Displacement Strategy Research Articles

Ureteroscopy and lasertripsy for lower pole stones

To investigate the outcomes of ureteroscopy and lasertripsy in lower pole renal stones <2 cm when treated in situ compared to displacement to the upper pole. Using the Medical Literature Analysis and Retrieval System Online (MEDLINE)/PubMed, the Excerpta Medica dataBASE (EMBASE), Cumulative Index to Nursing and Allied Health Literature (CINAHL), the Cochrane Library, and Clinicaltrials.gov we identified adult population, English language, studies published until March 2023 comparing surgical outcomes and stone-free rates (SFRs) in relation to lower pole stones <2 cm managed in situ vs those displaced (International Prospective Register of Systematic Reviews [PROSPERO] identifier: CRD42023432750). Analysis was performed using R with the 'meta' package. Bias analysis was performed using the Cochrane Risk of Bias 2 tool for randomised trials and the Newcastle-Ottawa scale for observational studies. The Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach was used to ascertain the certainty of evidence. A total of five studies were included, comprising two retrospective cohort studies, three randomised trials, with a total of 408 patients. Meta-analysis demonstrated SFRs are significantly higher in those patients undergoing displacement vs those managed in situ (risk ratio 1.21, 95% confidence interval [CI] 1.10-1.34, P < 0.001). There was no significant difference in complication rates. Operative time was significantly longer in the displacement group (mean difference 5.62 min, 95% CI 0.40-10.83 min; P = 0.03). Overall risk of bias was moderate. Certainty of evidence was moderate for stone-free status, and very low for all other outcomes. This systematic review and meta-analysis demonstrates that for lower pole stones <2 cm displacement strategies have significantly higher SFRs than treatment in situ, with no significant difference in complications. There is significantly increased operative time in the displaced group, but an additional 6 min is unlikely to be clinically significant.

Manifold Fluorescence Enhancement of a Styryl(pyridinium)-chromene Hybrid Dye upon Binding with an Elongated β-Cyclodextrin Cavity.

The interaction of a styryl(pyridinium)-chromene hybrid dye (DSP-C) with the 2-hydroxypropyl-β-cyclodextrin (HPβCD) macrocycle leads to a remarkably large increase (∼310-fold) in its fluorescence intensity, in contrast to the relatively smaller (∼45-fold) enhancement observed with native β-cyclodextrin (βCD). Both macrocycles (βCD and HPβCD) bind with the styryl(pyridinium) as well as the chromene fragments of the hybrid dye, with the simultaneous formation of 1:1 and 2:1 host:guest complexes. However, the binding constant (Keq1) is more than an order of magnitude higher for HPβCD than for βCD. The improved binding affinity of HPβCD is attributed to its elongated and deeper hydrophobic cavity. This is supported well by the optimized geometries of the host-guest complexes. Theoretical calculations also reveal that the energy change due to the release of high-energy water molecules from the host nanocavity is more favorable for HPβCD than βCD, resulting in greater stability of the HPβCD:DSP-C complex. Interestingly, though the fluorescence of DSP-C arises from its styryl(pyridinium) fragment, the complexation of the chromene unit with the host plays a major role in augmenting the fluorescence enhancement of the hybrid dye. The large fluorescence change in the HPβCD:DSP-C system has been utilized for the detection of bile salts by the indicator displacement strategy.

Smoothed-Interface SPH Model for Multiphase Fluid-Structure Interaction

Numerical simulation of multiphase flows with large density ratios presents considerable challenges. Traditional Smoothed Particle Hydrodynamics (SPH) methods, while efficient in tracking multi-phase interfaces, often suffer from non-physical gaps near interfaces, compromising accuracy. In this paper, we develop an advanced multiphase model with enhanced interface continuity and stability, offering a reliable approach to both multiphase flows and fluid-structure interaction. The model employs equivalent continuity equations across different phases and refines the treatment of pressure and its gradients at interfaces through a smoothing technique, which effectively eliminates the non-physical gaps prevalent in the conventional SPH multiphase models. Moreover, an efficient and accurate method for calculating interface normal vectors and identifying interfaces is proposed. Based on the method, we introduce a series of techniques, including an improved interface force model, a particle displacement strategy, and a new particle penetration detection scheme, all of which significantly improve the interface continuity and the overall simulation accuracy of multiphase flows. Finally, the proposed multiphase SPH model is validated through several numerical examples, including two-dimensional static water, standing waves, dam break, oscillating multi-fluid, and wedge entry, as well as three-dimensional sphere entry. Comparative results with the traditional model indicate that the multiphase SPH model in this work ensures interface continuity and stability in long-period simulations, even under intense flow conditions. These results suggest that the smoothed-interface SPH multiphase model can eliminate non-physical gaps at interfaces, greatly enhancing interface continuity and stability, and highlighting its potential for accurate multiphase flow simulations.

