A systematic approach to develop and characterize a compositionally equivalent buprenorphine in situ forming implant (Sublocade®).

Prophylactic sequential drug administration potentiates cancer radiotherapy by inhibiting cholesterol deposition and cellular senescence.

Injectable acid-labile thermosensitive magnetic hydrogel with responsive drug release for bridging liver transplantation in hepatocellular carcinoma.

Electrospun PVA-PCL/HA nanofiber scaffolds containing mupirocin for surgical wound healing in Sprague Dawley rats.

Mechanistic understanding of drug release in dissolution apparatuses - In-depth review.

Technical challenges and quality considerations for dissolving microneedles.

Three-dimensional (3D) printing by Fused Deposition Modeling (FDM) offers a flexible platform for fabricating personalized medicines with tunable release profiles. However, developing printable filaments with suitable mechanical properties and controlled drug release remains challenging. Ketoprofen was formulated into FDM-printed polyvinyl alcohol (PVA) capsule shells which were subsequently filled with ketoprofen powder and locked to form complete 3D‑printed capsules, spanning immediate-, sustained-, and delayed-release designs; a dual-compartment polypill with famotidine was also produced. Capsule shell geometry and internal density were systematically varied to modulate drug release, and performance was evaluated using pharmacopeial quality tests, dissolution studies, micro-computed tomography, and in silico pharmacokinetic simulation. Capsule geometry and polymer choice modulated release: low shells/infill density accelerated immediate-release (IR) whilst higher shells/infill density prolonged sustained-release (SR). Selected IR and SR capsules achieved a similarity factor f2 ≥ 50 vs references. Micro-CT confirmed design-porosity differences; solid-state data supportedthe formation of largely amorphous solid drug-polymer dispersions in Kollicoat IR formulations and solvent evaporation products. Simulations predicted distinct IR vs SR plasma profiles. These findings illustrate that FDM printing can modulate oral drug release through geometry and, together with in silico tools, provide a framework for designing customized capsules.

Red-light-activated living bacterial electron generator for on-demand drug release in colonic inflammation.

An injectable dual-drug-loaded hydrogel for the treatment of bacterial endophthalmitis.

Cancer research increasingly focuses on local drug release in tumorous tissue by using drug carriers. Concurrently, techniques to quantify the associated drug release are under investigation. This study presents a Inertial Cavitation-based Release Estimation (ICbRE) method. The estimation is based on the assessment of inertial cavitation (IC) noise and its correlation to release data. To develop ICbRE, we used poly(lactic-co-glycolic acid) (PLGA) nanocapsules loaded with a fluorescent dye, which were flowed through a tissue-mimicking phantom, and exposed them to focused ultrasound bursts at 550-950 kHz with peak rarefaction pressures (PRP) of 0.22-1.85 MPa, corresponding to mechanical index (MI) values of 0.3-1.9. Cavitation activity was recorded using a passive cavitation detection (PCD) system. By training on acoustic data, we derived weight functions, interpreted as transfer functions, to solve this inverse problem. These weight functions were multiplied by a test set of the acoustic data to estimate payload release. The most accurate estimation showed an absolute error of 0.3% and a standard deviation of 1.9% from the nominal value. Given its precision, we propose the integration of ICbRE into focused ultrasound systems to estimate drug carriers' payload release. In the course of prospective cancer treatments, a drug's released payload may be simultaneously quantified while monitoring the cavitation noise to ensure an effective therapy.

pH-responsive and self-adaptive hydrogel dressing based on a TA/PVA network co-loaded with cannabidiol and mupirocin for synergistic infected wound healing.

Enhanced ocular delivery of timolol maleate through thiolated chitosan nanoparticles/gellan gum-based hydrogels.

Bio-metal-organic framework-enhanced acrylate pressure-sensitive adhesive for transdermal drug delivery with improved adhesion and drug release

Beyond the skin barrier: from rational design to translational and market perspectives of hydrogel-forming microneedles.

Characterizations and controlled drug release behavior of acyclovir-loaded starch-based microneedles patches for transdermal herpes simplex virus therapy.

Esterase-activatable dimeric HDAC inhibitor nanotherapeutics for enhanced lymphoma epigenetic therapy.

Injectable thermosensitive hydrogel-based sustained delivery system for anti-diabetic peptides in type 2 diabetes mellitus therapy: A review.

Hyaluronic acid-based responsive hydrogel with sequential drug release: targeting oxidative stress and angiogenesis to accelerate diabetic wound healing.

Box-Behnken design-based development and optimization of potentiated antibacterial nanoemulgel for azithromycin

QbD-based optimisation and level A IVIVC of gliclazide sustained-release matrix tablets using Pectin and HPMC.