Direction Of Scientific Research Research Articles

School of ecological selection of academician of the Russian academy of sciences V.F. Pivovarova

The article outlines the main milestones in the formation of the scientific school of Academician of the Russian Academy of Sciences Viktor Fedorovich Pivovarov – a talented organizer of scientific research on vegetable growing, a leading scientist in the field of ecology, introduction, selection and seed production of vegetable crops, Honored Scientist of the Russian Federation, laureate of the State Prize and Government Prizes of the Russian Federation V. Pivovarov. F. has extensive experience both in Russia and abroad in solving theoretical and practical problems in the industry. He developed a new scientific direction of research on ecological selection and genetics of vegetable crops. The article presents the directions of the ecological selection scientific school: increasing the adaptability of agricultural crops to various environmental factors; identifying the peculiarities of the genotype-environment interaction; development of methods for accelerating the breeding process to create highly productive varieties and hybrids resistant to abiotic and biotic stressors; ecological selection for low levels of radionuclides and technologies that reduce the amount of pollutants in vegetable products. School of V.F. Pivovarov Academician of the Russian Academy of Sciences was organized on the basis of common scientific interests, the importance of environmental research for breeding, a high level of scientific results, continuity and great development prospects.

Beyond the P-Value: The Significance of Inconclusive Results and the Role of the IIRF in Advancing Scientific Inquiry

In scientific research, there is a noticeable lack of specific studies focused on inconclusive results, in contrast to the abundance of studies dedicated to conclusive or positive outcomes. While conclusive results offer definitive answers, inconclusive results, often viewed less favorably, do not provide such clarity. However, they play a vital role in the scientific process by identifying gaps and inspiring future research. This paper introduces the pioneering Integrated Inconclusive Results Framework (IIRF), a significant development that addresses the challenges associated with inconclusive results. The Framework aims to promote a shift in the perception of inconclusive results from setbacks to crucial components of scientific progress, ultimately enhancing scientific inquiry's rigor, transparency, and overall quality. The paper delves into the historical treatment of inconclusive results, causes, and strategies for handling them, offering insights into utilizing them to inspire and guide future research, thereby strengthening the scientific community and instilling confidence and reassurance in the direction of scientific research.

Criteria and levels of readiness of future physical training and sports instructors for professional activity

According to the results of the analysis of a number of scientific and methodological sources, it was established that the level of physical readiness of the representatives of the studied category directly affects the quality and efficiency of their performance of assigned tasks. This actualizes the need for all-round harmonious and physical development of the soldier's personality. Therefore, the high-quality and effective organization of the system of training future instructors in physical training and sports for the needs of institutions of the security and defense sector of Ukraine is relevant and timely. Taking into account the results of the monitoring of current scientific and methodological and special literature by the members of the scientific research group, it was established that studies that comprehensively reveal the peculiarities of the organization of the system of professional education of future instructors in physical training and sports are rare. In the process of theoretical research, the following methods were used: axiomatic, idealization, historical and logical, descent from the concrete, formalization, as well as the experience of organizing the system of professional education of military specialists in physical training and sports for the needs of institutions of the security and defense sector of Ukraine. As a result of the theoretical study, the members of the scientific research group determined the "criteria" (basic- motivational; substantive-content and analytical-evaluative), corresponding "indicators" and "levels" of the readiness of future physical training and sports instructors for professional activity. Prospects for further research in the chosen direction of scientific research provide for the development of organizational and pedagogical conditions for the formation of the readiness of future instructors in physical training and sports for professional activity.