Fluorescence-Based Multimodal DNA Logic Gates.

The use of DNA structures in creating multimodal logic gates bears high potential for building molecular devices and computation systems. However, due to the complex designs or complicated working principles, the implementation of DNA logic gates within molecular devices and circuits is still quite limited. Here, we designed simple four-way DNA logic gates that can serve as multimodal platforms for simple to complex operations. Using the proximity quenching of the fluorophore-quencher pair in combination with the toehold-mediated strand displacement (TMSD) strategy, we have successfully demonstrated that the fluorescence output, which is a result of gate opening, solely relies on the oligonucleotide(s) input. We further demonstrated that this strategy can be used to create multimodal (tunable displacement initiation sites on the four-way platform) logic gates including YES, AND, OR, and the combinations thereof. The four-way DNA logic gates developed here bear high promise for building biological computers and next-generation smart molecular circuits with biosensing capabilities.

Temperature-Tolerant Versatile Conductive Zwitterionic Nanocomposite Organohydrogel toward Multisensory Applications.

Conductive hydrogels (CHs) are emerging materials for next generation sensing systems in flexible electronics. However, the fabrication of competent CHs with excellent stretchability, adhesion, self-healing, photothermal conversion, multisensing, and environmental stability remains a huge challenge. Herein, a nanocomposite organohydrogel with the above features is constructed by in situ copolymerization of zwitterionic monomer and acrylamide in the existence of carboxylic cellulose nanofiber-carrying reduced graphene oxide (rGO) plus a solvent displacement strategy. The synergy of abundant dipole-dipole interactions and intermolecular hydrogen bonds enables the organohydrogel to exhibit high stretchability, strong adhesion, and good self-healing. The presence of glycerol weakens the formation of hydrogen bonds between water molecules, endowing the organohydrogel with excellent environmental stability (-40 to 60 °C) to adapt to different application scenarios. Importantly, the multimodal organohydrogel presents excellent sensing behavior, including a high gauge factor of 16.3 at strains of 400-1440% and a reliable thermal coefficient of resistance (-4.2 °C-1) over a wide temperature widow (-40 to 60 °C). Moreover, the organohydrogel displays a highly efficient and reliable photothermal conversion ability due to the favorable optical absorbing behavior of rGO. Notably, the organohydrogel can detect accurate human activities at ambient temperature, demonstrating potential applications in flexible intelligent electronics.

Simultaneous Coherent and Displacement Compounding for 2-D Noninvasive Carotid Strain Imaging: A Proof of Principle Study.

Arteriosclerosis results from lipid buildup in artery walls, leading to plaque formation, and is a leading cause of death. Plaque rupture can cause blood clots that might lead to a stroke. Distinguishing plaque types is a challenge, but ultrasound (US) elastography can help by assessing plaque composition based on strain values. Since the artery has a circular structure, an accurate axial and lateral displacement strategy is needed to derive the radial and circumferential strains. A high-precision lateral displacement is challenging due to the lack of phase information in the lateral direction of the beamformed RF data. Previously, our group has developed a compounding technique in which the lateral displacement is estimated using triangulation of the axial displacement estimated from transmitting and beamforming US beams at ±20°. However, transmitting with a single plane wave will reduce signal-to-noise and contrast-to-noise ratio as well as lateral resolution. In this article, we combine our displacement compounding with coherent compounding. Instead of transmitting a single plane wave, multiple plane waves are transmitted at certain angles centered on the angle of the beamforming grids, and then, the backscattered wavefronts are beamformed and coherently compounded on the center of the transmit beams (-20°, +20°, and 0°). The numerical investigation using the GE9LD probe ( f0 = 5.32 MHz, pitch = 230 μ m, and width = 43.9 mm) led us to 19 plane waves spanning angles within -10° to 10° (with respect to center of the transmit beams), resulting in a total of 57 plane wave transmit (for three beamforming grids at 0° and ±20°). FIELD II simulations of a cylindrically shaped phantom (mimicking the carotid artery) at a signal-to-noise ratio (SNR) ≥ 20 dB show that the proposed method decreases the root-mean-square error (RMSE) of the lateral displacement and strain estimations by 40% and 45% compared to the previous method, respectively. The results of our experiments with a carotid artery phantom [made out of 10% polyvinyl alcohol (PVA)] show that the proposed method provides strain images with higher quality and more in agreement with the theory, with 26% lower standard deviation, especially at the peak systolic phase. The proposed method paves the path toward improved quality in vivo 2-D strain imaging using our displacement compounding technique and translating it to 3-D with a row-column array.

