Disease In Young Women Research Articles

Hormone Receptor Positive Breast Cancer in Young Women: A Review.

The global incidence of hormone-positive breast cancer (HR+ BC) in young women is rising, though the underlying reasons remain unclear. HR+ disease in younger women appears to represent a distinct clinical entity compared to that in older women, exhibiting distinct clinicopathological characteristics, outcomes and responses to treatment. Despite these differences, there is a paucity of large-volume data focusing on young women with HR+ in contemporary literature. Hormone receptor positive breast cancer in young women is associated with poorer prognoses compared to older women. Additionally, early age onset breast cancer presents unique challenges, including concerns related to fertility, the toxic effects of therapeutic agents, and specific surgical considerations. The purpose of this review is to report the existing literature on HR+ disease in young women.

Pregnant Women with Multiple Sclerosis: An Overview of Gene Expression and Molecular Interaction Using Bioinformatics Analysis.

Multiple sclerosis (MS) is a common disease in young women of reproductive age, characterized by demyelination of the central nervous system (CNS). Understanding how genes related to MS are expressed during pregnancy can provide insights into the potential mechanisms by which pregnancy affects the course of this disease. This review article presents evidence-based studies on these patients' gene expression patterns. In addition, it constructs interaction networks using bioinformatics tools, such as STRING and KEGG pathways, to understand the molecular role of each of these genes. Bioinformatics research identified 25 genes and 21 signaling pathways, which allows us to understand pregnancy patients' genetic and biological phenomena and formulate new questions about MS during pregnancy.

ПРИОБРЕТЕННАЯ ГЕМОФИЛИЯ А В РЕАЛИЯХ СОВРЕМЕННОЙ МЕДИЦИНЫ: ОПЫТ КЛИНИЧЕСКОЙ ПРАКТИКИ

Abstract. Introduction. Acquired hemophilia A is a rare form of severe coagulopathy with an autoimmune mechanism of development. It occurs due to the formation of circulating inhibitory factor VIII (FVIII) antibodies, which leads to impaired activation of factor X and the occurrence of spontaneous bleeding in patients without previous hemostasis system pathology. In about a half of the cases, FVIII autoantibodies appear in patients without any comorbidities. It should be noted that the average age of patients was 74 years at the time of diagnosis. However, the occurrence of the disease in young women is rare and may be associated with pregnancy and childbirth. Given the rarity of this disease, the management of these patients is a challenging clinical problem. Aim. To describe a clinical case of diagnosis and treatment of a patient with the inhibitor form of acquired hemophilia A (AHA). Materials and Methods. A 38–year–old female patient had acute hemorrhagic syndrome of the hematoma type, manifested by large hematomas in different areas of the body. During the patient’s stay in the hospital, standard lab tests were made, the test results were evaluated over time, and instrumental diagnostics was performed. Results and Discussion. The typical hematoma type of bleeding detected during diagnosing, prolongation of coagulation parameters, presence of factor VIII inhibitor (605 BU), and a decrease in factor VIII level down to 0.5%) verified the AHA diagnosis. Methods of substitution, immunosuppressive therapy, and monoclonal antibodies were successfully used to treat AHA in this patient. The patient is followed up by a hematologist at the place of residence. Hematomas did not recur. Conclusions. This clinical observation demonstrates the peculiarities of the course, diagnostic algorithm, and management of patients with AHA without any concomitant pathology, with a history of only prolonged postpartum uterine bleeding, and with no autoimmune or malignant diseases.