Optimizing the individual technique of veteran Sambo wrestlers using modern technical training tools

Analytical reports of leading martial arts analysts indicate that today there is a positive trend in increasing the popularization of single combat among veteran athletes, especially Sambo wrestling. It is necessary to highlight that according to its essential and substantive characteristics (internal philosophy), Sambo wrestling is a living matter that has absorbed the best techniques of modern martial arts, and which is in a constant process of transformation in accordance with the requirements and realities of today. Taking into account the above, it is appropriate to summarize that the scientific and methodical (technical) support of the key components of the professional activity of veteran athletes who specialize in Sambo wrestling (other martial arts) acquires a dominant role. According to the results of the analysis of scientific and methodological and special literature, it was established that complex studies that reveal the peculiarities of the organization of the system of long-term training of sportsmen-veterans who specialize in Sambo wrestling are rare. In the process of research and analytical work, we used the following methods: axiomatic, idealization, historical and logical, descent from the concrete, formalization. As a result of a theoretical study, the members of the research group developed a program for improving the Sambo fighting technique of veteran athletes with an emphasis on the use of the video computer system "Katsumoto" (at the stage of direct preparation for the main competitions). Prospects for further research in the chosen direction of scientific research include conducting a pedagogical experiment to test the effectiveness of our proposed experimental program for improving the technical skills of veteran Sambo wrestlers with an emphasis on the use of modern technical training tools.

Organizational and pedagogical conditions for the formation of the readiness of future physical training and sports instructors for professional activity

Today, physical training and sports instructors play a key role in the training of military personnel of various categories and age groups, because in the process of professional activity they ensure the development and improvement of: physical qualities and military-applied skills; psychophysical readiness to act in extreme conditions, etc. The theoretical research was carried out in accordance with the plan of the initiative scientific project "SPT Instructor, 2022-2025" with the participation of leading specialists in physical training (physical education of various population groups) of representatives of specialized departments of higher military educational institutions (institutions of higher education) of Ukraine (in accordance with agreements on interdepartmental cooperation). According to the results of the analysis of the scientific and methodological literature by the members of the scientific research group, it was established that empirical studies that comprehensively reveal the peculiarities of the organization of the training process of instructors in physical training and sports in institutions of the security and defense sector of Ukraine are rare, which emphasizes the relevance of the chosen direction of scientific research. Research methods: axiomatic, experience of organizing the system of physical and special physical training of military personnel, idealization, instrumental, historical and logical, departure from the concrete, formalization. As a result of the research, we have developed organizational and pedagogical conditions for the formation of the readiness of future instructors in physical training and sports for professional activity (using the example of servicemen of the National Guard of Ukraine who study at the courses of instructors in physical training and sports).

Militarization of containment policy

The author makes an attempt to explore the interdependence between military and nonforce forms and methods of imposing one’s will on the enemy in the process of escalating military conflicts of our time. Important attention is paid to comparing the likely results of the use of tactical nuclear weapons as a tool of deterrence and hybrid warfare technologies as a new type of interstate confrontation. It is shown that hybrid warfare is a powerful means of infl uencing the enemy when solving complex problems of ensuring national security and turns into the most important factor in political and diplomatic influence and achieving national goals, without resorting to destructive nuclear influences. In the context of the transformation of the world order, new acute challenges and threats are emerging today, the response to which leads to powerful geopolitical shifts on all continents. In these conditions, the complexity of strategic forecasting and planning the actions of individual states and their coalitions requires serious collective eff orts to maintain stability and ensure sustainable development of the world, and the use of a full range of political, diplomatic, economic and information tools to influence the situation. An important condition for the successful solution of such a task is the coordination of national approaches to the development of philosophy and technologies for resolving modern military conflicts,the use for these purposes of the potential of international security organizations, the transformation of educational programs and the direction of scientific research. The primary tasks are to bring them into line with the realities of our time and improve the quality of Russia’s strategic planning documents, taking into account the experience of the Northern Military District.

