In Lake Baikal, the majority (87%) of fish biomass is generated in the pelagic zone. Two species of Comephorus, three species of Cottocomephorus and Coregonus migratorius inhabit in the pelagic zone of the lake. Currently, only C. migratorius is considered a resource species, the harvest of which accounts for about 50% of the total fish harvest. Food items for pelagic fish are copepods Epischura baikalensis and pelagic amphipods Macrohectopus branickii. The seasonal distribution and formation of zooplankton concentrations determine the food migrations of fish. The patterns of the seasonal distribution of zooplankton and pelagic fish were described by M.M.Kozhov (1954, 1964). Comparative analysis of the abundance of zooplankton in South Baikal over time, showed that during the period of maximum development of E. baikalensis in the months of July, August, and October, zooplankton concentration in the decade 1997 to 2007 was twice more than in 1951 (Kozhov 1954; Kiprushina 2010). The distribution of E. baikalensis is directly dependent on the water temperature. Yet there is an inverse relationship in the surface layer 0–25 meters. During warming up of the surface water layers, which had been observed in 2002 year E. baikalensis left the upper zone and migrated deeper, to a layer of 50–100 meters. In other months of the year, no changes in the average values of the E. baikalensis abundance were revealed. At present, when the ecosystem of Lake Baikal is changing, there is a need to restart such complex studies, and to use the results obtained by M.M. Kozhov for comparative analysis.