Duration Of Hydration Research Articles

The effect of plant extracts on the microbiological parameters of grain

Currently, ensuring high quality and food safety is an important condition for a rational diet, maintaining health, mental and physical performance and supporting the body's defense systems. The current ecological situation is one of the factors determining the nutritional status of the population. Extracts of leaves and stems of rosehip, sea buckthorn and barberry were used as plant raw materials. The use of these plant raw materials is explained by the fact that their extracts of leaves and stems contain polyphenols with antioxidant, antimicrobial and carcinogenic properties. The effective amount of extracts of plant raw materials has been established. The obtained extracts were injected in an amount of 0.05% by weight of their solids. The optimal duration of hydration is 6 and 12 hours, but depending on the effectiveness of the time ‒ 6 hours. The grain is moistened at 23 ° C (room temperature). The effect of plant extracts on the microbiological sowing of grain during soaking and preparation of grain for production and prevention of microbial destruction of bakery products during storage is investigated. Extracts of rosehip leaves and sea buckthorn stems showed a pronounced antimicrobial effect against fungi of the genus Pénicillium. This eliminates the diseases of bread and improves its rheological properties.

Explainable ensemble learning predictive model for thermal conductivity of cement-based foam

Cement-based foam has emerged as a strong contender in sustainable construction owing to its superior thermal and sound insulation properties, fire resistance, and cost-effectiveness. To effectively use cement-based foam as a thermal insulation material, it is important to accurately predict its thermal conductivity. The current study aims at coining an accurate methodology for predicting the thermal conductivity of cement-based foam using state-of-the-art machine learning techniques. A comprehensive experimental dataset of 504 data points was developed and used for training ensemble learning models including XGBoost, CatBoost, LightGBM and Random Forest. The independent variables of this dataset affecting the thermal conductivity are the cast density, percentage of pozzolan, porosity, percentage of moisture, and duration of hydration in days. Using the Isolation Forest algorithm proved effective in detecting and eliminating outliers in the dataset. All the ensemble learning techniques explored in this study achieved superior predictive accuracy with a coefficient of determination greater than 0.98 on the test dataset. The influence of the input features on the thermal conductivity was visualized using the SHapley Additive exPlanations (SHAP) approach and individual conditional expectation (ICE) plots. The cast density had the greatest effect on thermal conductivity. The explainable machine learning models demonstrated superior accuracy, efficiency, and reliability in estimating the thermal insulation of cement-based foam, opening the door for wider acceptance of this material in sustainable energy efficient construction.

Optimization of a Luteolin-Loaded TPGS/Poloxamer 407 Nanomicelle: The Effects of Copolymers, Hydration Temperature and Duration, and Freezing Temperature on Encapsulation Efficiency, Particle Size, and Solubility.

Luteolin is a flavonoid compound that has been widely studied for its various anti-cancer properties and sensitization to multidrug-resistant cells. However, the limited solubility and bioavailability of Lut hindered its potential clinical use. Theoretically, the combination of this compound with vitamin E TPGS and poloxamer 407 can produce a synergistic effect to enhance tumor apoptosis and P-glycoprotein inhibition. This study aimed to develop and optimize vitamin E TPGS/Poloxamer 407 micelles loaded with luteolin through investigating certain factors that can affect the encapsulation efficiency and particle size of the micelle. A micelle was prepared using the film hydration method, and the micellar solution was lyophilized. The cake formed was analyzed. The factors investigated include the concentrations of the surfactants, ratio of vitamin E TPGS/Poloxamer 407, temperature of the hydrating solution, duration of hydration, and freezing temperature before lyophilization. The effects of these factors on the encapsulation efficiency and particle size of the micelle were also studied. The encapsulation efficiency was measured using a UV-Vis spectrophotometer, while particle size was measured using dynamic light scattering. The optimized micelle was found to have 90% encapsulation efficiency with a particle size of less than 40 nm, which was achieved using a 10% concentration of surfactants at a vitamin E TPGS/Poloxamer 407 ratio of 3:1. The optimized temperature for hydrating the micellar film was 40 °C, the optimized mixing time was 1 h, and the optimized freezing temperature was -80 °C. The solubility of the luteolin-loaded micelles increased 459-fold compared to pure Lut in water. The critical micelle concentration of the vitamin E TPGS/Poloxamer 407 micelle was 0.001 mg/mL, and the release study showed that luteolin-loaded micelles exhibited sustained release behavior. The release of luteolin from a micelle was found to be higher in pH 6.8 compared to pH 7.4, which signified that luteolin could be accumulated more in a tumor microenvironment compared to blood. This study demonstrated that several factors need to be considered when developing such nanoparticles in order to obtain a well-optimized micelle.

