Dodecyl Sulfate Complexes Research Articles

Chitosan-graft-poly(lactide) nanocarriers: An efficient antioxidant delivery system for combating oxidative stress

Oxidative stress is a key factor in various diseases, and thus exogenous antioxidants offer effective therapeutic potential. While astaxanthin (ATX) is a potent natural antioxidant, its poor water solubility, bioavailability, and stability hinder its application. This study aimed to develop an amphiphilic chitosan-graft-poly(lactide) (CS-g-PLA) copolymer utilizing a new strategy by ring-opening polymerization of D, l-lactide via organosoluble CS/sodium dodecyl sulfate complex. Subsequently, CS-g-PLA micelles were prepared for efficient encapsulation and delivery of ATX. CS-g-PLA copolymers were characterized by FT-IR and 1H NMR. Transmission electron microscopy and dynamic light scattering revealed micellar morphology and size distribution. The antioxidant activity of CS-g-PLA/ATX was assessed using the DPPH assay, demonstrating significant improvement compared to free ATX. Furthermore, the cytotoxicity of micellar ATX was evaluated on H2O2-treated bone marrow mesenchymal stem cells (BMSCs) using MTT assay. Annexin V staining and mitochondrial membrane potential (∆Ψm) analysis revealed reduced apoptosis and enhanced protection by ATX-loaded micelles compared to free ATX. These findings suggest CS-g-PLA micelles as promising nanocarriers for ATX delivery, putatively enhancing its antioxidant potential and protecting stem cells in oxidative stress environments. This approach could hold significant implications for stem cell therapy in diseases associated with oxidative stress.

Maize‐derived zein/acrylic hybrid emulsion for superior skin adhesion and water resistance in cosmetic adhesives

AbstractWaterborne acrylic emulsions are considered suitable materials for cosmetic skin adhesives because of their positive attributes, such as their safe water‐based polymerization process and low volatile‐organic‐compound emissions. The significant challenge of inadequate water resistance in emulsion adhesives, which is primarily caused by the excess surfactants retained at the interface of emulsion particles upon film formation, necessitates urgent resolution for their viable application as cosmetic adhesives. Zein, a corn‐derived protein, possesses hydrophobic amino acids that provide exceptional water‐repellent characteristics. Therefore, zein is expected to exhibit a remarkable skin‐adhesion attribute. This paper presents the introduction of a pioneering zein/acrylic hybrid emulsion exhibiting remarkable skin adhesion and water resistance, which was achieved through the use of zein, a corn‐derived protein. After formation, the zein/ sodium dodecyl sulfate (SDS) complex can unfold the zein chain, thereby enhancing skin adhesion, while concurrently inhibiting surfactant migration to enhance water resistance. The zein/SDS complex was introduced into the Pre‐emulsion (PE) manufacturing process during emulsion polymerization. As expected, the zein/acrylic hybrid emulsion demonstrated favorable skin adhesion and a notable improvement in water resistance. This approach presents a promising avenue for the practical application of emulsion nanoparticles as eco‐friendly cosmetic adhesives, offering excellent durability and skin adhesion through the utilization of naturally derived proteins.

Investigation of critical micelles concentration of saccharide-surfactant-polymer complex

The diverse application of β-cyclodextrin grabbed the attention of research community. The encapsulation of hydrophobic molecules was the unique property of the β-cyclodextrin that suggested its application in enhanced oil recovery system. The well known Xanthan gum was one suggested polymer that could have its potential use in enhanced oil recovery systems along with the surfactant sodium dodecyl sulfate. However, this polymer surfactant complex show shear thinning behavior, the presence of β-cyclodextrin could alter the micelles structure. The present work focuses on the investigation of critical micelles concentration (CMC) of Xanthan gum, sodium dodecyl sulfate and β-cyclodextrin complex. Both conductivity and surface tension were followed to evaluate the critical micelles concentration of the complex at various β-cyclodextrin compositions in the mixture. The self assembly of the complex mixture shows reduction in the critical micelles concentration of the solutions.

Chitosan/Sodium Dodecyl Sulfate Complexes for Microencapsulation of Vitamin E and Its Release Profile-Understanding the Effect of Anionic Surfactant.