Київська лінгвістична славістика першої чверті ХХІ ст.: загальний огляд

Ahead of the 17th International Congress of Slavists in Paris in 2025, this article offers a general overview of the directions of scientific research in the first quarter of the 21st century by linguists-slavists of Kyiv, where leading academic and university Slavic centers are concentrated. From the perspective of terminology, linguistic Slavistics includes studies of the languages of Western and Southern Slavs, both separately and in a comparative plan, as well as against the broad background of Slavic linguistics. A brief overview of key works, mainly monographic, lexicographic, and linguistic didactic, is proposed. It is noted that linguists-slavists continue to research Slavic languages in comparative-historical, taxonomic, and communicative-functional paradigms, developing the ideas of leading Ukrainian Slavists of the 20th century and the first quarter of the 21st century — O. S. Melnychuk, V. M. Rusanivskyi, V. G. Sklyarenko, G. P. Pivtorak, O. B. Tkachenko, T. B. Lukinova, A. P. Nepokupny and others. The works of scholars are dedicated to theoretical and practical problems of semantics, etymology, dialectology, onomastics, ethnolinguistics, etc. Among the latest directions within which current issues of Western and Southern Slavic languages are researched are studies in linguocognitology, linguistic pragmatics, and linguofuturology. Attention is drawn to the prospects of Ukrainian linguistic Slavistics, which at the present stage is the work of enthusiasts devoted to their domain. The problem, among other things, is related to the training of personnel in universities, where study hours in the main linguistic and literary disciplines are reduced, interest in postgraduate studies diminishes, and economic difficulties have a negative impact.

Geoprocessing of archival aerial photos and their scientific applications: A review

Abstract Poland as well as other countries keep extensive collections of 20th and 21st-century aerial photos, which are underexploited compared to such other archival materials as satellite imagery. Meanwhile, they offer significant research potential in various areas, including urban development, land use changes, and long-term environmental monitoring. Archival photographs are detailed, often obtained every five to ten years, and feature high resolution, from 20 cm to 1 m. Their overlap can facilitate creating precise digital models that illustrate topography and land cover, which are essential variables in many scientific contexts. However, rapidly transforming these photographs into geographically accurate measurements of the Earth’s surface poses challenges. This article explores the obstacles in automating the processing of historical photographs and presents the main scientific research directions associated with these images. Recent advancements in enhancing work˚ows, including the development of modern digital photogrammetry tools, algorithms, and machine learning techniques are also discussed. These developments are crucial for unlocking the full potential of aerial photographs, making them easier accessible and valuable for a broader range of scientific fields. These underutilized photographs are increasingly recognized as vital in various research domains due to technological advancements. Integrating new methods with these historical images offers unprecedented opportunities for scientific discovery and historical understanding, bridging the past with the future through innovative research techniques.

Using the model of closed-loop economy in certain branches of the agro-industrial complex

From agricultural production to domestic consumption of products, the food industry produces huge amounts of waste every year, which leads to contamination of soil, water and air. Waste created upon processing agricultural raw materials and using axillary materials, such as additives, certain chemical components, fuel and so on, enhances an impact of the food chain on the environment leading to depletion of natural resources. In the last few years, production branches of economy, including the agro-industrial complex, have made attempts to maintain the balance between their impact on the environment, the use of resources, well-being of the population and economic benefits. This trend stimulates the intensive development of the theory of circular (cyclic) economy or closed-loop economy and facilitates a search for methods of its realization in the real economic system. The paper summarizes the main specific features typical of circular economy: strengthened control of supply of limited natural resources and maintenance of the stable balance of renewable resources; optimization of consumption processes by development and use of products, components and materials that correspond to the highest level of their reuse; detection and prevention of negative external effects of current production activities to increase efficiency of the economic and ecological systems. With that, despite the fact that the concept of circular economy was formulated several decades ago, its comprehensive definition is still a subject of discussions. Ambiguity of the existing definitions shows that the concept of closed-loop economy has different meaning for stakeholders. The paper examines several aspects of using elements of closed-loop economy in certain branches of the agro-industrial complex, including the meat industry. A special attention in this work is given to the introduction of modern technologies and equipment for efficient processing of waste from crop husbandry, animal husbandry and meat production to include it into the economic turnover. In addition, ecological problems arising in the course of activities of enterprises of the food and processing industries are examined and the possibilities of solving these problems by introduction of the model of circular economy have been established. Risks and barriers preventing transition of Russia to the model of circular economy have been revealed. The authors propose measures and directions of scientific research aimed at the development and introduction of elements of closed-loop economy in the meat sub-complex, including related branches of the agro-industrial complex.