The Return of the Oppressed: Notes on Kurdish Anti-colonialism

Abstract This article critically examines the historical trajectory and contemporary manifestations of Kurdish anti-colonialism. The analysis unfolds in two parts, dissecting the intricate relationship between theory and action within the Kurdish struggle. The historical dimension delves into Ottoman-era Turkish-style colonization, elucidating the displacement strategies employed by the Ottoman state. The study underscores the delayed integration of the colonialism concept into the Kurdish intellectual framework, shedding light on the challenges faced by the oppressed in articulating their anti-colonial narrative. The second part scrutinizes the ideological challenges within the Kurdish anti-colonial discourse. The instrumental use of the slogan “Kurdistan is a colony” is explored, emphasizing the dominance of socialist objectives over national liberation aspirations. The impact of socialism and pan-Islamism on Kurdish politics and the linguistic complexities that obscure the colonial difference through language are examined. Contemporary dynamics, such as the Peace and Democracy Process and political violence, are analyzed to provide insights into the evolving nature of the Kurdish struggle. The resurgence of colonial theory within Kurdish society, particularly through techno-Kurdishness, is explored, highlighting the role of modern communication technologies in reshaping the narrative. The article concludes by reflecting on the potential of the Kurdish struggle to inspire global resistance movements.

A bicarboxaminoquinoline-based ratiometric fluorescent sensor for the sequential detection of Zn2+ and PPi

A new ratiometric fluorescent sensor (LP) based on bicarboxaminoquinoline was designed and synthesized for sequentially recognizing Zn2+ and PPi. In aqueous solution, LP exhibited the ratiometric fluorescence response towards Zn2+, along with the about 4-folds enhancement of fluorescence quantum yield. Subsequently, the LP-Zn2+ complex displayed the fluorescence recovery upon adding PPi through the displacement strategy. And the LODs of LP and its Zn2+ complex for sensing Zn2+ and PPi were found to be 15 nM and 5.5 nM, respectively. Notably, the reversibility of LP for sequentially sensing Zn2+ and PPi had been employed to construct the INHIBIT logic gate. Moreover, LP and its Zn2+ complex had been successfully utilized for the detection of Zn2+ and PPi in two real water samples and cells imaging.

A novel approach to exploit Small-Molecule glucagon-like Peptide-1 receptor agonists with high potency

Small-molecule glucagon-like peptide-1 receptor (GLP-1R) agonists are recognized as promising therapeutics for type 2 diabetes mellitus (T2DM) and obesity. Danuglipron, an investigational small-molecule agonist, has demonstrated high efficacy in clinical trials. However, further development of danuglipron is challenged by a high rate of gastrointestinal adverse events. While these effects may be target-related, it is plausible that the carboxylic acid group present in danuglipron may also play a role in these outcomes by affecting the pharmacokinetic properties and dosing regimen of danuglipron, as well as by exerting direct gastrointestinal irritation. Therefore, this study aims to replace the problematic carboxylic acid group by exploring the internal binding cavity of danuglipron bound to GLP-1R using a water molecule displacement strategy. A series of novel triazole-containing compounds have been designed and synthesized during the structure–activity relationship (SAR) study. These efforts resulted in the discovery of compound 2j with high potency (EC50 = 0.065 nM). Moreover, docking simulations revealed that compound 2j directly interacts with the residue Glu387 within the internal cavity of GLP-1R, effectively displacing the structural water previously bound to Glu387. Subsequent in vitro and in vivo experiments demonstrated that compound 2j had comparable efficacy to danuglipron in enhancing insulin secretion and improving glycemic control. Collectively, this study offers a practicable approach for the discovery of novel small-molecule GLP-1R agonists based on danuglipron, and compound 2j may serve as a lead compound to further exploit the unoccupied internal cavity of danuglipron's binding pocket.