Beneficial effects of human umbilical cord mesenchymal stem cell (HUCMSC) transplantation on cyclophosphamide (CTX)-induced premature ovarian failure (POF) in Tibetan miniature pigs

BackgroundPremature ovarian failure (POF), also known as primary ovarian insufficiency, is a common endocrine disease in young women. The emergence of regenerative medicine using stem cells may improve ovarian function and structure, and represents a promising prospect for POF treatment. In his study, we explored the therapeutic effects of human umbilical cord mesenchymal stem cell (HUCMSC) transplantation in a Tibetan miniature pig model of cyclophosphamide (CTX)-induced POF. MethodsWe cultured and identified HUCMSCs, labeled them with DiR iodide red dye, and implanted them into a CTX-induced model of POF in Tibetan miniature pigs. The daily weight changes were recorded, and the levels of estradiol (E2) and follicle-stimulating hormone (FSH) were measured on days 0, 7, and 14. At the end of the 21-day observation period, in vivo imaging of the bilateral ovaries was performed, and the ovarian index was measured. Ovarian tissue morphology and follicles were examined by hematoxylin-eosin staining. The terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling assay was employed to assess cell apoptosis, and immunohistochemistry was used to determine the levels of p-AKT, p-ERK1/2, BAX, and BCL2 expression. ResultsOur analysis indicated successful delivery of HUCMSCs to the ovaries of the POF pig model. Significant increases were observed in body weight, E2 levels, ovarian index, and number of normal follicles (all p < 0.05). Moreover, FSH levels reduced and ovarian tissue morphology improved following HUCMSCs transplantation (all p < 0.05). Importantly, upregulated p-AKT, p-ERK1/2, and BCL2 expression were observed, whereas the expression of BAX was suppressed (all p < 0.05), suggesting the inhibition of ovarian cell apoptosis. ConclusionOur study highlights the significant therapeutic effects of HUCMSC transplantation on CTX-induced POF in a Tibetan miniature pig model.

Adenomyosis and endometriosis in adolescents and young women with pelvic pain: prevalence and risk factors.

The aim of this study was to evaluate the prevalence of ultrasound diagnosis of adenomyosis and endometriosis in young women complaining of pelvic pain and to find the symptoms and clinical characteristics associated with these diseases in young women. Cross-sectional study, including 100 young women (14-24 years) with a history of chronic pelvic pain. Women were asked detailed medical hystory and pain symptoms scores (Visual Analogue Scale) and underwent gynecological examination and ultrasound evaluation. The prevalence of endometriosis and adenomyosis in young women amounted to 25.0% and 46.0%, respectively. A significant correlation was found between ovarian endometriosis and adenomyosis. Dysmenorrhea and dyspareunia were risk factors for adenomyosis. Dyschezia, dyspareunia, chronic pelvic pain, presence of sonographic soft markers suggestive of pelvic adhesions, being a worker and having a previous surgery were risk factors for endometriosis. Young women (20-24 years) had a higher incidence of both adenomyosis and endometriosis than adolescents (14-19 years). Our outcomes strengthen the hypothesis of a progressive and common course of the natural history of endometriosis, which initially may manifest with symptoms, then with signs of pelvic adhesions and finally as adenomyosis, ovarian endometriomas or deep infiltrating endometriosis.

Abstract 12874: Risk of Ischemic Heart Disease in Young Women With Dysmenorrhea: A Cross-Sectional Study on Electronic Health Records

Introduction: Ischemic heart disease (IHD) incidence is increasing among young individuals, particularly women. Suboptimal primary prevention due to risk underestimation is thought to contribute to this trend. Non-traditional risk factors, such as stress and female-specific factors, are often overlooked but offer an opportunity to improve risk stratification. Dysmenorrhea is the most prevalent menstrual complaint, and associated with increased stress and autonomic dysfunction. To date, contribution of dysmenorrhea to cardiovascular disease risk has not been investigated. Hypothesis: Dysmenorrhea is associated with increased risk of IHD before 50 years of age. Methods: We extracted a cohort of 30,554 women with dysmenorrhea and 25,350 controls from Mount Sinai data warehouse as shown in Fig 1. For statistical analysis we performed full propensity score matching on demographic and clinical covariates, followed by weighted logistic regression with IHD before age 50 as a binary outcome. We then investigated IHD subtypes (angina, acute myocardial infarction (AMI), AMI complications, chronic IHD) in separate regression models, and evaluated the inclusion of menstrual abnormalities (MA) and endometriosis as additional covariates in the models (vs other covariates only). Results: Dysmenorrhea was associated with a significant increase in the OR for overall IHD, angina and chronic IHD (Table 1), independently from MA or endometriosis. Conclusions: Dysmenorrhea might be an important risk factor for early IHD. The risk appears to be largest for angina and chronic IHD. Further research can investigate dysmenorrhea as a predictor of future IHD risk.