Microencapsulation of bioactive substances is a common strategy for their protection and release rate control. The use of chitosan (Ch) is particularly promising due to its abundance, biocompatibility, and interaction with anionic surfactants to form complexes of different characteristics with relevance for use in microcapsule wall design. In this study, Ch/sodium dodecyl sulfate (SDS) microcapsules, without and with cross-linking agent (formaldehyde (FA) or glutaraldehyde (GA)), were obtained by the spray drying of vitamin E loaded oil-in-water emulsion. All of the microcapsules had good stability during the drying process. Depending on the composition, their product yield, moisture content, and encapsulation efficiency varied between 11–34%, 1.14–1.62%, and 94–126%, respectively. SEM and FTIR analysis results indicate that SDS as well as cross-linkers significantly affected the microcapsule wall properties. The profiles of in vitro vitamin E release from the investigated microcapsules fit with the Korsmeyer-Peppas model (r2 > 0.9). The chemical structure of the anionic surfactant was found to have a significant effect on the vitamin E release mechanism. Ch/SDS coacervates may build a microcapsule wall without toxic crosslinkers. This enabled the combined diffusion/swelling based release mechanism of the encapsulated lipophilic substance, which can be considered favorable for utilization in food and pharmaceutical products.

Stabilization mechanism of reverse emulsions containing chromium (III): effect of interphase modification and dispersed phase viscosity

The stabilization mechanism of concentrated and highly concentrated emulsions containing chromium (III) sulfate colloidal solution as dispersed phase is presented. It is concluded that the internal interphase is stabilized mechanically by a chromium (III)—dodecyl sulfate complex formed during emulsion preparation. Moreover, the dynamic viscosity of the colloidal solution plays a significant role in emulsion stabilization. Both formation of a mechanically stable interphase and the viscosity of the colloidal solution depend drastically on the initial composition of the phases. To derive the corresponding stabilization mechanism, we quantify this dependency by employing empirical modeling of the maximum content of the dispersed phase, taken as a measure of the emulsion stability. Analysis of the model reveals a complex interplay of the stabilization and destabilization processes involved which depend on the mechanical properties of both the interphase and the disperse phase. In particular, we demonstrate that the highest content of the dispersed phase can be achieved when the initial composition of the phases favors the formation of a stiff interphase and the viscosity of the dispersed phase is sufficiently high.

Analysis of natural gas hydrate formation in sodium dodecyl sulfate and quartz sand complex system under saline environment

ABSTRACTUnder natural conditions, natural gas hydrate occurs in the pores of porous media found in the sedimentary layer. Thus, the rapid formation and basic properties of the hydrate in the porous medium must be studied. Quartz sand with different particle sizes compounded with Sodium Dodecyl Sulfate solution was used to study the hydrate formation in the system at 275.15 K and 6 MPa under a saline environment. Results were as follows. 1) Methane gas uptake in a saline system with NaCl concentration of 50 mmol was higher than that in pure water. This finding indicated that although the salt is a thermodynamic inhibitor, low concentration of NaCl can promote the formation of hydrates. 2) In the initial stage of the experiment, the rate of hydrate formation in saline environment was significantly higher than that in pure water. After approximately 1 h, the formation rate of hydrate in the compound system decreased under a saltwater environment and was lower than that in the complex system under pure water. 3) The hydrogen bond network inside the high-concentration NaCl solution was seriously damaged. In this case, water molecules cannot easily form a cage structure, and the presence of chlorine ions weakens the stability of a small amount of formed hydrate cage, thereby further inhibiting the formation of hydrates. However, in the low-concentration NaCl system, mass transfer is improved, and the formation of hydrate is promoted because of the weakened hydrogen bonding at the gas–liquid interface.

