on the practical relevance of the intervention, confirming that the outcomes support the hypothesis that the program applied to the experimental group has a positive effect on developing balance in third-grade children.

The article presents a dynamic positioning system for a drilling vessel described by a nonlinear MIMO model. The proposed control method is based on a structure with a linear pole placement controller with stepwise switchable parameter values. The controller synthesis is carried out by linearization of the nonlinear plant model at its operating points. From a practical point of view, the main challenge in using this method is the appropriate selection of operating points for controller synthesis and minimizing their number. The number of selected operating points, as well as the proper definition of auxiliary signals on which these points are based, can significantly affect the resulting control quality. The article proposes a simple method for selecting nominal operating points based on three independent auxiliary signals. The operation of the proposed control system is illustrated with example simulation results of vessel positioning under different initial conditions.

Multi-dimensional epigenomic dynamics converge on H3K4-mediated regulation of low-CO2 adaptation in Nannochloropsis oceanica.

Abstract To address the issue that fault features of rolling bearings are difficult to extract effectively under strong background noise interference, leading to challenges in fault diagnosis, an adaptive diagnostic method optimized by an Improved Weighted Averaging Algorithm (IWAA) is proposed. The method incorporates three core techniques: smooth logistic chaotic map initialization, dynamic adaptive position updating, and thinking innovation strategy. These significantly enhance the global optimization capability of the algorithm, with a 59.4% improvement in convergence speed and a 72.4% increase in stability compared to WAA. A joint denoising framework is constructed by integrating Sparse Maximum Harmonic-to-Noise Ratio Deconvolution (SMHD) and Successive Variational Mode Decomposition (SVMD); in this framework, the filter length of SMHD and the penalty factor of SVMD are simultaneously optimized using IWAA, eliminating reliance on manual parameter tuning. An innovative adaptive fluctuation index is introduced, incorporating a dynamic weighting mechanism combining kurtosis and energy entropy to enable intelligent selection of modal components. Verified using public datasets and a custom experimental platform, the method successfully extracts fundamental to 9th and 11th harmonic features of outer race bearing faults under strong noise interference; it significantly enhances impulse periodicity and outperforms mainstream methods in high-order feature recognition, providing a robust diagnostic solution for complex industrial scenarios.

Aim This exploratory study investigated relationships between three proprioceptive modalities – joint movement sense (JMS), joint position sense (JPS), and dynamic position sense (DPS) – assessed with the sensor-based Proprioception Measurement Tool (ProMeTo) and motor outcomes in children with upper motor neuron (UMN) lesions. Methods In a cross-sectional study, 48 children with UMN lesions (mean age 11.0 ± 3.5; 27 girls) were recruited. Diagnoses included cerebral palsy, acquired brain injury, and other UMN-related conditions. Proprioception at the hip, knee, and ankle was assessed for JMS, JPS, and DPS. Motor outcomes included selective motor control, gait and balance, gross motor function, movement quality, and functional mobility. Statistical analyses comprised Mann–Whitney U-test, Wilcoxon’s signed-rank, and Spearman’s correlations (rho = ρ) tests. Results Children who correctly identified all JMS directions across joints showed significantly better motor outcomes. Negligible to moderate correlations (ρ = 0.01–0.55) emerged between proprioceptive modalities and motor outcomes, with the strongest relationships found between JPS at the hip (ρ = 0.431–0.46) and ankle (ρ = 0.36–0.55) and outcomes related to motor function, movement quality, and mobility. Conclusion Proprioceptive function, particularly JPS, shows moderate relationships with motor capacity and movement quality in children with UMN lesions. Further research is needed to confirm these associations and determine their clinical implications.

A predefined-time double-integral zeroing neural network model for linear equations flows and its application on dynamic position

Maritime Dynamic Precise Positioning in Southern High-Latitude Regions

The hysteresis of dynamic oblique shock induced by an oscillating ramp at three different motion scenarios is demonstrated by two-dimensional numerical simulations. The angle of the oscillating ramp varies between 7° and 9° in a supersonic flow with an incoming Mach number of 2.5, in which no separation flow occurs in the boundary layer around the compression corner. It is found that the dynamic flow downstream of the oblique shock exhibits a partition hysteresis phenomenon with two distinct hysteresis regions: one is in the vicinity of the ramp wall, and the other is adjacent to the oblique shock wave. The effects of centrifugal force, Coriolis force, viscous force, and the lag in dynamic shock position on these two hysteresis phenomena regions are discussed and elucidated based on a comparative analysis of viscous and inviscid results. Additionally, a method for accurately predicting the dynamic shock wave angle is proposed for the inviscid flow, with the verified error less than 0.5%.

ABSTRACT To address the complex challenges of subsea pipeline decommissioning under uncertain conditions, this article proposes a risk assessment methodology integrating the noisy‐or gate model, Bayesian networks (BNs), and Monte Carlo simulation (MCS). The methodology is applied to the decommissioning of the Hainan 8 subsea pipeline as a case study. Twenty‐three risk factors, including behavioral variability, state dependence, inherent uncertainty, cognitive limitations, and control vulnerability, were determined by noisy‐or gate model to establish BN model, risk level and potential losses were classified on the basis of risk probabilities; and the risk probability was analyzed by MCS. The sensitivity analysis is used to identify the key factors affecting the safety risk of subsea pipeline operation. The results indicate that the primary risk factors for subsea pipeline decommissioning include unstable seabed geology, the standardization of hosting operations, and the failure of dynamic positioning. Relevant scientific recommendations for risk prevention measures are provided.

