Domain Of Biomedicine Research Articles

Unveiling the Potential of Protein-Based Sustainable Antibacterial Materials.

The surge in bacterial growth and the escalating resistance against a multitude of antibiotic drugs have burgeoned into an alarming global threat, necessitating urgent and innovative interventions. In response to this peril, scientists have embarked on the development of advanced biocompatible antibacterial materials, aiming to counteract not only bacterial infections but also the pervasive issue of food spoilage resulting from microbial proliferation. Protein-based biopolymers and their meticulously engineered composites are at the forefront of this endeavor. Their potential in combating this severe global concern presents an approach that intersects the domains of biomedicine and environmental science. The present review article delves into the intricate extraction processes employed to derive various proteins from their natural sources, unraveling the complex biochemical pathways that underpin their antibacterial properties. Expanding on the foundational knowledge, the review also provides a comprehensive synthesis of functionalized proteins modified to enhance their antibacterial efficacy, unveiling a realm of possibilities for tailoring solutions to specific biomedical and environmental applications. The present review navigates through their antibacterial applications; from wound dressings to packaging materials with inherent antibacterial properties, the potential applications underscore the versatility and adaptability of these materials. Moreover, this comprehensive review serves as a valuable roadmap, guiding future research endeavors in reshaping the landscape of natural antibacterial materials on a global scale.

Fabrication of organogel strain sensor with self-healing property and extreme temperature tolerance by using phytic acid-liquid metal as initiator

Wearable strain sensors have aroused myriad of interest in the domain of electronic skin, soft robotics, and biomedicine. Organogels for wearable strain sensors require desirable stretchability, sensing stability, self-healing property, and a wide working temperature range. However, the synthesis of such organogels typically involves complex and time-consuming processes. Herein, we proposed a rapid copolymerization method for organogels composed of poly(acrylic acid-co-acrylic amide) (P(AA-co-AM)), phytic acid (PA), liquid metal (LM), and polyethylene oxide (PEO). The dispersion of GaInSn in PA solution (GaInSn-PA) was synthesized and employed to initiate the copolymerization of acrylic acid (AA) and acrylic amide (AM), which significantly reduced polymerization time to 2–3 min at room temperature. The release of Ga3+ ions from the LM facilitated cross-linking of P(AA-co-AM) chains through coordination bonds, while also imparted conductivity to the organogel. The synergistic effect between hydrogen bonds and metal coordination bonds extensive within the polymer chains imparted exceptional stretchability (1079 % strain) and self-healing efficiency (98 % at 60 °C) to the organogel. Consequently, the resulting strain sensor demonstrated the ability to accurately monitor both subtle and large human motion, exhibiting remarkable repeatability and durability across a wide temperature range (-20 °C∼40 °C). In addition, the integration of strain sensors on limbs for robotic control through limb movements underscored its practical viability. This optimized fabrication approach and structural design strategy set a new precedent for the development of organogel strain sensors in various applications.

Understanding individualised genetic interventions as research-treatment hybrids

Until recently, medicine has had little to offer most of the millions of patients suffering from rare and ultrarare genetic conditions. But the development in 2019 of Milasen, the first...

Harnessing stimuli‐responsive biomaterials for advanced biomedical applications

AbstractCell behavior is intricately intertwined with the in vivo microenvironment and endogenous pathways. The ability to guide cellular behavior toward specific goals can be achieved by external stimuli, notably electricity, light, ultrasound, and magnetism, simultaneously harnessed through biomaterial‐mediated responses. These external triggers become focal points within the body due to interactions with biomaterials, facilitating a range of cellular pathways: electrical signal transmission, biochemical cues, drug release, cell loading, and modulation of mechanical stress. Stimulus‐responsive biomaterials hold immense potential in biomedical research, establishing themselves as a pivotal focal point in interdisciplinary pursuits. This comprehensive review systematically elucidates prevalent physical stimuli and their corresponding biomaterial response mechanisms. Moreover, it delves deeply into the application of biomaterials within the domain of biomedicine. A balanced assessment of distinct physical stimulation techniques is provided, along with a discussion of their merits and limitations. The review aims to shed light on the future trajectory of physical stimulus‐responsive biomaterials in disease treatment and outline their application prospects and potential for future development. This review is poised to spark novel concepts for advancing intelligent, stimulus‐responsive biomaterials.

MXenes-polymer nanocomposites for biomedical applications: fundamentals and future perspectives.