Effect of Porous Media and Sodium Dodecyl Sulphate Complex System on Methane Hydrate Formation

Hydrates are mainly stored in the pores of the sedimentary layer, so their formation and storage characteristics in pores are particularly important for the exploitation and utilization of hydrates. Meanwhile, in order to study the rapid formation methods of hydrate, 300 ppm of sodium dodecyl sulfate (SDS) solutions mixed with alumina and silica particles, respectively, were used for investigating the hydrate formation in the pores of porous media under the conditions of 275.15 K and 7 MPa. The particle sizes of alumina and silica were 2, 4, and 6 mm. The experimental results indicated porous media with smaller size could shorten the induction time of the hydrate formation and increase the final gas uptake. In dissolution period and induction period, gas consumption of hydrate formation in alumina particles was larger than that in silica, but the reverse in the growth period. The hydrate formed in alumina particles had a better gas storage ability. In the used SDS solution, the positive charges produced by hydrolysis on the alumina surface and the negative charges produced by polarization and hydration on silica surface affected the distribution of the SDS active group around their surface, which led to the difference of gas storage density between the hydrates formed in these two particles. Finally, with the formation of the hydrate on the wall of the porous medium, the stronger capillary force caused by the decreasing pore size led to a migration of water, which further resulted in the hydrate form in the pores without SDS solution originally.

Quantum chemical study of the molecular structure of the sodium dodecylsulfate complexes with glycine and cysteine

The quantum chemical modeling of sodium dodecylsulfate (DDSNa) complexes with glycine (Gly) and cysteine (Cys) is carried out at the DFT/B97D level using the Grimme hybrid exchange-correlation functional with a dispersion correction and the 6-311++G(2d,2p) basis set. The structure of the Gly and Cys molecular and zwitterionic forms is examined. The structures and the formation energies of DDSNa…Gly and DDSNa…Cys complexes are determined. The effect of the amino acid structural features on the stability of the complexes they form with DDSNa is analyzed. The NBO analysis of the electron density distribution in the DDSNa molecule is performed.

Evaporation of aqueous solutions of organic acids through spread films of poly(diallyldimethylammonium chloride)/sodium dodecylsulfate complex

ABSTRACTThe films with the extreme concentration of poly (diallyldimethylammonium chloride)/sodium dodecylsulfate complex spread to the surface of aqueous solutions of formic and acetic acids reduce the evaporation rate of liquids by 3–6% and demonstrate selective properties increasing water content in the vapor by 1–3 abs.%. The concentrations of solutions were up to 30 vol.%. The formation conditions of such films were determined by means of the Wilhelmy plate technique. Surface tension isotherms of aqueous solutions of acids were also obtained.

Interfacial properties of chitosan/sodium dodecyl sulfate complexes

Contemporary formulations of cosmetic and pharmaceutical emulsions may be achieved by using combined polymer/surfactant system, which can form complexes with different structure and physicochemical properties. Such complexation can lead to additional stabilization of the emulsion products. For these reasons, the main goal of this study was to investigate the interfacial properties of chitosan/sodium dodecyl sulfate complexes. In order to understand the stabilization mechanism, the interface of the oil/water systems that contained mixtures of chitosan and sodium dodecyl sulfate, was studied by measuring the interfacial tension. Considering the fact that the properties of the oil phase has influence on the adsorption process, three different types of oil were investigated: medium-chain triglycerides (semi-synthetic oil), paraffin oil (mineral oil) and natural oil obtained from the grape seed. The surface tension measurements at the oil/water interface, for chitosan water solutions, indicate a poor surface activity of this biopolymer. Addition of sodium dodecyl sulfate to chitosan solution causes a significant decrease in the interfacial tension for all investigated oils. The results of this study are important for understanding the influence of polymer-surfactant interactions on the properties of the solution and stability of dispersed systems.

Квантово-химическое исследование молекулярного строения комплексов додецилсульфата натрия с глицином и цистеином

Квантово-химическое исследование молекулярного строения комплексов додецилсульфата натрия с глицином и цистеином

Exploring the Nature of the Nanocavity and Channels in Apoferritin and Apoferritin–Sodium Dodecyl Sulfate Complex Using an Enhanced Antenna Effect through the Encapsulation of EuIII–Tetracycline