Bright luminescent Zn2GeO4:Mn NP/MXene hydrogel-based ECL biosensor for glioblastoma diagnosis

In this work, miRNA-10b in the glioblastoma (GBM) tumor tissues has been detected by a novel electrochemiluminescence (ECL) biosensor. Firstly, a new kind of bright luminescent Zn2GeO4:Mn NPs were prepared as ECL nanoprobe, which possessed high fluorescence quantum yield and ECL quantum efficiency. Secondly, Ti3C2 MXene hydrogel (MXG) have been developed as the sensing interface. The MXG retained the inherent biocompatibility and mechanical features of hydrogel. Furthermore, the uniform distribution of metallic Ti3C2 MXene in the hydrogel microstructure provided the good conductivity and multiple binding sites for biomolecules. MXene also can promote the separation of the electrons and holes to accelerate the electron-transfer rate and improve ECL efficiency. Due to these synergistic effects, the screen printed electrode was successfully modified with MXG as sensing platform to enhance the ECL intensity of Zn2GeO4:Mn NP, which greatly improved the detection efficiency and facilitated the high-throughput analysis. Finally, the toehold mediated strand displacement (TMSD) strategy was employed with then biosensor to detect miRNA-10b with the range of 10 fM to 1 nM. The limit of detection was 5 fM. This ECL biosensor has been used to analyze miRNA-10b expression in GBM tumor tissues, which possessed the great potential value for clinical diagnosis.

Sectarianism, indiscriminate violence and displacement in the Syrian Regime’s Civil War strategy

ABSTRACT In the Syrian Civil War, external observers have often misunderstood and misrepresented the nature and significance of indiscriminate violence that drives displacement, with the result that it has been (mis)understood as being driven by primordial sectarian hatred. This is of course far from the only contemporary civil war in which sectarianism has been ascribed without due care and consideration. While this article acknowledges sectarianism as part of the conflict; however, it treats it as less of a natural ‘outgrowth’ and more as part of a calculated and deliberate ‘coercive counterinsurgency’ strategy that the Regime has applied across the country. The article suggests that indiscriminate violence, which we might otherwise be predisposed to view as an ‘excess’, should be understood as part of a strategy, and more specifically a ‘coercive counterinsurgency’. Therefore, the article identifies four population displacement strategies (bombings, blockades, starvation and massacres) that the Regime has applied in four parts of the country and brings out their strategic features in clearer detail. Ultimately, the reader will come to understand how sectarianism, indiscriminate violence, and displacement function as part of an integrated ‘coercive counterinsurgency’ strategy that the Regime has developed and applied over the course of the Civil War.

Probiotic Effect of Streptococcus dentisani on Oral Pathogens: An In Vitro Study.

Probiotics, including Streptococcus dentisani, have been proposed as an alternative to re-establish the ecology of the oral cavity and inhibit the formation of pathogenic biofilms. The main objective of this work was to assess the probiotic ability of S. dentisani against Streptococcus mutans, Streptococcus mitis, and Candida albicans biofilms. The ability of the strains to form a monospecies biofilm and the probiotic potential of S. dentisani using the competition, exclusion, and displacement strategies were determined. All strains were moderate biofilm producers. The ability of S. dentisani to compete with and exclude S. mutans and S. mitis during biofilm formation was not significant. However, S. dentisani significantly reduced pathologic streptococcal biofilms using the displacement strategy. Also S. dentisani reduced the formation of the C. albicans biofilm mainly through competition and displacement. In vitro, S. dentisani exhibited probiotic potential to reduce the formation of potentially pathogenic biofilms. Further investigation is required to understand the biofilm-inhibiting mechanisms exhibited by this probiotic strain.

Prosecutorial Language, Moral Disengagement, and Sentencing Outcomes in Real Capital Murder Cases

AbstractLanguage reflecting moral disengagement has been shown to influence juries in mock juror studies; however, little to no research has examined this in actual murder cases. Prosecutors play an influential role in capital murder cases during both the guilt phase and sentencing phase of the trial. If a defendant is found guilty, jurors must then decide the appropriate sentence, which can be difficult when the penalties include death versus life without parole. Self-report and mock trial studies suggest that jurors may engage in moral disengagement methods (e.g., moral justification, dehumanizing language) that allow them to distance themselves from the decision. Capital murder trial transcripts were analyzed to investigate the influence of moral disengagement variables on sentencing (“death” versus “life without the possibility of parole”). Results indicate that arguments for future dangerousness were positively correlated with death penalty verdicts, although other types of moral disengagement language strategies were not. An additional linguistic strategy was included, which investigated language that might garner empathy for the victim. This was also positively correlated with a death penalty verdict. This analysis of capital murder trial transcripts reveals differences in influential moral displacement strategies than mock juror studies suggest.