The article discusses the promising synergy between MXenes and polymers in developing advanced nanocomposites with diverse applications in biomedicine domains. MXenes, possessing exceptional properties, are integrated into polymer matrices through various synthesis and fabrication methods. These nanocomposites find applications in drug delivery, imaging, diagnostics, and environmental remediation. They offer improved therapeutic efficacy and reduced side effects in drug delivery, enhanced sensitivity and specificity in imaging and diagnostics, and effectiveness in water purification and pollutant removal. The perspective also addresses challenges like biocompatibility and toxicity, while suggesting future research directions. In totality, it highlights the transformative potential of MXenes-polymer nanocomposites in addressing critical issues across various fields.

From Synthesis to Solutions: Hydrogels' Impact on the Biomedical Landscape.

This review aims to examine the hydrogel structure concisely, approaches to hydrogel synthesis, and the most recent progressions in hydrogel technology along with its multifaceted applications within the domain of biomedicine, emphasizing its capacity to transform the delivery of drugs, tissue engineering, and diagnostics. This review employs an organized search of the literature to gather and evaluate state-of-the-art examines on hydrogel uses for biomedicine, synthesizing significant developments and breakthroughs to provide a holistic comprehension of their developing role and possible impact. The review's findings emphasize the revolutionary potential of recent advances in hydrogel uses within biomedicine, which includes improved drug delivery, cutting-edge tissue engineering, and recognized diagnostics. In summary, this scholarly article explores the intricacies of hydrogel structure, methodologies for hydrogel synthesis, and notable breakthroughs in the biomedical utilization of hydrogels. Given the extraordinary potential of hydrogels to transform diagnostic and therapeutic methodologies, this article emphasizes the growing significance of hydrogels in biomedicine and the critical need for further investigation into this subject matter. Consequently, hydrogels can pave the way for enhanced healthcare standards.

Design of ultra-thin multi-band sub-terahertz metamaterial absorber using three concentric ring resonators with same opening direction

In this paper, an ultra-thin sub-terahertz multi-band terahertz metamaterial absorber is proposed, its cell consists of three concentric ring resonators with the same opening direction, which can realize three discrete absorption peaks in the sub-terahertz frequency domain. The absorption peaks are mainly formed when the three open circular resonators interact with each other, and the superposition of the three discrete peaks creates a three-band absorption. The physical mechanisms of three-band absorption are illustrated by the electric fields and surface current distributions of three absorption peaks. Adjustment of the absorption effect could be obtained by altering the dimensions of the cleft circular resonator. By fixing the dimensions and changing the opening direction, these resonators will couple to each other and play an important role in regulating the frequency, intensity, and number of absorption peaks. Moreover, the multi-band metamaterial structure could be combined with vanadium dioxide, a phase change material, to actively modulate the absorption. In addition, the three-band metamaterial absorber has the characteristics of polarization-sensitive and wide-angle, which has extensive applications in the domains of security detection, biomedicine and communication.

Balancing Bioethics and Legal Frontiers: А Case Study of Brazil’s Supreme Federal Court Decision on Embryonic Stem Cell Research

Background. The present work focuses on the need to protect prenatal life, which is intricately entwined with delineating the precise biological and legal juncture marking an embryo’s transition into personhood. Drawing upon bioethical insights from domestic frameworks and international jurisprudence, we compare diverse perspectives on the moral and legal standing of the embryo, including its right to life, and invoking legal principles in the context of cellular and regenerative medicine.Aim. The goal of this article is to investigate the various biosafety policy approaches governing embryonic stem cell research, ranging from outright prohibition to authorization solely for therapeutic or scientific ends. Through our analysis, we focus on the unique national context of Brazil to scrutinize the underlying rationale behind a specific legal challenge questioning the constitutionality of the BiosafetyLaw. This law, which permits the utilization of human embryonic cells for research and therapeutic purposes, raises concerns about potential infringement upon the inviolability of the right to life.Methodology. The research is based on deductive reasoning alongside formal-legal methodologies, including textual interpretation and comparative-legal analysis. The research process involved documentary, bibliographic, and virtual analytical inquiries utilizing a variety of resources such as legislative texts, monographs, academic articles, databases, and online libraries. Results. Through our examination in a distinct national context, we delineate the theoretical-philosophical and normative-ethical foundations underpinning the stances of Brazilian Supreme Court justices concerning the utilization of embryonic stem cells. Their arguments predominantly invoked significant constitutional liberties such as freedom of family planning, scientific research, and academic pursuits, intertwined with considerations of human dignity and the sanctity of life. Additionally, some justices cautioned against the potential hazards inherent in genetic manipulation.Implications. The legal and ethical ramifications of Brazil’s approach to biosafety legislation concerning embryo rights invoke the necessity for conducting neutral, unfettered scientific inquiry and regenerative therapies according to specific operational parameters. These include safeguarding the integrity of genetic inheritance, preemptive evaluation of potential risks and benefits (adherence to the precautionary principle), and ensuring informed consent for treatments. A significant hurdle consists in the need to establish robust mechanisms for overseeing research involving human embryos within the domains of biomedicine and regenerative cell therapy