Female Genital Tuberculosis and Subfertility: Nobel Approaches for Successful Reproductive Outcome with Anti Tubercular Drug Therapy in Bangladesh Perspective

Background: Female Genital Tuberculosis is one of the important causes of infertility in Bangladesh. An early diagnosis and treatment with ATT (Anti Tubercular Therapy) is important to prevent adverse sequlae and can improve reproductive outcome. Aims and Objectives: The aim of the study is to evaluate the reproductive outcome of infertile patients with GTB. Methods: The present prospective observational study was conducted in Reproductive Endocrinology and Infertility Department of BSMMU from January 2018 to December 2021. Thirty (30) infertile women suspected of Genital Tuberculosis (GTB) who undergone hystero-laparoscopy as a part of infertility work up were included in our study. Results: GTB is the disease of young women with the mean age 27.5 ± 5.49 years in our study and most commonly present with primary infertility (63.33%). After completing antitubercular treatment, 90% of the study group had resumed normal menstrual cycles. A comparable proportion (16.67%) of GTB patients receiving ATT conceived, all without the aid of IVF. Among those who were conceived, 60% pregnancy remained uneventful, 20% had abortion, and 20% had ectopic pregnancy. The median length of time to conception after initiation of ATT was 4 months, stressing the role of ATT in conception in women with GTB. Conclusions: In low-income countries like Bangladesh where IVF is costly, Anti Tubercular Therapy may be started even on the basis of positive DNA PCR result or on the basis of laparoscopic and hysteroscopic findings. Effective anti- tubercular therapy can provide successful reproductive outcome in infertile patients with Genital TB.

Analysis of breast cancer development in young women: an integrative review

Breast cancer is the second most frequent type of cancer in the world and is a global public health problem due to its severity and magnitude, and despite being infrequent in younger women, it has recently been increasing in this age group. Breast cancer in young women stands out for presenting more aggressive histopathological aspects, are usually discovered as advanced disease, presenting worse prognosis and higher mortality rate. Objective: To analyze the scientific production regarding breast cancer in young women. Methodology: This is an Integrative Literature Review in the period from 2009 to 2018, being carried out by means of specific terms in the LILACS and Virtual Health Library databases. Articles that investigated breast cancer in young women were retrieved. Results and discussions: In the selected period, six studies were identified that met the established selection criteria, being four retrospective studies, one analytical-prospective and one did not discriminate the method. It was evidenced that after the year 2014 a deficit of publications with the specific theme, highlighting the need for more updated studies in addition to expanding the exploration of the subject to all geographic regions of Brazil, since the predominant regions in the studies found were the Southeast and South of the country. Conclusion: It is evident the limited exploration of the subject, being necessary to emphasize the need for expansion in scientific production, considering the greater aggressiveness, recurrence and worse prognosis of this disease in younger women.