Academician of medicine Z.V. Ermolyeva and the Department of Microbiology of the Central Institute for Advanced Medical Training: the main directions of scientific research in the early 1970s

The very difficult geopolitical situation of recent years has once again confirmed the need for our state to focus on its internal and self-sufficient development in its development. The story of the coronavirus pandemic that swept the whole world has shown a fairly high level of domestic virology, and microbiology in general. But, undoubtedly, we are still far from the Soviet level of science development today. In this regard, it seems advisable to pay attention to the generalization of the Soviet experience in the development of biomedical sciences. We have made an attempt to analyze the development of Soviet microbiology through an analysis of the scientific and organizational activities of the domestic scientist, Academician of Medicine Zinaida Vissarionovna Ermolyeva, carried out by her at the Department of Microbiology of the Central Institute of Advanced Medical Training in the first half of the 1970s. The source base of the publication was unpublished documents of the federal archives (the Russian State Archive of Scientific and Technical Documentation and the Russian State Archive of Economics), most of which are being introduced into scientific circulation for the first time. The article examines the scientific activity of Z.V. Ermolyeva herself, as well as those research areas that were developed by teachers and research staff of the department headed by her.

FORMATION OF INTERPERSONAL COMMUNICATION SKILLS IN THECONDITIONS OF UKRAINE'S INTEGRATION INTO THE EUROPEAN HIGHEREDUCATION COMMUNITY

The article summarizes the results of scientific work and highlights the experience and approaches to the formation of interpersonal communication skills in the context of Ukraine’s integration into the European higher education community. It is stated that the European integration progress of Ukraine is accompanied by positive changes in the socio-economic development of society and the introduction of innovative changes in the field of higher education, which are aimed at successful political, legal, economic, and educational integration into the European space. It is noted that since 2005, Ukraine has been participating in the Bologna process, i.e. an international initiative aimed at reforming and unifying higher education in the countries of the European area of higher education. It is found that the alignment of the national system of higher education with European and world standards involves the transition to the system of competence education. The classification of integrated characteristics of the quality of training of education seekers and the results of their training, i.e. competencies, is given. It is pointed out that one of the key positions among “soft” skills is occupied by communicative competence, which requires the formation of interpersonal communication skills. The categories of theories of interpersonal communication are defined and characterized. A model of effective interpersonal communication is proposed, which provides for the achievement of individual group and organizational results thanks to a properly adjusted process of filtering perception and cognitive selection, as well as taking into account the situational characteristics of communication. A taxonomy of interpersonal communication skills is given. It is noted that training students of higher education in effective interpersonal communication skills requires teachers with relevant knowledge, as well as guidance and instruction in learning to develop and improve these skills. It is substantiated that for the successful formation of interpersonal communication skills in higher education students of Ukraine, it is necessary to study the experience and implement the practices of the European educational space. Prospective directions for further scientific research on the formation of interpersonal communication skills among students of higher education are outlined.

Gear Hobs-Cutting Tools and Manufacturing Technologies for Spur Gears: The State of the Art.

The present work aims to provide the readers with a bird's-eye view of the general domain of cylindrical gear manufacturing technologies, including the cutting tools used, and related topics. The main scientific sources are explored to collect data about the subject. A systematization of the scientific works is completed, to emphasize the main issues the researchers have focused on in the past years in the domain. Several specific aspects are investigated: chip-forming process, cutting tool lifetime, the materials used to produce gear hobs, temperature and lubrication, the cutting tool geometry, cutting parameters, design methods, and optimization. Some gaps in the research have been identified, which are mainly related to the gear hob's design. These gaps, the organization of knowledge, the current requirements of the industry, and the actual socio-economic priorities form the basis for identifying new scientific research directions for the future in the area of spur gears manufacturing technologies and cutting tools. The main output of this work is a frame to guide the development of scientific research in the domain of spur gear production.