Numerical Simulations Reproduce Field Observations Showing Transient Weakening During Shear Zone Formation by Diffusional Hydrogen Influx and H2O Inflow

AbstractExposures on Holsnøy island (Bergen Arcs, Norway) indicate fluid infiltration through fractures into a dry, metastable granulite, which triggered a kinetically delayed eclogitization, a transient weakening during fluid‐rock interaction, and formation of shear zones that widened during shearing. It remains unclear whether the effects of grain boundary‐assisted aqueous fluid inflow on the duration of granulite hydration were influenced by a diffusional hydrogen influx accompanying the fluid inflow. To better estimate the fluid infiltration efficiencies and the parameter interdependencies, a 1D numerical model of a viscous shear zone is utilized and validated using measured mineral phase abundance distributions and H2O‐contents in nominally anhydrous minerals of the original granulite assemblage to constrain the hydration by aqueous fluid inflow and diffusional hydrogen influx, respectively. Both hydrations are described with a diffusion equation and affect the effective viscosity. Shear zone kinematics are constrained by the observed shear strain and thickness. The model fits the phase abundance and H2O‐content profiles if the effective hydrogen diffusivity is approximately one order of magnitude higher than the diffusivity for aqueous fluid inflow. The observed shear zone thickness is reproduced if the viscosity ratio between dry granulite and deforming, reequilibrating eclogite is ∼104 and that between dry granulite and hydrated granulite is ∼102. The results suggest shear velocities <10−2 cm/a, hydrogen diffusivities of ∼10−13±1 m2/s, and a shearing duration of <10 years. This study successfully links and validates field data to a shear zone model and highlights the importance of hydrogen diffusion for shear zone widening and eclogitization.

Исследование процессов термического разложения и регидратации Mg-Al СДГ, полученных методом твердофазного синтеза

Mg-Al LDH samples of Mg4Al2(OH)12CO33,85HO composition were obtained by solid-phase synthesis. It was found that as a result of heat treatment with subsequent rehydration, synthesized Mg-Al LDH samples are reduced to the composition Mg4Al2(OH)12CO33HO, regardless of the medium and duration of treatment. It has been shown that rehydration in NaHCO3 solutions contributes to an increase in the crystallite sizes of Mg-Al LDH samples being recovered, which is not observed when Mg-Al LDH is reduced in an aqueous medium. An increase in the duration of hydration in NaHCO3 solutions leads to an increase in the crystallites of Mg-Al reduced LDH, which is not observed during rehydration in an aqueous medium.

Interspecific and intraspecific variability of water use traits in macrolichen species in a fragmented landscape along a climatic ecotone area

Water use traits in lichens are important attributes that determine the duration of hydration and metabolically active periods. In this study, the water holding capacity (WHC) and specific thallus mass (STM) were measured for seven macrolichen species (Parmelia sulcata, Parmelina tiliacea, Evernia prunastri, Ramalina farinacea, Lobaria pulmonaria, Lobarina scrobiculata and Nephroma resupinatum) from a Temperate-Mediterranean fragmented landscape. Twenty Quercus forests with different environmental conditions were selected to gather therein five lichen samples of each species in order to analyse their interspecific and intraspecific variation in WHC and STM. The type of photobiont was mainly responsible for differences in the WHC and the water content per biomass among species. Lichens with cyanobacteria as the main or secondary photobiont showed the highest value for both parameters. However, particular features of species were more important in modulating STM, while growth form had a minor explanatory importance. At the intraspecific level, variation in WHC relied on climatic, microclimatic and forest structure factors, while STM variability was only dependent on the two last predictors. Future research should be focused on other drivers at the microscale to unveil the environmental conditions that shape WHC and STM in lichens.