The drug tetracycline hydrochloride (TC), which has cytotoxic and cytostatic effects on tumor cells, has been encapsulated within the nanocavity of apoferritin in the form of its EuIII complex (Eu3TC). The Eu3TC complex was encapsulated within apoferritin through disassembly followed by reassembly of the protein and exhibited significantly enhanced EuIII emission in comparison with that of free Eu3TC in aqueous buffer at pH 8. The steady‐state and transient measurement of the emission of each species in the ternary system suggest that the effective sensitization of EuIII emission may be ascribed to a comparatively rigid environment for the bound TC after encapsulation that promotes efficient energy transfer to the EuIII ions. Emission studies in D2O revealed that the microenvironment of the EuIII ion is shielded from O–H oscillators in the ternary system, and the extent of shielding is greater after the encapsulation of the complex within the apoferritin cavity. The rotational correlation time (θc) of bound TC and docking studies also support the contention that the TC is in a more buried environment after encapsulation within the apoferritin cavity. A competition study with sodium dodecyl sulfate (SDS) revealed that SDS does not interfere with the binding of TC to apoferritin. The biocompatible system consisting of Eu3TC encapsulated within the cavity of apoferritin may be used as an efficient targeted drug transporter, and the sensitization of the EuIII emission may also enable its use as a biosensor.

Polyvinylpyrrolidone-sodium dodecylsulfate complex is a family of pseudo-polyanions with different charge densities: Evidence from capillary electrophoresis, capillary viscosimetry and conductometry

Accordance with the previously supposed polyelectrolyte-like behaviour of neutral polymer-anionic surfactant complexes, direct evidence for the formation of the pseudo-polyanions in polyvinylpyrrolidone (PVP)-sodium dodecylsulfate (SDS) solution is put forward in this paper by capillary electrophoresis (CE) experiments in assistance with capillary viscosimetry and conductometry. The contradictory phenomena of the absolute value of relative electrophoretic mobility (re) increasing while the ionization degree (α) decreasing with the increasing specific clusterization [Г] in aqueous PVP-SDS solution are explained by the finding that the PVP-SDS complex is eventually a family of PVP-SDS pseudo-polyanions with different charge densities. And it is found countercations playing an important role in the formation of the PVP-SDS pseudo-polyanions in virtue of bridge effect.

Insights into the morphology of human serum albumin and sodium dodecyl sulfate complex: A spectroscopic and microscopic approach

Exploring and understanding the fundamental interaction between protein and surfactant is utmost important for various pharmaceutical and biomedical applications. However, very less is known about the arrangement of individual negatively charged sodium dodecyl sulfate (SDS) molecules on the human serum albumin (HSA). Here, we have investigated the morphology and mechanistic insights of complexation between HSA and SDS by means of photoluminescence (PL) spectroscopy, circular dichroism (CD) and PL microscopy using amine-functionalized silicon quantum dot (Si QD) as an external luminescent marker. The present study is based on a unique and dynamic SDS-Si QD system. The synthesized allylamine–functionalized Si QDs show a distinct PL band centered at 455nm upon excitation at 375nm. At neutral pH, these Si QDs form ordered aggregates in the presence of 1mM SDS due to the hydrogen bonding interaction with the sulfate head groups of surfactants, which is manifested in the appearance of a large Stokes shifted luminescence band centered at 610nm. It has been observed that the PL intensity of SDS-Si QD aggregates at 610nm decreases gradually with concomitant increase in the PL intensity of monomeric Si QDs at 455nm upon increasing the concentration of HSA from 1 to 10μM. These observations combined with PL lifetime, PL microscopy and CD results reveal that SDS forms micelle-like aggregates on the partially unfolded HSA mainly via electrostatic interaction between negatively charged sulfate head groups and positively charged residues of partially unfolded HSA. For the present HSA-SDS system, our results fit a model with type I “necklace and bead”-like structures, where micelle-like SDS aggregates wrap around by the partially unfolded HSA backbone.

Spontaneous Formation of CTAB/SLS Vesicles

Cetyl trimethyl ammonium bromide/sodium dodecyl sulfate (CTAB/SLS) complex formulation of scale effect on the spontaneous formation of vesicles and the influence of different factors on the stability of vesicles were discussed, structure and morphology of vesicles were observed.

Spontaneous Formation of DTAB/SLS Vesicles

Dodecyl trimethyl ammonium bromide/sodium dodecyl sulfate (DTAB/SLS) complex formulation of scale effect on the spontaneous formation of vesicles and the influence of different factors on the stability of vesicles were discussed, structure and morphology of vesicles were observed.