Implementation of a Digital Model of Thermal Characteristics Based on the Temperature Field

Introduction. Computer modeling allows engineers to make valid design decisions by accurately assessing the thermal characteristics of design objects. The implementation of digital twin technology in the process of designing technical facilities is the current direction of scientific research and development. To do this, it is necessary to develop computer models whose accuracy meets the requirements for digital twins. However, the scientific literature does not widely present the results of research aimed at implementing digital twin technology in the design process. The general issues related to the use of digital twins in various industries are mainly considered. Therefore, the objective of this study was the development of a digital model and a comparative analysis of the accuracy of calculations of thermal characteristics of the design object.Materials and Methods. The main tool for conducting the research was the methodology proposed by the authors for developing a computer model of thermal characteristics for the implementation of digital twin technology. The numerical solution was implemented through constructing a thermal model for calculating the temperature field based on the finite element method in the ANSYS engineering analysis system from ANSYS, Inc. (USA). For the analytical solution, a computer model of thermal characteristics developed on the basis of the state-space method, implemented in the ANSYS Twin Builder module, was used. The state-space model was matched to the behavior of the original thermal model through approximating the transfer function to the stepwise response of the thermal load using the time domain vector approximation method. Verification of the constructed analytical model was carried out in the engineering calculation system MATLAB from the MathWorks company (USA). The research was carried out for a 400V machine model manufactured by NPO “Stankostroenie” LLC, Sterlitamak (Russia).Results. The developed digital model makes it possible to calculate the thermal characteristics of the design object with high accuracy. The results of the comparative analysis showed a high degree of correspondence between the values of thermal characteristics obtained using the proposed digital model and the results of numerical simulation. The maximum error in calculating thermal characteristics did not exceed 0.1ºC.Discussion and Conclusion. Computer modeling that combines numerical calculation methods and a scientific approach based on digital twin technology, provides obtaining the result as close as possible to the results of experiments. The digital model proposed in the study is an effective solution, since it provides performing calculations to evaluate thermal characteristics in real time, which is one of the most important requirements for the implementation of digital twin technology.

Fraudulent act: essence and legal regulation

The article examines current issues of science and practice regarding the definition of the essence, signs and legal regulation of a fraudulent transaction as one of the types of contracts in civil law. The importance of the category of “deeds” for civil law is emphasized. Modern scientific positions on understanding the essence of the “fraudulent act” categories are defined and analyzed. The author's vision of the understanding of the above-mentioned category is proposed, under which, in a general sense, a transaction is defined where the debtor (as one of the parties) performs dishonest actions in order to avoid fulfilling his or her obligation to the creditor. The necessity of forming a unified approach to defining the essence of the category of fraudulent transaction is emphasized. The principles of civil legislation, which are violated as a result of the conclusion of a fraudulent transaction, and the court practice on this issue are defined. The essence of the violation of the principle of good faith when concluding a fraudulent transaction is clarified. The need to make appropriate changes to the current civil legislation of Ukraine in order to standardize judicial practice and eliminate existing legislative gaps is emphasized. The judicial practice is analyzed and a review of court decisions regarding the fraudulent transaction and its essential conditions is carried out. It has been established that private law instruments should not be used by participants in civil transactions to avoid paying a debt (money, damages, damage) or to execute a court decision on debt collection (money, damages, damage) that has entered into force. The article notes that a fraudulent contract can be both paid and unpaid. A paid fraudulent contract has its own specifics and features that distinguish it from another fraudulent contract (for example, a free one). The right to evil is singled out as a sign of a committed fraudulent act. Further prospective directions of scientific research on certain issues of fraudulent transactions have been established.

Оценка дефицита местного бюджета в условиях глобальных вызовов: содержание, причины и пути оптимизации