An efficient online successive reanalysis method for dynamic topology optimization

In this study, an efficient reanalysis strategy for dynamic topology optimization is proposed. Compared with other related studies, an online successive dynamic reanalysis method and a Proper Orthogonal Decomposition (POD)-based approximate dynamic displacement strategy are integrated. In the dynamic reanalysis, the storage of the stiffness matrix decomposition can be avoided, and the reduced basis vectors should be successively updated according to the structural state in each iteration. Thus, the bottleneck of the combined approximation method for large-scale dynamic topology optimization can be overcome. Sequentially, POD is applied to obtain the approximate dynamic displacement, in which the Proper Orthogonal Mode (POM) of the displacement field is applied to obtain the approximate equivalent static loads of the Equivalent Static Load (ESL) method. Compared to the exact equivalent static loads at all the time intervals, the number of equivalent static loads is significantly reduced. Finally, the 2D and 3D test results indicate that the proposed method has remarkable speed-up effect under the premise of small relative error, support the strength of the proposed strategy.

Impairment of Listeria monocytogenes biofilm developed on industrial surfaces by Latilactobacillus curvatus CRL1579 bacteriocin

The effect of lactocin AL705, bacteriocin produced by Latilactobacillus (Lat.) curvatus CRL1579 against Listeria biofilms on stainless steel (SS) and polytetrafluoroethylene (PTFE) coupons at 10 °C was investigated. L. monocytogenes FBUNT showed the greatest adhesion on both surfaces associated to the hydrophobicity of cell surface. Partially purified bacteriocin (800 UA/mL) effectively inhibited L. monocytogenes preformed biofilm through displacement strategy, reducing the pathogen by 5.54 ± 0.26 and 4.74 ± 0.05 log cycles at 3 and 6 days, respectively. The bacteriocin-producer decreased the pathogen biofilm by ∼2.84 log cycles. Control and Bac− treated samples reached cell counts of 7.05 ± 0.18 and 6.79 ± 0.06 log CFU/cm2 after 6 days of incubation. Confocal scanning laser microscopy (CLSM) allowed visualizing the inhibitory effect of lactocin AL705 on L. monocytogenes preformed biofilms under static and hydrodynamic flow conditions. A greater effect of the bacteriocin was found at 3 days independently of the surface matrix and pathogen growth conditions at 10 °C. As a more realistic approach, biofilm displacement strategy under continuous flow conditions showed a significant loss of biomass, mean thickness and substratum coverage of pathogen biofilm. These findings highlight the anti-biofilm capacity of lactocin AL705 and their potential application in food industries.

3D-printed Laponite/Alginate hydrogel-based suppositories for versatile drug loading and release.

Traditional approaches to solid rectal therapies have halted progress, leading to a continual decline in the use of conventional suppositories. Additive manufacturing techniques have been recently explored as a suitable innovative tool for suppository fabrication. However, little advancement has been made in composition materials for 3D-printed suppository (3DPS) manufacturing and still, conventional vehicles are often used for construct fabrication, hindering the growth in the field. As a novelty, this study unveils a ground-breaking Laponite-alginate hydrogel-based 3DPS. Interestingly, this study proposes a novel approach for loading drugs into the 3DPS employing for the first time the post-printing loading. Thus, a passive loading strategy of molecular models is developed, demonstrating the versatility and capacity to load molecules of different charges and molecular sizes within the matrix systems. This novel strategy allows adapting the load of a wide range of drugs into a single ink, which simplifies and speeds up the 3DPS technological development process for drugs with different physico-chemical properties. Additionally, in this research, a displacement strategy of the three-dimensional Laponite matrices is developed in order to enhance the drug release capacity through the 3DPS and their disintegration capacity, resulting in a significant improvement of the drug diffusion through the hydrogel matrix and a rapid disintegration of the 3DPS. Finally, our study demonstrates that the obtained 3DPS have a suitable in vivo behavior, being non-obstructive and allowing the normal motility of the rats intestine.

Supramolecular complexation of phenylephrine by cucurbit[7]uril in aqueous solution.

