It is with great sadness that we announce that C. Wayne Bardin, MD passed away peacefully on October 10, 2019 at his home in New York City, his wife Beatrice at his side. This was not unexpected, as he had been in declining health for several years, but his death nonetheless marks the loss of a true giant in the field of Endocrinology. Wayne was known not only for his intellect, creativeness, teaching, mentorship, and scientific leadership worldwide but also for his love of family, friends, and humanity. He is survived by his wife Beatrice, two daughters Stephanie Torre (Tony) and Charlotte Merritt (Michael), stepchildren, and grandchildren. Dr. Bardin was born in West Texas in 1934. He graduated from Rice University in 1957, matriculated to Baylor College of Medicine, pursued his medical residency at Cornell University, New York Hospital and then did his endocrine fellowship at the National Cancer Institute in 1962 under the mentorship of Drs. Mortimer Lipsett and Griff Ross. He remained at the NIH as a senior investigator until becoming Professor and Chief, Division of Endocrinology at the Pennsylvania State University College of Medicine, Hershey, in 1970. After eight years, Wayne joined the Population Council, at Rockefeller University, as Director of the Center for Biomedical Research and Vice President of the Population Council. Although he retired from the Population Council in 1996, he remained active as a private consultant to biomedical corporations seeking his expertise and advice regarding potential contraceptive products requiring FDA approval. Wayne Bardin’s research accomplishments are both numerous and legendary. On the eve of being able to measure hormone levels in small quantities of blood, he began his studies of the feedback regulation of pituitary hormones while at Baylor and his prescient studies of steroid metabolism during his medical residency at Cornell under the tutelage of Dr. Ralph Peterson. During his NIH tenure, he focused on animal models of androgen resistance and androgen regulation of cellular proliferation. Subsequently, however, his clinical research took a major turn to encompass studies of methods to regulate reproductive function in men and women, and pioneering effective and affordable contraceptive trials worldwide; particularly among impoverished populations. Most notably, he developed a subdermal implant (Norplant) that would provide effective reversible contraception for women up to five years. Additionally, he evaluated intra-uterine devices (copperT-200 and T-380), the effectiveness of RU-486 for medical termination of pregnancy, and synthesis and trials of Nestorone in various formulations including as a contraceptive vaginal ring. Wayne was prolific in his scientific reports publishing over 500 papers and book chapters. His teaching and mentorship included about 120 individuals worldwide who trained under him; many of whom have gone on in their own right to become senior investigators, thought leaders, department chairs, and award honorees. Dr. Bardin’s leadership role was exemplary. Within andrology, he was active in the National Prostate Cancer Task Force, NCI (1973-78), Council member and President of our American Society of Andrology (1988-89). Within the general endocrine community, he was Director of the Clinical Endocrinology Update course for many years; and member of the Endocrine Society Council before becoming its President (1993-94) and Chairman, of the International Committee for Contraception Research of the Population Council from 1978-96. His consultative endeavors and responsibilities included numerous NIH research grant study sections, journal editorial boards, and international committees too long to list. Dr. Bardin received numerous awards including Distinguished Andrologist (1984 and 1992), membership in the Institute of Medicine, awardee of Doctor Honoris Causa at the University of Caen, France; the University of Pierre and Marie Curie, Paris, France; and the University of Helsinki, Finland; and Commander of the Order of the Lion of Finland among others. Wayne was not all about science. He had an insatiable appetite for the arts and music and theater. He did not hesitate, at a later age, to learn how to ski with the encouragement of his wife Beatrice. Those of us who trained under Dr. Bardin deeply mourn his death. He was our mentor, inspiration, colleague, and friend. He gave generously of his personal time to enhance our own career success. We have all tried to emulate his style; but none can match his unique greatness.
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