Introduction. The impact of global challenges in the modern world establishes its own technologies for achieving balance in planning and using budget finances in Russia. These problems acquire a special spectrum within the framework of a large number, diversity of legal types, natural and geographical features of the territory and financial independence of local budgets. Local budgets are the most significant source of financing for public utility infrastructure facilities that residents of municipalities use every day, which ultimately determines the comfort and quality of living in the local area. This article aims to consider the theoretical and methodological approaches to the content and causes of the local budget deficit and to substantiate the criteria for the effectiveness of its financing with an uncertain revenue base and increasing costs for organizing the provision of municipal services in all areas of expenditure obligations of local governments. To substantiate the working hypothesis of the study, we point out that local budgets of all legal types of municipalities have gratuitous transfers from higher-level budgets as the main source of revenue base, a small amount of tax initiative and budgetary powers to assess their expenditure obligations. As a rule, all these powers are regulated at the federal and regional levels.The methodological basis of the study was the provisions of the Keynesian and neo-Keynesian schools of budget regulation, taking into account the new model of municipal governance. The empirical basis of the study was the control indicators of draft budgets of a number of municipalities of the Sverdlovsk region, obtained by the author from official sources and the results of the webinar with representatives of financial departments as part of local governments of the Sverdlovsk region.Results and conclusions. The results of the study identified the criteria for the formation and implementation of an effective budget deficit policy, formulated practical recommendations for local governments to optimize the financing of the local budget deficit and servicing the debt obligations of the municipality in the context of prevention and adaptation to global challenges. As further directions of scientific research, it is necessary to indicate an assessment of the possibilities of applying these criteria by local governments to the reformed provisions of the budget legislation of Russia, expected for 2030-2036.

APPLICATION OF MODERN METHODS OF ANALYSIS FOR DETERMINATION OF POLLUTION AND IDENTIFICATION OF PLANT RAW MATERIALS

Quality control of herbal preparations is an important component to ensure the effectiveness and safety of their use. Phytochemical medicines are made from medicinal plant materials that may contain unwanted chemical compounds, so careful quality control must be performed to ensure their safety and efficacy. The success of quality control of herbal materials requires an integrated approach, i.e. a combination of various techniques and methods that allow analyzing the main classes of compounds. Various methods of analysis are used to overcome these difficulties. Today, the main chemical methods for determining the quality of medicinal products are chromatographic, in particular gas chromatography (GC), often combined with mass spectrometry (MS), liquid chromatography (HPLC), thin-layer chromatography (TLC), column chromatography (CC). Besides, HILIC is the optimal method for the analysis of polar and ionized compounds that are too strongly retained on polar stationary phases and/or poorly separated by standard chromatographic methods. TLC/HPTLC methods are traditionally used by the SPhU and the European Pharmacopoeia for identification of herbs and detection of impurities by visual assessment, as well as for semi-quantitative determination of compounds when comparing the intensity of the spot in the zone of the tested solution with spots in the zones of reference compounds. The mentioned methods have still remained the most acceptable for the identification of herbs, which is explained by the unique chromatographic profile of each plant or extract based on it. At the same time, the instrumental method of HPLC has advantages due to the possibility of quantitative determination of substances that fluoresce in UV or visible light. Nowadays, the direction of scientific research devoted to the optimization of the previously described analytical methods and the development of new ones for the identification of both herbs and herbal materials, as well as herbal remedies, becomes relevant. In addition, the development of methods for the quantitative determination of herbal compounds is a relevant scientific and practical direction.

Methodological and legislative approaches regarding virtual reality / Artificial Intelligence as tools for interconnection between biodiversity and neuropsychiatric disorders

Neuropsychiatric disorders have an increasing percentage among the current human population, which is why the use of biodiversity elements in their treatment is a key aspect in the process of psychological rehabilitation, based on biophilia. It is currently used as an intermediate VR/AI tool to generate positive emotions and well-being, based on nature images of landscapes and biodiversity. Although there are a number of problems that arise in the use of VR / AI in the biomedical field, mainly due to legislative and ethical aspects, the digitization of the biomedical field represents the opening of new perspectives on the diagnosis and treatment of neuropsychiatric disorders, resulting in new directions of scientific research aimed at significantly improving the study and understanding of the healing mechanisms of psychopathologies.