The Effect of Concealing the Hydration Fluid on Anticipatory Nausea-Vomiting in Pediatric Hematology-Oncology Patients Undergoing Chemotherapy Treatment: A Randomized Controlled Study

PurposeThe aim of this study was to assess the effectiveness of concealing the hydration fluid bottle in order to reduce the experience of anticipatory nausea and vomiting before chemotherapy treatment in pediatric hematology oncology patients undergoing chemotherapy treatment. Design and methodsThe study was carried out as a randomized controlled clinical trial. The study was conducted sixty-two pediatric oncology patients who underwent chemotherapy in a hospital in Ankara, Turkey. The patients were randomly alloceted to an intervention group (n = 32) or a control group (n = 30). Patients in the intervention group concealing the hydration fluid bottle throughout the duration of hydration; patients in the control group received routine procedure (No concealment intervention) during hydration degree of nausea and vomiting were measured by the Baxter Retching Faces (BARF) scale. ResultsThis study found no differences in the characteristics of the patients or in degree of nausea and vomiting between groups at enrollment. After concealing the hydration fluid bottle during the hydration, BARF scores were lower in the intervention group (p < .001). ConclusionConcealing the hydration fluid had significant effects on degree of nausea and vomiting in pediatric oncology patient who received hydration before chemotherapy. Application to practiceThis approach can be added as routine care as an effective non pharmacological intervention for pediatric oncology patient with receiving chemotherapy.

P-113 Supportive medication in advanced biliary tract cancers with ABC-02 regimen

The ABC-02 trial published in 2010 demonstrated significant improvement in overall survival with gemcitabine in combination with cisplatin, compared with single-agent gemcitabine, in advanced biliary tract cancers. Since then, gemcitabine 1000mg/m2 with cisplatin 25mg/m2 at day 1 and day 8, on three weekly cycles, has been used as the first-line palliative chemotherapy for metastatic or locally advanced, inoperable cholangiocarcinomas, or gallbladder malignancies. The ABC-02 protocol recommended a shorter hydration regimen and shorter course of anti-emetics given the lower dose of cisplatin. Extra hydration with magnesium and furosemide were omitted from this protocol, reducing the infusion time by approximately 2 hours. This shorter regimen has been used at our oncology centre since 2010: cisplatin with 20mmol KCL over 60 minutes followed by 500ml 0.9% saline with MgSO4 over 30 minutes prior to gemcitabine, dexamethasone, and ondansetron are prescribed day 2 and 9 only. Our aim was to determine if the shorter duration of hydration and supportive medication as per ABC-02 protocol led to adverse outcomes. This was a retrospective, observational analysis of patients who received supportive medication and hydration, as per ABC-02 trial protocol between August 2010 and August 2019. We observed the number of patients with acute kidney injury within 4 weeks of administration of chemotherapy measured by RIFLE criteria, hypokalaemia and hypocalcaemia requiring electrolyte replacement, documented grade 3 or 4 nausea and vomiting, number of admissions related to toxicity and the number of patients with treatment delays. Patients were excluded if they received the long hydration regimen. We identified 44 patients with complete records who received cisplatin and gemcitabine with ABC-02 protocol for advanced biliary tract malignancy, in total there were 188 cycles with this regimen. The median age was 68 with age range 46-84 and ECOG performance status 0-2. All patients had confirmed metastatic or inoperable malignancy of biliary tract. One patient (2%) developed an acute kidney injury as defined by RIFLE criteria while on treatment. However, this was not directly related to chemotherapy as this patient had confirmed campylobacter diarrhoea and required admission for intravenous hydration. One patient (2%) reported grade 3 nausea and vomiting and nine patients (20%) reported grade 1-2 nausea and vomiting requiring additional antiemetic. 15 patients (34%) were admitted during their course of treatment. Seven patients (16%) were admitted with toxicities from chemotherapy, all related to infection. One patient (2%) developed hypocalcaemia requiring replacement during this time frame. Our data support the use of a shorter hydration and antiemetic regimen for cisplatin with gemcitabine in advanced biliary tract cancers and our results are comparable to ABC-02 trial showing a low incidence of renal toxicity and grade 3 or 4 nausea and vomiting. This demonstrates that shorter hydration schedules and anti-emetics with lower doses of cisplatin are safe to use in practice, reducing chemotherapy day unit chair time, improving capacity and patient experience.