Association between polycystic ovary syndrome and non-infectious uveitis

Polycystic ovary syndrome (PCOS) is a common endocrine disease in young women. It has been reported that increased proinflammatory cytokines can induce systemic inflammation. However, the association between PCOS and uveitis remains elusive. In this study, we investigate the possible association between PCOS and uveitis using Korean National Health Insurance Service-National Sample Cohort. The incidence of non-infectious uveitis was compared between patients with and without PCOS before and after propensity score matching. Hazard ratios were determined using univariate and multivariate Cox regression models. Of 558,302 female participants, 2039 had PCOS and 8122 had non-infectious uveitis. The incidence of non-infectious uveitis was 35.1 per 10,000 person-years in the PCOS patients compared to 16.6 in non-patients (P < .001). This tendency remained after 1:3 propensity score matching. The hazard ratio of PCOS using a multivariate Cox regression model was 2.79 (95% CI, 1.92–4.05; P < .001) and 2.87 (95% CI, 1.77–4.67; P < .001) before and after matching, respectively. Our results suggests that PCOS is associated with non-infectious uveitis, particularly in women of reproductive age. This may be due to hormonal changes and proinflammatory factors. Future investigations should examine the clinical features and underlying mechanisms.

Артериит Такаясу после перенесенной коронавирусной инфекции у молодой женщины: клиническое наблюдение

The article describes the clinical onset of Takayasu's arteritis (non-specific aortoarteritis) which occurred after coronavirus disease in a young woman with Still's disease in her medical history. Takayasu's arteritis primarily affects young women, most commonly of Asian race. Clinical manifestations of the disease can be conditionally divided into two groups: non-specific symptoms, indicating a systemic inflammatory response, and specific symptoms associated with the damage of the aorta and its branches. Physical examination plays an important role in diagnosing Takayasu's arteritis. Characteristic signs of the disease include vascular bruits over the large arteries, arterial blood pressure differentials in the right and left extremities, and failure to palpate pulse on the radial arteries (therefore it is also called pulseless disease). Imaging diagnostic techniques include contrast-enhanced angiography and Duplex sonography of the vessels. Etiology of the disease is not fully understood. Research papers present data showing that novel coronavirus infection could be a triggering factor in the emergence of vasculitis of the large vessels, including Takayasu's arteritis. This should be taken into consideration in the management of patients belonging to the risk group. KEYWORDS: Takayasu's arteritis, non-specific aortoarteritis, COVID-19, post-COVID-19 syndrome, vasculitis, Stills' disease. FOR CITATION: Gordeev I.G., Vechorko V.I., Otarova S.M. et al. Takayasu's arteritis after coronavirus disease in young woman: case report. Russian Medical Inquiry. 2023;7(3):181–186 (in Russ.). DOI: 10.32364/2587-6821-2023-7-3-181-186.

Cardiometabolic Risk and Cardiovascular Disease in Young Women With Uterine Fibroids.

Uterine fibroids are associated with hypertension and cardiometabolic risk factors, yet the onset and severity of cardiovascular disease (CVD) in women with fibroids remain understudied. We used data from the National Health and Nutrition Examination Survey to assess the association between uterine fibroids, cardiometabolic risk, and CVD (ischemic heart disease, heart failure, and stroke). Among 5,552 women aged 20-54 years in our sample. Hypertension was more common in those diagnosed with fibroids (n=700; 33.4% vs. 15.3% in controls, p<0.001), but these women were also older (44 (SD=7) years vs. 35 (SD=10) years). When stratified by median age, women aged 35 or younger with fibroids (n=97) were more likely than controls (n=2771) to have hypertension (14.1% vs. 2.4%), obesity (51.5% vs. 32.5%), and diabetes mellitus (4.8% vs. 1.9%). Women older than 35 with fibroids also had higher cardiometabolic risk and rates of CVD than controls (8.5% vs. 4.5%). The odds ratio of CVD in women with fibroids, compared to the controls, was 3.10 with 95% confidence interval (CI) of 2.21 to 4.34. The odds ratio decreased to 1.63 (95%CI: 1.11 to 2.38) after adjusting for age, BMI, African ancestry, fasting plasma glucose, cholesterol, education, smoking history, and postmenopausal status and to 1.60 (95%CI: 1.08 to 2.37) after further adjusting for systolic blood pressure. These data indicate that uterine fibroids are associated with a worse cardiovascular risk profile, including hypertension, in relatively young women, leading to early CVD. A women-specific research agenda is urgently needed to study the nature of these associations and design preventive strategies to prevent cardiovascular events in young women with fibroids.

