The Hanjiang River, as a water donor basin, plays a fundamental role in supporting water supply security in northern China while maintaining the health and stability of ecosystems within the basin. However, the combined influence of climate change and anthropogenic interference has resulted in a significant change in the flow regime of the basin, challenging the sustainability of the river system. In order to understand the impact of the above factors on the river runoff, we analyzed the temporal and spatial pattern of runoff and climate factors in the basin and quantitatively assessed the contribution of climate change and human activities to the change in runoff using the elasticity coefficient method. Our results indicate that annual runoff has experienced a significant downward trend over the past 60 years, which is projected to continue into the future. It is also found that the temporal pattern of the runoff regime differed upstream and downstream of the Danjiangkou Reservoir due to the joint operation of the reservoir and China’s Middle Route Project of South-to-North Water Diversion (MRP-SNWD). A significant decrease in runoff was primarily attributed to human activities, followed by precipitation. In contrast, evapotranspiration had the least effect. In particular, the MRP-SNWD was a significant anthropogenic factor, contributing to about 20.3% of the total change in runoff. Our results highlighted the unfavorable effects of human activity on the hydrological system in the Hanjiang River and provided some constructive suggestions to turn vulnerability into resilience.
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