Influence of Ultrafine Addition Obtained from Pre-Hydrated Cement on Cement Paste

This article focuses to influence of a pre-hydrated cement suspensions on hardening cement paste properties investigation. The pre-hydration was occurred by 2-th, 4-th 6-th hours during forced mixing. Changes of particle dispersion caused by hydration were determined. It is shown that by hydrolysis increase particles dispersion and subsequently increases quantity of new hydrate formations. Influence of the pre-hydrated cement suspensions on hardening cement paste properties is determined. It is shown that application pre-hydrated addition leads to increasing a cement paste water demand by 12, 17 and 14% for duration of hydration by 2, 4 and 6 hours consequently and to decreasing setting time. It caused by generating supplementary new formations of crystalline hydrate with subsequently increasing rate cement paste structuration. Rate of hardening was increased with increasing duration of the pre-hydration for 10% pre-hydrated cement addition. Obtained results may recommended the addition of pre-hydrated cement in form of cement suspension as cement gel for concrete nanomodification

Hydration of geosynthetic clay liners (GCLs) on compacted zeolite

The hydration performance of two geosynthetic clay liners (GCLs) over compacted zeolite is investigated in this paper. Zeolite was chosen as the subsoil because of its greater optimum water content with respect to other natural soils (41%). The water content changes of GCL-1 and GCL-2, which each had distinct properties, were the same until 30 days of hydration. The water content of GCL-1 increased from 120% to 147% after 62 days of hydration and then decreased to 117% after 90 days of hydration. However, the water content of GCL-2 was greater than that of GCL-1 (149% vs. 117%) after 90 days of hydration. The reduction in the water content of GCL-1 after 90 days was due to cation replacement. The exchangeable mole fractions of sodium cations (XNa) decreased whereas exchangeable mole fractions of divalent cations (XCa and XMg) increased with the duration of hydration. Cation replacement was more pronounced for GCL-1 than for GCL-2. Although swell indices decreased markedly with the durations of hydration, the final hydraulic conductivities of GCL-1 and GCL-2 were almost the same, around 2.0 × 10−11 m/s. This means higher water content masked the negative influence of cation replacement, resulting in comparable and low hydraulic conductivities for both GCLs.

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The incidence, risk factors, and clinical outcomes of acute kidney injury (staged using the RIFLE classification) associated with intravenous acyclovir administration

Intravenous (IV) acyclovir is commonly administered medication for viral infection but is well known for its nephrotoxicity. However, there was no study for incidence, risk factors, and clinical outcomes of acute kidney injury (AKI) associated with IV acyclovir administration. We retrospectively reviewed the medical records of 287 patients who were medicated IV acyclovir from January 2008 to May 2013 in Gyeongsang National University Hospital. All had documented medical histories and underwent medical review. Demographic data, risk factors, concomitant drugs, laboratory findings and outcome were gathered from the medical records and analyzed. AKI occurred in 51 patients (17.8%). As per RIFLE classification, renal injury was graded as either at risk of renal dysfunction (62.7%), renal injury (15.6%), and renal failure (21.6%). There was no significant difference in age, sex, total dose, drug duration, and presence of hydration between AKI and non-AKI group. However, systolic pressure, underlying diabetes, concomitant vancomycin and non-steroidal anti-inflammatory drugs (NSAIDs) use was positively correlated with AKI occurrence (p = .04, p < .001, 0.01, and 0.04, respectively). Two patients underwent hemodialysis and these patients died. Higher mortality was observed in AKI patients (p < .001). Multivariate analysis also presented that presence of diabetes, concomitant NSAIDs, and vancomycin use was independent risk factor of acyclovir associated with AKI (p = .001, OR 3.611 (CI: 1.708–7.633), p = .050, OR 2.630 (CI: 1.000–6.917), and p = .009, OR 4.349 (CI: 1.452–13.022), respectively). AKI is relatively common in patients administrating acyclovir injection. Physicians should attempt to prevent, detect, and manage acyclovir associated AKI in patients prescribing acyclovir due to possible association of poor prognosis.