Biosynthesis of Zinc Oxide-Zerumbone (ZnO-Zer) Nanoflakes Towards Evaluating Its Antibacterial and Reactive Oxygen Species (ROS)-Dependent Cytotoxic Activity.

Being the second most prevalent metal oxide, zinc oxide (ZnO) nanomaterials have been widely studied and found to exhibit promising applications in various domains of biomedicine and agriculture. Considering the enhanced bioactivities displayed by secondary metabolite (SM) derived ZnO nanomaterials, present study was undertaken to evaluate the efficacy of ZnO nanoflake (NF) derived from Zerumbone (Zer), a sesquiterpenoid from Zingiber zerumbet rhizome with diverse pharmacological properties. ZnO NF prepared by homogeneous precipitation method using ZnSO4.7H2O (0.1M) and NaOH (0.2M) as precursors with and without the addition of Zer (0.38 mM) were characterized by powder UV-visible spectroscopy, X-ray diffraction (XRD), FT-IR spectroscopy and Field emission scanning electron microscope (FESEM) analysis. Optical and physical properties of ZnO-Zer NF were found to match with the typical ZnO nanomaterial properties. XRD analysis revealed reduction in size (15nm) of the green synthesized ZnO-Zer NF compared to ZnO NF (21nm). ZnO-Zer NF displayed linear correlation between concentration and antimicrobial activity to Salmonella typhi, Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa. Determination of cytotoxic potential of the synthesized ZnO-Zer NF in cervical cancer cells (HeLa) showed higher cytotoxicity of ZnO-Zer NF (39.32 ± 3.01%) compared to Zer alone (27.02 ± 1.22%). Present study revealing improvement in bioactivity of Zer following conjugation with ZnO NF signifies potential of NF formation in improving therapeutic application of Zer that otherwise displays low solubility limiting its bioavailability.

Introduction to Computational Biomedicine.

The domain of computational biomedicine is a new and burgeoning one. Its areas of concern cover all scales of human biology, physiology, and pathology, commonly referred to as medicine, from the genomic to the whole human and beyond, including epidemiology and population health. Computational biomedicine aims to provide high-fidelity descriptions and predictions of the behavior of biomedical systems of both fundamental scientific and clinical importance. Digital twins and virtual humans aim to reproduce the extremely accurate duplicate of real-world human beings in cyberspace, which can be used to make highly accurate predictions that take complicated conditions into account. When that can be done reliably enough for the predictions to be actionable, such an approach will make an impact in the pharmaceutical industry by reducing or even replacing the extremely laboratory-intensive preclinical process of making and testing compounds in laboratories, and in clinical applications by assisting clinicians to make diagnostic and treatment decisions.

Multiple computations for MHD flow of graphene-oxide nanofluid with radiative heat transfer within porous medium

This paper describes the fundamental characteristics of cavitation in non-Newtonian liquids and bubble dynamics and then applies them to the domains of bioengineering and biomedicine. The goal of this paper is to examine how Newtonian nanomaterial flows hydromagnetically when subjected to a spinning disc considering such biomedical and bioengineering applications. The vertical axis of the disc rotates with a uniform angular frequency. The fundamental mathematical expressions are governed by the Navier–Stokes equations with the Maxwell equations of magnetism, we obtained ordinary differential equations utilizing Von Kármán’s similarity transformations. Additionally, the effects of the magnetic field and radiation restrictions are considered. The RK-4 technique is used to solve the transmuted nonlinear ODEs. The analysis of MATLAB generated flow profiles has looked for changes in the values of key parameters. It is discovered that an increase in the thermal radiation parameter causes a decrease in the nanofluid temperature while an increase in the volume fraction of magnetite nanoparticles causes an increase. The skin-friction and heat-transfer rate at the disc are highly influenced by its rotational, the porosity of the porous media, thermal radiation and nanoparticle size. The rotational parameter, which regulates the disk’s rotation, is a result of the rotating phenomenon. The research demonstrates that when the disk’s rotation increases, the fluid motion accelerates in both the radial and cross-radial directions. Additionally, increasing the Prandtl number significantly improves heat transport, and a higher value for the rotation parameter shows a lesser concentration phenomenon. Additionally, the Nusselt number shows a decrease curve for a changeable thermal conductivity parameter. Finally, the current research can effectively close a gap in the physique of knowledge.

