Introduction When it comes to blood transfusion and transplant medicine, the ABO as well as Rh blood group system are significant. There have been 700 RBC antigens found so far, and they've been divided into 30 blood groups as a result. For example, blood transfusion reaction, paternity testing, legal medicine, as well as associations with different illnesses are all medicolegally relevant when looking at ABO and Rh. Aim: The objective was to find out how much demand there is for a specific blood type compared to how much supply there is in society, to lower death rates caused by a shortage of that kind of blood. Compare the results with those from another comparable research performed in India and across the globe. Material and Methods: Between August 2018 to July 2021, researchers conducted a study on 7820 blood donors who visited the Zydus blood Centre. Tube agglutination testing and the Gel card method were used to find the patient's ABO as well as Rh blood groups. Both reverse as well as forward blood grouping methods are performed and confirmed only if both are identical. The age and sex groups as well as frequency of ABO and Rh blood groups were reported in percentages. Result The male-to-female ratio in our research was 30:1. The greatest number of male and female donors were between the ages of 18 to 30 years. For blood donation, it has been found that "O" blood donors are the most predominant, then those with B>A>AB blood groups. According to voluntary and replacement blood donors, AB & A blood groups are more (%) in replacement blood donors as compare to O and B blood groups. Voluntary donors are 33.67% and replacement donors were 66.64%. Distribution of Rh+ve and Rh-ve blood groups in our study was 98.78% and 1.22% respectively. Conclusion It is essential to have a thorough understanding of the distinct blood groups distribution for ensuring that blood as well as its components are always available to recipients in a particular area. The present work will provide insight on a deficiency of particular blood groups, in a particular area, like A and AB blood group are more in replacement donor showing deficiency of that blood groups in this area in our study.
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