A Systematic Review of Strategies to Prevent Cisplatin-Induced Nephrotoxicity

Cisplatin, a platinum-based antineoplastic agent, is the cornerstone for the treatment of many malignancies. Nephrotoxicity is the primary dose-limiting toxicity, and various hydration regimens and supplementation strategies are used to prevent cisplatin-induced kidney injury. However, evidence-based recommendations on specific hydration regimens are limited. A systematic review was performed to evaluate clinical studies that have examined hydration and supplementation strategies to prevent cisplatin-induced nephrotoxicity. PubMed and Excerpta Medica databases were searched from 1966 through October 2015 for clinical trials and other studies focused on hydration regimens to prevent nephrotoxicity in cancer patients treated with cisplatin. The University of Oxford Centre for Evidence-Based Medicine criteria were used to grade level of evidence. Among the 1,407 identified studies, 24 were included in this systematic review. All studies differed on type, volume, and duration of hydration. Among the 24 studies, 5 evaluated short-duration hydration, 4 evaluated low-volume hydration, 4 investigated magnesium supplementation, and 7 reviewed forced diuresis with hydration. Short-duration and lower-volume hydration regimens are effective in preventing cisplatin-induced nephrotoxicity. Magnesium supplementation may have a role as a nephroprotectant, and forced diuresis may be appropriate in some patients receiving cisplatin. Hydration is essential for all patients to prevent cisplatin-induced nephrotoxicity. Specifically, short-duration, low-volume, outpatient hydration with magnesium supplementation and mannitol forced diuresis (in select patients) represent best practice principles for the safe use of cisplatin. The Oncologist 2017;22:609-619 IMPLICATIONS FOR PRACTICE: The findings contained within this systematic review show that (a) hydration is essential for all patients to prevent cisplatin-induced nephrotoxicity, (b) short-duration, low-volume, outpatient hydration regimens appear to be safe and feasible, even in patients receiving intermediate- to high-dose cisplatin, (c) magnesium supplementation (8-16 milliequivalents) may limit cisplatin-induced nephrotoxicity, and (d) mannitol may be considered for high-dose cisplatin and/or patients with preexisting hypertension. These findings have broad implications for clinical practice and represent best practice principles for the prevention of cisplatin-induced nephrotoxicity.

Cement hydration with ultrasound treated clinoptilolite

There are many cement replacement materials and one of them is zeolites. Zeolites are crystalline solids structures made of silicon, aluminum and oxygen that form a framework with cavities and channels inside where cations, water and/or small molecules may reside. In this study natural zeolite clinoptilolite was used. Clinoptilolite is the most popular natural zeolite mineral with the chemical formula (Na, K, Ca)23Al3(Al,Si)2Si13O3612H2O. The present paper shows the results of using ultrasound treated clinoptilolite as Portland cement replacement material. The duration of ultrasound treatment was 5 min, 10 min, and 20 min. Results showed that the XRD of ultrasound-treated clinoptilolite slightly differs in comparison to conventional clinoptilolite. The cement samples with 5% and 10% clinoptilolite substitute provide the strength increase, 30% significantly reduces the strength compared to control samples. The heat measurements of Portland cement paste hydration, containing clinoptilolite, showed that the clinoptilolite slightly increases the duration of hydration, but hydration temperature is lower than in the controls samples. The experimental results suggest that ultrasound-treated clinoptilolite positively influence cement hydration processes, consolidation kinetics, CSH formation; the mechanical strength of the samples is increased. Typical content of Portland cement substituting does not exceed 20% of mass of Portland cement in samples. Reducing the consumption of Portland cement with substituting it with ultrasound treated clinoptilolite is preferred for reasons of environmental protection.DOI: http://dx.doi.org/10.5755/j01.sace.11.2.12430