Value of speckle tracking echocardiography for detection of clinically silent left ventricular dysfunction in patients with systemic lupus erythematosus

Background and Aims : Background: SLE is a chronic autoimmune inflammatory rheumatological disease. Characterized by autoantibodies directed against nuclear antigens. It is a disease of young women, with a peak incidence between the ages of 15 and 40 with a female: male ratio of 9:1. Cardiac involvement in patients with SLE is common. Subclinical involvement is more common than Clinically apparent cardiomyopathy or myocarditis Aim: Assess LV function in asymptomatic SLE patients by conventional, speckle tracking and tissue Doppler echocardiography.

Effects of Hypertension on the Incidence of Acute Coronary Syndrome and Severity of Coronary Artery Disease in Young Women

Abstract Background To investigate the effects of hypertension on the prevalence of acute coronary syndrome (ACS) and the severity of coronary artery disease in young women in northern China. Methods A retrospective analysis was performed on 840 young female patients (age &amp;lt;45 years old) underwent coronary angiography due to chest pain or chest discomfort between January 2007 and December 2016. The patients were divided into hypertension group (256 cases) and control group (584 cases). The risk factors and prevalence of ACS, and coronary stents implantation in the 2 groups were studied. Results The prevalence of ACS was higher in the hypertension group compared with the control group (80.9% vs. 36.5%, P &amp;lt; 0.05). The rates of hyperlipidemia (37.1% vs. 14.9%), hypercholesterolemia (8.6% vs. 3.4%), hyperuricemia (18.4% vs. 7.2%), and hyperhomocysteinemia (10.9% vs. 3.9%) were all significantly higher in the hypertensives compared with controls (all P &amp;lt; 0.05). The hypertension group had higher rates of overweight (63.7% vs. 29.5%), family history of early coronary heart disease (15.2% vs. 5.5%), smoking (5.5% vs. 4.3%), menopause (4.7% vs. 1.7%), and type 2 diabetes (24.2% vs. 8.9%) compared with the control group (all P &amp;lt; 0.05). Double branch lesions of coronary artery in hypertension and control groups were 14.1% and 5.7%, respectively (P &amp;lt; 0.05). Further, hypertensive patients with ACS had higher number (1.67 ± 1.05 vs. 1.41 ± 0.85) and longer (24.44 ± 6.97 vs. 22.85 ± 7.80 mm) stents implantation than the control group (P &amp;lt; 0.05). Conclusions Hypertension is the main risk factor of ACS in young women in northern China. Young women with hypertension have more risk factors for atherosclerotic cardiovascular disease.

Data Analytics of Electronic Health Records to Enhance Care of Coronary Artery Disease in Younger Women with Avoiding Possible Delay in Treatment.

Early detection plays a key role to enhance the outcome for Coronary Artery Disease. We utilized a big data analytics platform on ∼32,000 patients to trace patients from the first encounter to CAD treatment. There are significant gender-based differences in patients younger than 60 from the time of the first encounter to Coronary Artery Bypass Grafting with a p-value=0.03. This recognition makes significant changes in outcome by avoiding delay in treatment.

POSB140 Healthcare Utilization and Costs of Human Papillomavirus (HPV) Associated Anogenital Diseases in Young Women: An Analysis of Statutory Health Insurance Claims Data from Germany

Human Papillomavirus (HPV) is the most common and second most expensive sexually transmitted infection. Most sexually active individuals acquire HPV in adolescence and early adulthood. For Germany, local data on healthcare resource utilization (HCRU) and costs for HPV-related anogenital diseases (AGD) in young women are lacking. Our prior work demonstrated the burden of AGD in young women aged 23-25 years using German statutory health insurance claims data. Using this same database, this study aimed to investigate HCRU and incremental costs of AGD in these young women.