Cucurbiturils (CBn) are known to establish stable host-guest complexes with a variety of drug molecules. Herein, the supramolecular complexation between cucurbit[7]uril (CB7) and phenylephrine hydrochloride is reported in aqueous solution. Phenylephrine forms inclusion complex with CB7 with high binding affinity (Kaffinity = 4.0 × 106 M-1), which allows for the development of a fluorescence-based sensing assay applying the dye displacement strategy. The structure of the host-guest inclusion complex is investigated by 1H NMR spectroscopy, in which complexation-induced chemical shifts indicate the immersion of the aromatic ring inside the hydrophobic cavity of CB7. Density functional theory (DFT) calculations support the 1H NMR results, and reveal that the complex is stabilized through intermolecular interactions between the polar groups on the phenylephrine and the carbonyl rims of CB7, as well as the hydrophobic effect. Moreover, preferential binding of phenylephrine in its protonated over the neutral form results in a complexation-induced pKa shift.

Multiple hydrogen bonding driven supramolecular architectures and their biomedical applications.

Supramolecular chemistry combines the strength of molecular assembly via various molecular interactions. Hydrogen bonding facilitated self-assembly with the advantages of directionality, specificity, reversibility, and strength is a promising approach for constructing advanced supramolecules. There are still some challenges in hydrogen bonding based supramolecular polymers, such as complexity originating from tautomerism of the molecular building modules, the assembly process, and structure versatility of building blocks. In this review, examples are selected to give insights into multiple hydrogen bonding driven emerging supramolecular architectures. We focus on chiral supramolecular assemblies, multiple hydrogen bonding modules as stimuli responsive sources, interpenetrating polymer networks, multiple hydrogen bonding assisted organic frameworks, supramolecular adhesives, energy dissipators, and quantitative analysis of nano-adhesion. The applications in biomedical materials are focused with detailed examples including drug design evolution for myotonic dystrophy, molecular assembly for advanced drug delivery, an indicator displacement strategy for DNA detection, tissue engineering, and self-assembly complexes as gene delivery vectors for gene transfection. In addition, insights into the current challenges and future perspectives of this field to propel the development of multiple hydrogen bonding facilitated supramolecular materials are proposed.

TRAJECTORIES OF DISPLACEMENT: (NON)WRITTEN AND ERASED BIOGRAPHIES

The paper examines some ‘stories’ of female artists who were connected (in different ways) to Belarusian cultural space, mainly in the first half of the twentieth century. Despite women’s prominent and incontestable contribution to art, firstly, as producers, their role and place are still mainly invisible in ‘global’ and ‘local’ art history, whose ‘canon’ is oriented on the male experience. Exploring history and the strategies of displacement, erasing, forgetting, and non-recognition of female producers in art, the paper asks about so-called universal common patterns of how this marginalisation (and, as a result, absent) still happens, no matter what field — art, science, technology — in any area which is considered as a male realm. Discussing several obstacles scholars might face in the process of reconstructing women’s biographies, the author argues that the feminist approach of storytelling aims not merely to extend ‘history’. It is a strategy to trouble the existing male-oriented ‘canon’ that contributes to creating multidiverse and plural ‘epistemic spaces’ as the fundamental matter of transnational feminism.

Highly stretchable, environmentally stable, self-healing and adhesive conductive nanocomposite organohydrogel for efficient multimodal sensing

Conductive hydrogel (CH) has drawn widespread interest in flexible electronics, human–computer interaction, and electronic skins (e-skins). However, it is challenging to integrate satisfactory self-adhesion, self-healing, environmental stability, and multi-stimulus response into a single CH system. Herein, a conductive nanocomposite organohydrogel with the above characteristics is well-designed and developed via incorporating carboxylic cellulose nanofibers-carrying carboxylic carbon nanotubes (C-CNTs) and phytic acid (PA) into polyacrylamide network through free-radical polymerization plus glycerol solvent displacement strategy, aiming for a high-performance multimodal sensing platform. Here, the coupling of C-CNTs and ionization of PA contributes a favorable conductivity, and the coexistence of glycerol and PA is beneficial for the formation of amounts of hydrogen bonds that endow the organohydrogel with outstanding stretchability, self-healing, and favorable adhesion in a wide temperature range of −30 to 60 °C. Besides, the resultant organohydrogel can effectively detect multiple external stimuli, manifesting high strain sensitivity over a broad strain range (0–1566 %), good humidity detectability at 0–85 % RH, and reliable thermosensation capability over a wide temperature window (−30 to 60 °C). Significantly, the application of the organohydrogel as e-skins are conducted to detect full-range human activity movements even in the extreme environments, identify hand gestures, and recognize the spatial distribution of humidity in noncontact sensing. All these indicate the preponderance of our organohydrogel in the fields of flexible smart electronics.