ObjectiveLarge stimulus and myogenic artifacts usually prevent detection of sensory evoked potentials to electrical stimulation in trigeminal sensory territory (t-SEP). Stimulus Artifact (SA) removal can be obtained by means of two stimulating modes (Dual Mode Stimulation - DMS) having in common a fixed cathode alternatingly referred to opposed anodes, resulting in SAs of opposite polarity. Opposite SAs progressively cancel each other out during averaging, without interaction with the underlying bio-electrical events. MethodsUsing DMS, dermatomal t-SEP were recorded from C5/C6 scalp sites in 24 healthy volunteers after selective, electrical stimulation of five trigeminal nerve areas: supraorbital, infraorbital, superior alveolar, inferior alveolar and auriculotemporal. ResultsReproducible t-SEPs were obtained after stimulation at all sites and showed the classical W shape, without significant differences related to the stimulated area. Cortical responses were formed by a sequence of individual peaks labelled, according to polarity and mean latency, as P8, N13, P19, N27, P38. A later, less stable component followed (N55-P67), poorly defined or absent in about one third of subjects. ConclusionsThe described technique represents a novel approach, within reach of any neurophysiological unit, to record dermatomal SEPs to electrical stimulation of several, discrete areas of significant clinical interest, covering the whole trigeminal sensory territory. SignificanceDMS represents a simple and robust tool to remove SA as the main drawback that has so far prevented recording of t-SEPs in daily clinical practice.