Research Image Management Practices Reported by Scientific Literature: An Analysis by Research Domain

Abstract Research data management is essential for safeguarding and prospecting data generated in a scientific context. Specific issues arise regarding data in image format, as this data typology poses particular challenges and opportunities; however, not much attention has been given to data as images. We reviewed 109 articles from several research domains where images were used either as data or metadata to understand how researchers specifically deal with this data format, and what are your habits and behaviors. We use the Web of Science (WoS), considering its five main areas of research. We included in the initial corpus the most relevant articles by research domain, selecting the ten most cited articles in WoS, by year, between 2010 and 2021. The selected articles should be in English and in open access. The results found that images have been used in scientific works numerous times, but, unfortunately, few are those in which they are the central element of the study. Photography is the type of image most used in most domains. In terms of the instruments used, the Technology and Life Sciences and Biomedicine domains use the microscope more, while the Arts and Humanities and Physical Sciences domains use the camera more. We found that the images are mostly produced in the context of the project, rather than reused by third parties. As for their collection scenario, these are mostly produced/used in a laboratory context. The overwhelming majority of the images present in the articles are digital, and only a small part is analog. We verify that Arts and Humanities are more likely to perform qualitative types of analyses, while Life Sciences and Biomedicine overwhelmingly use quantitative analyses. As for the issues of sharing and depositing, Life Sciences and Biomedicine is the domain that stands out the most in the tasks of depositing and sharing images. It was found that the licenses of a project are intrinsically related to the motivations for sharing results with third parties. Description, a fundamental step in the data management process, is neglected by a large number of researchers. The images are mostly not described or annotated and when this happens, researchers don’t provide much detail about this.

An intriguing approach toward antibacterial activity of green synthesized Rutin-templated mesoporous silica nanoparticles decorated with nanosilver

In recent years, mesoporous silica nanoparticles (MSNs) have been applied in various biomedicine fields like bioimaging, drug delivery, and antibacterial alternatives. MSNs could be manufactured through green synthetic methods as environmentally friendly and sustainable synthesis approaches, to improve physiochemical characteristics for biomedical applications. In the present research, we used Rutin (Ru) extract, a biocompatible flavonoid, as the reducing agent and nonsurfactant template for the green synthesis of Ag-decorated MSNs. Transmission electron microscopy (TEM), zeta-potential, x-ray powder diffraction (XRD), fourier transform infrared (FTIR) spectroscopy analysis, scanning electron microscopy (SEM), brunauer–emmett–teller (BET) analysis, and energy-dispersive system (EDS) spectroscopy were used to evaluate the Ag-decorated MSNs physical characteristics. The antimicrobial properties were evaluated against Staphylococcus aureus (S. aureus), Escherichia coli (E. coli), and also different types of candida. The cytotoxicity test was performed by using the MTT assay. Based on the findings, the significant antimicrobial efficacy of Ru-Ag-decorated MSNs against both gram positive and gram negative bacteria and different types of fungi was detected as well as acceptable safety and low cytotoxicity even at lower concentrations. Our results have given a straightforward and cost-effective method for fabricating biodegradable Ag-decorated MSNs. The applications of these MSNs in the domains of biomedicine appear to be promising.