Oral Nutritional Support Can Shorten the Duration of Parenteral Hydration in End-of-Life Cancer Patients: A Randomized Controlled Trial

Tube feeding or hydration is often considered for end-of-life cancer patients despite the negative effects on quality of life. The efficacy of oral nutritional support in this setting is unknown. We conducted a randomized trial to compare the efficacies of an amino acid jelly, Inner Power® (IP), and a liquid enteral product, Ensure Liquid® (EL), in terminally ill cancer patients. We randomly assigned patients to 3 arms: EL, IP, and EL+IP. The primary endpoint was drip infusion in vein (DIV)-free survival, which was defined as the duration from nutritional support initiation to administration of parenteral hydration. Twenty-seven patients were enrolled in the study, of whom 21 were included in the intention-to-treat analysis. The median age of the subjects was 69 yr. There were significant differences between the arms with regard to the median DIV-free survival (0.5, 6.0, and 4.5 days in the EL, IP, and EL + IP arms, respectively; P = 0.05). The median overall survival was 7, 9, and 8 days in the EL, IP, and EL + IP arms, respectively. IP may shorten the duration of parenteral hydration in terminally ill cancer patients and does not affect their survival.

Evidence-Based Practice Recommendations for Hydration in Children and Adolescents With Cancer Receiving Intravenous Cyclophosphamide

Hemorrhagic cystitis is a known complication of cyclophosphamide, an antineoplastic agent used to treat a variety of oncologic diseases in children. Hydration can prevent hemorrhagic cystitis; however, use varies in clinical practice. A team was assembled to develop evidence-based practice recommendations to address the following question: in a population of children with cancer, what is the appropriate pre- and posthydration for the administration of different dose levels of intravenous cyclophosphamide to prevent bladder toxicity? The purpose was to identify the appropriate rate, duration, and route of hydration to prevent bladder toxicity with low, intermediate, and high dose cyclophosphamide. After a systematic search of the literature, 15 pieces of evidence were evaluated and used. There is a moderate level of quality evidence related to hydration for high dose cyclophosphamide and very low quality evidence related to intermediate or low dose cyclophosphamide. Three general recommendations were made for hydration associated with cyclophosphamide. There is a need for further research related to the prevention of bladder toxicity in children with cancer receiving cyclophosphamide.

Antisecretory factor effectively and safely stops childhood diarrhoea: a placebo‐controlled, randomised study

We studied the response to high doses of egg yolk containing antisecretory factor (B221® , Salovum®) in young children with acute diarrhoea, presenting to the Children's Hospital, Lahore, Pakistan. In a randomised, placebo-controlled trial, 36 children aged 7 to 60 months with acute diarrhoea of unknown aetiology, with mild-to-moderate dehydration, were randomised to the Salovum® or placebo groups. Initially, 16 grams of Salovum® or ordinary egg yolk (placebo) mixed in oral rehydration salts was given, followed by 8 g every 5 h until recovery. The number and consistency of stools were recorded. The two groups were comparable in age, gender, duration of diarrhoea, hydration and nutritional status, although the proportion with watery stools was higher in the Salovum® group (p = 0.04). Reduction in the frequency of stools was seen at 7 versus 18 h (p < 0.0001) and normalising of stool consistency was 10 versus 18 h, p < 0.03) in the Salovum® and placebo groups. The overall effect was 35 versus 70 h in the two groups (p = 0.001). No side effects were reported. High doses of AF in the form of Salovum® effectively and safely reduce childhood diarrhoea of a likely broad aetiology.

