BackgroundTumor of the follicular infundibulum (TFI) is considered as a rare benign neoplasm providing two distinctive clinical patterns: the solitary and the eruptive form. The clinical presentations resemble many other dermatologic conditions and require histopathological study to make a definite diagnosis.ObjectiveTo inform physicians of a clinical presentation of TFI.Case ReportWe report on a 50-year-old man who presented with multiple asymptomatic hypopigmented macules resistant to the treatments. The histopathological study was consistent with tumors of the follicular infundibulum.ConclusionHypopigmented macules are one of the more common clinical presentations in dermatological practices. It is important to include TFI in the differential diagnosis when a patient with hypopigmented lesions does not respond to the treatment based on the clinical diagnosis.Electronic supplementary materialThe online version of this article (doi:10.1007/s13555-015-0079-0) contains supplementary material, which is available to authorized users.