Influence of nanofillers (Ag NPs and C. dots) on the controlled drug release profile of gelatin-grafted-polyacrylamide hydrogel: An in vitro study

Hydrogel nanocomposites, one of the essential biomaterials, because of its enhanced mechanical strength, improved swelling properties and stimuli responsiveness has recently become quite popular in the domains of drug delivery, tissue engineering, and biomedicine. In this work, silver nanoparticles (Ag NPs) / carbon dots (C. dots) embedded gelatin-grafted polyacrylamide hydrogel nanocomposites were fabricated to understand their role in drug release, a characteristics feature of the hydrogel system. Different parameters such as swelling, thermal stability, biodegradation and antibacterial properties were adopted in order to investigate the effect of incorporation of the nanofillers on pre-synthesized hydrogel. The swelling properties and thermal stability of the hydrogel were significantly improved due to the presence of nanofillers. The in vitro release of ciprofloxacin (CFX) was performed from these nanocomposite systems at different pH conditions, i.e. pH 1.2, pH 6.8 and pH 7.4. CFX release was found to be more at pH 7.4 as compared to pH 1.2. As compared to bare hydrogel, hydrogel nanocomposite systems have demonstrated more controlled release of CFX, thus making them an appealing delivery system candidate. Antibacterial studies on E. coli and S. aureus revealed that incorporation of Ag NPs imparted antibacterial property to the hydrogel system. C. dots enhanced the hydrophilicity of the system, also, it has great potential to be employed as bioimaging agent to track the drug release process.

Physical activity and sports sciences field in Italian scientific research products and its distinct composition in biomedicine, exercise and sports sciences and pedagogy domains

PurposeThis study aims to measure the number of scientific production of Italian professors, as framed on academic disciplines of Physical training and methodology (code M-EDF/01) and Sport sciences and methodology (code M-EDF/02), afferents to academic recruitment field of Exercise and sports sciences (code 06/N2) and Didactics, special education and educational research (code 11/D2).MethodsThe sample consisted of the entire population of full professors (n = 30) of M-EDF/01 and M-EDF/02, plus a proportional representation of the two academic recruitment fields with at least one associate professor per university, for a total of 78 professors. The titles of the first ten scientific products in terms of more citations from the Google Scholar database were analysed for each scientist. The title's full coherence at the scientific declaration of the two academic disciplines of M-EDF/01 and M-EDF/02 and biomedicine and pedagogy domains were assessed. One-way ANOVA with Bonferroni post hoc test was used to compare the two academic disciplines of the two academic recruitment fields with the three domains to highlight the separated data’s greater, average and lesser significance.ResultsThe aggregate data showed a prevalence of the biomedicine domain over the sport and physical activity ones in M-EDF/01 and M-EDF/02 in the academic recruitment field of 06/N2. On the other hand, in the academic recruitment of 11/D2, there was a prevalence of sport and physical activity domain over the biomedicine ones. In addition, a modest pedagogy scientific production in 06/N2 and biomedical in 11/D2 were found.ConclusionThe existence of the problem of the different coherence of the scientific profiles of the researchers concerning the relevant academic recruitment field and possibly also to the two academic disciplines was confirmed.

Development of Antimalarial Pharmacotherapy and its importance in Malaria Treatment/Public Health Program

Aim/Objective: The primary objective of this review is to describe the Evolution of current allopathic Anti-malarial Pharmacotherapy and understanding significance of Antimalarial drugs in Malaria Program/Public Health Program in India. Subject/Method: Review of Research Literature and Context-Content-Outcome Analysis of Antimalarial Drug Policy. Findings: Antimalarial drug list expanded extensively and the drug dose intensity is proportional to disease transmission in region/area; both the factors medicalizing the community significantly. The conceptual understanding of malaria remains within biomedicine domain evidenced by the fact that much of importance (over-reliance) given to least effective individual level technical interventions like drugs that too; without considering immunity and nutritional status of both individual and community. Indian Planners seems confused to differentiate (or ignoring) between Malaria’s behavior at Individual level and community level. Thus, the Malaria planning lacks ethical consideration for resource allocation in Public Health Planning evidenced by the fact that large resources allocated to least effective intervention that serves the profit making purpose of private sector pharma industry. Sufferings of the most impoverished household of community remain unaddressed in Health planning. Policy for Antimalarial Pharmacotherapy is unable to serve its primary purpose of relieving suffering of community, prevention of mortalities, reducing morbidities, slowing down the resistance, and reducing drug load in community. Conclusion: The investment in medications to tackle malaria as Public Health problem looks costly investments as it consumes heavy resources and its benefits/success claim is questionable. There is mismatch in planning and field reality as intervention in the form of drugs does not match the requirement as per epidemiological complexity. Health Planning is comprehensive exercise for any country. Ignoring voices from field/frontline workers prove detrimental for health planning. Every organization or individual involved in health planning would be having different opinions as per their interest but the final decision regarding resource allocation should consider the field reality following good public health ethics.