As coal mine intelligentization advances, precise navigation for rapid excavation systems is critical for efficiency and safety. This study addresses several challenges, including GPS denial, a limited visual line-of-sight, and a lack of multiequipment collaboration in tunnels, by proposing an INS + Vision "mutual reference" collaborative positioning scheme. The method meets high-precision positioning requirements under complex working face conditions. Leveraging the alternating operation of the Bolter Miners (BMs) and the Bolt Transfer Units (BTUs), the scheme uses coordinate transformation and data fusion. When the BM moves while the BTU remains stationary, the BTU's vision-inertial system acts as a local reference to update the BM's pose in real-time. Conversely, when the BTU moves with the BM stationary, the BM's fixed pose becomes the reference for reverse calculation of the BTU's pose. This enables dynamic relative positioning between equipment, solving issues such as single-sensor error accumulation, visual occlusion, and long-range dependency. Experiments show that the BTU achieves maximum lateral/longitudinal errors of 34mm/66mm, whereas the BM achieves 28mm/66mm. These satisfy underground positioning requirements, confirming the feasibility and expected performance of the proposed integrated navigation method for rapid excavation systems.

Computer-aided polyp detection tools (CADe) utilizing artificial intelligence (AI) have been shown to demonstrate benefit with improved polyp detection during colonoscopy. Questions remain around the impact of CADe when combined with additional techniques that improve polyp detection such as lengthening withdrawal time, cecal and rectal retroflexion, dynamic position change, and narrow band imaging (NBI) use. A single-center prospective, randomized control trial comparing ENDO-AID AI module to conventional colonoscopy was conducted between October 11, 2023 and March 16, 2024 at Waitakere Hospital. Additional techniques to improve polyp detection were recorded but left to the discretion of participating 26 endoscopists. Seven hundred seventy-six patients (mean ± SD age, 61.2 ± 13.0 years; 344 females) were recruited, 383 patients allocated to AI and 393 to control. Position change was used in 43%, antispasmodic in 25%, distal cap in 25%, NBI in 21%. Overall, univariate analysis demonstrated a nonsignificant trend towards higher adenoma detection rate (ADR) in the CADe than control group (63.4% vs. 57.3%, p = 0.08). AI was most effective in the screening cohort (ADR 79% vs. 68%, average polyp rate 3.7 vs. 2.8 p < 0.05). Multivariable analysis demonstrated CADe was independently associated with increased adenoma detection rate (odds ratio [OR], 1.38; 95% confidence interval [CI], 1.01-1.89; p = 0.042), as was use of NBI, OR 2.00; (95% CI: 1.23-3.25; p = 0.006) and increased withdrawal time, OR 1.11; (95% CI: 1.08-1.15; p < 0.001). ADR was increased by CADe in a cohort of high detectors and was further augmented by traditional techniques known to be beneficial. It is important to incorporate traditional techniques with CADe to maximize ADR.

The small waterplane area twin hull (SWATH) is a type of high-performance vessel known for its excellent seakeeping performance, remarkable maneuverability, and high lateral stability. These advantages have led to its growing application in scientific research ships. Since many research operations require a vessel to maintain a fixed position, Dynamic Positioning Systems (DPSs) are essential. To better support diverse scientific tasks, the R/V SHIYAN 1 was upgraded with an enhanced dynamic positioning system. A ship motion model was established after comprehensively accounting for environmental factors such as wind, waves, and currents. By automatically controlling three actuators, the system successfully achieved effective dynamic positioning. In comparative tests conducted under conditions of wind speed at 13.4 m/s, wave height at 3.2 m, and current at 0.2 m/s, the power system was able to maintain a positioning radius within 5 m. Analysis of data from three dynamic positioning experiments revealed that wave loads had the most significant impact on positioning accuracy, followed by wind loads, while ocean current loads had the least influence. This upgrade not only improves the vessel’s operational capability but also enhances its effectiveness in marine scientific exploration.

Relevance. Diagnosis and visualization of the anterior segment in IOL dislocation is fundamental in choosing the most effective method of repositioning dislocated IOL, ultrasound biomicroscopy (UBM) is practically the only highly informative method that allows non-invasive visualization of the pre-equatorial zone of the eyeball in vivo. Goal. To evaluate the dynamic position of the IOL using the UBM method in patients with IOL dislocation. Materials and methods. The study included 12 patients (12 eyes) with a diagnosis of grade 2.3 IOL dislocation and secondary uncompensated glaucoma. Grade 2 dislocation was detected in 41.6% of patients (5 eyes), grade 3 dislocation in 58.4% of patients (7 eyes). In order to assess the dynamic position of the IOL, all patients underwent an additional diagnostic examination, which included performing UBM axial scanning in the horizontal and vertical meridians in the “sitting” and “lying” positions of the subject. The statistical analysis was performed using the StatTech v. 4.8.11 software (developed by Stattech LLC, Russia). Results. IOL contact with uveal structures in the “lying” position was observed in 16.7% of cases (2 eyes), while in the “sitting” position, IOL contact with uveal structures was observed in 100% of cases (12 eyes). According to the data obtained, when performing UBM in the “lying” position of the subject in comparison with the “sitting” position of the subject, there is a deepening of the anterior chamber, an increase in the CPC, and a posterior displacement of the IOL, therefore, the possibility of assessing the dynamic position of the IOL when performing UBM in the horizontal and vertical positions of the subject makes it possible to more reliably assess the nature of changes in the anterior segment of the eye. Conclusion. The use of UBM in various positions of the patient’s body makes it possible to identify significant changes in the position of the intraocular lens and clarify the mechanisms of development of postoperative complications.