Anticancer properties of 1,2,4-triazole derivatives (literature review)

Cancer is still one of the leading causes of death worldwide. Statistical data show that more than 130,000 people in Ukraine receive this diagnosis as a sentence every year. Cancer can affect any organ and eventually the whole body. In most cases, cancer is a tumor affecting epithelial, mucous, muscle, fat, and bone tissues. Also, processes related to malignant formations can occur in the blood and lymph. The main mechanism that triggers the process of formation of neoplasms is a violation of growth and, accordingly, cell division. They begin to grow uncontrollably, multiply, and can also migrate, spreading to nearby tissue structures, and later degenerate into atypical (malignant) ones. Cancer is one of the most life-threatening diseases. Literature data show that more than 90 % of cancer patients die due to chronic metastases. Cancer therapy involves the use of drugs that block the growth and spread of cancer cells by affecting certain molecular structures involved in the growth, progression, and spread of cancer. The diversity of the use of means for cancer therapy, namely, hormone therapy, the use of angiogenesis inhibitors and apoptosis inducers, has provided scientists with various options for finding effective means to fight this disease. Aim. The aim of the work is the analysis and systematization of new data on the anticancer activity of 1,2,4-triazole derivatives and the selection of the most promising directions for further scientific research based on the results of the analysis. Materials and methods. The study employed various methods, including analysis, information search, bibliosemantic analysis, descriptive techniques, and generalization. Research materials primarily comprised literary sources containing information on the promising array of new biologically active compounds, particularly 1,2,4-triazole derivatives, known for their targeted anticancer properties. Results. A literature search was carried out, 1,2,4-triazole derivatives with antitumor activity were analysed, characterized and summarized. Based on the study of available information and conducting an information and patent search, it was established that the market of Ukraine is insufficiently saturated with 1,2,4-triazole-containing drugs with anticancer activity of domestic production. It was determined that the development of new effective drugs based on 1,2,4-triazole and potential drugs with clearly directed anticancer activity requires a systematic approach both in conducting synthetic tests and screening new compounds for further structural optimization of molecules. Conclusions. The analysis of scientific literature in recent years devoted to the study of the anticancer activity of 1,2,4-triazole derivatives convincingly proves the prospect of further research in this direction. Numerous publications indicate the possibility of constant improvement of molecules with regard to the presence of anticancer activity. Domestic and foreign authors have clearly and argumentatively proven the perspective of the scientific direction for the creation of new original drugs to combat various oncopathologies.

The scientific legacy of professor Y.V. Krykavskyi: development of logistics theory in Ukraine and future perspectives

The article presents the first attempt at scientometric analysis of the scientific legacy of the prominent Ukrainian scholar, Doctor of Economic Sciences, Professor Yevhen Vasylovych Krykavskyi. The main stages of his scientific work and its impact on the development of the general theory and practice of logistic science in Ukraine are identified. It is demonstrated that Y.V. Krykavskyi himself formulated the theoretical foundations of logistics as a separate direction of scientific research in the field of economic sciences, established the basic conceptual framework, founded a scientific school of marketing and logistics, and trained a large number of candidates and doctors of sciences who continue and deepen the theoretical developments of the great scientist, as well as expand the spheres of practical application of logistic concepts, tools, and methods, and supply chain management in new economic conditions.

The Importance of Investments in Scientific Research in the Innovative Activity of Industrial Enterprises

In the article, the importance of investments in scientific research in the implementation of digital transformation and automation in industrial enterprises is studied on the example of developed countries, such as USA, theoretical and practical proposals are made for directing investments in scientific research in digitization and automation of industrial enterprises of Uzbekistan. The innovative activity of industrial enterprises should be such that it creates innovations in all processes: from research and development to production, from production to management, from sales to delivery to consumers, to study of the post-consumer situation, introduction of new digital and automated technologies, management system evaluation of activities, improvement of the functionality of products and technologies, reduction of costs and increase of efficiency, organization and production of marketing and advertising activities, with coverage of consumers, convenient delivery to customers, packaging, clarification of product description and rules of use of the product, as well as benefits or advantages obtained as a result processes should be covered. In addition, having a certain share of the main products in the total volume of production, it is possible to create business models with the aim of achieving a large amount of income from the main products due to the increase in the volume of sales with new technologies of production. The use of investment funds by industrial enterprises in the direction of scientific research in their innovative activities has a great effect.