Prognostic factors and molecular subtypes in young women with breast cancer

Introduction: Because of its high incidence, breast cancer is the subject of numerous studies today. Despite being an uncommon disease in young women, when it affects this population, it tends to be more aggressive and has high mortality rates. Objective: The objective of this study was to evaluate the prognostic factors present in the immunohistochemical profile of young women with breast cancer, comparing the age groups of very young women (&lt;35 years old — Group I) and young women (between 35 and 40 years old — Group II), to see if the data obtained match what is reported in the literature. Methods: A cross-sectional study was carried out, analyzing the immunohistochemical tests of 90 female patients with invasive breast carcinoma. The groups were classified on the basis of molecular subtype: luminal A, luminal B, hybrid luminal, human epidermal growth factor receptor 2 positive and triple-negative. Results: The histological type with the highest incidence was invasive breast carcinoma of no special type. The most frequent molecular subtypes were luminal B and triple-negative. With regard to estrogen and progesterone receptors, there was a slight predominance of positive receptors. Ki-67 levels showed that in the triple-negative and human epidermal growth factor receptor 2 positive subtypes, there was a predominance of high cell proliferation index. Conclusion: In the population of young women in this cohort of patients, there was agreement with literature data regarding the predominance of the invasive carcinoma of no special type histological type and the luminal B and triple-negative molecular subtypes, and the presence of high cell proliferation rates, attesting to the higher prevalence of more aggressive tumors in the younger population. There was also no statistically significant difference in all aspects analyzed when comparing Groups I and II. However, a higher frequency of negative hormone receptors or overexpressed human epidermal growth factor receptor 2 molecular subtypes was not detected, characteristics that are common to young women with breast cancer, which has been pointed out in several studies worldwide.

Coronary Artery Disease in Young Women After Radiation Therapy for Breast Cancer: The WECARE Study

BackgroundRadiation therapy (RT) for breast cancer increases risk of coronary artery disease (CAD). Women treated for left- vs right-sided breast cancer receive greater heart radiation exposure, which may further increase this risk. The risk of radiation-associated CAD specifically among younger breast cancer survivors is not well defined. ObjectivesThe purpose of this study was to report CAD risk among participants in the Women’s Environmental Cancer and Radiation Epidemiology Study. MethodsA total of 1,583 women who were <55 years of age when diagnosed with breast cancer between 1985 and 2008 completed a cardiovascular health questionnaire. Risk of radiation-associated CAD was evaluated by comparing women treated with left-sided RT with women treated with right-sided RT using multivariable Cox proportional hazards models. Effect modification by treatment and cardiovascular risk factors was examined. ResultsIn total, 517 women who did not receive RT and 94 women who had a pre-existing cardiovascular disease diagnosis were excluded, leaving 972 women eligible for analysis. Their median follow-up time was 14 years (range 1-29 years). The 27.5-year cumulative incidences of CAD for women receiving left- vs right-sided RT were 10.5% and 5.8%, respectively (P = 0.010). The corresponding HR of CAD for left- vs right-sided RT in the multivariable Cox model was 2.5 (95% CI: 1.3-4.7). There was no statistically significant effect modification by any factor evaluated. ConclusionsYoung women treated with RT for left-sided breast cancer had over twice the risk of CAD compared with women treated with RT for right-sided breast cancer. Laterality of RT is independently associated with an increased risk of CAD and should be considered in survivorship care of younger breast cancer patients.

Sporadic multiple parathyroid gland disease in young woman with primary hyperparathyroidism

Sporadic multiple parathyroid gland disease in young woman with primary hyperparathyroidism

Health behaviour of women with Turner Syndrome.