Good Law to Fight Bad Bugs: Legal Responses to Epidemics

Although epidemics are generally understood as lying within the domain of biomedicine, legal and social arrangements play crucial roles in determining whether or not infectious disease outbreaks grow into epidemics and even pandemics. Yet epidemics are challenging terrain for legal regulation. Because epidemics cross political borders and span jurisdictional boundaries, funding for epidemic prevention, preparedness, and response is always inadequate and coordination is difficult. Because epidemics require rapid and nimble responses, governments and international organizations often declare states of emergency, thereby evading some of the usual strictures of law. And because they involve massive uncertainty and rapidly evolving health crises, they require legal actors to work more quickly and with lower standards of proof than is common in law and to intrude on the turf of medical and scientific professionals. Legal contributions to pandemic management could be improved if legal measures such as global treaties and domestic public health law took account of these special features of epidemics.

Green synthesis and characterization of Ag and Ag/Fe3O4 nanocomposites for antimicrobial effect and rhodamine- B dye degradation

We used a simple two-stage tactic to design and synthesize a magnetically separable catalyst (MSC) Ag/Fe3O4 by combining independently synthesized Fe3O4 and Jatropha curcas root functionalized Ag nanoparticles (NPs) at room temperature. The phase composition of Ag/Fe3O4 NCs was revealed by morphological and structural assessment. The derived Ag/Fe3O4 nanocomposites demonstrated outstanding antimicrobial activity against Gram-negative Pseudomonas aeruginosa comparing to Gram-positive Bacillus subtilis which was determined by the agar well diffusion method. This is due to positively charged surface of metal oxide NPs that may bind to cell membrane. Interestingly, Ag–Fe3O4 NCs demonstrated good photocatalytic activity for organic dye degradation. According to a kinetic study, Ag/Fe3O4 MSC removed 99% of Rhodamine B at a rate constant of 1.89 min−1. The photoelectron could perhaps ultimately collide only with dissolved solids in the substrate to form superoxides, which can damage the dye. Notably, the MSCs reusability was tested using magnetic detachment without sacrificing photocatalytic efficiency. This finding represents a significant breakthrough in the domain of wastewater treatment and biomedicine.

A multi-network integration approach for measuring disease similarity based on ncRNA regulation and heterogeneous information

BackgroundMeasuring similarity between complex diseases has significant implications for revealing the pathogenesis of diseases and development in the domain of biomedicine. It has been consentaneous that functional associations between disease-related genes and semantic associations can be applied to calculate disease similarity. Currently, more and more studies have demonstrated the profound involvement of non-coding RNA in the regulation of genome organization and gene expression. Thus, taking ncRNA into account can be useful in measuring disease similarities. However, existing methods ignore the regulation functions of ncRNA in biological process. In this study, we proposed a novel deep-learning method to deduce disease similarity.ResultsIn this article, we proposed a novel method, ImpAESim, a framework integrating multiple networks embedding to learn compact feature representations and disease similarity calculation. We first utilize three different disease-related information networks to build up a heterogeneous network, after a network diffusion process, RWR, a compact feature learning model composed of classic Auto Encoder (AE) and improved AE model is proposed to extract constraints and low-dimensional feature representations. We finally obtain an accurate and low-dimensional feature representation of diseases, then we employed the cosine distance as the measurement of disease similarity.ConclusionImpAESim focuses on extracting a low-dimensional vector representation of features based on ncRNA regulation, and gene–gene interaction network. Our method can significantly reduce the calculation bias resulted from the sparse disease associations which are derived from semantic associations.

Comment on: “Dissolved oxygen sensing characteristics of plastic optical fiber coated with hydrogel film” – The wider context of fibre optic oxygen sensing

A recently published article by Bian et al. (2021) presents a novel plastic optical fibre coated with hydrogel film to measure dissolved oxygen via luminescence quenching. The article concludes that “The sensor with biocompatible material is expected to be applied to the monitor of dissolved oxygen in the domain of biomedicine”. However, the oxygen sensor presented contains ruthenium, a toxic material that is considered unsafe for clinical applications. It is unclear whether the hydrogel film coating may be sufficient to prevent direct contact between ruthenium and human tissue in clinical applications. However, platinum porphyrin has been used in fibre optic oxygen sensors in pre-clinical applications. This Comment article provides a brief overview of some platinum porphyrin-based fibre optic oxygen sensors that, despite an advanced degree of maturity and biocompatibility, were overlooked in the recently published article.