Efficacy of ophthalmic viscosurgical devices in maintaining corneal epithelial hydration and clarity: In vitro assessment

To determine the efficacy of hydroxypropyl methylcellulose (HPMC) and hyaluronic acid (HA) in maintaining corneal hydration and optical clarity. Department of Ophthalmology, Medical University of Vienna, Vienna, Austria. Experimental study. In porcine autopsy eyes, the effect of 13 ophthalmic viscosurgical devices (OVDs) (5 formulations of HPMC; 8 formulations of HA) in maintaining corneal hydration and optical clarity was tested. The main outcome variables were the time to reach optical clarity of the cornea during dissipation of the OVD and duration of corneal hydration. These variables were assessed after the first application of the OVD, after balanced salt solution application to rehydrate the gel matrix, and after the second application of OVD on top of the first layer. The study used 57 porcine eyes. High-molecular-weight HA 1.5% (zero shear viscosity [ZSV] 55,122 millipascal seconds [mPa.s]) took a significantly shorter time to reach optical clarity than HA 1.4% (ZSV 36,882 mPa.s) (P=.04). Hyaluronic acid 1.4% and HA 1.5% maintained corneal hydration significantly longer than HPMC 2.0% (P<.001). For corneal hydration during short-lasting surgical procedures such as cataract surgery, the results suggest using HPMC because it distributes quickly and provides an adequate duration of sufficient corneal hydration. For corneal hydration during prolonged surgical procedures, such as vitreoretinal surgery, results suggest using HA 1.5% in the formulation because it provides long-lasting corneal hydration. Dr. Prinz has a proprietary interest in Croma Pharma GmbH, Leobendorf, Austria. Dr. Findl is a scientific advisor to Croma Pharma GmbH. No other author has a financial or proprietary interest in any material or method mentioned.

Hydration and Cation Exchange during Subgrade Hydration and Effect on Hydraulic Conductivity of Geosynthetic Clay Liners

AbstractExperiments were conducted to evaluate cation exchange during hydration of geosynthetic clay liners (GCLs) used in composite hydraulic barriers and the effect on their hydraulic conductivity. GCLs arranged in a composite barrier configuration were hydrated by contact with moist compacted subgrades (two clays, one silt, and one sand) under a confining stress of 10 kPa for 30 days to 1 year. No measurable exchange occurred in GCLs hydrated for 30 days. For hydration periods longer than 30 days, the exchange increased as the duration of hydration increased. The exchange during subgrade hydration had no measurable effect on the hydraulic conductivity to deionized (DI) water. However, if the GCL was desiccated after hydration, the hydraulic conductivity increased more than 1,000-fold. Dissolution of calcite within the bentonite during permeation with DI water also induced the replacement of sodium by calcium; however, this additional exchange had no measurable effect on the hydraulic conductivity to DI...

Clinical Practice in Management of Hydration for Lung Cancer Patients Receiving Cisplatin-based Chemotherapy in Japan: A Questionnaire Survey

A questionnaire survey was performed to investigate the actual hydration methods used with cisplatin-containing regimens at various institutions in Japan to gain an overview of the varieties employed. Replies were received from 368 of 686 institutions board-certified by the Japanese Respiratory Society. In 233 institutions (63%), new lung cancer patients were treated regularly with regimens containing cisplatin at ≥60 mg/m2. In 172 institutions (48%), hydration with <3000 ml of intravenous saline was performed on day 1. In 225 institutions (65%), hydration was performed for up to 3 days at most, but no more than 48 (14%) of the institutions that responded did so on day 1 only. Two to three weeks of hospitalization was needed for the initial course at most institutions (76%). Thirteen institutions (4%) treated patients as outpatients after the second course, whereas none did so from the beginning of treatment. Despite inconsistencies among the methods used by the various institutions, 84% of those surveyed considered their approaches to be appropriate. Some useful objective indices for deciding the volume or duration of hydration are needed.