We formulate the momentum-space Dokshitzer–Gribov–Lipatov-Altarelli–Parisi (DGLAP) evolution equations for structure functions measurable in deeply inelastic scattering. We construct a six-dimensional basis of structure functions that allows for a full three flavor structure and thereby provides a way to calculate perturbative predictions for physical cross sections directly without unobservable parton distribution functions (PDFs) and without the associated scheme dependence. We derive the DGLAP equations to first non-zero order in strong coupling αs\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$\\alpha _\ extrm{s}$$\\end{document}, but the approach can be pursued to arbitrary order in perturbation theory. We also numerically check our equations against the conventional PDF formulation.