AimThis study assessed lifestyle‐related risk factors for cardiovascular disease in young women with Turner syndrome.MethodsIn 2012, we sent a questionnaire to women with Turner syndrome aged ≥18 years and living in Switzerland with questions on socio‐demographic and medical data as well as health behaviour. We compared the reported lifestyle with that of women from the Swiss Health Survey 2012, a representative survey of the general population.ResultsFifty‐seven per cent (45/79) of women with Turner syndrome answered the questionnaire (mean age: 24 years). Eighty per cent (36/45) had never smoked compared with 58% (1156/1972) of the general population (p < 0.01). Women with Turner syndrome engaged less often in binge drinking (34% vs. 71%) (p < 0.001), but consumed alcohol equally often as the general population (p = 0.327). They performed sports as often as the general population (p = 0.34), but only one quarter (11/45) of women with Turner syndrome adhered to official physical activity recommendations.ConclusionAlthough most women with Turner syndrome had a healthy lifestyle, only a minority had sufficient physical activity. Paediatricians should promote structured physical activity in girls with Turner syndrome from early childhood onwards to reduce their cardiovascular risk in adulthood and to increase long‐term health‐related quality of life.

Abstract IA25: Black Lives Matter Worldwide: Retooling Precision Oncology for True Equity of Cancer Care

Abstract Analysis of cancer genomes has provided fundamental insights into the process of malignant transformation, and cancer genomes have rapidly become an integral part of the practice of clinical oncology, with implications for diagnosis, prognosis, treatment and prevention. Inherited and sporadic cancers often share common mutational events. When inherited mutations are identified, genetic counseling is an essential component of care. Risk-stratified breast cancer screening strategies are a paradigm shift from the one-size-fits-all screening approach. Previous age-based screening strategies proved to be disadvantageous to specific minority populations, particularly those at high risk for interval breast cancers developed at a younger age with a poorer prognosis. With the increasing use of personalized risk assessment tools in the clinic and the uptake of risk-reducing prevention and early detection interventions, risk-stratified screening approaches promise to reduce racial disparity in breast cancer outcomes. Using high throughput whole genome strategies, including genome-wide association studies, whole exome sequencing, and whole genome sequencing, we can now deeply explore the most foundational instigators of the most aggressive forms of breast cancer. Work from our group and others have demonstrated the significant burden of early onset ER negative breast cancer as well as high rates of pathogenic BRCA1 and BRCA2 mutations among African American and Hispanic women in the US. Globally, breast cancer is a disease of young women and pathogenic mutations in BRCA1 and BRCA2 are the strongest predictors of risk and have also been categorized as the strongest predictors of aggressive prostate cancer risk. Our work is informed by attentive, interdisciplinary study of the most aggressive phenotypes of breast cancer in diverse populations in the US and abroad. BRCA-associated basal-like breast cancers have defects in homologous recombination pathways and based on the fundamental biology of these tumors, there are novel pathways including DNA repair, metabolic and immune pathways that can potentially be targeted for more effective management strategies. While basal-like breast cancer remains the molecular subtype with the worst outcome in all populations, we have evidence from randomized clinical trials that it is most curable when diagnosed early and treated promptly with multimodality cancer therapies. Work from our group as well as other laboratories show that high temporal resolution Dynamic Contrast Enhanced Magnetic Resonance Imaging (DCE-MRI) is likely to increase lesion conspicuity and diagnostic accuracy. Our group is also pioneering the potential of an automated, quantitative radiomics platform on DCE-MRI breast imaging for inferring underlying activity of clinically relevant gene expression pathways of invasive breast cancers at diagnosis. Waiting to treat advanced cancer with targeted therapies is a failure of primary prevention and population-based strategies for risk assessment and management in high-risk populations will be needed. I will discuss our recent findings and future directions for the early detection and prevention of the most aggressive subtypes of breast cancer in vulnerable high-risk populations. Citation Format: Olufunmilayo Olopade. Black Lives Matter Worldwide: Retooling Precision Oncology for True Equity of Cancer Care [abstract]. In: Proceedings of the AACR Virtual Conference: Thirteenth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2020 Oct 2-4. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(12 Suppl):Abstract nr IA25.