Hydrogen peroxide detection under physiological conditions by Prussian blue stabilized using a polyelectrolyte–surfactant complex matrix

Poly(allylamine)–dodecylsulfate complex (PA–DS) is able to form a stable and layered structure onto graphite electrodes and can efficiently retain negatively charged ions like ferrocyanide. In this context, Prussian blue (PB) is electrochemically synthesized from a solution containing K3[Fe(CN)6] and FeCl3 at pH 1.7. The electrochemical behavior of the new system is investigated in different supporting electrolytes (K+ and Na+) and in acid and neutral media. Remarkable, well-defined and reversible voltammetric responses are obtained, especially under physiological conditions (neutral pH and 150mM NaCl). In these conditions, the modified electrode is able to electrocatalyze the reduction of hydrogen peroxide (H2O2) at micromolar levels, with a low detection limit and good sensitivity. These results represent an important improvement regarding further uses of PB in bioanalytical applications.

Poly(vinyl pyrrolidone)-Sodium Dodecyl Sulfate Complex as a Probe to Study the Effect of Benzyl Alcohol on Micellization Behaviour of Sodium Dodecyl Sulfate

Poly(vinyl pyrrolidone)-Sodium Dodecyl Sulfate Complex as a Probe to Study the Effect of Benzyl Alcohol on Micellization Behaviour of Sodium Dodecyl Sulfate

Structure investigation of poly((2-dimethylamino)ethyl methacrylate)/sodium dodecylsulfate complexes in concentrated poly((2-dimethylamino)ethyl methacrylate) solutions using small angle neutron scattering

The structure of poly((2-dimethylamino)ethyl methacrylate)/sodium dodecylsulfate complexes in water was investigated as a function of poly((2-dimethylamino)ethyl methacrylate) concentration at a fixed sodium dodecylsulfate concentration using small angle neutron scattering. When either hydrogenated or deuterated sodium dodecylsulfate was added to poly((2-dimethylamino)ethyl methacrylate) solutions in D2O, a peak was observed in the small angle neutron scattering which was characteristic of charged micelles. This peak shifted to higher q in both cases as poly((2-dimethylamino)ethyl methacrylate) concentration increased, indicating that the size and shape of micelles changed due to favorable interactions between poly((2-dimethylamino)ethyl methacrylate) and sodium dodecylsulfate. The small angle neutron scattering intensity of the micelles in the polymer/surfactant solutions was measured at the condition where poly((2-dimethylamino)ethyl methacrylate) was contrast-matched. It was possible to obtain information about the structure of the micelles using the Hayter–Penfold model. Based on the results from the fit of the SANS data, it was found that partial shielding provided by poly((2-dimethylamino)ethyl methacrylate) monomers being incorporated into the micelle shell significantly influenced both the form factor and the structure factor of micelles in the polymer/surfactant solutions. This led to a decrease in the micelle size and an increase in the number of micelles. It was found that any increased repulsive potential resulting from a smaller distance between the charged micelles was relieved by a decrease in the surface charge.

A Critical Approach to the Thermodynamic Characterization of Inclusion Complexes: Multiple-Temperature Isothermal Titration Calorimetric Studies of Native Cyclodextrins with Sodium Dodecyl Sulfate

Inclusion complexes based on native cyclodextrins are basic building blocks for the design of a new generation of promising materials. The design process can be optimized by maximizing the population of the desired chemical species. This is greatly facilitated by an accurate characterization of the thermodynamic parameters for their formation. A critically assessed literature review of equilibrium constants for cyclodextrin:sodium dodecyl sulfate (CD:SDS) complexes is reported. We performed multiple-temperature isothermal titration calorimetric (283-323 K) measurements for these systems, leading to the first reported heat capacity changes of binding. Data were analyzed using two thermodynamic models by homemade programs that also provide the distribution of chemical species as a function of the experimental variables. Assisted by earlier molecular dynamic simulations, a microscopic-level discussion of the contributions to the thermodynamic parameters is given. On the basis of our results, a number of recommendations to obtain reliable association parameters for CD-based inclusion complexes are listed.